Latest & greatest articles for adverse events

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Top results for adverse events

221. Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials

Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials Swenson J R, Doucette S, Fergusson D CRD summary This review assessed the incidence of cardiovascular adverse events in (...) patients at high risk treated with selective serotonin re-uptake inhibitor (SSRI) antidepressants. The authors concluded that the available evidence was too scarce to clearly establish the risk associated with SSRI administration. There were limitations to this review but, overall, these conclusions are likely to be reliable. Authors' objectives To evaluate the risk of cardiovascular adverse events (AEs) in patients treated with selective serotonin re-uptake inhibitor (SSRI) antidepressants. Searching

DARE.2006

222. A comparison of adverse events and functional outcomes after restorative proctocolectomy for familial adenomatous polyposis and ulcerative colitis

A comparison of adverse events and functional outcomes after restorative proctocolectomy for familial adenomatous polyposis and ulcerative colitis A comparison of adverse events and functional outcomes after restorative proctocolectomy for familial adenomatous polyposis and ulcerative colitis A comparison of adverse events and functional outcomes after restorative proctocolectomy for familial adenomatous polyposis and ulcerative colitis Lovegrove R E, Tilney H S, Heriot A G, von Roon A C (...) , Athanasiou T, Church J, Fazio V W, Tekkis P P CRD summary The authors concluded that patients with ulcerative colitis appear to be at higher risk of pouch-related fistulation and pouchitis after restorative proctocolectomy than patients with familial polyposis coli. The reliance upon biased, retrospective comparative observational studies means that any conclusions are likely to be suggestive rather than definitive. Authors' objectives To evaluate adverse events and functional outcomes after restorative

DARE.2006

223. Empirical evaluation of the association between methodological shortcomings and estimates of adverse events

Empirical evaluation of the association between methodological shortcomings and estimates of adverse events Empirical evaluation of the association between methodological shortcomings and estimates of adverse events Empirical evaluation of the association between methodological shortcomings and estimates of adverse events Chou R, Fu R, Carson S, Saha S, Helfand M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Chou R, Fu R, Carson S, Saha S, Helfand M. Empirical evaluation of the association between methodological shortcomings and estimates of adverse events. Rockville: Agency for Healthcare Research and Quality (AHRQ). Technical Review 13. 2006 Authors' objectives Accurate harms data are necessary to appropriately assess the balance between benefits and harms of interventions. Numerous deficiencies in the quality and reporting of harms

Health Technology Assessment (HTA) Database.2006

224. Expirations: Does End-Tidal CO2 Monitoring Predict Adverse Respiratory Events In Sedation?

Expirations: Does End-Tidal CO2 Monitoring Predict Adverse Respiratory Events In Sedation? Expirations: Does End-Tidal CO2 Monitoring Predict Adverse Respiratory Events In Sedation? « Sinai EM Journal Club Emergency Medicine Discussion Forum Expirations: Does End-Tidal CO2 Monitoring Predict Adverse Respiratory Events In Sedation? In the growing backlog of articles and journal club presentations I’d like to write up, I came across this publication which was presented a few months back — from (...) 30 mmHg or more than 50 mmHg, were considered investigational acute respiratory events. They planned to enroll 250 patients but, in dramatic fashion, had to stop the study early, after just 59 patients (60 sedations). Abnormal ETCO2 findings (as described above) were found in 36 of the 60 encounters — 32 low and five high (yeah, one guy had both low and high). Of course, 44% of these “abnormal” ETCO2 readings were not associated with any adverse respiratory event or intervention. Some were just

Sinai EM Journal Club2006

225. Adverse events reported following live, cold-adapted, intranasal influenza vaccine.

Adverse events reported following live, cold-adapted, intranasal influenza vaccine. CONTEXT: In June 2003, the US Food and Drug Administration licensed a trivalent live, attenuated influenza vaccine (LAIV-T) for intranasal administration to healthy persons 5 to 49 years of age. Although prelicensure testing involved 20 228 vaccinees, clinical trials were not of sufficient size to detect rare adverse events reliably. OBJECTIVE: To identify adverse events reported following LAIV-T administration (...) after licensure. DESIGN, SETTING, AND PARTICIPANTS: All adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) during the 2003-2004 and the 2004-2005 influenza seasons. MAIN OUTCOME MEASURES: Numbers and proportions of reported adverse events and reporting rates of adverse events per 100,000 vaccinees. RESULTS: Approximately 2,500,000 persons received LAIV-T during the first 2 postlicensure seasons. As of August 16, 2005, VAERS received 460 adverse event reports

JAMA2005

226. Adverse events associated with smallpox vaccination in the United States, January-October 2003.

Adverse events associated with smallpox vaccination in the United States, January-October 2003. CONTEXT: On January 24, 2003, the US Department of Health and Human Services (DHHS) implemented a preparedness program in which smallpox (vaccinia) vaccine was administered to federal, state, and local volunteers who might be first responders during a bioterrorism event. OBJECTIVE: To describe results from the comprehensive DHHS smallpox vaccine safety monitoring and response system. DESIGN, SETTING (...) , AND PARTICIPANTS: Descriptive study of adverse event reports from the DHHS smallpox vaccine safety monitoring and response system received between January 24 and October 31, 2003, through the Vaccine Adverse Event Reporting System (VAERS) and the Centers for Disease Control and Prevention. A total of 37,901 volunteers in 55 jurisdictions received at least 1 dose of smallpox vaccine. MAIN OUTCOME MEASURES: Number of vaccinations administered and description of adverse events and reporting rates. RESULTS

JAMA2005

227. Neurologic adverse events associated with smallpox vaccination in the United States, 2002-2004.

Neurologic adverse events associated with smallpox vaccination in the United States, 2002-2004. CONTEXT: Neurologic illness is an infrequent but severe adverse event associated with smallpox vaccination. The reinstatement of smallpox vaccination in the United States in response to possible bioterrorism renewed concerns about vaccine-related adverse neurologic events. OBJECTIVE: To determine rates and describe the clinical features of neurologic events associated with smallpox vaccination (...) . DESIGN AND SETTING: We assessed reports of adverse events obtained through active case reporting and review of data reported to the Vaccine Adverse Event Reporting System among 665,000 persons vaccinated against smallpox by the Departments of Defense (n = 625,400 [corrected]) and Health and Human Services (n = 39,400 [corrected]) during the 2002-2004 US Smallpox Vaccination Program. MAIN OUTCOME MEASURE: Adverse neurologic events temporally associated with smallpox vaccination. RESULTS: Between

JAMA2005

228. Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in childre

Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in childre Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children Article Text Therapeutics Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh

Evidence-Based Medicine (Requires free registration)2005

229. Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children

Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts (...) Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children Article Text Treatment Review: most selective serotonin reuptake inhibitors lead

Evidence-Based Nursing (Requires free registration)2005

230. The investigation and analysis of critical incidents and adverse events in healthcare

The investigation and analysis of critical incidents and adverse events in healthcare The investigation and analysis of critical incidents and adverse events in healthcare Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information

NIHR HTA programme2005

231. The Research on Adverse Drug Events and Reports (RADAR) project.

The Research on Adverse Drug Events and Reports (RADAR) project. CONTEXT: In 1998, a multidisciplinary team of investigators initiated RADAR (Research on Adverse Drug events And Reports), a clinically based postmarketing surveillance program that systematically investigates and disseminates information describing serious and previously unrecognized adverse drug and device reactions (ADRs). OBJECTIVE: To describe the structure, operations, and preliminary findings from the RADAR project (...) and related dissemination efforts by pharmaceutical suppliers and the US Food and Drug Administration (FDA). DESIGN: After identifying a serious and unexpected clinical event suitable for further investigation, RADAR collaborators postulated clinical hypotheses and derived case series and incidence estimates from physician queries, published and unpublished clinical trials, published case reports, FDA databases, and manufacturer sales figures. RESULTS: RADAR investigators identified 16 types of serious

JAMA2005

232. Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events

Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events van Iersel MB, Zuidema SU, Koopmans RT, Verhey FR, Rikkert MG CRD summary This review concluded (...) that there was a need for better reporting of harms in randomised controlled trials of antipsychotics for behavioural and psychological symptoms of dementia. This conclusion appears appropriate given the evidence presented. Authors' objectives To evaluate adverse events in relation to antipsychotic medications for behavioural and psychological symptoms of dementia Searching MEDLINE, EMBASE, PsycINFO and Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to 2005. Search terms were reported

DARE.2005

233. Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids Moore R A, McQuay H J CRD summary The review concluded that the majority of patients using opioids for chronic non-malignant pain (...) experience at least one adverse event, and that a significant proportion stop using them because of an adverse event. The conclusion appears to follow from the evidence presented, although lack of detail about the methods and the short duration of the trials make it difficult to verify the findings. Authors' objectives To determine the prevalence of opioid adverse events in chronic non-malignant pain (CNMP); to identify major differences in opioid adverse events in CNMP of different aetiology

DARE.2005

234. Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review

Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review Romsing J, Moiniche S, Mathiesen O, Dahl J B CRD summary This review evaluated opioid (...) -related adverse events in studies of opioid sparing with cyclooxygenase-2 (COX-2) inhibitors compared with placebo in post-operative pain. The authors concluded that opioid sparing with COX-2 inhibitors does not have a clinically beneficial effect on opioid-related adverse events. The conclusion appears reliable based on the data presented, although relevant studies might not have been included. Authors' objectives To review opioid-related adverse events in studies of opioid-sparing post-operative

DARE.2005

235. Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials

Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S (...) CRD summary This review evaluated the risk of adverse events associated with testosterone replacement in older men. The authors concluded that testosterone replacement is associated with a significantly higher risk of prostate events and of a haematocrit of more than 50% relative to placebo. A limited search, unclear review methodology, and the unknown quality of the primary studies limit the reliability of the conclusions. Authors' objectives To determine the risk of adverse events associated

DARE.2005

236. Biphasic insulin aspart 30: literature review of adverse events associated with treatment

Biphasic insulin aspart 30: literature review of adverse events associated with treatment Biphasic insulin aspart 30: literature review of adverse events associated with treatment Biphasic insulin aspart 30: literature review of adverse events associated with treatment Davidson J, Vexiau P, Cucinotta D, Vaz J, Kawamori R CRD summary This review assessed the safety of biphasic insulin aspart 30 (BIAsp 30) for patients with diabetes. The authors concluded that the safety profile is comparable (...) studies examined BIAsp 30 as a monotherapy or in conjunction with an oral antidiabetic medication, and used a range of dosing schedules. The comparators were biphasic human insulin 30 (BHI 30), neutral protamine Hagedorn (NPH) insulin and Mix 25. Study duration ranged from a single dose to 2 years. The safety outcomes reported included hypoglycaemic events, major hypoglycaemia, nocturnal hypoglycaemia, minor hypoglycaemia, weight gain and other adverse events. No inclusion criteria for the study

DARE.2005

237. Vitex agnus castus: a systematic review of adverse events

Vitex agnus castus: a systematic review of adverse events Vitex agnus castus: a systematic review of adverse events Vitex agnus castus: a systematic review of adverse events Daniele C, Thompson Coon J, Pittler M H, Ernst E CRD summary This review assessed the safety of Vitex agnus castus (VAC) monopreparations. The authors concluded that the available data indicate that VAC is not associated with serious health risks, but further rigorous studies are needed. The authors' conclusion about (...) adverse event rates may be optimistic given the paucity of well-controlled studies, but the need for further rigorous studies is supported. Authors' objectives To evaluate the safety of Vitex agnus castus (VAC) monopreparations. Searching MEDLINE, AMED, CINAHL, EMBASE, PsycINFO and the Cochrane Library were searched (September 2004) for relevant articles; the search terms were reported and no language restrictions were applied. In addition, personal files and the references of identified articles were

DARE.2005

238. The cost of glucocorticoid-associated adverse events in rheumatoid arthritis

The cost of glucocorticoid-associated adverse events in rheumatoid arthritis The cost of glucocorticoid-associated adverse events in rheumatoid arthritis The cost of glucocorticoid-associated adverse events in rheumatoid arthritis Pisu M, James N, Sampsel S, Saag K G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) were derived from a review and synthesis of published studies, supplemented with authors' assumptions. Link between effectiveness and cost data The costing was carried out retrospectively on the basis of a hypothetical sample of patients. Modelling A Markov model was developed to compare the health care costs. However, it also calculated the number of deaths that resulted from the use and non-use of glucocorticoids. The model incorporated seven health states. Specifically, no adverse events

NHS Economic Evaluation Database.2005

240. The investigation and analysis of critical incidents and adverse events in healthcare

The investigation and analysis of critical incidents and adverse events in healthcare The investigation and analysis of critical incidents and adverse events in healthcare The investigation and analysis of critical incidents and adverse events in healthcare Woloshynowych M, Rogers S, Taylor-Adams S, Vincent C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation Woloshynowych M, Rogers S, Taylor-Adams S, Vincent C. The investigation and analysis of critical incidents and adverse events in healthcare. Health Technology Assessment 2005; 9(19): 1-158 Authors' objectives The aim of this report was to carry out a review of published and unpublished work on the analysis on methods of accident investigation in high-risk industries, and of critical incidents in healthcare. To develop and pilot guidelines for the analysis of critical incidents

Health Technology Assessment (HTA) Database.2005