Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

1. Trifarotene (Aklief) - acne vulgaris

Trifarotene (Aklief) - acne vulgaris Drug Approval Package: AKLIEF U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: AKLIEF Company: Galderma Research and Development, LLC Application Number: 211527 Approval Date: 10/04/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2019 FDA - Drug Approval Package

2. British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa)

British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 4 Fitzroy Square, London W1T 5HQ Tel: 020 7383 0266 Fax: 020 7388 5263 e-mail: admin@bad.org.uk Registered Charity No. 258474 HIDRADENITIS SUPPURATIVA What are the aims of this leaflet? This leaflet has been written to help you understand more about hidradenitis suppurativa (HS). It tells you what it is, what may cause it, what can be done about it, and where you can find out more (...) system is involved in producing inflammation and treatments that reduce the immune system activity may be helpful (see below). ? In a few people with HS there is a link to the bowel condition Crohn ’s disease. ? There may be a link with acne and pilonidal sinus (a chronic abscess at the base of the spine). ? Smoking and obesity are linked with HS, but the condition can also affect non-smokers of normal weight. ? Poor hygiene does not cause hidradenitis suppurativa. Is hidradenitis suppurativa

2019 British Association of Dermatologists

3. Oral isotretinoin for acne. Full Text available with Trip Pro

Oral isotretinoin for acne. Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit associated with socialisation and mental health problems, may affect more than 80% of teenagers. Isotretinoin is the only drug that targets all primary causal factors of acne; however, it may cause adverse effects.To assess efficacy and safety of oral isotretinoin for acne vulgaris.We searched the following databases up to July 2017: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE (...) with clinically diagnosed acne compared against placebo, any other systemic or topical active therapy, and itself in different formulation, doses, regimens, or course duration.We used standard methodological procedures expected by Cochrane.We included 31 RCTs, involving 3836 participants (12 to 55 years) with mild to severe acne. There were twice as many male participants as females.Most studies were undertaken in Asia, Europe, and North America. Outcomes were generally measured between eight to 32 weeks

2018 Cochrane

4. Sarecycline (Seysara) - To treat inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older

Sarecycline (Seysara) - To treat inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older Drug Approval Package: Seysara (sarecycline) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: Seysara (sarecycline) Company: Allergan, Inc. Application Number: 209521 Approval Date: 10/01/2018 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA

2018 FDA - Drug Approval Package

5. Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018 Full Text available with Trip Pro

Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018 Acne vulgaris is a common heath problem affecting adolescents with considerable impact on their quality of life.To determine the prevalence of Acne vulgaris and its psychological impact among female secondary school students.A cross-sectional study was conducted during the period from January to March 2018, among all female secondary school students in 3 randomly (...) selected schools, in Arar city (Saudi Arabia). The participants were clinically examined by a dermatologist to identify acne cases. Dermatological quality of life of acne cases were assessed using an Arabic version of Dermatology Life Quality Index (DLQI). Data collected were analyzed by IBM-SPSS version 20, using Chi-square, Fisher's Exact test, Mann-Whitney U, and Kruskal Wallis test. P-value ≤0.05 was considered statically significant.The overall prevalence of Acne vulgaris was 14.3

2018 Electronic physician

6. Acne

. These can be found via searching the site. Top results for acne 1. Acne vulgaris Acne vulgaris - NICE CKS Clinical Knowledge Summaries Share Acne vulgaris - Summary Acne vulgaris is a chronic skin condition in which blockage or inflammation of the hair follicles and accompanying sebaceous glands (known as pilosebaceous units) occurs. It principally affects the face, the back, and the chest, and usually first occurs around the age of puberty. Acne is most prevalent among adolescents and young adults (...) by placing the search numbers in the top search box and pressing the search button. An example 2018 7. Acne vulgaris Acne vulgaris - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acne vulgaris Last reviewed: August 2018 Last updated: June 2018 Summary Acne may affect any age group, but it is most common in adolescents. Lesions consist of non-inflammatory comedones (whiteheads and blackheads) and inflammatory papules, pustules

2018 Trip Latest and Greatest

7. Acne

Acne Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

8. Safety and effectiveness of amoxicillin in the treatment of inflammatory acne Full Text available with Trip Pro

Safety and effectiveness of amoxicillin in the treatment of inflammatory acne Acne is a common skin disease that predominantly affects teenagers and young adults. Systemic antibiotic therapy, including tetracyclines, macrolides, and trimethoprim-sulfamethoxazole, is indicated in moderate-to-severe inflammatory disease. However, in certain cases, these antibiotics and other commonly prescribed treatments including oral contraceptives, spironolactone, and isotretinoin may be prohibited (...) , especially in cases of pregnancy and drug intolerance. In this retrospective study, we assessed the safety and efficacy of systemic amoxicillin, which has a favorable tolerability profile and compatibility with pregnancy in the treatment of inflammatory acne.

2018 International journal of women's dermatology

9. Acne - Guidelines for Prescribing Topical Treatment

Acne - Guidelines for Prescribing Topical Treatment Acne - Guidelines for Prescribing Topical Treatment - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Acne - Guidelines for Prescribing Topical Treatment Acne vulgaris (acne) is the formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland (...) want to assess the severity of the patient’s acne: Mild: Some papules or pustules; no nodules or cysts Moderate: Many papules and pustules; few nodules, no cysts Severe: Numerous papules and pustules; many nodules or cysts Rule out the following conditions which have signs / symptoms that may resemble acne vulgaris: Comedones Pustules Papules Nodules Other Open Closed Vulgaris X X X X X Conglobata X XX XX Cysts, abscesses, sinus tracts Fulminans X XX XX Ulcerating cysts Contact pomade use XX X

2018 medSask

10. Acne vulgaris

Acne vulgaris Acne vulgaris - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acne vulgaris Last reviewed: February 2019 Last updated: June 2018 Summary Acne may affect any age group, but it is most common in adolescents. Lesions consist of non-inflammatory comedones (whiteheads and blackheads) and inflammatory papules, pustules, nodules, and cysts. Systemic effects may be present with acne fulminans, a rare variant (...) of nodulocystic acne. Treatments include topical retinoids, keratolytics, and antibiotics; severe nodulocystic acne may require oral isotretinoin. Definition Acne vulgaris is a skin disease affecting the pilosebaceous unit. It is characterised by comedones, papules, pustules, nodules, cysts, and/or scarring, primarily on the face and trunk. Clinical manifestations range from mild comedonal acne to severe nodulocystic acne, which can be permanently disfiguring. In addition to the physical lesions, acne can

2018 BMJ Best Practice

11. Acne vulgaris

Acne vulgaris Acne vulgaris - NICE CKS Share Acne vulgaris: Summary Acne vulgaris is a chronic inflammatory skin condition affecting mainly the face, back and chest - it is characterised by blockage and inflammation of the pilosebaceous unit (the hair follicle, hair shaft and sebaceous gland). It presents with lesions which can be non-inflammatory (comedones), inflammatory (papules, pustules and nodules) or a mixture of both. Up to 95% of adolescents in Western industrialized countries (...) , adverse effects and use of comedongenic make up or face creams should be considered before swapping to an alternative product or the next treatment step. Have I got the right topic? Have I got the right topic? From age 12 years onwards. This CKS topic covers the management of acne vulgaris. This CKS topic does not cover the management of acne secondary to drugs or an underlying condition. There is a separate CKS topic on . The target audience for this CKS topic is healthcare professionals working

2018 NICE Clinical Knowledge Summaries

12. Rosacea - acne

(phymatous rosacea), most commonly rhinophyma. Ocular symptoms (ocular rosacea), such as red, gritty, dry or irritated eyes, and the person may describe a foreign body sensation in the eyes. Additional features such as burning, dry skin, oedema, and plaques may be present. Alternative conditions that present similarly to acne rosacea should be excluded (such as acne vulgaris, seborrhoeic dermatitis, and contact dermatitis). Management of acne rosacea is largely guided by the type and severity of symptoms (...) [ ]; expert opinion in the review articles Rosacea [ ] and Rosacea: A review [ ]; and the British Medical Journal (BMJ) Best practice review Rosacea [ ]. What else might it be? What else might it be? Acne rosacea may present similarly to other skin conditions, such as: Acne vulgaris — usually features comedones, without telangiectasia, flushing, or significant erythema. It can also affect the back and chest, and usually first occurs around puberty, although older people may be affected. For more

2018 NICE Clinical Knowledge Summaries

13. A review of diagnosis and treatment of acne in adult female patients Full Text available with Trip Pro

A review of diagnosis and treatment of acne in adult female patients This review focuses on the treatment options for adult female patients with acne. Acne in adult female patients may start during adolescence and persist or have an onset in adulthood. Acne has various psychosocial effects that impact patients' quality of life. Treatment of acne in adult women specifically has its challenges due to the considerations of patient preferences, pregnancy, and lactation. Treatments vary widely (...) and treatment should be tailored specifically for each individual woman. We review conventional therapies with high levels of evidence, additional treatments with support from cohort studies and case reports, complementary and/or alternative therapies, and new agents under development for the treatment of patients with acne.

2017 International journal of women's dermatology

14. How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem Full Text available with Trip Pro

How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem Acne vulgaris is one of the most common dermatologic complaints. Although dermatologists are skilled at treating acne, invisible psychological scars can be left by the disease. We review 13 articles that examined the effect of acne vulgaris on patients' self-esteem. Overall, these studies demonstrated that acne has a negative effect on self-esteem among patients of all age groups. These effects most strongly affect (...) women and those with severe acne (both subjectively and objectively). Despite the impact on self-esteem, only a minority of patients seek medical treatment, and even fewer seek treatment from a dermatologist. As dermatologists, we are trained in managing acne. We can provide early and effective treatment that improves both the physical and psychological effects. It is up to us to bridge the gap between those suffering from acne and their access to medical treatment.

2017 International journal of women's dermatology

15. Adalimumab (Humira) - hidradenitis suppurativa (acne inversa)

Adalimumab (Humira) - hidradenitis suppurativa (acne inversa) Final Appraisal Recommendation Advice No: 1217 – July 2017 Adalimumab (Humira ® ) 40 mg solution for injection (pre-filled pen, pre-filled syringe and vial) Limited submission by AbbVie Ltd In reaching the above recommendation AWMSG has taken account of the appraisal documentation prepared by the AWMSG Secretariat (reference number 3371), which includes the AWMSG Secretariat Assessment Report (ASAR), the Preliminary Appraisal (...) – 1217: Adalimumab (Humira ® ) 40 mg solution for injection (pre-filled pen, pre-filled syringe and vial). July 2017 Recommendation of AWMSG Adalimumab (Humira ® ) is recommended as an option for use within NHS Wales for the treatment of active moderate to severe hidradenitis suppurativa (acne inversa) in adolescents from 12 years of age with an inadequate response to conventional systemic hidradenitis suppurativa (HS) therapy. This recommendation applies only in circumstances where the approved

2017 All Wales Medicines Strategy Group

16. Management of severe acne during pregnancy: A case report and review of the literature Full Text available with Trip Pro

Management of severe acne during pregnancy: A case report and review of the literature The treatment of acne during pregnancy is often limited by the potential toxicities that are posed to the fetus by the most common and effective acne therapies. As with all dermatoses during pregnancy, the treatment of acne vulgaris in this population requires a thorough understanding of the risks and benefits that are inherent to each treatment. We report on a case of a 30-year-old pregnant patient (...) with severe acne conglobata who showed significant improvement with a combination treatment of topical modalities, oral metronidazole, and low dose prednisone during pregnancy. We also review the literature and present an approach for the care of these patients.

2017 International journal of women's dermatology

17. Dienogest/ethinylestradiol can be used for acne after certain other treatments have failed

Dienogest/ethinylestradiol can be used for acne after certain other treatments have failed Dienogest/ethinylestradiol can be used for acne after certain other treatments have failed | European Medicines Agency Search Search Menu Dienogest/ethinylestradiol can be used for acne after certain other treatments have failed Press release 27/01/2017 Use should be limited to women who choose oral contraception The European Medicines Agency (EMA) has recommended that medicines containing a combination (...) of dienogest 2 mg and ethinylestradiol 0.03 mg can continue to be used to treat moderate acne when suitable treatments applied to the skin or antibiotics taken by mouth have not worked. However, these medicines, which are also approved as hormonal contraceptives, should only be used in women who choose oral contraception. Having evaluated the existing data on the effectiveness of the combination in the treatment of acne, EMA's ( ) concluded that there is sufficient evidence to support its use in moderate

2017 European Medicines Agency - EPARs

18. A Review of hormone-based therapies to treat adult acne vulgaris in women Full Text available with Trip Pro

A Review of hormone-based therapies to treat adult acne vulgaris in women Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted (...) and spironolactone as adjuvant and monotherapies are safe and effective to treat women with adult acne. However, appropriate clinical examinations, screening, and individual risk assessments particularly for venous thromboembolism risk must be conducted prior to initiating therapy.

2017 International journal of women's dermatology

19. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients Full Text available with Trip Pro

Spironolactone for the treatment of acne in women, a retrospective study of 110 patients There is limited evidence on the safety and efficacy of spironolactone in the treatment of women with acne. Thus, for many dermatologists spironolactone remains an alternative rather than a mainstay treatment for female patients with acne.An electronic medical records search tool was used to select data from a group of women who received spironolactone to treat acne and were evaluated with the comprehensive (...) acne severity scale (CASS) before treatment and at all follow-up visits. Data points were collected for CASS scores at each follow-up visit, concurrent and previous treatments, and side effects. These data points were used to draw conclusions about the safety and efficacy of spironolactone in this patient population.There were 110 patients that met all eligibility requirements. Of these, 94 patients saw an improvement in their CASS score and 61 patients completely cleared their score to 0

2017 International journal of women's dermatology