Latest & greatest articles for acute pain

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acute pain or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acute pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for acute pain

201. Single dose oral fenbufen for acute postoperative pain in adults.

Single dose oral fenbufen for acute postoperative pain in adults. BACKGROUND: Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. There is no known systematic review of its use in acute postoperative pain. OBJECTIVES: To assess efficacy, duration of action, and associated adverse events of single dose oral fenbufen in acute postoperative pain in adults. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE (...) and the Oxford Pain Relief database for studies to June 2009. SELECTION CRITERIA: Randomised, double blind, placebo-controlled trials of single dose orally administered fenbufen in adults with moderate to severe acute postoperative pain. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over 4 to 6 hours

Cochrane2009

202. Single dose oral nabumetone for acute postoperative pain in adults.

Single dose oral nabumetone for acute postoperative pain in adults. BACKGROUND: Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 1000 mg daily, and higher doses are not advised in older patients. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy and safety of oral nabumetone in acute postoperative (...) pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish whether drugs have analgesic properties. OBJECTIVES: To assess the efficacy of single dose oral nabumetone in acute postoperative pain, and any associated adverse events. SEARCH STRATEGY: We searched The Cochrane Library (Issue 2, 2009), MEDLINE (May 2009); EMBASE via Ovid (May 2009); and the Oxford

Cochrane2009

203. Single dose oral meloxicam for acute postoperative pain in adults.

Single dose oral meloxicam for acute postoperative pain in adults. BACKGROUND: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 15 mg daily, but lower doses of 7.5 mg are advised in older patients. This review sought to evaluate the efficacy and safety of oral meloxicam in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured (...) primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties. OBJECTIVES: To assess the efficacy of single dose oral meloxicam in acute postoperative pain, and any associated adverse events. SEARCH STRATEGY: We searched Cochrane CENTRAL (Issue 2, 2009), MEDLINE (June 2009); EMBASE (June 2009); the Oxford Pain Relief Database. SELECTION CRITERIA: Randomised, double-blind, placebo-controlled clinical trials of oral

Cochrane2009

204. Single dose oral flurbiprofen for acute postoperative pain in adults.

Single dose oral flurbiprofen for acute postoperative pain in adults. BACKGROUND: Flurbiprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), related to ibuprofen and naproxen, used to treat acute and chronic painful conditions. There is no systematic review of its use in acute postoperative pain. OBJECTIVES: To assess efficacy, duration of action, and associated adverse events of single dose oral flurbiprofen in acute postoperative pain in adults. SEARCH STRATEGY: We searched (...) Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to January 2009. SELECTION CRITERIA: Randomised, double blind, placebo-controlled trials of single dose orally administered flurbiprofen in adults with moderate to severe acute postoperative pain. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants

Cochrane2009

205. Topical rubefacients for acute and chronic pain in adults.

Topical rubefacients for acute and chronic pain in adults. BACKGROUND: Rubefacients (containing salicylates or nicotinamides) cause irritation of the skin, and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. A non-Cochrane review in 2004 found limited evidence for efficacy. OBJECTIVES: To review current evidence for efficacy and safety of topically applied rubefacients in acute and chronic painful (...) musculoskeletal conditions in adults. SEARCH STRATEGY: Cochrane CENTRAL, MEDLINE, EMBASE, the Oxford Pain Relief Database, and reference lists of articles were searched; last search December 2008. SELECTION CRITERIA: Randomised, double blind, placebo or active controlled clinical trials of topical rubefacient for musculoskeletal pain in adults, with at least 10 participants per treatment arm, and reporting outcomes at close to 7 (minimum 3, maximum 10) days for acute conditions and 14 (minimum 7) days

Cochrane2009

206. Single dose oral nefopam for acute postoperative pain in adults.

Single dose oral nefopam for acute postoperative pain in adults. BACKGROUND: Nefopam is a centrally-acting but non-opioid analgesic drug of the benzoxazocine chemical class, developed in the early 1970s. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs, and used in rheumatic disease and other musculoskeletal disorders in the UK. This review sought to evaluate the efficacy and safety of oral nefopam in acute (...) postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties. OBJECTIVES: To assess the efficacy of single dose oral nefopam in acute postoperative pain, and any associated adverse events. SEARCH STRATEGY: We searched CENTRAL (Issue 2, 2009), MEDLINE (1966 to May 2009); EMBASE via Ovid (1980 to May 2009); the Oxford

Cochrane2009

207. Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. BACKGROUND: Dexibuprofen (S(+)-ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide. It is an active isomer of ibuprofen. This review sought to evaluate the efficacy and safety of oral dexibuprofen in acute postoperative pain, using clinical studies of patients (...) with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties. OBJECTIVES: To assess efficacy, duration of action, and associated adverse events of single dose oral dexibuprofen in acute postoperative pain in adults. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to May 2009. SELECTION CRITERIA: Randomised, double

Cochrane2009

208. Single dose oral acemetacin for acute postoperative pain in adults.

Single dose oral acemetacin for acute postoperative pain in adults. BACKGROUND: Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide. This review sought to evaluate the efficacy and safety of oral acemetacin in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using (...) standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties. OBJECTIVES: To assess the efficacy of single dose oral acemetacin in acute postoperative pain, and any associated adverse events. SEARCH STRATEGY: We searched CENTRAL (Issue 2, 2009), MEDLINE via Ovid (1966 to May 2009); EMBASE via Ovid (1980 to May 2009); the Oxford Pain Relief Database (1950 to 1994); and reference lists of articles. SELECTION CRITERIA: Randomised, double-blind

Cochrane2009

209. Single dose oral tenoxicam for acute postoperative pain in adults.

Single dose oral tenoxicam for acute postoperative pain in adults. BACKGROUND: Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and is widely available in other countries worldwide. This review sought to evaluate the efficacy and safety of oral tenoxicam in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using (...) standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties. OBJECTIVES: To assess the efficacy of single dose oral tenoxicam in acute postoperative pain, and any associated adverse events. SEARCH STRATEGY: We searched The Cochrane Library (Issue 1, 2009), MEDLINE (March 2009); EMBASE via Ovid (March 2009); the Oxford Pain Relief Database. SELECTION CRITERIA: Randomised, double-blind, placebo-controlled clinical trials of oral tenoxicam

Cochrane2009

210. Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: a randomized clinical trial

Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: a randomized clinical trial 18692428 2009 04 28 2009 07 15 2009 04 28 1532-2769 14 3 2009 Jun Manual therapy Man Ther Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: a randomized clinical trial. 306-13 10.1016/j.math.2008.04.006 Our aim (...) was to examine the effects of a seated thoracic spine distraction thrust manipulation included in an electrotherapy/thermal program on pain, disability, and cervical range of motion in patients with acute neck pain. This randomized controlled trial included 45 patients (20 males, 25 females) between 23 and 44 years of age presenting with acute neck pain. Patients were randomly divided into 2 groups: an experimental group which received a thoracic manipulation, and a control group which did not receive

EvidenceUpdates2009

211. Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study

Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study 19478654 2009 05 29 2009 09 25 2015 11 19 1528-1159 34 13 2009 Jun 01 Spine Spine Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. 1349-54 10.1097/BRS (...) for painful osteoporotic fractures. Fifty patients (41 females) were included from January 2001 until January 2008. Patients with acute (<2 weeks) and subacute (between 2 and 8 weeks) osteoporotic fractures were included and randomized to either PVP or conservative treatment. Pain was assessed with a visual analogue scale and physical and mental outcome were assessed by validated questionnaires and tests. Tests, questionnaires, and plain radiographs were performed at the inclusion and after 3 months

EvidenceUpdates2009

212. Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection

Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection 19478653 2009 05 29 2009 09 25 2015 11 19 1528-1159 34 13 2009 Jun 01 Spine Spine Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral (...) injection. 1337-44 10.1097/BRS.0b013e3181a3c18d Multicenter randomized, double-blind, simulated therapy-controlled trial in a cohort of patients with acute low back pain (LBP) due to lumbar disc herniation (LDH). To assess the benefit of intramuscular-paravertebral injections of an oxygen-ozone (O2O3) mixture. Recent findings have shown that O2O3 therapy can be used to treat LDH that fails to respond to conservative management. However, these findings are based on intradiscal/intraforaminal O2O3

EvidenceUpdates2009

213. Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study.

Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study. OBJECTIVE: To identify an optimal imaging strategy for the accurate detection of urgent conditions in patients with acute abdominal pain. DESIGN: Fully paired multicentre diagnostic accuracy study with prospective data collection. SETTING: Emergency departments of two university hospitals and four large teaching hospitals in the Netherlands. PARTICIPANTS: 1021 patients (...) with non-traumatic abdominal pain of >2 hours' and <5 days' duration. Exclusion criteria were discharge from the emergency department with no imaging considered warranted by the treating physician, pregnancy, and haemorrhagic shock. INTERVENTION: All patients had plain radiographs (upright chest and supine abdominal), ultrasonography, and computed tomography (CT) after clinical and laboratory examination. A panel of experienced physicians assigned a final diagnosis after six months and classified

BMJ2009 Full Text: Link to full Text with Trip Pro

214. Transcutaneous electrical nerve stimulation for acute pain.

Transcutaneous electrical nerve stimulation for acute pain. BACKGROUND: Transcutaneous Electrical Nerve Stimulation (TENS) is a non-pharmacological agent, based on delivering low voltage electrical currents to the skin. TENS is used for the treatment of a variety of pain conditions. OBJECTIVES: To assess the analgesic effectiveness of TENS for acute pain in adults to see if it had any clear analgesic effect in its own right. SEARCH STRATEGY: The following databases were searched: Cochrane Pain (...) , Palliative and Supportive Care Group Specialised Register; the Cochrane Central Register of Controlled Trials, CENTRAL (in The Cochrane Library); MEDLINE; EMBASE; CINAHL; AMED; PEDro; OTseeker; OpenSIGLE; and, reference lists of included studies. The most recent search was undertaken in August 2008. SELECTION CRITERIA: Randomised controlled trials (RCTs) of adults with acute pain (less than 12 weeks) were included if they examined TENS given as a sole treatment and assessed pain with subjective pain

Cochrane2009

215. Management of acute undifferentiated abdominal pain

Management of acute undifferentiated abdominal pain application/octet-stream

Monash Health Evidence Reviews2009

216. Shoulder acute pain in primary health care: is retraining GPs effective? The SAPPHIRE randomized trial: a cost-effectiveness analysis

Shoulder acute pain in primary health care: is retraining GPs effective? The SAPPHIRE randomized trial: a cost-effectiveness analysis Shoulder acute pain in primary health care: is retraining GPs effective? The SAPPHIRE randomized trial: a cost-effectiveness analysis Shoulder acute pain in primary health care: is retraining GPs effective? The SAPPHIRE randomized trial: a cost-effectiveness analysis McKenna C, Bojke L, Manca A, Adebajo A, Dickson J, Helliwell P, Morton V, Russell I, Torgerson D (...) study with a one-year horizon. The authors reported that both a health system and a societal perspective were adopted. Effectiveness data: The clinical data were mainly from the Shoulder Acute Pain in Primary Health Care: Is Retraining GPs Effective? (SAPPHIRE) multi-centre randomised controlled trial (RCT). Patients recruited to this trial were blind to the injection received. A sample of 200 patients and 155 GPs was used, with 101 patients randomised to lignocaine and 99 to cortisone, while 106

NHS Economic Evaluation Database.2009

218. Single dose etoricoxib effective for acute postoperative pain in adults

Single dose etoricoxib effective for acute postoperative pain in adults PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Single dose etoricoxib effective for acute postoperative pain in adults Clinical question How effective is single dose etoricoxib for acute postoperative pain in adults? Bottom line All 5 studies reported on a single 120mg dose, in comparison with placebo. At least 50% pain (...) event withdrawals. Context Etoricoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor, prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis, and for acute pain. The drug is believed to be associated with fewer upper gastrointestinal adverse effects than conventional non- steroidal anti-inflammatory drugs. Cochrane Systematic Review Clarke R et al. Single dose etoricoxib for acute postoperative pain in adults. Cochrane Reviews 2009, Issue 2. Article No. CD004309

Cochrane PEARLS2009

219. The Paediatric Appendicitis Score (PAS) was useful in children with acute abdominal pain

The Paediatric Appendicitis Score (PAS) was useful in children with acute abdominal pain The Paediatric Appendicitis Score (PAS) was useful in children with acute abdominal pain | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword (...) Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here The Paediatric Appendicitis Score (PAS) was useful in children with acute abdominal pain Article Text Clinical prediction guide The Paediatric Appendicitis Score (PAS) was useful in children with acute abdominal pain Statistics from Altmetric.com No Altmetric data available for this article. R D Goldman Dr R D Goldman

Evidence-Based Medicine (Requires free registration)2009

220. Oral versus Intravenous Opioid Dosing for the Initial Treatment of Acute Musculoskeletal Pain in the Emergency Department

Oral versus Intravenous Opioid Dosing for the Initial Treatment of Acute Musculoskeletal Pain in the Emergency Department 18945240 2009 08 20 2009 10 13 2013 11 21 1553-2712 15 12 2008 Dec Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med Oral versus intravenous opioid dosing for the initial treatment of acute musculoskeletal pain in the emergency department. 1234-40 10.1111/j.1553-2712.2008.00266.x The objective was to compare the time (...) to 0.1 mg/kg IV morphine in the treatment of severe acute musculoskeletal pain when difficult or delayed IV placement greater than 30 minutes presents a barrier to treatment. Miner James R JR Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA. jimminer@hotmail.com Moore Johanna J Gray Richard O RO Skinner Lisa L Biros Michelle H MH eng Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't 2008 10 17 United States Acad Emerg

EvidenceUpdates2009