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Latest & greatest articles for Topical Corticosteroid
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Corticosteroids - topical (skin), nose, and eyes Corticosteroids - topical (skin), nose, and eyes - NICE CKS Share Corticosteroids - topical (skin), nose, and eyes: Summary Corticosteroids are synthetic analogues of the natural hormones that are produced by the adrenalcortex. Local corticosteroids are predominantly glucocorticoids. They have 4 main effects: Anti-inflammatory. Immunosuppressive. Anti-proliferative (anti-mitotic). Vasoconstrictive. Topicalcorticosteroids exert these effects (...) of this topic. Background information Background information Definition What are corticosteroids? Corticosteroids are synthetic analogues of the natural hormones that are produced by the adrenalcortex. Like the natural hormones, synthetic corticosteroids can have glucocorticoid and/or mineralocorticoid properties. The glucocorticoid properties are anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive. The glucocorticoid properties also support a variety of metabolic functions
. Applicability The evidence, while of low quality, still supports the application of topicalcorticosteroids to reduce the healing time of aphthous ulcers. The studies also report a reduction in the occurrence of new ulcers, the size of the ulcers, and the pain experienced by the patient due to the ulcers. A study evaluated in the systematic review shows that topicalcorticosteroids used intraorally do not cause adrenal suppression, if the patient uses them as instructed. Specialty/Discipline (Oral Medicine (...) TopicalCorticosteroids Improve Healing Time in Patients with Aphthous Ulcers UTCAT3273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title TopicalCorticosteroids Improve Healing Time in Patients with Aphthous Ulcers Clinical Question In patients with aphthous ulcers, does treatment with topicalcorticosteroids, as compared to a placebo, improve healing time of the ulcers? Clinical Bottom Line Patients treated
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topicalcorticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial. Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab (...) substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis. We aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topicalcorticosteroids versus placebo with topicalcorticosteroids in adults with moderate-to-severe atopic dermatitis.In this 1-year, randomised, double-blinded, placebo-controlled, phase 3 study (LIBERTY AD CHRONOS
2017LancetControlled trial quality: predicted high
Long-term topicalcorticosteroid use and risk of skin cancer: a systematic review protocol. The objective of this systematic review is to synthesize the best available research evidence to determine the risk of skin cancer in patients on long-term use of topicalcorticosteroids. Specifically the review question is: In people using long-term (regular use over one month) topicalcorticosteroids, what is the risk of developing skin cancer (clinically or histologically confirmed basal cell
Psoriasis patientsâ€™ experiences concerning medical adherence to treatment with topicalcorticosteroids Nonadherence to topical treatment of psoriasis is a common cause of treatment failure. This focus group study was conducted to obtain the patients' own experiences and explanations regarding medical adherence. The participants consisted of eight primary adherent patients with moderate psoriasis treated with corticosteroid or corticosteroid-calcipotriol combinations, purposefully sampled (...) in the prescriber, diverging information from health care personnel, experiencing side effects, having fear of side effects, impractical formulations of topical products, and impatience regarding time before an effect of the treatment was observed. From this study, the recommendations for the prescribing doctor to improve medical adherence are, the doctor needs to take time to listen to the patient, prescribe a topical product that is easy to apply and less greasy, inform the patients about benefits from
Association of TopicalCorticosteroid Use and Bone Mineral Density in Patients with Atopic Dermatitis "Association of TopicalCorticosteroid Use and Bone Mineral Density in " by Carsten Paulson < > > > > > Title Author Date of Graduation Summer 8-8-2015 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers, PA-C, MS Rights . Abstract Background Atopic dermatitis (AD) is a common pruritic inflammatory skin disease. First-line (...) therapy for AD involves the use of topicalcorticosteroids. With long-term use, these agents exert systemic effects and have been associated with adverse effects on bone health. This review assesses the current evidence for an association between topicalcorticosteroid use and bone mineral density in patients with atopic dermatitis. Methods An exhaustive search of available literature was conducted in using the MEDLINE-Ovid, Web of Science, CINAHL, and Evidence-Based Medicine Reviews Multifile
Topicalcorticosteroids as adjunctive therapy for bacterial keratitis. Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma, and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis, whereas the use of topicalcorticosteroids as an adjunctive therapy to antibiotics (...) remains controversial. Topicalcorticosteroids are usually used to control inflammation using the smallest amount of the drug. Their use requires optimal timing, concomitant antibiotics, and careful follow-up.The objective of the review was to assess the effectiveness and safety of corticosteroids as adjunctive therapy for bacterial keratitis. Secondary objectives included evaluation of health economic outcomes and quality of life outcomes.We searched CENTRAL (which contains the Cochrane Eyes
Topicalcorticosteroids for treating phimosis in boys. Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topicalcorticosteroids applied for four to eight weeks have been favourable. The efficacy and safety of topicalcorticosteroids for treating phimosis in boys has not been previously systematically reviewed.We aimed to 1) compare the effectiveness of the use of topicalcorticosteroid ointment applied (...) to the distal stenotic portion of the prepuce in the resolution of phimosis in boys compared with the use of placebo or no treatment, and 2) determine the rate of partial resolution (improvement) of phimosis, rate of re-stenosis after initial resolution or improvement of phimosis, and the rate of adverse events of topicalcorticosteroid treatment in boys with phimosis.We searched the Cochrane Renal Group's Specialised Register through contact with the Trials' Search Co-ordinator using search terms relevant
Safety of topicalcorticosteroids in pregnancy. Topicalcorticosteroids are the most frequently prescribed dermatological treatment and are frequently used by pregnant women with skin conditions. However, little is known about their safety in pregnancy.To assess the effects of topicalcorticosteroids on pregnancy outcomes.On 5th May 2009 we searched the Cochrane Skin Group Specialised Register, the Cochrane Pregnancy and Childbirth Group Specialised Register, CENTRAL (The Cochrane Library 2009 (...) , Issue 2), MEDLINE (from 2003), and EMBASE (from 2005). We searched LILACS, CINAHL, British Nursing Index, SCI-EXPANDED, BIOSIS Previews, Conference Papers Index, and Conference Proceedings Citation Index-Science from inception to May 2009. We scanned the bibliographies of the included studies, published reviews, and articles that had cited the included studies. Pharmaceutical companies that have introduced an original topicalcorticosteroid product were contacted.Randomised controlled trials
A double-blind randomised placebo controlled trial of topical intranasal corticosteroids in 4- to11-year-old children with persistent bilateral otitis media with effusion in primary care Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Topical intranasal corticosteroids in 4-11 year old children with persistent bilateral otitis media with effusion in primary care: double blind randomised placebo controlled trial. To determine the clinical effectiveness of topical intranasal corticosteroids in children with bilateral otitis media with effusion.Double blind randomised placebo controlled trial.76 Medical Research Council General Practice Research Framework practices throughout the United Kingdom, between 2004 and 2007.217 (...) ) at one month (primary end point), three months, and nine months; adverse events; three month diary symptoms. Results 41% (39/96) of the topical steroid group and 45% (44/98) of the placebo group were cured in one or both ears at one month (difference favouring placebo 4.3% (95% confidence interval -9.3% to 18.1%). Poisson regression was done with adjustment for four pre-specified covariates (clinical severity, P=0.003; atopy, P=0.67; age, P=0.92; season, P=0.71). The adjusted relative risk at one
Topicalcorticosteroids as adjunctive therapy for bacterial keratitis. Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis where as the use of topicalcorticosteroids remains controversial. Topical (...) , an online database of ongoing trials (www.clinicaltrials.gov), reference lists of included trials, earlier reviews and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and ongoing randomized trials.We included randomized controlled trials evaluating adjunctive therapy with topicalcorticosteroids in people with bacterial keratitis.Two review authors independently screened all the retrieved articles. Methodological quality of the one included trial
A cost-utility analysis of pimecrolimus vs. topicalcorticosteroids and emollients for the treatment of mild and moderate atopic eczema A cost-utility analysis of pimecrolimus vs. topicalcorticosteroids and emollients for the treatment of mild and moderate atopic eczema A cost-utility analysis of pimecrolimus vs. topicalcorticosteroids and emollients for the treatment of mild and moderate atopic eczema Pitt M, Garside R, Stein K Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of topicalcorticosteroids (TCS) as a first-line treatment followed by pimecrolimus as a second-line treatment, and pimecrolimus as a first-line treatment followed by TCS, in the treatment of mild and moderate atopic eczema. Type
of the findings is limited. Further research is required on the clinical and cost-effectiveness of once-daily versus more frequent use of same potency corticosteroids, specifically on mild potency products for mild to moderate atopic eczema. Outcomes should include quality of life and compliance. Project page URL Indexing Status Subject indexing assigned by CRD MeSH AdrenalCortexHormones; Costs and Cost Analysis; Dermatitis, Atopic Language Published English Country of organisation England Address (...) Clinical and cost-effectiveness of once-daily versus more frequent use of same potency topicalcorticosteroids for atopic eczema: a systematic review and economic evaluation Clinical and cost-effectiveness of once-daily versus more frequent use of same potency topicalcorticosteroids for atopic eczema: a systematic review and economic evaluation Clinical and cost-effectiveness of once-daily versus more frequent use of same potency topicalcorticosteroids for atopic eczema: a systematic review
Frequency of application of topicalcorticosteroids for atopic eczema (TA81) Overview | Frequency of application of topicalcorticosteroids for atopic eczema | Guidance | NICE Frequency of application of topicalcorticosteroids for atopic eczema Technology appraisal guidance [TA81] Published date: 25 August 2004 Share Guidance on using topicalcorticosteroids for people with atopic eczema. Guidance development process Is this guidance up to date? . We found nothing new that affects
in AD. Future research should therefore attempt to further assess this issue. Bibliographic details Schiffner R, Schiffner-Rohe J, Landthaler M, Stolz W. Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids. PharmacoEconomics 2003; 21(3): 159-179 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Administration, Topical; AdrenalCortexHormones /administration & Adult; Balneology; Child; Dermatitis, Atopic /classification (...) Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids Schiffner R, Schiffner-Rohe J, Landthaler M, Stolz W CRD summary This review assessed the impact on quality of life of different topically applicable