Latest & greatest articles for acute pain

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Top results for acute pain

2. Efficacy of preemptive analgesia on acute postoperative pain in children undergoing major orthopedic surgery of the lower extremities

Efficacy of preemptive analgesia on acute postoperative pain in children undergoing major orthopedic surgery of the lower extremities 30288096 2018 11 14 1178-7090 11 2018 Journal of pain research J Pain Res Efficacy of preemptive analgesia on acute postoperative pain in children undergoing major orthopedic surgery of the lower extremities. 2061-2070 10.2147/JPR.S175169 Children undergoing major orthopedic surgery of the lower extremities can experience severe postoperative pain; yet, the ideal (...) postoperative pain management strategy is unknown. Thus, in this patient population, we investigated the effect of intraoperative epidural infusion of local anesthetic on acute postoperative pain and analgesic consumption. Patients (N=50, 3-12 years) randomly received either ropivacaine 0.15% (preemptive group) or normal saline (control group) as an initial bolus of 0.2 mL/kg, followed by continuous infusion of 0.15 mL/kg/h throughout surgery. Following surgery, patient-controlled epidural analgesia with

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

3. Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department

Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department 30119941 2018 08 18 1097-6760 2018 Aug 14 Annals of emergency medicine Ann Emerg Med Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department. S0196-0644(18)30550-X 10.1016/j.annemergmed.2018.06.019 As clinicians look to nonnarcotic analgesics in (...) the emergency department (ED), it is essential to understand the effectiveness and adverse effects of nonopioid medications in comparison with existing opioid treatments. Studies of intravenous acetaminophen for acute pain in the ED demonstrate mixed results and suffer from small sample sizes and methodological limitations. This study compares intravenous hydromorphone with intravenous acetaminophen in adult ED patients presenting with acute pain. This was a prospective, randomized, clinical trial comparing

EvidenceUpdates2018

4. A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department

A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department 30019434 2018 07 18 1553-2712 2018 Jul 17 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med A Systematic Review and Meta-analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department. 10.1111/acem.13502 Opioids are commonly prescribed in the emergency department (ED) for the treatment (...) of acute pain. Analgesic alternatives are being explored in response to an epidemic of opioid misuse. Low-dose ketamine (LDK) is one opioid alternative for the treatment of acute pain in the ED. This systematic review and meta-analysis sought to quantify whether LDK is an effective and safe opioid alternative for acute pain reduction in adults in the ED setting. (PROSPERO Registration Number CRD42017065303). This was a systematic review of randomized controlled trials comparing intravenous opioids

EvidenceUpdates2018

5. Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial

Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial 29939959 2018 08 16 1872-6623 159 9 2018 Sep Pain Pain Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial. 1790-1801 10.1097/j.pain.0000000000001276 No randomized controlled trial has investigated the efficacy of hypnosis for reducing pain and improving wound-healing in children (...) with burns. This randomized controlled trial aimed to investigate whether hypnosis decreases pain, anxiety, and stress and accelerates wound-healing in children undergoing burn wound procedures. Children (4-16 years) with acute burns presenting for their first dressing change were randomly assigned to a Hypnosis Group who received hypnosis plus standard care or a Standard Care Group who received standard pharmacological and nonpharmacological intervention. Repeated measures of pain intensity, anxiety

EvidenceUpdates2018

6. Single-dose intravenous diclofenac for acute postoperative pain in adults.

Single-dose intravenous diclofenac for acute postoperative pain in adults. BACKGROUND: Postoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) reduces patient opioid requirements and, in turn, reduces the incidence and severity of opioid-induced adverse events (AEs). OBJECTIVES: To assess the analgesic efficacy and adverse effects of single-dose intravenous diclofenac, compared with placebo or an active comparator, for moderate to severe postoperative pain in adults (...) . SEARCH METHODS: We searched the following databases without language restrictions: the Cochrane Central Register of Controlled Trials (Cochrane Register of Studies Online), MEDLINE, and Embase on 22 May 2018. We checked clinical trials registers and reference lists of retrieved articles for additional studies. SELECTION CRITERIA: We included randomized trials that compared a single postoperative dose of intravenous diclofenac with placebo or another active treatment, for treating acute postoperative

Cochrane2018

7. Is oral orphenadrine beneficial for acute low back pain?

Is oral orphenadrine beneficial for acute low back pain? Is oral orphenadrine beneficial for acute low back pain? – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2018\/08\/mo_2018-08_p46-7_cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Aug 21 2018 Is oral orphenadrine beneficial for acute (...) low back pain? By in , Journal reference: Friedman BW, Cisewski D, Irizarry E, et al. A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. Ann Emerg Med 2018 Mar;71(3):348-56 e5 Link: Published: March 2018 Evidence cookie says… Orphenadrine provides no benefit when used in addition to naproxen for acute low back pain the point estimate is close to zero, with the imprecision of the estimate well within the minimal

Morsels of Evidence2018

8. Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial

Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial 29624535 2018 04 06 1526-7598 2018 Apr 05 Anesthesia and analgesia Anesth. Analg. Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial. 10.1213/ANE.0000000000003315 In patients undergoing total knee (...) arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with propofol. Forty-eight patients were enrolled and randomly assigned to either a dexmedetomidine group (n = 24), which received a loading dose of 1 μg/kg dexmedetomidine over 10 minutes, followed by a continuous infusion of 0.1-0.5

EvidenceUpdates2018

9. Acute pain

Acute pain Top results for acute pain - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search (...) button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for acute pain The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory

Trip Latest and Greatest2018

11. Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management

Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management Consensus Guidelines on the Use of Intravenous Ketamine Infu... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. You currently have no recent searches Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy (...) to your colleague. Some error has occurred while processing your request. Please try after some time. Export to End Note Procite Reference Manager Save my selection doi: 10.1097/AAP.0000000000000806 Regional Anesthesia and Acute Pain: Special Article Background Ketamine infusions have been used for decades to treat acute pain, but a recent surge in usage has made the infusions a mainstay of treatment in emergency departments, in the perioperative period in individuals with refractory pain

American Society of Regional Anesthesia and Pain Medicine2018

12. Cebranopadol: A Novel, First-in-Class, Strong Analgesic: Results from a Randomized Phase IIa Clinical Trial in Postoperative Acute Pain

Cebranopadol: A Novel, First-in-Class, Strong Analgesic: Results from a Randomized Phase IIa Clinical Trial in Postoperative Acute Pain 29871387 2018 06 06 2150-1149 21 3 2018 May Pain physician Pain Physician Cebranopadol: A Novel, First-in-Class, Strong Analgesic: Results from a Randomized Phase IIa Clinical Trial in Postoperative Acute Pain. E193-E206 Cebranopadol is a potent, first-in-class analgesic with a novel mechanistic approach combining nociceptin/orphanin FQ peptide (NOP) and opioid (...) peptide receptor agonism. We aim to evaluate, for the first time, the analgesic efficacy, safety, and tolerability of cebranopadol in patients suffering from moderate to severe acute pain following bunionectomy. We conducted a phase IIa, randomized, multi-center, double-blind, double-dummy, placebo- and active-controlled, parallel group clinical trial. A total of 258 patients who underwent a primary bunionectomy were randomly assigned to receive a single oral administration of cebranopadol 200 µg, 400

EvidenceUpdates2018

13. Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial.

Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial. OBJECTIVE: To assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body. DESIGN: Randomised, double blind, sham controlled clinical trial. SETTING: Four community hospitals in the Netherlands, 2011-15. PARTICIPANTS: 180 (...) participants requiring treatment for acute osteoporotic vertebral compression fractures were randomised to either vertebroplasty (n=91) or a sham procedure (n=89). INTERVENTIONS: Participants received local subcutaneous lidocaine (lignocaine) and bupivacaine at each pedicle. The vertebroplasty group also received cementation, which was simulated in the sham procedure group. MAIN OUTCOME MEASURES: Main outcome measure was mean reduction in visual analogue scale (VAS) scores at one day, one week, and one

BMJ2018

15. The Effect of Intraoperative Nefopam Administration on Acute Postoperative Pain and Chronic Discomfort After Robotic or Endoscopic Assisted Thyroidectomy: A Randomized Clinical Trial

The Effect of Intraoperative Nefopam Administration on Acute Postoperative Pain and Chronic Discomfort After Robotic or Endoscopic Assisted Thyroidectomy: A Randomized Clinical Trial 29288309 2017 12 30 1432-2323 2017 Dec 29 World journal of surgery World J Surg The Effect of Intraoperative Nefopam Administration on Acute Postoperative Pain and Chronic Discomfort After Robotic or Endoscopic Assisted Thyroidectomy: A Randomized Clinical Trial. 10.1007/s00268-017-4421-9 Acute postoperative pain (...) and chronic discomfort are reported after robotic or endoscopic thyroidectomy. The purpose of this prospective, randomized, and double-blinded clinical trial was to investigate whether intraoperative infusion of nefopam decreases acute postoperative pain and chronic discomfort following either a robotic or endoscopic thyroidectomy via the bilateral axillo-breast approach (BABA). Patients were randomized into two groups: The control group (n = 29) or the nefopam group (n = 29). Patients in each group were

EvidenceUpdates2018

16. Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain

Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain 28591082 2018 01 04 1536-5409 34 2 2018 Feb The Clinical journal of pain Clin J Pain Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain. 138-144 10.1097/AJP.0000000000000525 To report the opioid-sparing effects of SoluMatrix indomethacin, developed using SoluMatrix Fine Particle Technology, in a phase 3 study in patients (...) with acute pain following bunionectomy. This phase 3, placebo-controlled study randomized 462 patients with moderate-to-severe pain following bunionectomy surgery to receive SoluMatrix indomethacin 40 mg 3 times daily, SoluMatrix indomethacin 40 mg twice daily, SoluMatrix indomethacin 20 mg 3 times daily, celecoxib 400-mg loading dose followed by 200 mg twice daily, or placebo. Patients were permitted to receive opioid-containing rescue medication throughout the study. The proportion of patients who used

EvidenceUpdates2018

17. A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain

A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain 29089169 2017 12 19 1097-6760 2017 Oct 28 Annals of emergency medicine Ann Emerg Med A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. S0196-0644(17)31700-6 10.1016/j.annemergmed.2017.09.031 In US emergency departments (EDs), patients with low back pain are often treated (...) with nonsteroidal anti-inflammatory drugs and muscle relaxants. We compare functional outcomes among patients randomized to a 1-week course of naproxen+placebo versus naproxen+orphenadrine or naproxen+methocarbamol. This was a randomized, double-blind, comparative effectiveness trial conducted in 2 urban EDs. Patients presenting with acute, nontraumatic, nonradicular low back pain were enrolled. The primary outcome was improvement on the Roland-Morris Disability Questionnaire (RMDQ) between ED discharge and 1 week later. All patients

EvidenceUpdates2018

18. A Rare Cause of Abdominal Pain in a Patient with Acute Necrotizing Pancreatitis

A Rare Cause of Abdominal Pain in a Patient with Acute Necrotizing Pancreatitis E-Mail karger@karger.com Clinical Case Study GE Port J Gastroenterol 2018;25:253–257 DOI: 10.1159/000484939 A Rare Cause of Abdominal Pain in a Patient with Acute Necrotizing Pancreatitis Joana C. Branco a Mariana F. Cardoso a Luís Carvalho Lourenço a Liliana Santos a David Valadas Horta a Élia Coimbra b Jorge A. Reis a a Serviço de Gastrenterologia, Hospital Professor Doutor Fernando Fonseca, Amadora, and b Serviço (...) Pancreatite Aguda Necrotizante Palavras Chave Pancreatite aguda · Necrose pancreática coletada · Drenagem percutânea guiada por TC · Infeção a Citrobacter freundii · Dor abdominal Resumo Introdução: A necrose pancreática coletada (NPC) é uma complicação potencialmente fatal da pancreatite aguda (PA) e ocorre em menos de 10% dos casos. Pode estar lo- Keywords Acute pancreatitis · Walled-off necrosis · Computed tomography-guided percutaneous drainage · Citrobacter freundii infection · Abdominal pain

GE Portuguese journal of gastroenterology2017 Full Text: Link to full Text with Trip Pro

19. Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines

Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines Published on: December 6, 2017 Project Number: RB1167-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question (...) What is the clinical effectiveness of intranasal sufentanil for acute pain in adults? What are the evidence-based guidelines regarding the use of intranasal opioids for acute pain in adults? Key Message Three evidence-based guidelines were identified regarding the use of intranasal opioids for acute pain in adults. Tags anesthesia, administration, intranasal, analgesics, opioid, drug delivery systems, fentanyl, ketamine, sufentanil, ear, nose, and throat, nasal delivery, transmucosal, Opioid

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

20. A randomized, Phase IIb study investigating oliceridine (TRV130), a novel micro-receptor G-protein pathway selective (mu-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty

A randomized, Phase IIb study investigating oliceridine (TRV130), a novel micro-receptor G-protein pathway selective (mu-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty 29062240 2017 12 19 1178-7090 10 2017 Journal of pain research J Pain Res A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (μ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty (...) Clin North Am. 2015 Apr;95(2):301-18 25814108 TRV130 acute pain analgesic biased ligand opioid Disclosure This study was supported by Trevena, Inc (King of Prussia, PA, USA). Neil Singla is an employee of Lotus Clinical Research, LLC, contracted by the sponsor to conduct the study; Dr Singla has also received consulting fees from Trevena, Inc. Harold S Minkowitz has received investigator fees and consulting fees from Trevena, Inc, AcelRx, and The Medicines Company. Ruth Ann Subach was an employee

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro