Latest & greatest articles for Sublingual Immunotherapy

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Top results for Sublingual Immunotherapy

1. Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma

Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinically efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must demonstrate their efficacy and safety in pivotal phase III trials for registration.We sought to investigate (...) the efficacy and safety of sublingual high-dose liquid birch pollen extract (40,000 allergy units native [AUN]/mL) in adults with birch pollen allergy.A randomized, double-blind, placebo-controlled, parallel-group multicenter trial was conducted in 406 adult patients with moderate-to-severe birch pollen-induced allergic rhinoconjunctivitis with or without mild-to-moderate controlled asthma. Treatment was started 3 to 6 months before the birch pollen season and continued during the season in 40 clinical

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2019 EvidenceUpdates

2. Oral and sublingual immunotherapy for egg allergy. (PubMed)

Oral and sublingual immunotherapy for egg allergy. Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy might be an optional treatment, through desensitization to egg allergen.To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with immunoglobulin E (IgE)-mediated egg allergy as compared to a placebo treatment or an avoidance strategy.We searched 13 databases for journal articles (...) , conference proceedings, theses and trials registers using a combination of subject headings and text words (last search 31 March 2017).We included randomized controlled trials (RCTs) comparing oral immunotherapy or sublingual immunotherapy administered by any protocol with placebo or an elimination diet. Participants were children or adults with clinical egg allergy.We retrieved 97 studies from the electronic searches. We selected studies, extracted data and assessed the methodological quality. We

2018 Cochrane

3. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy

Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult subjects and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy.We (...) sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations containing either rMal d 1 or rBet v 1 on birch pollen-related apple allergy.Sixty participants with birch pollen-related apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 μg of rMal d 1 (n = 20) or rBet v 1 (n = 20) for 16 weeks. Adverse events were regularly recorded. Sublingual challenges with standardized doses of rMal d 1, skin prick tests with recombinant

2017 EvidenceUpdates

4. Treatment Satisfaction During Sublingual Immunotherapy with a Five-Grass Pollen Tablet for Allergic Rhinoconjunctivitis: A Prospective, Non-Interventional Study (PubMed)

Treatment Satisfaction During Sublingual Immunotherapy with a Five-Grass Pollen Tablet for Allergic Rhinoconjunctivitis: A Prospective, Non-Interventional Study Sublingual immunotherapy (SLIT) is a safe/well-tolerated alternative to allergen injection immunotherapy for allergic rhinoconjunctivitis (ARC). Patient adherence is essential and patient-related outcome measures including treatment satisfaction are informative/indicative of adherence.The aim was to assess treatment satisfaction

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2017 Drugs - real world outcomes

5. Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial. (PubMed)

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial. Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following (...) discontinuation of treatment.To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up.A randomized double-blind, placebo-controlled, 3-parallel-group study performed in a single academic center, Imperial College London, of adult patients with moderate to severe seasonal allergic rhinitis (interfering with usual daily activities or sleep). First enrollment was March 2011, last follow-up

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2017 JAMA

7. Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines

Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Sublingual and Injectable Customized Allergy Immunotherapy: Clinical and Cost-Effectiveness and Guidelines Published on: May 31, 2016 (...) Project Number: RC0784-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of sublingual versus injectable forms of customized allergy immunotherapy in patients with allergies? What is the comparative clinical effectiveness of either the sublingual or injectable forms of customized allergy immunotherapy versus oral antihistamines in patients with allergies? What is the comparative cost

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. (PubMed)

Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.To evaluate the efficacy and adverse events of the HDM SLIT tablet vs placebo for asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.Double-blind, randomized, placebo-controlled trial conducted

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2016 JAMA

9. Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. (PubMed)

Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. Specific allergen immunotherapy is the only treatment modality that might change the natural course of allergic diseases in childhood. We sought to prospectively compare the long-term clinical and immunological effects of sublingual (SLIT) and subcutaneous (SCIT) immunotherapy compared with pharmacotherapy alone.In this single

2016 Journal of investigational allergology & clinical immunology

10. Immunotherapy (oral and sublingual) for food allergy to fruits. (PubMed)

Immunotherapy (oral and sublingual) for food allergy to fruits. Food allergy is an abnormal immunological response following exposure (usually ingestion) to a food. Elimination of the allergen is the principle treatment for food allergy, including allergy to fruit. Accidental ingestion of allergenic foods can result in severe anaphylactic reactions. Allergen-specific immunotherapy (SIT) is a specific treatment, when the avoidance of allergenic foods is problematic. Recently, studies have been (...) conducted on different types of immunotherapy for the treatment of food allergy, including oral (OIT) and sublingual immunotherapy (SLIT).To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with food allergy to fruits, when compared with placebo or an elimination strategy.The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, and AMED were searched for published results along with trial registries and the Journal of Negative

2015 Cochrane

11. Sublingual immunotherapy for asthma. (PubMed)

Sublingual immunotherapy for asthma. Asthma is a common long-term respiratory disease affecting approximately 300 million people worldwide. Approximately half of people with asthma have an important allergic component to their disease, which may provide an opportunity for targeted treatment. Sublingual immunotherapy (SLIT) aims to reduce asthma symptoms by delivering increasing doses of an allergen (e.g. house dust mite, pollen extract) under the tongue to induce immune tolerance. However (...) , it is not clear whether the sublingual delivery route is safe and effective in asthma.To assess the efficacy and safety of sublingual immunotherapy compared with placebo or standard care for adults and children with asthma.We identified trials from the Cochrane Airways Group Specialised Register (CAGR), ClinicalTrials.gov (www.ClinicalTrials.gov), the World Health Organization (WHO) trials portal (www.who.int/ictrp/en/) and reference lists of all primary studies and review articles. The search is up to date

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2015 Cochrane

12. [Sublingual immunotherapy for respiratory allergies]

[Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] Martin G Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Martin G. L'immunothérapie sublinguale comme traitement des allergies respiratoires . [Sublingual immunotherapy for respiratory allergies] . Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Administration, Sublingual; Desensitization, Immunologic; Humans; Respiratory Hypersensitivity Language Published French Country of organisation Canada Province or state Quebec

2014 Health Technology Assessment (HTA) Database.

13. Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma

Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Article Text Aetiology Systematic review Sublingual immunotherapy improves symptoms of allergical

2014 Evidence-Based Medicine (Requires free registration)

14. Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: a systematic review and indirect comparison (PubMed)

Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: a systematic review and indirect comparison Severe allergic rhinitis uncontrolled by pharmacotherapy can adversely affect quality of life. Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) have demonstrated effectiveness in this patient group; however, it remains uncertain which route of administration is more effective.We sought to update existing systematic reviews on the clinical effectiveness

2013 EvidenceUpdates

15. A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis

A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry

2013 NIHR HTA programme

16. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review

Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Lin SY, Erekosima N, Kim JM, Ramanathan M, Suarez-Cuervo C, Chelladurai Y, Ward D, Segal JB CRD summary This well-conducted review concluded that there was moderate evidence (...) to support the effectiveness of sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma, but high-quality trials were needed to determine the best dosing strategies. These findings are likely to be reliable. Authors' objectives To systematically review the effectiveness and safety of aqueous sublingual immunotherapy for allergic rhinoconjunctivitis and asthma. Searching The following databases were searched for articles from inception to December 2012: MEDLINE, EMBASE

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2013 DARE.

17. Sublingual immunotherapy reduces symptoms of asthma and hay fever, systematic review finds. (PubMed)

Sublingual immunotherapy reduces symptoms of asthma and hay fever, systematic review finds. 23550050 2013 05 20 2018 10 23 1756-1833 346 2013 Apr 02 BMJ (Clinical research ed.) BMJ Sublingual immunotherapy reduces symptoms of asthma and hay fever, systematic review finds. f2056 10.1136/bmj.f2056 bmj.f2056 Ramsey Sophie S eng News 2013 04 02 England BMJ 8900488 0959-8138 AIM IM Administration, Sublingual Asthma diagnosis drug therapy Humans Immunotherapy methods Review Literature as Topic

2013 BMJ

18. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. (PubMed)

Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. Allergic rhinitis affects up to 40% of the US population. To desensitize allergic individuals, subcutaneous injection immunotherapy or sublingual immunotherapy may be administered. In the United States, sublingual immunotherapy is not approved by the Food and Drug Administration. However, some US physicians use aqueous allergens, off-label, for sublingual desensitization.To systematically (...) review the effectiveness and safety of aqueous sublingual immunotherapy for allergic rhinoconjunctivitis and asthma.The databases of MEDLINE, EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials were searched through December 22, 2012. English-language randomized controlled trials were included if they compared sublingual immunotherapy with placebo, pharmacotherapy, or other sublingual immunotherapy regimens and reported clinical outcomes. Studies of sublingual immunotherapy

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2013 JAMA

19. High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study (PubMed)

High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study Sublingual allergen-specific immunotherapy is a viable alternative to subcutaneous immunotherapy particularly attractive for use in children.This study investigated efficacy and safety of high-dose sublingual immunotherapy (SLIT) in children allergic to grass pollen in a randomized, double-blind, placebo-controlled trial.After a baseline

2012 EvidenceUpdates

20. Sublingual immunotherapy for treating allergic conjunctivitis. (PubMed)

Sublingual immunotherapy for treating allergic conjunctivitis. Allergic ocular symptoms, although frequently trivialised, are common and represent an important comorbidity of allergic rhinitis. Sublingual Immunotherapy (SLIT) is an effective and well-tolerated treatment for allergic rhinitis, but its effects on symptoms of ocular allergy have not been well established.To evaluate the efficacy of SLIT compared with placebo for reductions in ocular symptoms, topical ocular medication requirements (...) Review Manager software.Forty-two trials (n = 3958 total participants; n= 2011 SLIT and n = 1947 placebo) had available data to evaluate the efficacy of SLIT on AC and were included in the meta-analyses. Heterogeneity among studies (I(2) statistic) was around 50% or below for all endpoints. Sublingual immunotherapy induced a significant reduction in both total ocular symptom scores (SMD -0.41; 95% confidence interval (CI) -0.53 to -0.28; P < 0.00001; I(2) = 59%) and individual ocular symptom scores

2011 Cochrane