Latest & greatest articles for acetaminophen

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Top results for acetaminophen

22. Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. BACKGROUND: Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES: To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults. SEARCH (...) METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase from inception to July 2016, together with reference lists of retrieved papers and reviews, and two online study registries. SELECTION CRITERIA: We included randomised, double-blind studies of two weeks' duration or longer, comparing paracetamol, alone or in combination with codeine or dihydrocodeine, with placebo or another active treatment in chronic neuropathic pain. DATA COLLECTION AND ANALYSIS

Cochrane2016

23. Limited Knowledge of Acetaminophen in Patients with Liver Disease

Limited Knowledge of Acetaminophen in Patients with Liver Disease 28097095 2018 11 13 2225-0719 4 4 2016 Dec 28 Journal of clinical and translational hepatology J Clin Transl Hepatol Limited Knowledge of Acetaminophen in Patients with Liver Disease. 281-287 10.14218/JCTH.2016.00049 Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from (...) acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to assess knowledge of acetaminophen dosing and presence of acetaminophen in common combination products in patients with liver disease. Methods: We performed a cross-sectional study of patients with liver disease at the Pfleger Liver Institute at the University of California, Los Angeles between June 2015 and August 2016

Journal of clinical and translational hepatology2016 Full Text: Link to full Text with Trip Pro

24. Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety

Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety | CADTH.ca Find the information you need Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Published on: September 9, 2016 Project Number: RA0864-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness (...) and safety of different individual doses of acetaminophen for patients with pain or fever? What is the clinical effectiveness and safety of doses in excess of the recommended daily maximum dose (4 g) for patients with pain or fever? What is the safety of chronic use of acetaminophen? Key Message Thirty-three systematic reviews and meta-analyses were identified regarding the effectiveness and safety of acetaminophen. Tags acetaminophen, Tylenol, paracetamol Files Rapid Response Reference List Published

Canadian Agency for Drugs and Technologies in Health - Rapid Review2016

25. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 (...) children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial. RESULTS: Participants received a median of 5.5 doses

NEJM2016 Full Text: Link to full Text with Trip Pro

26. Acetaminophen and Asthma - A Small Sigh of Relief?

Acetaminophen and Asthma - A Small Sigh of Relief? Acetaminophen and Asthma--A Small Sigh of Relief? - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27532835 Format MeSH and Other Data E-mail Subject Additional (...) text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 18;375(7):684-5. doi: 10.1056/NEJMe1607629. Acetaminophen and Asthma--A Small Sigh of Relief? 1 . 1 From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston. Comment on [N Engl J Med. 2016] PMID: 27532835 DOI: [Indexed for MEDLINE] Free

NEJM2016

27. 1000 mg versus 650 mg Acetaminophen for Pain or Fever: A Review of the Clinical Efficacy

1000 mg versus 650 mg Acetaminophen for Pain or Fever: A Review of the Clinical Efficacy 1000 mg versus 650 mg Acetaminophen for Pain or Fever: A Review of the Clinical Efficacy | CADTH.ca Find the information you need 1000 mg versus 650 mg Acetaminophen for Pain or Fever: A Review of the Clinical Efficacy 1000 mg versus 650 mg Acetaminophen for Pain or Fever: A Review of the Clinical Efficacy Published on: June 17, 2016 Project Number: RC0786-000 Product Line: Research Type: Drug Report Type (...) : Summary with Critical Appraisal Result type: Report Question What is the comparative clinical efficacy of 1000 mg acetaminophen compared with 600/650 mg acetaminophen for the treatment of pain? What is the comparative clinical efficacy of 1000 mg acetaminophen compared with 600/650 mg acetaminophen for managing fever? Key Message Acetaminophen 1000 mg single dose led to a higher percentage of people with at least 50% of pain relief over six hours, and a larger decrease in pain intensity, as compared

Canadian Agency for Drugs and Technologies in Health - Rapid Review2016

28. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update 27350943 2016 06 28 2018 11 13 2225-0719 4 2 2016 Jun 28 Journal of clinical and translational hepatology J Clin Transl Hepatol Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update. 131-42 10.14218/JCTH.2015.00052 Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take (...) Appl Pharmacol. 2015 Apr 15;284(2):180-7 25708609 APAP Acetaminophen toxicity Acute liver failure (ALF) Hepatotoxicity Paracetamol 2015 12 22 2016 04 07 2016 05 18 2016 6 29 6 0 2016 6 29 6 0 2016 6 29 6 1 ppublish 27350943 10.14218/JCTH.2015.00052 JCTH-4-2-052 PMC4913076

Journal of clinical and translational hepatology2016 Full Text: Link to full Text with Trip Pro

29. 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction

400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction UTCAT2994, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction Clinical Question In patients (...) receiving acetaminophen (paracetamol) and ibuprofen combination therapy, what is the effective dosage to relieve postoperative pain? Clinical Bottom Line For patients with postoperative pain, 400 mg ibuprofen/1000 mg acetaminophen (paracetamol) is the suggested effective dosage for short-term pain management. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Mehlisch/2010 234 patients post extraction

UTHSCSA Dental School CAT Library2016

30. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27028921 (...) Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Mar 31;374(13):1292-3. doi: 10.1056/NEJMc1601361. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. , , . Comment on [N Engl J Med. 2016] [N Engl J Med. 2016] [N Engl J Med. 2016] [N Engl J Med. 2015] PMID: 27028921 DOI: [Indexed for MEDLINE] Free full

NEJM2016

31. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27028922 (...) Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Mar 31;374(13):1291. doi: 10.1056/NEJMc1601361#SA1. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1 . 1 Medical College of Wisconsin, Milwaukee, WI jpatel2@mcw.edu. Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2015] PMID: 27028922 DOI

NEJM2016 Full Text: Link to full Text with Trip Pro

32. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27028923 (...) Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Mar 31;374(13):1291-2. doi: 10.1056/NEJMc1601361#SA2. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1 . 1 Mission Neighborhood Health Center, San Francisco, CA steven.leiner@gmail.com. Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2015

NEJM2016 Full Text: Link to full Text with Trip Pro

33. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27028924 (...) Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Mar 31;374(13):1292. doi: 10.1056/NEJMc1601361#SA3. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1 , 1 , 1 . 1 Gazi University, Ankara, Turkey guneseken@yahoo.com. Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2015] PMID: 27028924 DOI

NEJM2016 Full Text: Link to full Text with Trip Pro

34. Preoperative Acetaminophen Use in Hysterectomy to Reduce Postoperative Opioid Consumption

Preoperative Acetaminophen Use in Hysterectomy to Reduce Postoperative Opioid Consumption "Preoperative Acetaminophen Use in Hysterectomy to Reduce Postoperative" by Anna Lee < > > > > > Title Author Date of Award Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers Second Advisor Brent Norris Rights . Abstract Background: Hysterectomy is a common surgery amongst females and is occasionally considered a same (...) -day outpatient surgery. There is a lack of adequate postoperative pain control thus leading to extended use of postoperative opioid use. As a result, in addition to other postoperative side effects, patients suffer from adverse side effects of opioid use, including sedation, respiratory depression, constipation, nausea, and pruritus. This indirectly prolongs patients’ hospital stay and recovery. There have been recent studies suggesting non-opioids, such as acetaminophen, could decrease opioid use

Pacific University EBM Capstone Project2016

35. AcetaMINophen for Back Osteoarthritis Pain: Is the effect in the name?

AcetaMINophen for Back Osteoarthritis Pain: Is the effect in the name? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,400 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research (...) . www.acfp.ca September 26, 2016 AcetaMINophen for Back and Osteoarthritis Pain: Is the effect in the name? Clinical Question: Is acetaminophen effective for the management of back pain or osteoarthritis? Bottom Line: Acetaminophen is not efficacious for back pain, and provides no clinically meaningful impact on osteoarthritis. There are many other better interventions for these conditions like: short-term oral NSAIDs for back pain; topical NSAIDs or intra-articular steroids for osteoarthritis; and exercise

Tools for Practice2016

36. Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge

Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge 26479162 2015 11 09 2016 06 02 2015 11 09 1553-2712 22 11 2015 Nov Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge. 1254-60 (...) 10.1111/acem.12813 The objective was to test the hypothesis that oxycodone/acetaminophen provides superior analgesia to hydrocodone/acetaminophen for the treatment of acute extremity pain following emergency department (ED) discharge. This was a prospective, randomized, double-blind clinical trial of nonelderly adult ED patients with acute musculoskeletal extremity pain, randomly allocated at discharge to receive oxycodone/acetaminophen (5 mg/325 mg) or hydrocodone/acetaminophen (5 mg/325 mg

EvidenceUpdates2015 Full Text: Link to full Text with Trip Pro

37. Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness

Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness | CADTH.ca Find the information you need Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Published on: November 3, 2015 Project Number: RB0927-000 Product Line (...) : Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients? Key Message Two randomized controlled trials and four non-randomized studies were identified regarding the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol, Tramacet Files Rapid Response Summary of Abstracts

Canadian Agency for Drugs and Technologies in Health - Rapid Review2015

38. Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial.

Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. 26516435 2015 10 30 2015 10 30 2017 02 20 7 6 2015 Oct Electronic physician Electron Physician Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. 1310-7 10.14661/1310 N-acetylcysteine (...) (NAC) has been used as a classic treatment for hepatotoxicity induced by N-acetyl-p-benzoquinone imine (NAPQI) as a metabolite of acetaminophen. However, cimetidine theoretically can reduce the production of toxic metabolites through the inhibition of cytochrome p450, and it recently was proposed as a complementary treatment for acetaminophen toxicity. The aim of this study was to compare the effects of treating acute acetaminophen toxicity with NAC alone and with a combination of NAC

Electronic physician2015 Full Text: Link to full Text with Trip Pro

39. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.

Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. 26501533 2015 10 27 2015 11 04 2016 10 17 1538-3598 314 15 2015 Oct 20 JAMA JAMA Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. 1572-80 10.1001/jama.2015.13043 Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients (...) are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination. To compare functional outcomes and pain at 1 week and 3 months after an ED visit for acute LBP among patients randomized to a 10-day course of (1) naproxen + placebo; (2) naproxen + cyclobenzaprine; or (3) naproxen + oxycodone/acetaminophen. This randomized, double-blind, 3-group study was conducted at one urban ED in the Bronx, New York City. Patients who presented

JAMA2015 Full Text: Link to full Text with Trip Pro

40. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. BACKGROUND: Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown. METHODS: We randomly assigned 700 ICU patients with fever (body temperature, ≥38°C) and known or suspected infection to receive either 1 g of intravenous acetaminophen or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial (...) therapy, or death. The primary outcome was ICU-free days (days alive and free from the need for intensive care) from randomization to day 28. RESULTS: The number of ICU-free days to day 28 did not differ significantly between the acetaminophen group and the placebo group: 23 days (interquartile range, 13 to 25) among patients assigned to acetaminophen and 22 days (interquartile range, 12 to 25) among patients assigned to placebo (Hodges-Lehmann estimate of absolute difference, 0 days; 96.2% confidence

NEJM2015