Latest & greatest articles for acetaminophen

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Top results for acetaminophen

81. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization

Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization Manley J, Taddio A CRD summary This review investigated use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. The authors concluded (...) that acetaminophen and ibuprofen may prevent adverse events in young infants receiving diphtheria-tetanus toxoids-whole pertussis vaccine. No benefits were demonstrated for the diphtheria-tetanusoxides acellular pertussis vaccine. The conclusions may not be reliable due to methodological limitations. Authors' objectives To evaluate prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunisation. Searching MEDLINE (1966 to February 2007), PubMed (1966

DARE.2007

82. Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis

Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis Article Text Therapeutics Prednisolone plus

Evidence-Based Medicine (Requires free registration)2007

83. Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management.

Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. | National Guideline Clearinghouse Search Sign In Username or Email * Password * Remember Me Don't have an account? Guideline Summary NGC:004507 This guideline summary has been withdrawn from NGC. Please update your bookmarks. View all withdrawn summaries in the . About NGC Guideline Summaries NGC's

American Association of Poison Control Centers2006

84. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. 16820551 2006 07 05 2006 07 07 2016 10 17 1538-3598 296 1 2006 Jul 05 JAMA JAMA Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. 87-93 During a clinical trial of a novel hydrocodone/acetaminophen combination, a high incidence of serum alanine aminotransferase (ALT) elevations was observed. To characterize (...) the incidence and magnitude of ALT elevations in healthy participants receiving 4 g of acetaminophen daily, either alone or in combination with selected opioids, as compared with participants treated with placebo. A randomized, single-blind, placebo-controlled, 5-treatment, parallel-group, inpatient, diet-controlled (meals provided), longitudinal study of 145 healthy adults in 2 US inpatient clinical pharmacology units. Each participant received either placebo (n = 39), 1 of 3 acetaminophen/opioid

JAMA2006

85. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials Remy C, Marret E, Bonnet F CRD summary The authors concluded that the addition of acetaminophen (...) to intravenous patient-controlled analgesia with morphine reduces the need for morphine in patients undergoing major surgery, but does not affect morphine-related side-effects. The authors' conclusions appear to be supported by the data presented, but limited reporting of review methods means it is not possible to confirm their reliability. Authors' objectives To determine the effect of adding acetaminophen (paracetamol) to intravenous (i.v.) patient-controlled analgesia (PCA) with morphine on opioid-related

DARE.2005

86. Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery

Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery Watcha M F, Issioui T, Klein K W, White P F Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three oral analgesic regimens for preventing pain after ambulatory surgery were examined. The regimens were acetaminophen (2 g), celecoxib (200 mg) and rofecoxib (50 mg). The drugs were administered 15 to 45 minutes before entering the operating room. Type

NHS Economic Evaluation Database.2003

87. Acetaminophen for osteoarthritis.

Acetaminophen for osteoarthritis. BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis. Published guidelines and expert opinion are divided over the relative role of acetaminophen (also called paracetamol or Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) as first-line pharmacologic therapy. The comparative safety of acetaminophen and NSAIDs is important to consider as NSAIDs have the potential for serious gastrointestinal, renal, and cardiovascular toxicities (...) , and acetaminophen in high dosages (greater than or equal to 2 grams per day), may also have the potential for serious upper gastrointestinal toxicity. OBJECTIVES: To assess the efficacy and safety of acetaminophen versus placebo and versus NSAIDs (ibuprofen, arthrotec, celecoxib,naproxen, rofecoxib) for treating OA. SEARCH STRATEGY: We searched the Cochrane Controlled Trials Register (Issue 3, 2002), MEDLINE (up to July 2002), and Current Contents (up to March 2002). Reference lists of identified RCTs

Cochrane2003

88. Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery

Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery Issioui T, Klein K W, White P F, Watcha M F, Skrivanek G D, Jones S B, Hu J, Marple B F, Ing C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Selective non-steroidal anti-inflammatory drugs (NSAIDs) given alone, or in combination, prior to outpatient otolaryngologic surgery were considered. The NSAIDs studied were rofecoxib (a cyclooxygenase-2 inhibitor; 50 mg) and acetaminophen (2 mg). Type of intervention Secondary prevention and treatment

NHS Economic Evaluation Database.2002

89. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.

Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. 11754710 2001 12 28 2002 01 18 2016 10 17 0098-7484 287 1 2002 Jan 02 JAMA JAMA Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. 64-71 Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2). To assess the relative therapeutic efficacy (...) of rofecoxib, celecoxib, and acetaminophen in adults with OA. Randomized, parallel-group, double-blind trial, conducted from June 1999 to February 2000, in 29 clinical centers in the United States. Three hundred eighty-two patients aged at least 40 years who had OA of the knee that was previously treated with NSAIDs or acetaminophen. Patients were randomly assigned to receive rofecoxib, 12.5 mg/d (n = 96); rofecoxib, 25 mg/d (n = 95); celecoxib, 200 mg/d (n = 97); or acetaminophen, 4000 mg/d (n = 94) for 6

JAMA2002

90. Interventions for paracetamol (acetaminophen) overdoses.

Interventions for paracetamol (acetaminophen) overdoses. BACKGROUND: Self-poisoning with paracetamol (acetaminophen) is a common cause of hepatotoxicity in the Western World. Interventions for paracetamol poisoning encompass inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation. OBJECTIVES: The objective was to assess the beneficial and harmful effects of interventions or combination of interventions for paracetamol overdose. SEARCH STRATEGY (...) to treat. The methodological quality of the included trials was evaluated by components of methodological quality. MAIN RESULTS: Nine RCTs (all small and of low methodological quality), one quasi-randomised trials, 37 observational studies, and nine randomised trials including human volunteers were identified. It was impossible to perform meta-analyses including more than two RCTs. Activated charcoal, gastric lavage, and ipecacuanha are able to reduce the absorption of paracetamol but the clinical

Cochrane2002

91. Acetaminophen, aspirin, and chronic renal failure.

Acetaminophen, aspirin, and chronic renal failure. BACKGROUND: Several epidemiologic studies have demonstrated an association between heavy consumption of nonnarcotic analgesics and the occurrence of chronic renal failure, but it is unclear which is the cause and which is the effect METHODS: In a nationwide, population-based, case-control study of early-stage chronic renal failure in Sweden, face-to-face interviews were conducted with 926 patients with newly diagnosed renal failure and 998 (...) control subjects, of whom 918 and 980, respectively, had complete data. We used logistic-regression models to estimate the relative risks of disease-specific types of chronic renal failure associated with the use of various analgesics RESULTS: Aspirin and acetaminophen were used regularly by 37 percent and 25 percent, respectively, of the patients with renal failure and by 19 percent and 12 percent, respectively, of the controls. Regular use of either drug in the absence of the other was associated

NEJM2001

92. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review

Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Dart R C, Kuffner E K, Rumack B H Authors' objectives To evaluate whether the administration of therapeutic doses of paracetamol cause hepatic injury in the alcoholic patient (...) . Searching MEDLINE (from 1966 to November 1999), Best Evidence and the Cochrane Database of Systematic Reviews were searched. The MEDLINE search was limited to the headings of 'adverse event', 'poisoning' and 'toxicity of paracetamol in humans'. The reference lists of the included papers were also examined for additional relevant studies. Articles written in any language were considered. Study selection Study designs of evaluations included in the review The inclusion criteria stated that experimental

DARE.2000

93. Single dose dextropropoxyphene, alone and with paracetamol (acetaminophen), for postoperative pain.

Single dose dextropropoxyphene, alone and with paracetamol (acetaminophen), for postoperative pain. BACKGROUND: Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Dextropropoxyphene is one example of an opioid analgesic in current use, and is widely prescribed for pain relief in combination with paracetamol under names such as Co-proxamol (...) and Distalgesic. OBJECTIVES: To determine the analgesic efficacy and adverse effects of single dose oral Dextropropoxyphene alone and in combination with paracetamol (acetaminophen) for moderate to severe postoperative pain. SEARCH STRATEGY: Published reports were identified from: Medline (1966 - November 1996), Biological Abstracts (1985 - 1996), Embase (1980 - 1996), the Cochrane Library (Issue 4 1996), and the Oxford Pain Relief Database (1954 - 1994). Additional studies were identified from the reference

Cochrane2000

94. Single dose paracetamol (acetaminophen), with and without codeine, for postoperative pain.

Single dose paracetamol (acetaminophen), with and without codeine, for postoperative pain. BACKGROUND: Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Paracetamol (acetaminophen) is an important non-opiate analgesic, commonly prescribed, as well as being available for retail sale. This review seeks to examine the efficacy of paracetamol alone (...) and in combination with codeine, and also considers adverse effects. OBJECTIVES: To assess the analgesic efficacy and adverse effects of a single dose of oral paracetamol (acetaminophen) alone and in combination with codeine for moderate to severe postoperative pain. SEARCH STRATEGY: Published trials were identified from: Medline (1966 to May 1996), Embase (1980 to 1996), Cochrane Library (Issue 2 1996) and the Oxford Pain Relief Database (1950 to 1994). Additional trials were identified from reference lists

Cochrane2000

95. Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies

Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Bond G R, Krenzelok E P, Normann S A, Tendler J D, Morriskukoski C L, Mccoy D J,Thompson M W, McCarthy T, Roblez J, Taylor C, Dolan M A, Requa R K, Curry S C Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Management of acetaminophen ingestion in childhood. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Children who ingested acetaminophen, aged one to six years and referred

NHS Economic Evaluation Database.1994

96. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.

Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. 2052056 1991 07 22 1991 07 22 2015 11 19 0028-4793 325 2 1991 Jul 11 The New England journal of medicine N. Engl. J. Med. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. 87-91 The optimal short-term, symptomatic (...) therapy for osteoarthritis of the knee has not been fully determined. Accordingly, we compared the efficacy of a nonsteroidal antiinflammatory drug, ibuprofen, given in either an antiinflammatory dose (high dose) or an analgesic dose (low dose), with that of acetaminophen, a pure analgesic. In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day. They were evaluated after

NEJM1991

97. Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.

Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. 299896 1977 03 31 1977 03 31 2016 11 23 0098-7484 237 10 1977 Mar 07 JAMA JAMA Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. 976-81 The feasibility of determining the exact site and amount of drug (...) -induced gastric bleeding was tested. Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2.4 gm/day, in randomized order for seven days. Acetaminophen was given for 14 days just prior to each of these periods. By fiberoptic gastroscopy, antral ulceration and acute mucosal lesions were found in seven patients following aspirin ingestion, in one taking fenoprofen, and in none taking acetaminophen. Fecal

JAMA1977

98. Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning.

Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. 54634 1976 03 18 1976 03 18 2015 06 16 0140-6736 1 7951 1976 Jan 17 Lancet (London, England) Lancet Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. 111-5 A randomised controlled trial of the use of intravenous cysteamine in the treatment of severe paracetamol poisoning has been performed. Thirty-eight patients presenting 3-17 h after ingestion were admitted (...) to the trial; of these eighteen received cysteamine. Two patients died from hepatic failure, one in each treatment group. Analysis of the series as a whole showed no advantage of cysteamine in preventing biochemical abnormalities of liver function except for aspartate aminotranferase and serum ferritin levels, which were significantly less after cysteamine therapy. Separate analysis of the patients treated within 9 h of paractamol ingestion and of those treated 9-17 h after paracetamol ingesion similarly

Lancet1976