Latest & greatest articles for acyclovir

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Top results for acyclovir

21. Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis

Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis Clinical question How effective is acyclovir for treating primary herpetic gingivostomatitis (PHG)? Bottom line One trial (n=72) provided some limited evidence (...) to suggest for children under 6 years of age with PHG acyclovir is effective in reducing the number of oral lesions (NNT* 2), preventing the development of new extraoral lesions (NNT 3), decreasing the difficulty experienced in eating (NNT 3) and drinking (NNT 5) and reducing admissions to hospital (NNT 12). * NNT = number needed to treat to benefit 1 individual. Caveat Only 2 trials, one with 72 participants and the other with 20 participants, were included in this review. The second study failed

Cochrane PEARLS2008

22. Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy

Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu (...) Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Article Text Therapeutics Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Statistics from Altmetric.com No Altmetric data available for this article. Request permissions If you wish to reuse any or all of this article

Evidence-Based Medicine (Requires free registration)2008

23. Early treatment with prednisolone or acyclovir in Bell's palsy.

Early treatment with prednisolone or acyclovir in Bell's palsy. 17942873 2007 10 18 2007 10 25 2013 11 21 1533-4406 357 16 2007 Oct 18 The New England journal of medicine N. Engl. J. Med. Early treatment with prednisolone or acyclovir in Bell's palsy. 1598-607 Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain. We conducted a double-blind, placebo-controlled, randomized (...) , factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone, acyclovir, both agents, or placebo. The primary outcome was recovery of facial function, as rated on the House-Brackmann scale. Secondary outcomes included quality of life, appearance, and pain. Final outcomes were assessed for 496 of 551 patients who underwent randomization. At 3 months, the proportions

NEJM2007

24. Acyclovir for treating varicella in otherwise healthy children and adolescents.

Acyclovir for treating varicella in otherwise healthy children and adolescents. BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox. OBJECTIVES: 1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration of illness. 2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant (...) trials. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 2, 2005), MEDLINE (January 1966 to June 2005), and EMBASE (1988 to June 2005). The reference lists of all relevant articles were reviewed. The primary author of relevant studies and the pharmaceutical company that manufactures acyclovir were contacted. SELECTION CRITERIA: Randomized controlled trials that evaluated otherwise healthy children zero to 18 years of age

Cochrane2005

25. Should acyclovir be prescribed for immunocompetent children presenting with chickenpox?

Should acyclovir be prescribed for immunocompetent children presenting with chickenpox? BestBets: Should acyclovir be prescribed for immunocompetent children presenting with chickenpox? Should acyclovir be prescribed for immunocompetent children presenting with chickenpox? Report By: Dr Dan Harris - SpR Emergency Medicine Search checked by Dr Julian Redhead - Consultant Emergency Medicine Institution: St Mary's Hospital W2 Date Submitted: 13th August 2004 Date Completed: 25th May 2005 Last (...) Modified: 25th May 2005 Status: Green (complete) Three Part Question In [uncomplicated chicken pox infection in immunocompetent children] is [oral acyclovir] beneficial in [reducing severity and duration of infection]? Clinical Scenario A 4-year-old child is brought to the emergency department by her mother because of a rash that has developed over the preceding 24 hours. The rash is that of uncomplicated chicken pox infection and the child has no medical history of note and is not immunocompromised

BestBETS2005

26. Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis

Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Little S E, Caughey A B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined prophylactic antiviral (acyclovir) therapy for women with a history of herpes simplex virus (HSV) but without recurrence during pregnancy. Type of intervention Secondary prevention. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical

NHS Economic Evaluation Database.2005

27. Acyclovir for treating varicella in otherwise healthy children and adolescents.

Acyclovir for treating varicella in otherwise healthy children and adolescents. BACKGROUND: Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox. OBJECTIVES: 1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration of illness. 2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant (...) trials. SEARCH STRATEGY: We searched The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2003), MEDLINE (January 1966 to May 2003), and EMBASE (1988 to April 2003). The reference lists of all relevant articles were reviewed. The primary author of relevant studies and the pharmaceutical company that manufactures acyclovir were contacted. SELECTION CRITERIA: Randomized controlled trials that evaluated otherwise healthy children zero to 18 years of age

Cochrane2004

28. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review

Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Sheffield J S, Hollier L M, Hill J B, Stuart G S, Wendel G D CRD summary This review assessed prophylactic acyclovir for pregnant women with genital herpes simplex virus (HSV) near term. The authors (...) concluded that acyclovir at 36 weeks' gestation reduces clinical HSV recurrence at delivery, Caesarean section for recurrent genital herpes and shedding of HSV at delivery. This was a well-conducted and clearly presented review. The authors' conclusions are likely to be reliable. Authors' objectives To assess the effects of prophylactic acyclovir administered to pregnant women with genital herpes simplex virus (HSV) near term on HSV recurrence at delivery. Searching MEDLINE (from 1966 to March 2003

DARE.2003

29. Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology

Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards (...) Subcommittee of the American Academy of Neurology Grogan P M, Gronseth G S Authors' objectives To determine the effectiveness of steroids, acyclovir, and surgical facial nerve decompression in Bell's palsy. Searching MEDLINE was searched from 1966 to June 2000. The search terms included 'facial paralysis', 'Bell's palsy', 'prednisone', 'prednisolone', 'hydrocortisone', 'acyclovir' and 'surgery'. The references of the retrieved studies were examined for additional studies. Study selection Study designs

DARE.2001

30. Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data

Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Ioannidis J P, Collier A C, Cooper D (...) A, Corey L, Fiddian A P, Gazzard B G, Griffiths P D, Contopoulos-Ioannidis D G, Lau J, Pavia A T, Saag M S, Spruance S L, Youle M S Authors' objectives To determine the efficacy of high-dose acyclovir in patients with the human immunodeficiency virus (HIV). Searching The trials were identified by searching MEDLINE, abstracts from meetings and trial directories, and through correspondence with experts, investigators of the identified trials and industry personnel. Study selection Study designs

DARE.1998

31. Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy

Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Scott L L, Alexander J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Acyclovir suppression to prevent recurrent genital herpes (HSV) in term pregnancy. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Pregnant women with a history of HSV or with their first episode diagnosed during pregnancy. Setting Community and secondary care. The economic study was conducted

NHS Economic Evaluation Database.1998

32. Superior efficacy of oral ganciclovir over oral acyclovir for cytomegalovirus prophylaxis in kidney-pancreas and pancreas alone recipients

Superior efficacy of oral ganciclovir over oral acyclovir for cytomegalovirus prophylaxis in kidney-pancreas and pancreas alone recipients Superior efficacy of oral ganciclovir over oral acyclovir for cytomegalovirus prophylaxis in kidney-pancreas and pancreas alone recipients Superior efficacy of oral ganciclovir over oral acyclovir for cytomegalovirus prophylaxis in kidney-pancreas and pancreas alone recipients Somerville T, Hurst G, Alloway R, Gaber A, Shokouh-Amiri M H, Stratta R Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Oral ganciclovir and oral acyclovir used as prophylaxis for patients who have previously received intravenous ganciclovir therapy following pancreas only (PO) or pancreas and kidney

NHS Economic Evaluation Database.1998

33. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group.

Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. 9696640 1998 08 04 1998 08 04 2014 11 20 0028-4793 339 5 1998 Jul 30 The New England journal of medicine N. Engl. J. Med. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. 300-6 Long-term treatment with antiviral agents has been shown to prevent recurrences of genital and orofacial herpes simplex virus (HSV) disease (...) , but it is uncertain whether prophylactic treatment can prevent recurrences of ocular HSV disease. We randomly assigned 703 immunocompetent patients who had had ocular HSV disease within the preceding year to receive 400 mg of acyclovir or placebo orally twice daily. The study outcomes were the rates of development of ocular or nonocular HSV disease during a 12-month treatment period and a 6-month observation period. The cumulative probability of a recurrence of any type of ocular HSV disease during the 12-month

NEJM1998

34. The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia: a meta-analysis

The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia: a meta-analysis The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia: a meta-analysis The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia: a meta-analysis Jackson J L, Gibbons R, Meyer G, Inouye L Authors' objectives To determine if treatment with oral acyclovir reduces the incidence of postherpetic (...) neuralgia in immunocompetent adults. Searching MEDLINE was searched from 1966 to 1996 for English language publications, using the MeSH terms 'acyclovir', 'herpes zoster' and 'randomised clinical trials'; it was also searched for citations using 'acyclovir' and 'herpes zoster', and articles thus identified were manually reviewed. In addition, a supplementary search was performed by a professional librarian, and the National Institute of Health database and Cochrane Controlled Trials Register were searched for published

DARE.1997

35. Comparison of valaciclovir and acyclovir for the treatment of herpes zoster in immunocompetent patients over 50 years of age: a cost-consequence model

Comparison of valaciclovir and acyclovir for the treatment of herpes zoster in immunocompetent patients over 50 years of age: a cost-consequence model Comparison of valaciclovir and acyclovir for the treatment of herpes zoster in immunocompetent patients over 50 years of age: a cost-consequence model Comparison of valaciclovir and acyclovir for the treatment of herpes zoster in immunocompetent patients over 50 years of age: a cost-consequence model Grant D M, Mauskopf J A, Bell L, Austin R (...) Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Valaciclovir and acyclovir in the treatment of herpes zoster. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Immunocompetent patients

NHS Economic Evaluation Database.1997

36. Studies evaluating high-dose acyclovir, intravenous immune globulin, and cytomegalovirus hyperimmunoglobulin for prophylaxis against cytomegalovirus in kidney transplant recipients

Studies evaluating high-dose acyclovir, intravenous immune globulin, and cytomegalovirus hyperimmunoglobulin for prophylaxis against cytomegalovirus in kidney transplant recipients Studies evaluating high-dose acyclovir, intravenous immune globulin, and cytomegalovirus hyperimmunoglobulin for prophylaxis against cytomegalovirus in kidney transplant recipients Studies evaluating high-dose acyclovir, intravenous immune globulin, and cytomegalovirus hyperimmunoglobulin for prophylaxis against (...) cytomegalovirus in kidney transplant recipients Dickinson B I, Gora-Harper M L, McCraney S A, Gosland M Authors' objectives To critically analyse the studies evaluating the cost, safety, and efficacy of high-dose acyclovir, intravenous immunoglobulin (IVIG) and cyclomegalovirus hyperimmunoglobulin (CMVIG) for prophylaxis against CMV in kidney transplant recipients. Searching MEDLINE was searched using combinations of the following MeSH: 'immunoglobulins', 'intravenous' 'acyclovir' 'CMVIG' 'CMV infections

DARE.1996

37. Acyclovir prophylaxis in late pregnancy to prevent neonatal herpes: a cost-effectiveness analysis

Acyclovir prophylaxis in late pregnancy to prevent neonatal herpes: a cost-effectiveness analysis Acyclovir prophylaxis in late pregnancy to prevent neonatal herpes: a cost-effectiveness analysis Acyclovir prophylaxis in late pregnancy to prevent neonatal herpes: a cost-effectiveness analysis Randolph A G, Hartshorn R M, Washington A E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Antiviral (Acyclovir) prophylaxis in the prevention of neonatal herpes. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population A hypothetical cohort of 10,000 pregnant women with at least one previously documented outbreak of genital herpes. Setting Hospital. The study was conducted in the USA

NHS Economic Evaluation Database.1996

38. Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients: a British perspective

Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients: a British perspective Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients: a British perspective Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients: a British perspective Nathwani D, Macdonald T, Davey P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of oral acyclovir in the treatment of chickenpox in children and chickenpox and shingles in adults. Type of intervention Secondary prevention Economic study type Cost-effectiveness analysis. Study population The general population of Tayside in Scotland. Setting A combination of primary and community care

NHS Economic Evaluation Database.1995

39. Acyclovir given as prophylaxis against oral ulcers in acute myeloid leukaemia: randomised, double blind, placebo controlled trial.

Acyclovir given as prophylaxis against oral ulcers in acute myeloid leukaemia: randomised, double blind, placebo controlled trial. 7767151 1995 07 03 1995 07 03 2013 11 21 0959-8138 310 6988 1995 May 06 BMJ (Clinical research ed.) BMJ Acyclovir given as prophylaxis against oral ulcers in acute myeloid leukaemia: randomised, double blind, placebo controlled trial. 1169-72 To evaluate (a) the prophylactic effect of the antiherpetic drug acyclovir on oral ulcers in patients with acute myeloid (...) leukaemia receiving remission induction chemotherapy and thus (b), indirectly, the role of herpes simplex virus in the aetiology of these ulcers. Randomised, double blind, placebo controlled trial. 74 herpes simplex virus seropositive patients aged 18-84. Thirty seven patients received acyclovir (800 mg by mouth daily) and 37 placebo. The patients were examined daily for 28 days. Occurrence of herpes labialis, intraoral ulcers, and acute necrotising ulcerative gingivitis. The two populations were

BMJ1995 Full Text: Link to full Text with Trip Pro

40. Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients.

Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. 7603215 1995 08 10 1995 08 10 2015 06 16 0140-6736 346 8967 1995 Jul 08 Lancet (London, England) Lancet Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. 69-74 Despite current approaches to prophylaxis, cytomegalovirus (CMV) continues to be a common cause of infection (...) and disease in solid-organ-transplant patients. Thus, we conducted a controlled trial comparing long-term administration of ganciclovir with high-dose acyclovir for prevention of CMV infection and disease in liver transplant recipients. At the time of transplant, patients were randomised to receive either ganciclovir (6 mg/kg body weight per day intravenously from postoperative day 1 to day 30, then 6 mg/kg per day Monday through Friday until day 100) or acyclovir (10 mg/kg intravenously every 8 h from

Lancet1995