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Salbutamol Administration via Nebulizer Versus Metered-Dose Inhalers: Clinical Effectiveness and Cost-Effectiveness Salbutamol Administration via Nebulizer Versus Metered-Dose Inhalers: Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Salbutamol Administration via Nebulizer Versus Metered-Dose Inhalers: Clinical Effectiveness and Cost-Effectiveness Salbutamol Administration via Nebulizer Versus Metered-Dose Inhalers: Clinical Effectiveness and Cost (...) -Effectiveness Last updated: August 2, 2019 Project Number: RB1367-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of administering salbutamol via nebulizer versus metered dose inhalers in pre-hospital or emergency settings? What is the cost-effectiveness of administering salbutamol via nebulizer versus metered dose inhalers in pre-hospital or emergency settings? Key Message One randomized controlled trial and one non
Effect of Albuterol Premedication vs Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: The REACT Randomized Clinical Trial Tonsillectomy is a common pediatric procedure for the treatment of sleep-disordered breathing and chronic tonsillitis. Up to half of children having this procedure experience a perioperative respiratory adverse event.To determine whether inhaled albuterol sulfate (salbutamol sulfate) premedication decreases the risk (...) was conducted between July 15, 2014, and May 18, 2017.Participants were randomized to receive either albuterol (2 actuations, 200 μg) or placebo before their surgery.Occurrence of perioperative respiratory adverse events (bronchospasm, laryngospasm, airway obstruction, desaturation, coughing, and stridor) until discharge from the postanesthesia care unit.Of 484 randomized children (median [range] age, 5.6 [1.6-8.9] years; 285 [58.9%] boys), 479 data sets were available for intention-to-treat analysis
have questions please contact us via firstname.lastname@example.org Top results for albuterol 1. Clinical comparison of fenoterol and albuterol administered by inhalation. A double-blind study. 344007 1978 05 17 1978 05 17 2013 11 21 0012-3692 73 3 1978 Mar Chest Chest Clinical comparison of fenoterol and albuterol administered by inhalation. A double-blind study. 348-51 The effects of inhaling 0.4 mg of fenoterol hydrobromide (Berotec), 0.2 mg of albuterol (salbutamol), or placebo were compared (...) of Cardiogenic Pulmonary Edema. Congestive Heart Failure Drug: Albuterol Drug: Normal Saline Phase 2 Phase 3 Study Type: Interventional 2010 8. A Study to Look at Day to Day Changes in Lung Function in COPD Subjects Taking Albuterol /Salbutamol and Ipratropium A Study to Look at Day to Day Changes in Lung Function in COPD Subjects Taking Albuterol /Salbutamol and Ipratropium - Full Text View - ClinicalTrials.gov A service of the U.S. National Institutes of Health Example: "Heart attack" AND "Los Angeles
Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation: A Randomized Clinical Trial. It remains uncertain whether nebulization of mucolytics with bronchodilators should be applied for clinical indication or preventively in intensive care unit (ICU) patients receiving invasive ventilation.To determine if a strategy that uses nebulization for clinical indication (on-demand) is noninferior (...) to one that uses preventive (routine) nebulization.Randomized clinical trial enrolling adult patients expected to need invasive ventilation for more than 24 hours at 7 ICUs in the Netherlands.On-demand nebulization of acetylcysteine or salbutamol (based on strict clinical indications, n = 471) or routine nebulization of acetylcysteine with salbutamol (every 6 hours until end of invasive ventilation, n = 473).The primary outcome was the number of ventilator-free days at day 28, with a noninferiority
A Model-Based Meta-Analysis Evaluating Gender Differences on Blood Flow Responses to Brachial Artery Infusions of Acetylcholine, Albuterol, ATP, Bradykinin, Estradiol, Glyceryl Trinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance Numerous studies have emerged over the course of several decades describing the properties of drugs eliciting vasodilatory or vasoconstrictor responses in the human vasculature. During drug development, decisions to move forward with testing (...) with a new chemical entity are very costly. To fund or not to fund development, go or no-go, decisions are often limited by efficacy comparisons with the current products on the market. The primary aim of this paper is to use dose-response modeling and simulations to quantify differences in blood flow to Acetylcholine, Albuterol, ATP, Bradykinin, 17β-Estradiol, Glyceryl Trinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance P, and Verapamil.Five studies were identified
Salbutamol for transient tachypnea of the newborn. Transient tachypnea of the newborn is characterized by tachypnea and signs of respiratory distress. Transient tachypnea typically appears within the first two hours of life in term and late preterm newborns. Although transient tachypnea of the newborn is usually a self limited condition, it is associated with wheezing syndromes in late childhood. The rationale for the use of salbutamol (albuterol) for transient tachypnea of the newborn is based (...) on studies showing that β-agonists can accelerate the rate of alveolar fluid clearance.To assess whether salbutamol compared to placebo, no treatment or any other drugs administered to treat transient tachypnea of the newborn, is effective and safe in the treatment of transient tachypnea of the newborn in infants born at 34 weeks' gestational age or more.We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 3), MEDLINE (1996 to March 2016), EMBASE (1980 to March 2016
Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Beta-Agonist Lung (...) injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Gates S, Perkins G, Lamb S, Kelly C, Thickett D, Young J, McAuley D, Snaith C, McCabe C, Hulme C, Gao Smith F Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been
Combivent Respimat (ipratropium bromide and albuterol) Inhalation Spray Drug Approval Package: Combivent Respimat (ipratropium bromide and albuterol) NDA #021747 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Combivent Respimat (ipratropium bromide and albuterol) Inhalation Spray Company: Boehringer Ingelheim Pharmaceutical, Inc. Application No.: 021747 Approval Date: 10/07/2011 Persons with disabilities having problems accessing the PDF files below may
Active albuterol or placebo, sham acupuncture, or no intervention in asthma. In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma.In a double-blind, crossover pilot study, we randomly assigned 46 patients (...) with asthma to active treatment with an albuterol inhaler, a placebo inhaler, sham acupuncture, or no intervention. Using a block design, we administered one each of these four interventions in random order during four sequential visits (3 to 7 days apart); this procedure was repeated in two more blocks of visits (for a total of 12 visits by each patient). At each visit, spirometry was performed repeatedly over a period of 2 hours. Maximum forced expiratory volume in 1 second (FEV(1)) was measured
benefit (1 mg/ml: 20×2.5 ml (2.5 mg) @ £1.99 and 2 mg/ml: 20×2.5 ml (5 mg) @ £3.98). Clinical Bottom Line Patients admitted with acute exacerbations of COPD requiring nebulised therapy should be considered for 2.5 mg nebulised salbutamol in place of 5 mg. References Nair S. A Randomised Controlled Trial to Assess the Optimal Dose and Effect Of Nebulised Albuterol in Acute Exacerbations of COPD. Chest 2005;128;48-54. (...) Should I use 2.5mg or 5mg Nebulised Salbutamol in Acute Exacerbations of COPD? BestBets: Should I use 2.5mg or 5mg Nebulised Salbutamol in Acute Exacerbations of COPD? Should I use 2.5mg or 5mg Nebulised Salbutamol in Acute Exacerbations of COPD? Report By: Sandeep Rahul Kusre - Senior House Officer Search checked by Jonathan Costello - Consultant A&E Institution: Royal Free Hospital Date Submitted: 4th April 2009 Date Completed: 21st October 2010 Last Modified: 21st October 2010 Status: Green
Nebulised salbutamol or nebulised adrenaline for wheeze in anaphylaxis BestBets: Nebulised salbutamol or nebulised adrenaline for wheeze in anaphylaxis Nebulised salbutamol or nebulised adrenaline for wheeze in anaphylaxis Report By: Deepak Doshi - Specialist Registrar in Emergency Medicine Search checked by Bernard A Foëx - Consultant in Emergency Medicine and Critical Care Institution: Manchester Royal Infirmary Date Submitted: 2nd April 2007 Date Completed: 14th October 2009 Last Modified (...) : 1st September 2009 Status: Green (complete) Three Part Question In [patients with anaphylaxis] is [nebulised salbutamol better than nebulised adrenaline] at [reducing wheeze]? Clinical Scenario A 33 year school teacher arrives in the Emergency Department following a trip to the local botanical gardens. She has breathing difficulty with extensive expiratory wheeze and a florrid urticarial rash. She was given salbutamol by nebulizer in the ambulance. She continued to wheeze in the Emergency
Periodic salbutamol in facioscapulohumeral muscular dystrophy: a randomized controlled trial To evaluate the effects on muscle strength of salbutamol administered for 6 months using a periodic regimen in patients presenting with facioscapulohumeral muscular dystrophy (FSHD).Placebo-controlled double-blind randomized study.Three clinical centers involved in neuromuscular disorders.Ambulatory patients (N=112), 56 per group, with genetically confirmed FSHD, age 18 to 60 years.Salbutamol (sustained (...) released formulation) administered orally at a daily dose of 16 mg using a periodic dosage regimen (3 wks on, 1 wk off).Muscle strength was assessed with quantitative muscle testing (QMT), manual muscle testing (MMT), and timed motor tests. Patients were evaluated at baseline, and 3 and 6 months later. Plasma drug assays were carried out at each visit.There was no significant change with periodic use of salbutamol in the total composite QMT z-score, MMT score, or timed motor tests. Salbutamol was well
of nebulised salbutamol in patients with bronchiolitis. References Schuh S, Canny G, Reismann JJ, Kerem E, Bentur L, Petric M, Levison H. Nebulised albuterol in acute bronchiolitis. Journal of Pediatrics. 1990;117(4):633-637. Klassen TP, Rowe PC, Sutcliffe T, Ropp LJ, McDowell IW, Li MM. Randomised trial of salbutamol in acute bronchiolitis. The Journal of Pediatrics. 1991;118(5):807-811. Gadomski AM, Aref GH, EL Din OB, EL Sawy IH, Khallaf N, Black RE. Oral versus nebulised albuterol in the management (...) of bronchiolitis. Singapore Medical Journal. 1997;38(8):326-328. Dobson JV, Stephen -Groff SM, McMahon SR, Stemmler MM, Brallier SL, Bay C. The use of albuterol in hospitalised infants with bronchiolitis. Pediatrics. 1998;101(3 Pt 1):361-368. Ho L, Collis G, Landau LI, Le Souf PN. Effect of salbutamol on oxygen saturation in bronchiolitis. Archives of Disease in Childhood. 1991;66(9):1061-1064. Wang EE, Milner R, Allen U, Maj H. Bronchodilators for treatment of mild bronchiolitis : a factorial randomised trial
Aerosolized Salbutamol Accelerates the Resolution of Pulmonary Edema After Lung Resection Ischemia-reperfusion injuries, fluid overload, and cardiac insufficiency may all contribute to alveolar and interstitial lung edema. We hypothesized that aerosolized salbutamol would reduce extravascular lung water and improve oxygenation after lung resection by stimulating epithelial fluid clearance and cardiovascular function.Blinded, randomized, cross-over trial.We selected 24 patients with risk factors (...) for lung edema. Aerosolized drugs (salbutamol, 5 mg; vs ipratropium, 0.5 mg) were administered on two consecutive trials, with a 6-h washout period, on the day of surgery (postoperative day [POD]-0) as well as on POD-1. Before and 50 min after the end of drug administration, we determined the oxygenation index (Pao(2)/fraction of inspired oxygen [Fio(2)] ratio), the extravascular lung water index (EVLWI), the pulmonary vascular permeability index (PVPI), and the cardiac index (CI) using the single
Formoterol fumarate inhalation powder vs albuterol nebulizer for the treatment of asthma in the acute care setting Although albuterol remains the standard treatment for asthma in the emergency department, formoterol fumarate may be more advantageous, with its rapid and long-lasting bronchodilation.To compare formoterol fumarate with albuterol in controlling acute asthma exacerbation.Patients aged 18 to 65 years who presented to the emergency department with mild to moderate asthma exacerbation (...) (peak expiratory flow rate [PEFR], 40%-60% of predicted) were randomized to receive either formoterol fumarate aerolizer (12 microg) or albuterol nebulizer (2.5 mg) every 30 minutes up to 2 treatments. Symptom scores and PEFRs were measured at each treatment.Thirty-four patients (19 in the albuterol arm and 15 in the formoterol fumarate arm) were enrolled. At 30 and 60 minutes, the mean PEFR of the albuterol group increased from 43.7% of predicted to 51.9% of predicted and 54.6% of predicted
Pretreatment with Albuterol versus Montelukast for Exercise-Induced Bronchospasm in Children To compare pretreatment with albuterol versus montelukast added to the current asthma regimen for protection against exercise-induced bronchospasm in children with mild-to-moderate asthma, and to determine whether cysteinyl leukotriene (Cys-LT) concentrations measured in the exhaled breath condensate correlated with response to montelukast.Prospective, randomized, double-blind, double-dummy, crossover (...) study.Asthma clinic at a university-affiliated medical center.Eleven children aged 7-17 years with physician-diagnosed mild-to-moderate asthma for at least 6 months and with self-reported exercise-induced bronchospasm (defined as > or = 15% decrease in forced expiratory volume in 1 sec [FEV(1)] at screening and baseline visit).Patients were randomly assigned to receive 3-7 days of oral montelukast 5-10 mg/day or 2 puffs of an albuterol metered-dose inhaler just before an exercise challenge and then were
Drugs - Salbutamol (Ventolin) Drugs October 2006 Page 1 of 2 Drugs Salbutamol (Ventolin) SLB PRESENTATION Nebules containing salbutamol 2.5 milligrams/ 2.5ml or 5 milligrams/2.5 ml. ACTIONS Salbutamol is a selective beta2-adrenoreceptor stimulant drug. This has a relaxant effect on the smooth muscle in the medium and smaller airways, which are in spasm in acute asthma attacks. If given by nebuliser, especially if oxygen powered, its smooth-muscle relaxing action, combined with the airway (...) moistening effect of nebulisation, can relieve the attack rapidly. CAUTIONS Salbutamol should be used with care in patients with: hypertension. angina. overactive thyroid. late pregnancy (can relax uterus). Severe hypertension may occur in patients on beta-blockers and half doses should be used unless there is profound hypotension. ADDITIONAL INFORMATION In acute severe or life threatening asthma ipratropium should be given concurrently with the ?rst dose of salbutamol. In acute asthma or COPD
Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. Treatment guidelines recommend the regular use of inhaled corticosteroids for patients with mild persistent asthma. We investigated whether the symptom-driven use of a combination of beclomethasone dipropionate and albuterol (also known as salbutamol) in a single inhaler would be as effective as the regular use of inhaled beclomethasone and superior to the as-needed use of inhaled albuterol.We conducted a 6-month (...) , double-blind, double-dummy, randomized, parallel-group trial. After a 4-week run-in, patients with mild asthma were randomly assigned to receive one of four inhaled treatments: placebo twice daily plus 250 microg of beclomethasone and 100 microg of albuterol in a single inhaler as needed (as-needed combination therapy); placebo twice daily plus 100 microg of albuterol as needed (as-needed albuterol therapy); 250 microg of beclomethasone twice daily and 100 microg of albuterol as needed (regular