Latest & greatest articles for amitriptyline

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Top results for amitriptyline

1. Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial

Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial 30285054 2018 11 05 2168-6114 178 11 2018 Nov 01 JAMA internal medicine JAMA Intern Med Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial. 1474-1481 10.1001/jamainternmed.2018.4222 Antidepressants at low dose are commonly prescribed for the management of chronic low back pain and their use is recommended in international clinical guidelines. However (...) , there is no evidence for their efficacy. To examine the efficacy of a low-dose antidepressant compared with an active comparator in reducing pain, disability, and work absence and hindrance in individuals with chronic low back pain. A double-blind, randomized clinical trial with a 6-month follow-up of adults with chronic, nonspecific, low back pain who were recruited through hospital/medical clinics and advertising was carried out. Low-dose amitriptyline (25 mg/d) or an active comparator (benztropine mesylate, 1

EvidenceUpdates2018

2. Amitriptyline

Amitriptyline Top results for amitriptyline - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for amitriptyline The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical

Trip Latest and Greatest2018

3. Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial

Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial 28719594 2017 07 18 2017 07 18 1572-0241 2017 Jul 18 The American journal of gastroenterology Am. J. Gastroenterol. Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. 10.1038/ajg.2017.194 Cyclic vomiting syndrome (CVS) is a common functional gastrointestinal disorder (...) characterized by recurrent episodes of nausea and vomiting. There is no definite treatment for the condition, although some medications are recommended. We aimed to compare the efficacy of amitriptyline and cyproheptadine in prophylactic therapy of CVS. This is a single-blinded randomized clinical trial conducted during 2015-2016 in Isfahan, Iran. Sixty-four children who were 3-15 years old, with a diagnosis of CVS (based on Rome III criteria), were included in the study and were randomly divided into two

EvidenceUpdates2017

4. Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency

Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency UTCAT3159, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency Clinical Question In adults with migraine headaches, is melatonin superior than (...) amitriptyline in preventing the frequency and intensity of migraine headaches? Clinical Bottom Line For patients with migraine headaches, melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline, and as effective as amitriptyline 25 mg. Tolerability measures included the incidences of adverse events, including those that led to the premature withdrawal from the study as well as those that were life threatening. Best Evidence (you may view more info by clicking

UTHSCSA Dental School CAT Library2017

5. Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine.

Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. BACKGROUND: Which medication, if any, to use to prevent the headache of pediatric migraine has not been established. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per kilogram of body weight per day), topiramate (2 mg per kilogram per day), and placebo in children and adolescents 8 to 17 years of age with migraine. Patients were randomly assigned in a 2:2:1 ratio (...) in the amitriptyline group, 130 in the topiramate group, and 66 in the placebo group). The trial was concluded early for futility after a planned interim analysis. There were no significant between-group differences in the primary outcome, which occurred in 52% of the patients in the amitriptyline group, 55% of those in the topiramate group, and 61% of those in the placebo group (amitriptyline vs. placebo, P=0.26; topiramate vs. placebo, P=0.48; amitriptyline vs. topiramate, P=0.49). There were also no significant

NEJM2016

6. Amitriptyline

Amitriptyline USE OF AMITRIPTYLINE IN PREGNANCY 0344 892 0909 USE OF AMITRIPTYLINE IN PREGNANCY (Date of issue: June 2014 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Amitriptyline is a tricyclic antidepressant (TCA) which (...) inhibits the re-uptake of both serotonin and noradrenaline, and is used in the treatment of depression (especially where sedation is required), neuropathic pain, and in migraine prophylaxis. The published data regarding exposure to amitriptyline in pregnancy are limited to around 1,200 exposed pregnancies, with even fewer exposed in the first trimester. However, the majority of data are derived from case reports and cohort studies, or from studies examining antidepressants in general which included

UK Teratology Information Service2014

7. Amitriptyline overdose

Amitriptyline overdose AMITRIPTYLINE OVERDOSE IN PREGNANCY 0344 892 0909 AMITRIPTYLINE OVERDOSE IN PREGNANCY (Date of issue: August 2013 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Amitriptyline is a tricyclic antidepressant (TCA) which is also used in the treatment of neuropathic pain (...) . There are no available data on which to assess the risk of fetal loss, low birth weight, prematurity or neonatal complications following overdose of amitriptyline in pregnancy. An association with an increased risk of spontaneous abortion, low birth weight and IUGR has been proposed with therapeutic use of TCAs and other antidepressants, however there is evidence to suggest that any increase in risk is linked to the underlying maternal depression and not necessarily to treatment with an antidepressant. No reports

UK Teratology Information Service2014

8. Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial.

Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. IMPORTANCE: Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist. OBJECTIVE: To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial of 135 youth (79 (...) % female) aged 10 to 17 years diagnosed with chronic migraine (≥15 days with headache/month) and a Pediatric Migraine Disability Assessment Score (PedMIDAS) greater than 20 points were assigned to the CBT plus amitriptyline group (n = 64) or the headache education plus amitriptyline group (n = 71). The study was conducted in the Headache Center at Cincinnati Children's Hospital between October 2006 and September 2012; 129 completed 20-week follow-up and 124 completed 12-month follow-up. INTERVENTIONS

JAMA2013

9. Limited evidence for benefit of amitriptyline for neuropathic pain and fibromyalgia in adults

Limited evidence for benefit of amitriptyline for neuropathic pain and fibromyalgia in adults Limited evidence for benefit of amitriptyline for neuropathic pain and fibromyalgia in adults | Cochrane Primary Care Top menu Trusted evidence. Informed decisions. Better health. Enter terms Limited evidence for benefit of amitriptyline for neuropathic pain and fibromyalgia in adults Cochrane Trusted evidence. Informed decisions. Better health. Copyright © 2017 The Cochrane Collaboration | |

Cochrane PEARLS2013

10. Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial.

Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. 24368463 2013 12 25 2013 12 31 2017 04 04 1538-3598 310 24 2013 Dec 25 JAMA JAMA Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. 2622-30 10.1001/jama.2013.282533 Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist (...) . To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. A randomized clinical trial of 135 youth (79% female) aged 10 to 17 years diagnosed with chronic migraine (≥15 days with headache/month) and a Pediatric Migraine Disability Assessment Score (PedMIDAS) greater than 20 points were assigned to the CBT plus amitriptyline group (n = 64) or the headache education plus amitriptyline group (n = 71). The study was conducted

JAMA2013

11. Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia.

Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. 21178598 2011 04 08 2011 08 04 2013 11 21 1536-5409 27 4 2011 May The Clinical journal of pain Clin J Pain Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. 285-8 10.1097/AJP.0b013e3181ffbfde The objective of this study (...) was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels. A prospective, randomized, double-blind comparative study was conducted in 30 patients. All patients received 25 mg amitriptyline; monotherapy group (n=15) received 125 mL saline, and combined therapy group (n=15) received 240 mg lidocaine in 125 mL saline once a week for 4 weeks. Serotonin, norepinephrine, and dopamine were measured in plasma at time zero

EvidenceUpdates2011

12. A Comparative Evaluation of Amitriptyline and Duloxetine in Painful Diabetic Neuropathy: A randomized, double-blind, cross-over clinical trial

A Comparative Evaluation of Amitriptyline and Duloxetine in Painful Diabetic Neuropathy: A randomized, double-blind, cross-over clinical trial 21355098 2011 03 30 2011 07 15 2015 11 19 1935-5548 34 4 2011 Apr Diabetes care Diabetes Care A comparative evaluation of amitriptyline and duloxetine in painful diabetic neuropathy: a randomized, double-blind, cross-over clinical trial. 818-22 10.2337/dc10-1793 To compare the efficacy and safety of duloxetine and amitriptyline in painful diabetic (...) neuropathy (PDN). In this randomized, double-blind, cross-over, active-control trial, 58 patients received amitriptyline and duloxetine orally once daily at bedtime, each for 6 weeks with optional dose uptitration fortnightly. Single-blinded placebo washout was given for 2 weeks between the two treatments and a single-blinded placebo run-out phase of 4 weeks was given at the end of the treatment period. Pain relief was measured by the patient's global assessment of efficacy, using a visual analog scale

EvidenceUpdates2011 Full Text: Link to full Text with Trip Pro

13. Low-dose amitriptyline for treatment of persistent arm pain due to repetitive use

Low-dose amitriptyline for treatment of persistent arm pain due to repetitive use 20172654 2010 03 08 2010 06 09 2016 11 22 1872-6623 149 1 2010 Apr Pain Pain Low-dose amitriptyline for treatment of persistent arm pain due to repetitive use. 117-23 10.1016/j.pain.2010.01.016 Amitriptyline is sometimes used to treat arm pain related to repetitive use, but rigorous evidence of its benefit is lacking. This randomized controlled trial investigated whether amitriptyline provided greater pain (...) relief or improved arm function than a placebo pill in adults with arm pain associated with repetitive use that had persisted for at least 3 months. Participants (N=118) were randomly assigned to receive 25mg of amitriptyline or a placebo pill for 6 weeks. The primary outcome was intensity of pain (10-point numerical rating scale) and secondary outcomes were arm symptoms, arm function, grip strength, mood, and sleep. Assessments were done at baseline, 3 and 6 weeks of treatment, and 1 month after the treatment

EvidenceUpdates2010 Full Text: Link to full Text with Trip Pro

14. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders

Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders 19596010 2009 10 05 2009 10 15 2016 11 22 1528-0012 137 4 2009 Oct Gastroenterology Gastroenterology Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. 1261-9 10.1053/j.gastro.2009.06.060 There are no prospective, multicenter, double-blind, placebo-controlled, randomized pharmacologic trials (...) for the treatment of pain-predominant functional gastrointestinal disorders in children. The aim of this study was to evaluate the efficacy of amitriptyline in children with pain-predominant functional gastrointestinal disorders. In this multicenter placebo-controlled trial, children with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia were randomized to 4 weeks of placebo or amitriptyline (10 mg/d, weight <35 kg; 20 mg/d, weight >35 kg). Assessment of gastrointestinal symptoms

EvidenceUpdates2010 Full Text: Link to full Text with Trip Pro

15. Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial

Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial 19900234 2009 11 10 2010 05 11 2015 11 19 1464-5491 26 10 2009 Oct Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. 1019-26 10.1111/j.1464-5491.2009.02806.x To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated (...) with diabetic peripheral neuropathy. A randomized, double-blind, crossover, active-control, clinical trial with variable dose titration was carried out (n = 51). Amitriptyline orally, at doses of 10, 25 and 50 mg at night-time and pregabalin orally, at doses of 75, 150 and 300 mg twice daily, by optional titration was used. Each drug treatment was of 5 weeks. There was a placebo washout period for 3 weeks between the two drugs. Assessment for pain relief, overall improvement and adverse events were carried

EvidenceUpdates2010

16. Cost effectiveness of venlafaxine compared with generic fluoxetine or generic amitriptyline in major depressive disorder in the UK

Cost effectiveness of venlafaxine compared with generic fluoxetine or generic amitriptyline in major depressive disorder in the UK Cost effectiveness of venlafaxine compared with generic fluoxetine or generic amitriptyline in major depressive disorder in the UK Cost effectiveness of venlafaxine compared with generic fluoxetine or generic amitriptyline in major depressive disorder in the UK Lenox-Smith A, Greenstreet L, Burslem K, Knight C Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of venlafaxine versus either generic fluoxetine or generic amitriptyline for the first-line treatment of patients with major depressive disorder. The authors concluded that, despite its relatively high

NHS Economic Evaluation Database.2009

17. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents

Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents 18410774 2008 04 15 2008 05 06 2013 11 21 1097-6833 152 5 2008 May The Journal of pediatrics J. Pediatr. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. 685-9 10.1016/j.jpeds.2007.10.012 To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents. Adolescents 12 (...) , and Nutrition, UCLA Geffen School of Medicine, Los Angeles, CA 91316, USA. bahar@bizla.rr.com Collins Brynie S BS Steinmetz Barry B Ament Marvin E ME eng Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't 2008 02 20 United States J Pediatr 0375410 0022-3476 0 Antidepressive Agents, Tricyclic 1806D8D52K Amitriptyline AIM IM J Pediatr. 2008 Dec;153(6):872; author reply 872-4 19014828 Abdominal Pain etiology prevention & control Adolescent Amitriptyline therapeutic use Antidepressive

EvidenceUpdates2008

18. Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy

Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy Nishishinya B, Urrutia G, Walitt B, Rodriguez A, Bonfill X, Alegre C, Darko G CRD summary The authors concluded that there was some evidence to support the short-term efficacy of amitriptyline 25mg/day for fibromyalgia, but no evidence to support (...) the efficacy of amitriptyline at higher doses or for periods longer than eight weeks. Much of the review was well conducted, but the analyses may be misleading and the overall results should not be considered as reliable. Authors' objectives To review the effectiveness of amitriptyline in the treatment of fibromyalgia. Searching EMBASE, MEDLINE and The Cochrane Library were searched. Search terms and dates were reported. An RCT filter was used and no language restrictions were applied. Databases of ongoing

DARE.2008

19. Amitriptyline for depression.

Amitriptyline for depression. BACKGROUND: For many years amitriptyline has been considered one of the reference compounds for the pharmacological treatment of depression. However, new tricyclic drugs, heterocyclic compounds and selective serotonin reuptake inhibitors have been introduced on the market with the claim of a more favourable tolerability/efficacy profile. OBJECTIVES: The aim of the present systematic review was to investigate the tolerability and efficacy of amitriptyline (...) amitriptyline with another tricyclic/heterocyclic antidepressant or with one of the selective serotonin reuptake inhibitors. DATA COLLECTION AND ANALYSIS: Data were extracted using a standardised form. The number of patients undergoing the randomisation procedure, the number of patients who completed the study and the number of improved patients were extracted. In addition, group mean scores at the end of the trial on Hamilton Depression Scale or any other depression scale were extracted

Cochrane2007

20. Amitriptyline for inpatients and SSRIs for outpatients with depression: systematic review and meta-regression analysis

Amitriptyline for inpatients and SSRIs for outpatients with depression: systematic review and meta-regression analysis Amitriptyline for inpatients and SSRIs for outpatients with depression: systematic review and meta-regression analysis Amitriptyline for inpatients and SSRIs for outpatients with depression: systematic review and meta-regression analysis Barbui C, Guaiana G, Hotopf M CRD summary This review examined the influence of study setting on the effect of amitriptyline compared (...) with other antidepressants. The authors concluded that it may be reasonable to use newer antidepressants as first-line treatment in out-patients with depression, and to use amitriptyline for in-patients with severe depression. Differences among the studies were not examined adequately, thus the conclusions may not be reliable. Authors' objectives To examine the effect of study setting (in-patient versus out-patient) on outcomes in clinical trials comparing amitriptyline with other antidepressants (ADs

DARE.2004