Latest & greatest articles for Sublingual Immunotherapy

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on Sublingual Immunotherapy or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on Sublingual Immunotherapy and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for Sublingual Immunotherapy

1. Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma Full Text available with Trip Pro

Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinically efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must demonstrate their efficacy and safety in pivotal phase III trials for registration.We sought to investigate (...) the efficacy and safety of sublingual high-dose liquid birch pollen extract (40,000 allergy units native [AUN]/mL) in adults with birch pollen allergy.A randomized, double-blind, placebo-controlled, parallel-group multicenter trial was conducted in 406 adult patients with moderate-to-severe birch pollen-induced allergic rhinoconjunctivitis with or without mild-to-moderate controlled asthma. Treatment was started 3 to 6 months before the birch pollen season and continued during the season in 40 clinical

2019 EvidenceUpdates

2. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy Full Text available with Trip Pro

Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult subjects and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy.We (...) sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations containing either rMal d 1 or rBet v 1 on birch pollen-related apple allergy.Sixty participants with birch pollen-related apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 μg of rMal d 1 (n = 20) or rBet v 1 (n = 20) for 16 weeks. Adverse events were regularly recorded. Sublingual challenges with standardized doses of rMal d 1, skin prick tests with recombinant

2017 EvidenceUpdates

3. Treatment Satisfaction During Sublingual Immunotherapy with a Five-Grass Pollen Tablet for Allergic Rhinoconjunctivitis: A Prospective, Non-Interventional Study Full Text available with Trip Pro

Treatment Satisfaction During Sublingual Immunotherapy with a Five-Grass Pollen Tablet for Allergic Rhinoconjunctivitis: A Prospective, Non-Interventional Study Sublingual immunotherapy (SLIT) is a safe/well-tolerated alternative to allergen injection immunotherapy for allergic rhinoconjunctivitis (ARC). Patient adherence is essential and patient-related outcome measures including treatment satisfaction are informative/indicative of adherence.The aim was to assess treatment satisfaction

2017 Drugs - real world outcomes

4. Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial. Full Text available with Trip Pro

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial. Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following (...) discontinuation of treatment.To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up.A randomized double-blind, placebo-controlled, 3-parallel-group study performed in a single academic center, Imperial College London, of adult patients with moderate to severe seasonal allergic rhinitis (interfering with usual daily activities or sleep). First enrollment was March 2011, last follow-up

2017 JAMA Controlled trial quality: predicted high

6. Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines

Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Published on: May 31, 2016 (...) Project Number: RC0784-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of sublingual versus injectable forms of customized allergy immunotherapy in patients with allergies? What is the comparative clinical effectiveness of either the sublingual or injectable forms of customized allergy immunotherapy versus oral antihistamines in patients with allergies? What is the comparative cost

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. Full Text available with Trip Pro

Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.To evaluate the efficacy and adverse events of the HDM SLIT tablet vs placebo for asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.Double-blind, randomized, placebo-controlled trial conducted

2016 JAMA Controlled trial quality: predicted high

8. Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. (Abstract)

Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. Specific allergen immunotherapy is the only treatment modality that might change the natural course of allergic diseases in childhood. We sought to prospectively compare the long-term clinical and immunological effects of sublingual (SLIT) and subcutaneous (SCIT) immunotherapy compared with pharmacotherapy alone.In this single

2016 Journal of investigational allergology & clinical immunology Controlled trial quality: uncertain

9. Immunotherapy (oral and sublingual) for food allergy to fruits. Full Text available with Trip Pro

Immunotherapy (oral and sublingual) for food allergy to fruits. Food allergy is an abnormal immunological response following exposure (usually ingestion) to a food. Elimination of the allergen is the principle treatment for food allergy, including allergy to fruit. Accidental ingestion of allergenic foods can result in severe anaphylactic reactions. Allergen-specific immunotherapy (SIT) is a specific treatment, when the avoidance of allergenic foods is problematic. Recently, studies have been (...) conducted on different types of immunotherapy for the treatment of food allergy, including oral (OIT) and sublingual immunotherapy (SLIT).To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with food allergy to fruits, when compared with placebo or an elimination strategy.The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, and AMED were searched for published results along with trial registries and the Journal of Negative

2015 Cochrane

10. Sublingual immunotherapy for asthma. Full Text available with Trip Pro

Sublingual immunotherapy for asthma. Asthma is a common long-term respiratory disease affecting approximately 300 million people worldwide. Approximately half of people with asthma have an important allergic component to their disease, which may provide an opportunity for targeted treatment. Sublingual immunotherapy (SLIT) aims to reduce asthma symptoms by delivering increasing doses of an allergen (e.g. house dust mite, pollen extract) under the tongue to induce immune tolerance. However (...) , it is not clear whether the sublingual delivery route is safe and effective in asthma.To assess the efficacy and safety of sublingual immunotherapy compared with placebo or standard care for adults and children with asthma.We identified trials from the Cochrane Airways Group Specialised Register (CAGR), ClinicalTrials.gov (www.ClinicalTrials.gov), the World Health Organization (WHO) trials portal (www.who.int/ictrp/en/) and reference lists of all primary studies and review articles. The search is up to date

2015 Cochrane

11. [Sublingual immunotherapy for respiratory allergies]

[Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] Martin G Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Martin G. L'immunothérapie sublinguale comme traitement des allergies respiratoires . [Sublingual immunotherapy for respiratory allergies] . Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Administration, Sublingual; Desensitization, Immunologic; Humans; Respiratory Hypersensitivity Language Published French Country of organisation Canada Province or state Quebec

2014 Health Technology Assessment (HTA) Database.

12. Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma

Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Article Text Aetiology Systematic review Sublingual immunotherapy improves symptoms of allergical

2014 Evidence-Based Medicine

13. High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study (Abstract)

High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study Sublingual allergen-specific immunotherapy is a viable alternative to subcutaneous immunotherapy particularly attractive for use in children.This study investigated efficacy and safety of high-dose sublingual immunotherapy (SLIT) in children allergic to grass pollen in a randomized, double-blind, placebo-controlled trial.After a baseline

2012 EvidenceUpdates Controlled trial quality: predicted high

14. One-year follow-up of clinical and inflammatory parameters in children allergic to grass pollen receiving high-dose ultrarush sublingual immunotherapy. (Abstract)

One-year follow-up of clinical and inflammatory parameters in children allergic to grass pollen receiving high-dose ultrarush sublingual immunotherapy. In a previous double-blind placebo-controlled study, we analyzed a high-dose sublingual immunotherapy (SLIT) ultrarush protocol in asthmatic children monosensitized to grass pollen. In the present open-label study, we assessed the effect of SLIT on symptom score and nonspecific bronchial hyperreactivity in the same cohort followed for 1

2011 Journal of investigational allergology & clinical immunology

15. [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma]

[Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] S Shin, HJ Song, SY Park, YJ Jung, JY Park, J Ahn, YM Yea Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation S Shin, HJ Song, SY Park, YJ Jung, JY Park, J Ahn, YM Yea. [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] Seoul: National Evidence-based Healthcare Collaborating Agency (NECA). NECA-A-11-006. 2011 Authors' conclusions Disease burdens of allergic rhinitis and asthma have recently been

2011 Health Technology Assessment (HTA) Database.

16. Sublingual immunotherapy for allergic rhinitis

Sublingual immunotherapy for allergic rhinitis Sublingual immunotherapy for allergic rhinitis Sublingual immunotherapy for allergic rhinitis Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Sublingual immunotherapy for allergic rhinitis. Lansdale: HAYES, Inc.. Directory Publication. 2011 Authors' conclusions Sublingual immunotherapy involves the administration (...) of a diluted dose of an allergen under the tongue, which allows the material to contact the oral mucosa. Sublingual immunotherapy has been investigated in patients with allergic rhinitis and/or asthma associated with sensitivity to seasonal allergens, and to allergens such as dust mites, mold, pet dander, or nuts. In contrast to standard immunotherapy, which requires subcutaneous injections, sublingual therapy may offer a lower risk of serious side effects, and may be more comfortable and acceptable

2011 Health Technology Assessment (HTA) Database.

17. Sublingual immunotherapy for allergic rhinitis and asthma

Sublingual immunotherapy for allergic rhinitis and asthma Sublingual immunotherapy for allergic rhinitis and asthma Sublingual immunotherapy for allergic rhinitis and asthma Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Report may be purchased from . Citation Sublingual immunotherapy for allergic rhinitis and asthma . Lansdale: HAYES, Inc.. 2009 Authors' objectives (...) Sublingual immunotherapy involves the administration of a diluted dose of an allergen under the tongue, which allows the material to contact the oral mucosa. Sublingual immunotherapy has been investigated in patients with allergic rhinitis and/or asthma associated with sensitivity to seasonal allergens, and to allergens such as dust mites, mold, pet dander, or nuts. In contrast to standard immunotherapy, which requires subcutaneous injections, sublingual therapy may offer a lower risk of serious side

2009 Health Technology Assessment (HTA) Database.

18. Short term coseasonal sublingual immunotherapy reduced the development of asthma in children with hay fever Full Text available with Trip Pro

Short term coseasonal sublingual immunotherapy reduced the development of asthma in children with hay fever Short term coseasonal sublingual immunotherapy reduced the development of asthma in children with hay fever | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Short term coseasonal sublingual immunotherapy reduced the development of asthma in children with hay fever Article Text Treatment Short term coseasonal sublingual immunotherapy

2006 Evidence-Based Nursing

19. Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study

Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy (...) : the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study Berto P, Passalacqua G, Crimi N, Frati F, Ortolani C, Senna G, Canonica G W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study investigated the use of sublingual

2006 NHS Economic Evaluation Database.

20. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method

Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.