Latest & greatest articles for acetaminophen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acetaminophen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acetaminophen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for acetaminophen

42. Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective

Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our (...) use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve

Evidence-Based Medicine (Requires free registration)2015

43. Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review

Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy: A Rapid Review Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review Health Quality Ontario Citation Health Quality Ontario. Pre-emptive oral non-steroidal anti-inflammatory drugs or acetaminophen for knee arthroscopy: a rapid review (...) . Toronto: Health Quality Ontario (HQO). Rapid Review. 2014 Authors' conclusions Based on 2 RCTs, both with limitations due to risk of bias, there were inconsistent results regarding the effectiveness of pre-emptive oral celecoxib, a selective COX-2 inhibitor NSAID, for post-operative pain control in patients undergoing knee arthroscopy. No evidence was identified that evaluated the oral pre-emptive use of acetaminophen or conventional NSAIDs for post-operative pain control in patients undergoing knee

Health Technology Assessment (HTA) Database.2014

44. Codeine, alone and with paracetamol (acetaminophen), for cancer pain.

Codeine, alone and with paracetamol (acetaminophen), for cancer pain. BACKGROUND: Pain is very common in patients with cancer. Opioid analgesics, including codeine, play a significant role in major guidelines on the management of cancer pain, particularly for mild to moderate pain. Codeine is widely available and inexpensive, which may make it a good choice, especially in low-resource settings. Its use is controversial, in part because codeine is not effective in a minority of patients who (...) cannot convert it to its active metabolite (morphine), and also because of concerns about potential abuse, and safety in children. OBJECTIVES: To determine the efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2014, Issue 2), MEDLINE and EMBASE from inception to 5 March 2014, supplemented by searches of clinical trial registries

Cochrane2014

45. Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Take advantage of endorsed, discounted business products Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only (...) Council's children's oral health website Evidence Education About * Associated Topics Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Ferne Kraglund DDS . Overview Systematic Review Conclusion Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone. Critical Summary Assessment The authors

ADA Center for Evidence-Based Dentistry2014

46. Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Make a difference with dentistry's (...) the Ad Council's children's oral health website Evidence Education About * Associated Topics Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone Ferne Kraglund DDS . Overview Systematic Review Conclusion Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone. Critical Summary Assessment

ADA Center for Evidence-Based Dentistry2014

47. For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone

For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone UTCAT2734, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Post-Dental Extraction Pain, Co-therapy with Acetaminophen and Ibuprofen is More Effective in Pain Management than Acetaminophen or Ibuprofen Alone Clinical Question In patients following a dental extraction (...) is the post-operative administration of combined acetaminophen and ibuprofen better than therapy with acetaminophen or ibuprofen alone for pain management? Clinical Bottom Line The post-operative use combined acetaminophen and ibuprofen provides superior pain relief compared to acetaminophen or ibuprofen alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Bailey/2013 Patient Group 2,241 patients ages 16-65

UTHSCSA Dental School CAT Library2014

48. Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery

Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery UTCAT2725, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery Clinical Question Following dental surgery, does Tramadol provide adequate analgesia when compared to hydrocodone/APAP or codeine/APAP (...) combination drug preparations? Clinical Bottom Line Tramadol/Acetaminophen 75/650mg tablets provide effective, rapid ( Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Jung/2004 128 healthy adults undergoing extraction of > or = 1 impacted 3rd molars Randomized Controlled Trial Key results Tr/APAP 75/650mg and Co/APAP/Ibuprofen 20/500/400mg mean total pain relief and the sum of pain intensity difference were

UTHSCSA Dental School CAT Library2014

49. Intravenous acetaminophen for acute postoperative pain in adults

Intravenous acetaminophen for acute postoperative pain in adults Intravenous acetaminophen for acute postoperative pain in adults Intravenous acetaminophen for acute postoperative pain in adults Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intravenous acetaminophen for acute postoperative pain in adults. Lansdale: HAYES, Inc.. Healthcare Technology Brief (...) the medications acetaminophen, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), selective inhibitors of cyclo-oxygenase-2, ketamine, aspirin, and nonpharmacologic therapies. Opioids have side effects that can be dose limiting such as nausea, vomiting, constipation, decreased gastrointestinal motility, urinary retention, sedation, confusion, and respiratory depression. NSAIDs are contraindicated in patients with renal impairment and may cause bleeding, platelet dysfunction, renal toxicity

Health Technology Assessment (HTA) Database.2014

50. Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy

Pre-emptive Oral Non-Steroidal Anti-Inflammatory Drugs or Acetaminophen for Knee Arthroscopy

Health Quality Ontario2014

51. Intravenous or rectal acetaminophen for post-operative pain

Intravenous or rectal acetaminophen for post-operative pain Intravenous or rectal acetaminophen for post-operative pain Intravenous or rectal acetaminophen for post-operative pain Mitchell MD, Umscheid CA Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Umscheid CA. Intravenous or rectal acetaminophen for post-operative pain. Philadelphia: Center (...) for Evidence-based Practice (CEP). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetaminophen; Administration, Intravenous; Administration, Rectal; Pain, Postoperatives Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104 Email: Cep2@uphs.upenn.edu

Health Technology Assessment (HTA) Database.2013

52. Acetaminophen (paracetamol) for the common cold in adults.

Acetaminophen (paracetamol) for the common cold in adults. BACKGROUND: Acetaminophen is frequently prescribed for treating patients with the common cold, but there is little evidence as to whether it is effective. OBJECTIVES: To determine the efficacy and safety of acetaminophen in the treatment of the common cold in adults. SEARCH METHODS: We searched CENTRAL 2013, Issue 1, Ovid MEDLINE (1950 to January week 5, 2013), EMBASE (1980 to February 2013), CINAHL (1982 to February 2013) and LILACS (...) (1985 to February 2013). SELECTION CRITERIA: We included randomised controlled trials (RCTs) comparing acetaminophen to placebo or no treatment in adults with the common cold. Studies were included if the trials used acetaminophen as one ingredient of a combination therapy. We excluded studies in which the participants had complications. Primary outcomes included subjective symptom score and duration of common cold symptoms. Secondary outcomes were overall well being, adverse events and financial

Cochrane2013

53. King`s College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children

King`s College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children 22906509 2013 01 16 2013 03 11 2016 10 19 1097-6833 162 2 2013 Feb The Journal of pediatrics J. Pediatr. King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children. 319-23.e1 10.1016/j.jpeds.2012.07.002 S0022-3476(12)00757-3 To validate King's College Hospital criteria (KCHC) in children with non-acetaminophen (...) M01 RR008084 RR NCRR NIH HHS United States UL1 RR02501-04 RR NCRR NIH HHS United States UL1RR024153 RR NCRR NIH HHS United States U01-DK072146-05 DK NIDDK NIH HHS United States UL1 TR000077 TR NCATS NIH HHS United States U01 DK072146 DK NIDDK NIH HHS United States Journal Article Research Support, N.I.H., Extramural Validation Studies 2012 08 18 United States J Pediatr 0375410 0022-3476 0 Analgesics, Non-Narcotic 362O9ITL9D Acetaminophen AIM IM Ann Intern Med. 2002 Dec 17;137(12):947-54 12484709

EvidenceUpdates2013 Full Text: Link to full Text with Trip Pro

54. For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone

For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone UTCAT2379, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone Clinical Question In patients (...) with inflammatory pain, does the combination of ibuprofen and acetaminophen compared to ibuprofen alone produce greater analgesia? Clinical Bottom Line Combination therapy with ibuprofen and acetaminophen produces greater analgesia than ibuprofen alone in patients with inflammatory pain. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 patients at least 16 years old with at least 3 impacted 3rd

UTHSCSA Dental School CAT Library2013

55. Is Intravenous Acetylcysteine More Effective Than Oral Administration For the Prevention of Hepatotoxicity in Acetaminophen Overdose?

Is Intravenous Acetylcysteine More Effective Than Oral Administration For the Prevention of Hepatotoxicity in Acetaminophen Overdose? DEFINE_ME_WA This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

Annals of Emergency Medicine Systematic Review Snapshots2013

56. Does Combination Treatment With Ibuprofen and Acetaminophen Improve Fever Control?

Does Combination Treatment With Ibuprofen and Acetaminophen Improve Fever Control? DEFINE_ME_WA This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

Annals of Emergency Medicine Systematic Review Snapshots2013

57. Hydrocodone-acetaminophen for pain control in first-trimester surgical abortion: a randomized controlled trial

Hydrocodone-acetaminophen for pain control in first-trimester surgical abortion: a randomized controlled trial 23090523 2012 10 23 2013 07 08 2013 11 21 1873-233X 120 5 2012 Nov Obstetrics and gynecology Obstet Gynecol Hydrocodone-acetaminophen for pain control in first-trimester surgical abortion: a randomized controlled trial. 1060-9 http://10.1097/AOG.0b013e31826c32f0 Although hydrocodone-acetaminophen is commonly used for pain control in first-trimester abortion, the efficacy of oral (...) opioids for decreasing pain has not been established. Our objective was to estimate the effect of hydrocodone-acetaminophen on patient pain perception during first-trimester surgical abortion. We conducted a randomized, double-blinded, placebo-controlled trial. Patients (before 11 weeks of gestation) received standard premedication (ibuprofen and lorazepam) and a paracervical block with the addition of 10 mg hydrocodone and 650 mg acetaminophen or placebo 45-90 minutes before surgical abortion

EvidenceUpdates2012

58. Codeine and acetaminophen for pain relief: a review of the clinical efficacy and safety

Codeine and acetaminophen for pain relief: a review of the clinical efficacy and safety Codeine and acetaminophen for pain relief: a review of the clinical efficacy and safety Codeine and acetaminophen for pain relief: a review of the clinical efficacy and safety CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Codeine (...) and acetaminophen for pain relief: a review of the clinical efficacy and safety. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2012 Authors' conclusions Based on this review, both codeine and acetaminophen/codeine provide better chronic pain relief than placebo. Chronic use of acetaminophen at doses higher than 2000 mg per day may be associated with increased risk of gastrointestinal events, liver toxicity, and renal dysfunction or failure. This review found evidence of increased risk

Health Technology Assessment (HTA) Database.2012

59. Use of Aspirin, Other Nonsteroidal Anti-Inflammatory Drugs, and Acetaminophen and Postmenopausal Breast Cancer Incidence

Use of Aspirin, Other Nonsteroidal Anti-Inflammatory Drugs, and Acetaminophen and Postmenopausal Breast Cancer Incidence 22927520 2012 10 01 2012 12 10 2016 10 19 1527-7755 30 28 2012 Oct 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence. 3468-77 The associations between use of aspirin, other (...) nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen and breast cancer incidence in postmenopausal women are uncertain. We examined these associations with breast cancer, both overall and by molecular subtype. We observed 84,602 postmenopausal women, free of cancer in 1980, until June 2008 and prospectively collected data on analgesic use, reproductive history, and other lifestyle factors using biennial questionnaires. Proportional hazards models were used to estimate multivariable relative risks (RRs) and 95% CIs. We

EvidenceUpdates2012 Full Text: Link to full Text with Trip Pro