Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

41. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study.

Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. BACKGROUND: A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of adapalene 0.1% -BPO 2.5% fixed combination gel (adapalene-BPO) for the treatment of acne. METHODS: A total of 517 subjects were randomized (...) tolerability profile for adapalene-BPO were similar to adapalene monotherapy. LIMITATIONS: These data were generated in a controlled trial. Results obtained in clinical practice could differ. CONCLUSIONS: The fixed-dose combination of adapalene and BPO provides significantly greater efficacy for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene.

EvidenceUpdates2007

42. Combined oral contraceptive pills for treatment of acne.

Combined oral contraceptive pills for treatment of acne. BACKGROUND: Acne is a common skin disorder among women. Although no uniform approach to the management of acne exists, combination oral contraceptives (COCs), which contain an estrogen and a progestin, often are prescribed for women. OBJECTIVES: To determine the effectiveness of combined oral contraceptives (COCs) for the treatment of facial acne compared to placebo or other active therapies. SEARCH STRATEGY: We searched the computerized (...) databases of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, POPLINE, Biological Abstracts and LILACS for randomized controlled trials of COCs and acne. We wrote to authors of identified trials to seek any unpublished or published trials that we might have missed. SELECTION CRITERIA: All randomized controlled trials reported in any language that compared the effectiveness of a COC containing an estrogen and a progestin to placebo or another active therapy for acne in women

Cochrane2007

43. Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context

Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Magin P J, Adams J, Pond C D, Smith W CRD summary This review examined topical and oral complementary and alternative treatments for acne. The authors concluded that the evidence base was limited (...) ; this reflects the poor quality of most of the included studies. The review methodology was poorly reported and the reliability of the review's conclusions is therefore unclear. Authors' objectives To examine the efficacy of different methods of complementary and alternative medicine (CAM) in the treatment of acne. Searching MEDLINE, EMBASE, AMED, DARE and the Cochrane Library were searched using the reported search terms. The dates of the search were not reported. The reference lists of identified articles

DARE.2006

44. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review

Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review Marqueling A L, Zane L T CRD summary This review assessed whether treatment with isotretinoin increases the risk of depression or suicide in people with acne. The authors concluded that the evidence does (...) not show an increased risk. The evidence was examined thoroughly and supported the authors' conclusions. Nevertheless, there was uncertainty about aspects of the review process and not all relevant studies might have been included. Authors' objectives To assess the association between isotretinoin treatment and the risk of depression and suicidal behaviour in patients with acne. Searching MEDLINE, EMBASE, PsycINFO and BIOSIS Previews were searched; the search terms, but not dates, were reported

DARE.2005

45. A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight

A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight Magin P, Pond D, Smith W, Watson A CRD summary This review assessed diet, face washing and sunlight exposure in the management of acne (...) . It concluded that the evidence base on which to make recommendations is incomplete. The authors' conclusion is appropriate on the basis of the evidence presented, although the review itself had several methodological limitations. Authors' objectives To assess the evidence of effects of diet, face washing and sunlight exposure in the management of acne. Searching MEDLINE, EMBASE, CINAHL, AMED, the Cochrane CENTRAl Register and DARE were searched for articles published in English; the search terms were

DARE.2005

47. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne

Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Ozolins M, Eady E A, Avery A, Cunliffe W J, O'Neill C, Simpson N (...) B, et al Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Ozolins M, Eady E A, Avery A, Cunliffe W J, O'Neill C, Simpson N B, et al. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne. Health Technology Assessment 2005; 9(1): 1-212 Authors

Health Technology Assessment (HTA) Database.2005

48. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne

Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you

NIHR HTA programme2005

49. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial.

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. 15610805 2004 12 21 2005 01 19 2015 06 16 1474-547X 364 9452 2004 Dec 18-31 Lancet (London, England) Lancet Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. 2188-95 We investigated the efficacy and cost-effectiveness of five (...) antimicrobial regimens for mild to moderate facial acne and whether propionibacterial antibiotic resistance affects treatment response. In this randomised, observer-masked trial, 649 community participants were allocated one of five antibacterial regimens. Primary outcomes were patients' self-assessed improvement and reduction in inflamed lesions at 18 weeks. Analyses were by intention to treat. Moderate or greater improvement at 18 weeks was reported in 72 (55%) of 131 participants assigned oral

Lancet2004

50. Treatment of acne vulgaris.

Treatment of acne vulgaris. CONTEXT: Management of acne vulgaris by nondermatologists is increasing. Current understanding of the different presentations of acne allows for individualized treatments and improved outcomes. OBJECTIVE: To review the best evidence available for individualized treatment of acne. DATA SOURCES: Search of MEDLINE, EMBASE, and the Cochrane database to search for all English-language articles on acne treatment from 1966 to 2004. STUDY SELECTION: Well-designed randomized (...) controlled trials, meta-analyses, and other systematic reviews are the focus of this article. DATA EXTRACTION: Acne literature is characterized by a lack of standardization with respect to outcome measures and methods used to grade disease severity. DATA SYNTHESIS: Main outcome measures of 29 randomized double-blind trials that were evaluated included reductions in inflammatory, noninflammatory, and total acne lesion counts. Topical retinoids reduce the number of comedones and inflammatory lesions

JAMA2004

51. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Ozolins M, Eady E A, Avery A J (...) , Cunliffe W J, Po A L, O'Neill C, Simpson N B, Walters C E, Carnegie A, Lewis J B, Dada J, Haynes M, Williams W, Williams H C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Five antimicrobial regimens for mild to moderate facial acne

NHS Economic Evaluation Database.2004

52. Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial.

Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. 15199033 2004 06 16 2004 06 18 2016 10 17 1538-3598 291 23 2004 Jun 16 JAMA JAMA Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. 2834-9 The high prevalence of acne vulgaris and its significant morbidity underscore the need for convenient, low-risk, and efficacious therapy. Treatment with various lasers has been reported to improve acne. To evaluate the clinical efficacy (...) of pulsed dye laser therapy in the treatment of acne. Randomized, single-blind, controlled, split-face clinical trial of a volunteer sample of 40 patients aged 13 years or older with facial acne conducted at an academic referral center from August 2002 to September 2003. One or 2 nonpurpuric pulsed dye laser treatments to half of the face (fluence of 3 J/cm2), serial blinded clinical assessments (lesion counts), and grading of acne severity using standardized bilateral serial photographs. Comparison

JAMA2004

53. European directive for prescribing systemic isotretinoin for acne vulgaris

European directive for prescribing systemic isotretinoin for acne vulgaris The European Agency for the Evaluation of Medicinal Products Pre-authorisation Evaluation of Medicines for Human Use 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 86 13 E-mail: mail@emea.eu.int http://www.emea.eu.int ?EMEA 2003 Reproduction and/or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged London, 17 (...) October 2003 CPMP/2811/03 COMMITTEE FOR PROPRIETARY MEDICINAL PRODUCTS (CPMP) SUMMARY INFORMATION ON A REFERRAL OPINION FOLLOWING AN ARBITRATION PURSANT TO ARTICLE 29 OF DIRECTIVE 2001/83/EC, FOR ISOTRETINOIN / LURANTAL / TRIVANE / REXIDAL / SCHERITONIN (See Annex I) International Non-Proprietary Name (INN): Isotretinoin BACKGROUND INFORMATION Isotretinoin (13-cis-retinoic acid) is a retinoid compound and a derivative of vitamin A. Isotretinoin is used for the systemic treatment of acne. Like all

Publication 10832003

54. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial.

Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. 14585635 2003 10 30 2004 01 12 2015 06 16 1474-547X 362 9393 2003 Oct 25 Lancet (London, England) Lancet Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. 1347-52 Low-fluence (low irradiation energy density) pulsed-dye lasers (PDLs) have been used for atrophic acne scarring, and anecdotal experience suggests that long-term improvements in inflammatory acne can be seen (...) after one PDL treatment. Our aim was to compare the efficacy and tolerability of such PDL treatment with sham treatment in patients with facial inflammatory acne in a double-blind, randomised controlled trial. We recruited 41 adults with mild-to-moderate facial inflammatory acne. We randomly assigned patients to PDL (n=31) or sham treatment (n=10). Treatment was given at baseline and patients were seen after 2, 4, 8, and 12 weeks. Assessors and participants were unaware of treatment allocations

Lancet2003

55. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne.

Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. BACKGROUND: Hirsutism is the presence of excessive hair growth in women and is an important cosmetic condition often resulting in severe distress. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair follicles, and the secretory glands around the hair follicles, called sebaceous glands (...) . Spironolactone is an antiandrogen and aldosterone antagonist used to treat hirsutism. OBJECTIVES: The objective of this review was to investigate the effectiveness of spironolactone and/or in combination with steroids (oral contraceptive pill included) in reducing excess hair growth and/or acne in women. SEARCH STRATEGY: We searched the Cochrane Menstrual Disorders and Subfertility Group trials register (searched 12 June 2003). The Cochrane Menstrual Disorders and Subfertility Group register is based

Cochrane2003

56. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.

High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. BACKGROUND: Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect. OBJECTIVE: To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome. DESIGN: Cross-sectional (...) comparison. SETTING: University hospital in Lausanne, Switzerland. PARTICIPANTS: 102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated. MEASUREMENTS: Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype. RESULTS

Annals of Internal Medicine2002

57. Management of acne

Management of acne Management of acne Management of acne Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Management of acne. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 17. 2001 Authors (...) ' objectives Acne is a common condition, particularly in adolescents and young adults, with potentially significant physical and psychological morbidity from scarring and from adverse effects of treatment, as well as significant economic burdens. The purpose of this review was to provide a comprehensive review of the literature on acne management. Authors' conclusions Despite the large number of English-language controlled trials regarding acne therapy, their methodological limitations prevent our ability

Health Technology Assessment (HTA) Database.2001

58. Management of acne

Management of acne Management of acne Management of acne Lehmann H P, Andrews J S, Robinson K A, Holloway V L, Goodman S N Authors' objectives To provide a comprehensive review on the management of acne. Searching The search utilised several electronic databases from inception to 1999, including the CENTRAL Register in the Cochrane Library, MEDLINE, OLDMEDLINE (from 1960 to 1965), EMBASE, CINAHL and PsycINFO amongst others. Details of the searches were given in the report. In addition (...) of first-, second- and third-line treatments for acne were eligible for inclusion in the review. The included studies were of 140 different treatments, which were classified as: cleansers, keratolytics, topical antibacterials, keratolytic/topical antibacterial combinations, topical retinoids, topical antibacterial/retinoid combinations, oral antibacterials, oral antibacterial/keratolytics, oral antibacterial/topical retinoids, oral retinoids, anti-androgens and other. All individual treatments

DARE.2001

59. Laser resurfacing for facial acne scars.

Laser resurfacing for facial acne scars. BACKGROUND: Most people have acne at some stage during their life, with about one per cent being left with permanent acne scars. Recent laser techniques are thought to be more effective than chemical peels and dermabrasion. OBJECTIVES: To assess the effects of laser resurfacing for treating facial acne scars. SEARCH STRATEGY: We searched MEDLINE (1966 to April 1999), EMBASE (1980 to April 1999), Science Citation Index (1981 to April 1999), the Cochrane (...) Controlled Trials Register (April 1999), DARE (April 1999), INAHTA (April 1999), NHS HTA Internet site (April 1999). Dermatological Surgery (1995 to March 1999) and the British Journal of Dermatology (1995 to September 1999) were handsearched. We searched the reference lists of relevant articles and contacted experts and commercial laser manufacturers. SELECTION CRITERIA: Randomised controlled trials which compare different laser resurfacing techniques for treating patients with facial acne scars

Cochrane2001

60. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D Authors' objectives To identify (...) in the review Patients with acne. Patients taking minocycline for reasons other than acne were excluded, as were those for whom there were no details of their age and gender. The age of participants ranged from 14 to 73 years, with the majority of cases in their teens or early 20s. Outcomes assessed in the review Liver damage. Studies reporting findings of laboratory investigations indicating liver dysfunction, or where a specific reference was made by the authors to liver dysfunction, were included. How

DARE.2000