Latest & greatest articles for acetaminophen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acetaminophen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acetaminophen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for acetaminophen

61. NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes

NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes Verkleij SP, Luijsterburg PA, Bohnen AM, Koes BW, Bierma-Zeinstra SM CRD summary This review concluded that none (...) of the variables evaluated had a clinically relevant influence on the relative effectiveness of non-steroidal anti-inflammatory drugs versus paracetamol (acetaminophen) for knee and hips osteoarthritis. Future trials should present the results of patients with hip and knee osteoarthritis separately. The authors’ conclusions reflect the evidence presented and the lack of higher quality data. Authors' objectives To explore variations in findings of randomised controlled trials (RCTs) that compared non-steroidal

DARE.2011

62. Liver Toxicity in Patients using Acetaminophen

Liver Toxicity in Patients using Acetaminophen UTCAT842, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Liver Toxicity In Patients Using Acetaminophen Clinical Question In patients with Post-operative pain, does the use of acetaminophen cause hepatotoxicity versus other analgesics? Clinical Bottom Line Use of acetaminophen has caused increased rates of hepatotoxicity. (See Comments on the CAT below) Best Evidence (you (...) may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Guggenheimer/2011 N/A Systematic Review Key results Increased use of acetaminophen has increased the number of cases of hepatotoxicity. Since acetaminophen is found in many analgesics, unintentional overdose can occur. Evidence Search Liver toxicity and acetaminophen Comments on The Evidence The study is a systematic review of articles. The authors reviewed the literature

UTHSCSA Dental School CAT Library2011

63. Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Make a difference with dentistry's premier charitable organization Take advantage (...) Evidence Education About * Associated Topics Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo. Critical Summary Assessment An updated, high-quality of mostly high-quality evidence indicates

ADA Center for Evidence-Based Dentistry2010

64. Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Take advantage of endorsed, discounted business products Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Make a difference (...) Evidence Education About * Associated Topics Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo. Critical Summary Assessment An updated, high-quality of mostly high-quality evidence indicates

ADA Center for Evidence-Based Dentistry2010

65. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction.

Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Make a difference with dentistry's premier charitable (...) children's oral health website Evidence Education About * Associated Topics Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Carlos Flores-Mir DDS, DSc, FRCD(C); Analia Veitz-Keenan DDS . Overview Systematic Review Conclusion A single dose of acetaminophen plus codeine provides clinical useful levels of pain relief in patients with moderate to severe post –operative pain. Critical Summary Assessment This represents an update of a previously

ADA Center for Evidence-Based Dentistry2010

66. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction.

Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Take advantage of endorsed, discounted business products Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content (...) children's oral health website Evidence Education About * Associated Topics Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Carlos Flores-Mir DDS, DSc, FRCD(C); Analia Veitz-Keenan DDS . Overview Systematic Review Conclusion A single dose of acetaminophen plus codeine provides clinical useful levels of pain relief in patients with moderate to severe post –operative pain. Critical Summary Assessment This represents an update of a previously

ADA Center for Evidence-Based Dentistry2010

67. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review

Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Pierce CA, Voss B CRD summary The review found that ibuprofen was similarly or more efficacious than acetaminophen for treatment of pain and fever in adults (...) and children and was equally safe. The authors' cautious conclusions reflected the evidence presented, but shortcomings in the review process, a lack of quality assessment and substantial clinical differences made the reliability of the conclusions unclear. Authors' objectives To evaluate the analgesic and antipyretic efficacy and safety of ibuprofen compared with acetaminophen in children and adults. Searching PubMed (to August 2009) and EMBASE (to January 2008) were searched. Searches were restricted

DARE.2010

68. Randomised controlled trial: Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures

Randomised controlled trial: Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log (...) compared with acetaminophen plus codeine in children with uncomplicated fractures Article Text Therapeutics Randomised controlled trial Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures Carie A Braun Carie A Braun College of Saint Benedict/Saint John’s University, 37 College Avenue South, Saint Joseph, MN 56374, USA; cbraun{at}csbsju.edu Statistics from Altmetric.com No Altmetric

Evidence-Based Nursing (Requires free registration)2010

69. Systematic review: NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects

Systematic review: NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects Article Text Therapeutics Systematic review NSAIDs similarly effective to acetaminophen plus codeine for post

Evidence-Based Nursing (Requires free registration)2010

70. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain

Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain Ong CK (...) , Seymour RA, Lirk P, Merry AF CRD summary This review concluded that a combination of paracetamol and NSAIDs provided superior analgesia to either agent administered alone in the management of acute postoperative pain. Poor reporting of review methodology and high levels of clinical and statistical heterogeneity between included studies made the reliability of this conclusion unclear. Authors' objectives To assess the combination of paracetamol with a non-steroidal anti-inflammatory drug (NSAID

DARE.2010

71. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis

Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis 19696122 2009 11 06 2010 01 06 2013 11 21 1931-3543 136 5 2009 Nov Chest Chest Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. 1316-23 10.1378/chest.09-0865 Epidemiologic studies have identified an increased risk of asthma with acetaminophen use, but the results have been conflicting. We sought to quantify the association between (...) acetaminophen use and the risk of asthma in children and adults. We searched all the major medical databases, including MEDLINE (from 1966 to 2008) and EMBASE (from 1980 to 2008) to identify pertinent articles. All clinical trials and observational studies were considered. For observational studies, we selected those that clearly defined acetaminophen use and asthma diagnosis. Study quality was assessed by two reviewers, and data were extracted into a spreadsheet. A random-effects model was used to combine

EvidenceUpdates2010

72. Ofirmev (acetaminophen) Injection

Ofirmev (acetaminophen) Injection Drug Approval Package: Ofirmev (acetaminophen) NDA #022450 Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - Ofirmev (acetaminophen) Injection, 10 mg/mL Company: Cadence Pharmaceuticals Application No.: 022450 Approval Date: 11/02/2010 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

FDA - Drug Approval Package2010

73. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis

Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis Etminan M, Sadatsafavi M, Jafari S, Doyle-Waters M, Aminzadeh K, FitzGerald JM CRD summary The authors concluded that there was an increased risk of asthma in adults and children who used (...) acetaminophen. Further research was needed. In light of unclear quality of the included studies and limited study information, the authors' conclusions should be treated with caution. Authors' objectives To determine the association between acetaminophen use and asthma or wheezing in children and adults and to assess the effect of prenatal acetaminophen use on the risk of asthma in young children. Searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), DARE, American College

DARE.2009

74. Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials

Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials Nauta M, Landsmeer ML, Koren G (...) CRD summary This review compared the efficacy and safety of NSAIDs with acetaminophen plus codeine for pain control after post-laporotomy pain. The authors concluded that NSAIDs appeared to have an overall better risk-benefit ratio than acetaminophen plus codeine for postpartum pain. Given that review scoping decisions and study selection were not fully explained, the reliability of the conclusion is unclear. Authors' objectives To compare the efficacy and safety of non-steroidal anti-inflammatory

DARE.2009

75. Effectiveness of oral vs rectal acetaminophen: a meta-analysis

Effectiveness of oral vs rectal acetaminophen: a meta-analysis 18981352 2008 11 04 2008 12 01 2013 11 21 1538-3628 162 11 2008 Nov Archives of pediatrics & adolescent medicine Arch Pediatr Adolesc Med Effectiveness of oral vs rectal acetaminophen: a meta-analysis. 1042-6 10.1001/archpedi.162.11.1042 To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain. MEDLINE, PubMed, and the Cochrane database as well as major (...) pharmacologic textbooks and the references of all included studies were searched for studies comparing oral and rectal administration of acetaminophen. Randomized and quasi-randomized controlled studies comparing rectal and oral administration of acetaminophen were included. Reviews, letters, and studies that compared combined treatments or additional drugs were excluded. Main Exposure Oral vs rectal acetaminophen. Standardized measures of temperature and pain reduction. For temperature reduction, 4 studies

EvidenceUpdates2008

76. Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children

Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search (...) for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children Article Text Therapeutics Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children Statistics from Altmetric.com No Altmetric data available for this article. Request permissions If you wish

Evidence-Based Medicine (Requires free registration)2008

77. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities

Acetaminophen use during pregnancy: effects on risk for congenital abnormalities 18226618 2008 01 29 2008 02 19 2013 11 21 1097-6868 198 2 2008 Feb American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. 178.e1-7 10.1016/j.ajog.2007.08.040 We evaluated if acetaminophen, one of the most frequently used drugs among pregnant women is associated with an increased prevalence of congenital abnormalities (...) . We selected 88,142 pregnant women and their liveborn singletons from the Danish National Birth Cohort who had information on acetaminophen use during the first trimester of pregnancy. We used the National Hospital Registry to identify 3784 (4.3%) children from the cohort diagnosed with 5847 congenital abnormalities. Children exposed to acetaminophen during the first trimester of pregnancy (n = 26,424) did not have an increased prevalence of congenital abnormalities (hazard ratio = 1.01, 0.93-1.08

EvidenceUpdates2008

78. Effectiveness of oral vs rectal acetaminophen: a meta-analysis

Effectiveness of oral vs rectal acetaminophen: a meta-analysis Effectiveness of oral vs rectal acetaminophen: a meta-analysis Effectiveness of oral vs rectal acetaminophen: a meta-analysis Goldstein L H, Berlin M, Berkovitch M, Kozer E CRD summary The authors concluded that oral and rectal acetaminophen had comparable effects on temperature reduction. Given the unclear quality of the included trials and the small numbers of participants included for analysis, the reliability of the authors (...) ' conclusions is unclear. Authors' objectives To compare the effectiveness of oral versus rectal acetaminophen as a treatment for fever and pain. Searching PubMed (1950 to October 2007) and the Cochrane Database of Systematic Reviews (2007) were searched for articles published in any language with an English abstract. Search terms were reported. References of major pharmacological textbooks, relevant reviews and the included studies were handsearched. Study selection Randomised (RCT) or quasi-randomised

DARE.2008

79. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery

A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery 18308218 2008 02 29 2008 03 27 2013 11 21 1879-1190 206 3 2008 Mar Journal of the American College of Surgeons J. Am. Coll. Surg. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. 472-9 10.1016/j.jamcollsurg.2007.09.006 Narcotics are used (...) extensively in outpatient general surgery but are often poorly tolerated with variable efficacy. Acetaminophen combined with NSAIDs is a possible alternative. The objective of this study was to compare the efficacy of acetaminophen, codeine, and caffeine (Tylenol No. 3) with acetaminophen and ibuprofen for management of pain after outpatient general surgery procedures. A double-blind randomized controlled trial was performed in patients undergoing outpatient inguinal/umbilical/ventral hernia repair

EvidenceUpdates2008