Latest & greatest articles for adverse events

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Top results for adverse events

181. Impact of treatment completion, intolerance and adverse events on health system costs in a randomised trial of 4 months rifampin or 9 months isoniazid for latent TB Full Text available with Trip Pro

Impact of treatment completion, intolerance and adverse events on health system costs in a randomised trial of 4 months rifampin or 9 months isoniazid for latent TB Treatment for latent tuberculosis infection with isoniazid for 9 months (9INH) has poor completion and serious adverse events, while treatment for 4 months with daily rifampin (4RIF) has significantly higher completion and fewer adverse events.To compare the health system costs of 4RIF and 9INH.In a randomised trial conducted (...) with $970 for 9INH (p<0.0001). The average cost per patient for the 328 of 420 (78%) who completed 4RIF therapy was $1094 compared with $1625 for the 254 of 427 (60%) completing 9INH (p<0.0001). Costs were modestly increased in patients with minor intolerance and substantially increased if the treating physician stopped treatment because of possible adverse events. Total costs related to management of adverse events with 9INH were $48 142 compared with $25 684 for 4RIF (p=0.008). Using these data

2010 EvidenceUpdates Controlled trial quality: uncertain

182. Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study Full Text available with Trip Pro

Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study To evaluate toxicity profiles in patients with rheumatoid arthritis (RA) treated either according to an intensive or a conventional treatment strategy approach with methotrexate (MTX) and to study factors associated with MTX-related toxicity.Data were used from the Computer-Assisted Management in Early Rheumatoid Arthritis (CAMERA (...) ) study, in which clinical efficacy of an intensive treatment strategy with MTX was more beneficial than a conventional treatment strategy approach. In this study, data on adverse events (AEs) were compared between the two strategy groups. Logistic regression analyses were used to identify possible associations between factors assessed at baseline and withdrawal due to MTX-related AEs or liver toxicity at follow-up.Although significantly more patients in the intensive strategy group experienced MTX

2010 EvidenceUpdates Controlled trial quality: uncertain

183. A randomised trial of target-vessel versus multi-vessel revascularisation in ST-elevation myocardial infarction: major adverse cardiac events during long-term follow-up Full Text available with Trip Pro

A randomised trial of target-vessel versus multi-vessel revascularisation in ST-elevation myocardial infarction: major adverse cardiac events during long-term follow-up Few reports described outcomes of complete compared with infarct-related artery (IRA)-only revascularisation in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). Moreover, no studies have compared the simultaneous treatment of non-IRA with the IRA treatment followed (...) at least one major adverse cardiac event (MACE), 13 (20.0%) in the SR group and 15 (23.1%) in the CR group, p<0.001. Inhospital death, repeat revascularisation and re-hospitalisation occurred more frequently in the COR group (all p<0.05), whereas there was no significant difference in re-infarction among the three groups. Survival free of MACE was significantly reduced in the COR group but was similar in the CR and SR groups.Culprit vessel-only angioplasty was associated with the highest rate of long

2010 EvidenceUpdates Controlled trial quality: uncertain

184. Use of manometry for laryngeal mask airway reduces postoperative pharyngolaryngeal adverse events: a prospective, randomized trial Full Text available with Trip Pro

Use of manometry for laryngeal mask airway reduces postoperative pharyngolaryngeal adverse events: a prospective, randomized trial Adverse events such as pharyngolaryngeal complications are indicators of quality patient care. Use of manometry to limit the laryngeal mask airway (LMA) intracuff pressure is not currently a routine practice. This double-blind randomized trial compared pharyngolaryngeal complications in patients managed with manometers to limit the LMA intracuff pressure (<44 mmHg

2010 EvidenceUpdates Controlled trial quality: predicted high

185. Associations between renal duplex parameters and adverse cardiovascular events in the elderly: a prospective cohort study Full Text available with Trip Pro

Associations between renal duplex parameters and adverse cardiovascular events in the elderly: a prospective cohort study Atherosclerotic renovascular disease is associated with an increased risk of cardiovascular disease (CVD) events. This study examines associations between Doppler-derived parameters from the renal artery and renal parenchyma and all-cause mortality and fatal and nonfatal CVD events in a cohort of elderly Americans.Cohort study.A subset of participants from the Cardiovascular (...) renal artery peak systolic velocity.Proportional hazard regression analysis was used to determine associations between renal duplex sonography-derived Doppler signals and CVD events and all-cause mortality adjusted for accepted cardiovascular risk factors. Index CVD outcomes were defined as coronary events (angina, myocardial infarction, and coronary artery bypass grafting/percutaneous coronary intervention), cerebrovascular events (stroke or transient ischemic attack), and any CVD event (angina

2010 EvidenceUpdates

186. Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs (D:A:D) study Full Text available with Trip Pro

Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs (D:A:D) study BACKGROUND. The risk of myocardial infarction (MI) in patients with human immunodeficiency virus (HIV) infection has been assessed in 13 anti-HIV drugs in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. METHODS. Poisson regression models were adjusted

2010 EvidenceUpdates

187. Systematic review: Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events

Systematic review: Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your (...) to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events Article Text Therapeutics Systematic review Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events Gabor I Keitner Gabor I Keitner Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; GKeitner

2010 Evidence-Based Medicine

188. Anhedonia predicts adverse cardiac events in people with acute coronary syndromes Full Text available with Trip Pro

Anhedonia predicts adverse cardiac events in people with acute coronary syndromes Anhedonia predicts adverse cardiac events in people with acute coronary syndromes | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Anhedonia predicts adverse cardiac events in people with acute coronary syndromes Article Text Prognosis Anhedonia predicts adverse cardiac events in people with acute coronary syndromes Statistics from Altmetric.com Question

2010 Evidence-Based Mental Health

189. Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain

Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain Langley PC, Patkar AD, Boswell KA, Benson CJ, Schein JR CRD summary This review assessed the safety of long-acting formulations of tramadol hydrochloride in the treatment of chronic osteoarthritis pain and concluded (...) that differences in formulations may influence rates of adverse events. However, these differences should be interpreted with caution. Potential bias in the review, heterogeneity among studies and their unclear quality, support the authors' recommendation to interpret the findings with caution. Authors' objectives To assess the safety of various long-acting formulations of tramadol hydrochloride in the treatment of chronic osteoarthritis pain. Searching MEDLINE and EMBASE were searched between 1997 and 2008

2010 DARE.

190. Meta-analysis of the role of high-dose statins administered prior to percutaneous coronary intervention in reducing major adverse cardiac events in patients with coronary artery disease

Meta-analysis of the role of high-dose statins administered prior to percutaneous coronary intervention in reducing major adverse cardiac events in patients with coronary artery disease Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

191. Adverse events associated with testosterone administration. Full Text available with Trip Pro

Adverse events associated with testosterone administration. Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied.Community-dwelling men, 65 years of age or older, with limitations in mobility and a total serum testosterone level of 100 to 350 ng per deciliter (3.5 to 12.1 nmol per liter) or a free serum testosterone level of less (...) than 50 pg per milliliter (173 pmol per liter) were randomly assigned to receive placebo gel or testosterone gel, to be applied daily for 6 months. Adverse events were categorized with the use of the Medical Dictionary for Regulatory Activities classification. The data and safety monitoring board recommended that the trial be discontinued early because there was a significantly higher rate of adverse cardiovascular events in the testosterone group than in the placebo group.A total of 209 men (mean

2010 NEJM Controlled trial quality: uncertain

192. Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation: a systematic review and meta-analysis of one hundred and twenty studies involving 177,390 individuals

Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation: a systematic review and meta-analysis of one hundred and twenty studies involving 177,390 individuals Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

193. Meta-analysis of adverse cardiovascular events associated with echocardiographic contrast agents

Meta-analysis of adverse cardiovascular events associated with echocardiographic contrast agents Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

194. Predicting major adverse events after cardiac surgery in children

Predicting major adverse events after cardiac surgery in children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2009 PedsCCM Evidence-Based Journal Club

195. Adverse events after outpatient colonoscopy in the medicare population. (Abstract)

Adverse events after outpatient colonoscopy in the medicare population. Although use of colonoscopy has increased substantially among elderly Medicare beneficiaries, no one has described colonoscopy-related adverse events in a representative sample of Medicare patients.To determine risk for adverse events after outpatient colonoscopy in elderly patients.Population-based, matched cohort study.Surveillance, Epidemiology, and End Results cancer registry areas.Random 5% sample of Medicare (...) . Logistic regression was used to estimate adjusted predictive risks for adverse events and to assess whether these events varied by age, comorbid conditions, or type of colonoscopy.Persons undergoing colonoscopy had a higher risk for adverse gastrointestinal events than their matched group. Rates of adverse events after colonoscopy increased with age. Patients having polypectomy had higher risk for all adverse events compared with their matched group and with the screening and diagnostic colonoscopy

2009 Annals of Internal Medicine

196. Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial Full Text available with Trip Pro

Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial Medication reconciliation at transitions in care is a national patient safety goal, but its effects on important patient outcomes require further evaluation. We sought to measure the impact of an information technology-based medication reconciliation intervention on medication discrepancies with potential for harm (potential adverse drug events [PADEs

2009 EvidenceUpdates Controlled trial quality: predicted high

197. Effect of a pharmacist on adverse drug events and medication errors in outpatients with cardiovascular disease Full Text available with Trip Pro

Effect of a pharmacist on adverse drug events and medication errors in outpatients with cardiovascular disease Adverse drug events and medication errors are threats to quality care. Inpatient studies suggest that a pharmacist may reduce these events, but outpatient studies have not been forthcoming.We conducted a pooled analysis of 2 randomized controlled trials to determine the effect of pharmacist intervention on adverse drug events and medication errors. We studied 800 outpatient cases (...) of hypertension stratified into complicated (n = 535) and uncomplicated (n = 265). Patients in the complicated stratum had heart failure or other cardiovascular complication. Computer programs examined 1-year electronic record data to identify events classified as adverse drug events and preventable or potential adverse drug events. Medication errors included preventable and potential adverse drug events.Of the 800 participants (mean [SD] age, 59 [10] years), 484 (90.5%) and 258 (97.4%) participants remained

2009 EvidenceUpdates Controlled trial quality: uncertain

198. Usefulness of electrocardiographic and echocardiographic left ventricular hypertrophy to predict adverse events in patients with a first non-ST-elevation acute myocardial infarction (Abstract)

Usefulness of electrocardiographic and echocardiographic left ventricular hypertrophy to predict adverse events in patients with a first non-ST-elevation acute myocardial infarction Left ventricular hypertrophy (LVH) portends a worse outcome after non-ST-elevation acute myocardial infarction (NSTEMI). However, its definition has varied and the incremental prognostic information provided by echocardiography has been unclear. Different electrocardiographic and echocardiographic criteria for LVH (...) were compared for their ability to predict in-hospital complications in 451 consecutive patients with a first NSTEMI, 337 of whom had a reliable echocardiogram. Five to 8% had LVH using Sokolow-Lyon or Cornell (voltage or product) criteria on admission; 15%, using either electrocardiographic criteria; and 24%, using echocardiography. LVH predicted the occurrence of adverse events (death, reinfarction, or severe angina or heart failure), with the strongest association found for the Cornell product

2009 EvidenceUpdates

199. Multiple antipsychotic use associated with metabolic and cardiovascular adverse events in children and adolescents

Multiple antipsychotic use associated with metabolic and cardiovascular adverse events in children and adolescents Multiple antipsychotic use associated with metabolic and cardiovascular adverse events in children and adolescents | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Multiple antipsychotic use associated with metabolic and cardiovascular adverse events in children and adolescents Article Text Aetiology Multiple antipsychotic use

2009 Evidence-Based Mental Health

200. Review: formoterol increases serious adverse events in children and adults with chronic asthma

Review: formoterol increases serious adverse events in children and adults with chronic asthma Review: formoterol increases serious adverse events in children and adults with chronic asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: formoterol increases serious adverse events in children and adults with chronic asthma Article Text Therapeutics Review: formoterol increases serious adverse events in children and adults

2009 Evidence-Based Medicine