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The evaluation of serum homocysteine, folicacid, and vitamin B12 in patients complicated with preeclampsia Increased plasma homocysteine may be associated with adverse pregnancy outcomes, such as preeclampsia. The aim of this study was to determine the plasma homocysteine, serumfolate, and vitamin B12 levels in preeclamptic pregnant women.This case-control study was conducted in 2016 in Ahwaz on 51 pregnant women with preeclampsia and 51 healthy pregnant women of the same gestational age, who (...) vitamin B12, but it was not statistically significant (p = 0.160; r = -0.200). Significant differences occurred in serum homocysteine and folate levels between the severe and non-severe subgroups (p < 0.001, p < 0.001).Women complicated with preeclampsia displayed higher maternal serum homocysteine and lower serumfolate and vitamin B12. Further studies are needed to confirm if the prescription of folicacid and vitamin B12 in women with a deficiency of these vitamins could decrease the level of serum
for prevention of neural tube defects WHO Library Cataloguing-in-Publication Data Guideline: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects 1.FolicAcid – administration and dosage. 2.FolicAcid – blood. 3.Neural Tube Defects – prevention and con- trol. 4.Congenital Abnormalities – etiology. 5.Nutritional Requirements. 6.Maternal Nutritional Physiological Phenomena. 7.Guideline. I.World Health Organization. ISBN 978 92 4 154904 2 (...) , and the strength of this association may vary across geographic regions, probably owing to differences in genetic background and environmental factors. In the general population, the gene polymorphism MTHFR 677C àT is considered the strongest determinant of folate status in women of reproductive age. ¦ ¦ Bloodfolate concentrations and risk of neural tube defects In September 2013, a search was conducted on electronic databases, for studies assessing folicacid intake, bloodfolate concentrations and NTDs
Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects.Bayesian model.Data from two population based studies in China.247,831 participants in a prospective community intervention project in China (1993-95) to prevent neural tube defects with 400 μg/day folicacid supplementation and 1194 participants in a population based (...) randomized trial (2003-05) to evaluate the effect of folicacid supplementation on bloodfolate concentration among Chinese women of reproductive age.Folic acid supplementation (400 μg/day).Estimated RBC folate concentration at time of neural tube closure (day 28 of gestation) and risk of neural tube defects.Risk of neural tube defects was high at the lowest estimated RBC folate concentrations (for example, 25.4 (95% uncertainty interval 20.8 to 31.2) neural tube defects per 10,000 births at 500 nmol/L
Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folicacid, blood levels, and breast-feeding A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folicacid and prenatal vitamin K use and the clinical implications of placental and breast-milk transfer of antiepileptic drugs (AEDs). The committee evaluated (...) the available evidence based on a structured literature review and classification of relevant articles. Preconceptional folicacid supplementation is possibly effective in preventing major congenital malformations in the newborns of WWE taking AEDs. There is inadequate evidence to determine if the newborns of WWE taking AEDs have a substantially increased risk of hemorrhagic complications. Primidone and levetiracetam probably transfer into breast milk in clinically important amounts. Valproate
Practice Parameter update: Managment issues for women with epilepsy - Focus on pregnancy: Vitamin K, folicacid, blood levels, and breastfeeding DOI 10.1212/WNL.0b013e3181a6b325 2009;73;142-149 Published Online before print April 27, 2009 Neurology C. L. Harden, P. B. Pennell, B. S. Koppel, et al. of Neurology and American Epilepsy Society Technology Assessment Subcommittee of the American Academy the Quality Standards Subcommittee and Therapeutics and Vitamin K, folicacid, blood levels (...) Neurology Society has endorsed the following guidelines: ? Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency ? Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes ? Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Vitamin K, folicacid, blood levels, and breastfeeding Neurology 73 July 14, 2009
Management issues for women with epilepsy-focus on pregnancy: vitamin k, folicacid, blood levels, and breastfeeding Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Vitamin K, folicacid, blood levels, and breastfeeding | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share July 14, 2009 ; 73 (2) Special (...) Article Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Vitamin K, folicacid, blood levels, and breastfeeding Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society C. L. Harden , P. B. Pennell , B. S. Koppel , C. A. Hovinga , B. Gidal , K. J. Meador , J. Hopp , T. Y. Ting , W. A. Hauser , D. Thurman , P. W. Kaplan , J. N
High-dose folicacid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folicacid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Asse Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folicacid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics (...) and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folicacid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ
or B12, folicacid plus both and placebo. Participants included in the review The participants had a mean age of 52 years (range of trial means 23 to 75 years). The median pre-treatment blood concentration of homocysteine was 11.8 micromoles/L and of folate was 11.6 nmol/L. Outcomes assessed in the review The main outcome assessed was the reduction in blood homocysteine in the treated group compared with the controls. How were decisions on the relevance of primary studies made? The authors do (...) of homocysteine, folate, vitamin B12 and B6 before and at the end of the treatment schedule. The proportional reductions in blood homocysteine in the treatment compared to the control groups was calculated. Methods of synthesis How were the studies combined? Multivariate regression analysis was used to determine the effects on homocysteine concentration of different doses of folicacid and the addition of vitamin B12 or B6. The proportionate reductions in blood homocysteine among treatment groups were
Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. In a prospective, multicentre, double-blind controlled study, the effect of an intramuscular vitamin supplement containing 1 mg vitamin B12, 1.1 mg folate, and 5 mg vitamin B6 on serum concentrations of methylmalonic acid (MMA), homocysteine (HCYS), 2-methylcitric acid (2-MCA), and cystathionine (CYSTA) was compared with that of placebo in 175 elderly subjects living at home (...) ; and 42% vs 25% for CYSTA. The response rate to vitamin supplements supports the notion that metabolic evidence of vitamin deficiency is common in the elderly, even in the presence of normal serum vitamin levels. Metabolite assays permit identification of elderly subjects who may benefit from vitamin supplements.