Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

61. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.

High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. BACKGROUND: Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect. OBJECTIVE: To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome. DESIGN: Cross-sectional (...) comparison. SETTING: University hospital in Lausanne, Switzerland. PARTICIPANTS: 102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated. MEASUREMENTS: Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype. RESULTS

Annals of Internal Medicine2002

62. Management of acne

Management of acne Management of acne Management of acne Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Management of acne. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 17. 2001 Authors (...) ' objectives Acne is a common condition, particularly in adolescents and young adults, with potentially significant physical and psychological morbidity from scarring and from adverse effects of treatment, as well as significant economic burdens. The purpose of this review was to provide a comprehensive review of the literature on acne management. Authors' conclusions Despite the large number of English-language controlled trials regarding acne therapy, their methodological limitations prevent our ability

Health Technology Assessment (HTA) Database.2001

63. Management of acne

Management of acne Management of acne Management of acne Lehmann H P, Andrews J S, Robinson K A, Holloway V L, Goodman S N Authors' objectives To provide a comprehensive review on the management of acne. Searching The search utilised several electronic databases from inception to 1999, including the CENTRAL Register in the Cochrane Library, MEDLINE, OLDMEDLINE (from 1960 to 1965), EMBASE, CINAHL and PsycINFO amongst others. Details of the searches were given in the report. In addition (...) of first-, second- and third-line treatments for acne were eligible for inclusion in the review. The included studies were of 140 different treatments, which were classified as: cleansers, keratolytics, topical antibacterials, keratolytic/topical antibacterial combinations, topical retinoids, topical antibacterial/retinoid combinations, oral antibacterials, oral antibacterial/keratolytics, oral antibacterial/topical retinoids, oral retinoids, anti-androgens and other. All individual treatments

DARE.2001

64. Laser resurfacing for facial acne scars.

Laser resurfacing for facial acne scars. BACKGROUND: Most people have acne at some stage during their life, with about one per cent being left with permanent acne scars. Recent laser techniques are thought to be more effective than chemical peels and dermabrasion. OBJECTIVES: To assess the effects of laser resurfacing for treating facial acne scars. SEARCH STRATEGY: We searched MEDLINE (1966 to April 1999), EMBASE (1980 to April 1999), Science Citation Index (1981 to April 1999), the Cochrane (...) Controlled Trials Register (April 1999), DARE (April 1999), INAHTA (April 1999), NHS HTA Internet site (April 1999). Dermatological Surgery (1995 to March 1999) and the British Journal of Dermatology (1995 to September 1999) were handsearched. We searched the reference lists of relevant articles and contacted experts and commercial laser manufacturers. SELECTION CRITERIA: Randomised controlled trials which compare different laser resurfacing techniques for treating patients with facial acne scars

Cochrane2001

65. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D Authors' objectives To identify (...) in the review Patients with acne. Patients taking minocycline for reasons other than acne were excluded, as were those for whom there were no details of their age and gender. The age of participants ranged from 14 to 73 years, with the majority of cases in their teens or early 20s. Outcomes assessed in the review Liver damage. Studies reporting findings of laboratory investigations indicating liver dysfunction, or where a specific reference was made by the authors to liver dysfunction, were included. How

DARE.2000

66. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne.

Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. BACKGROUND: Hirsutism is the presence of excessive hair growth in women and is an important cosmetic condition often resulting in severe distress. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair follicles, and the secretory glands around the hair follicles, called sebaceous glands (...) . Spironolactone is an antiandrogen and aldosterone antagonist used to treat hirsutism. Since 1978, many studies have been conducted to determine its effectiveness. OBJECTIVES: The objective of this review was to investigate the effectiveness of spironolactone and/or in combination with steroids (oral contraceptive pill included) in reducing excess hair growth and/or acne in women. SEARCH STRATEGY: All publications of randomised controlled trials of spironolactone versus placebo and/or in combination

Cochrane2000

67. Minocycline for acne vulgaris: efficacy and safety.

Minocycline for acne vulgaris: efficacy and safety. BACKGROUND: Minocycline is a tetracycline antibiotic that is commonly used in the treatment of moderate to severe acne vulgaris. Although it is more convenient for patients to take than first-generation tetracyclines, as it only needs to be taken once or twice a day and can be taken with food, it is more expensive. Concerns have also been expressed over its safety following the deaths of two patients taking the drug. There is a lack (...) of consensus among dermatologists over the relative risks and benefits of minocycline. As most acne prescribing is undertaken by general practitioners, it is important that guidelines issued to them are based on the best available evidence rather than personal judgements. OBJECTIVES: To collate and evaluate the evidence on the clinical efficacy of minocycline in the treatment of inflammatory acne vulgaris. Specific objectives were to compare the efficacy of minocycline with other drug treatments for acne

Cochrane2000

68. The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model

The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model Wessels F, Anderson A N, Kropman K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS (...) EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Systemic isotretinoin at a daily dose of 1mg/kg (cumulative dose of 120 mg/kg) in the treatment of patients with a diagnosis of moderate to severe acne. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients with a diagnosis of moderate

NHS Economic Evaluation Database.1999

69. Laser resurfacing of the skin for the improvement of facial acne scarring

Laser resurfacing of the skin for the improvement of facial acne scarring Laser resurfacing of the skin for the improvement of facial acne scarring Laser resurfacing of the skin for the improvement of facial acne scarring Jordan R, Cummins C, Burls A Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Jordan R, Cummins C, Burls A. Laser resurfacing of the skin (...) for the improvement of facial acne scarring. Birmingham: West Midlands Health Technology Assessment Collaboration (WMHTAC). DPHE Report No. 11. 1998 Authors' objectives To assess the effectiveness and cost effectiveness of laser resurfacing of the skin for the improvement of facial acne scarring. Authors' conclusions Poor quality evidence indicates that there is some improvement of acne scarring with laser resurfacing techniques. There is not enough evidence to compare the two types of laser adequately; RCTs

Health Technology Assessment (HTA) Database.1998

70. Topical agents alone in acne. A blind assessment study.

Topical agents alone in acne. A blind assessment study. 6444678 1980 05 30 1980 05 30 2016 10 17 0098-7484 243 16 1980 Apr 25 JAMA JAMA Topical agents alone in acne. A blind assessment study. 1640-3 The comparative effectiveness of three comprehensive therapeutic programs was studied in 118 patients with mild to moderate acne vulgaris. A topical program of tretinoin, benzoyl peroxide, and water avoidance was found to be as effective as the more commonly employed program of systemic tetracycline (...) therapy with topically applied tretinoin and better than a program using systemic tetracycline therapy with abradant cleansers. At 16 weeks of therapy for all groups, the degree of skin dryness correlated with lack of improvement. Skin dryness is established as an aggravating factor in both the pathogenesis and treatment of acne. The topical program was nonirritating, well accepted by patients, and less expensive than the other two regimens. Swinyer L J LJ Swinyer T A TA Britt M R MR eng Clinical

JAMA1980