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Latest & greatest articles for Serum Ferritin
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Serum hepcidin, the hepcidin/ferritin ratio and the risk of type 2 diabetes: a systematic review and meta-analysis. To perform a meta-analysis on the relationship type 2 diabetes has with serum hepcidin and the hepcidin/ferritin ratio.The following databases were searched using all relevant keywords: Web of Science, Medline, Scopus, Embase and Google Scholar. All studies that examined the relationship type 2 diabetes has with serum hepcidin or the hepcidin/ferritin ratio were included (...) /ferritin ratio was examined across five studies (n cases=229; n controls=1426) and was found to be negatively associated with the risk of type 2 diabetes (SMD: -0.52; 95% confidence interval (CI): -0.85 to -0.19). There was no publication bias found for the associations serum hepcidin (Egger´s test: P =0.97) or the hepcidin/ferritin ratio (Egger´s test: P =0.75) had with type 2 diabetes.Although hepcidin has been proposed as a risk marker for type 2 diabetes, our meta-analysis found that the hepcidin
Decreased serumferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients. Objective: Restless legs syndrome (RLS) is one of the most common non-motor symptoms of Parkinson's disease (PD), but its pathogenesis in a PD background is unclear. Abnormal iron metabolism may be involved, in which case it may be a marker of RLS risk. Here, the literature was systematically searched and meta-analyzed to compare (...) iron metabolism markers between PD patients with or without RLS. Method: The databases PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, Web of Science, and SinoMed were searched for case-control and observational studies examining RLS-related changes in iron metabolism in PD, in terms of serum iron, serumferritin and hemoglobin. Eligible studies were meta-analyzed using Stata 12.0. Results: Meta-analysis of 11 case-control studies showed that serumferritin concentration
Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review. Chronic liver disease (CLD) is a major health problem worldwide. Non-alcoholic fatty liver disease (NAFLD), chronic hepatitis C (CHC), chronic hepatitis B (CHB), and alcoholic liver disease (ALD) are the most common etiologies of CLD. Liver biopsy is the gold standard for assessment of liver fibrosis, however, it is an invasive method. This review attempts (...) to evaluate the usefulness of serum adiponectin, serum leptin, serumferritin, serum transforming growth factor-β1 (TGF-β1), and serum platelet derived growth factor-BB (PDGF-BB) as non-invasive markers in the diagnosis of liver fibrosis/cirrhosis. A systematic search in MEDLINE, Web of Science, Scopus, and local databases was performed to identify articles published in English or Persian as of November 2017. Studies conducted among CLD patients, with biopsy proven fibrosis/cirrhosis, and providing
Serumferritin as a candidate diagnostic biomarker of polycystic ovarian syndrome: a meta-analysis. Objective: In this study, we investigated about the potential of serumferritin as a complementary diagnostic biomarker of polycystic ovarian syndrome (PCOS) by performing a meta-analysis of existing literature. Materials and methods: Eleven studies written in English were retrieved up to 30 June 2018. Data were extracted from the selected studies by two of the authors and was subjected (...) to statistical analysis. Levels of serumferritin were compared between women with PCOS and controls using the standardized mean difference (SMD) and 95% confidence interval (CI). Subgroup analysis was also performed and stratified by ethnicity (Asians versus Caucasians). Results: Overall post-outlier outcomes indicated that elevated serumferritin is strongly associated with PCOS (SMD: 0.52; 95% CI: 0.40-0.64; PA = 10-5). Subgroup analysis by ethnicity showed no significant difference between Asian
The impact of iron chelation therapy on patients with lower/intermediate IPSS MDS and the prognostic role of elevated serumferritin in patients with MDS and AML: A meta-analysis. Serumferritin (SF) has been identified as a potential prognostic factor for patients undergoing stem cell transplantation, but the prognostic value of SF in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) patients and the impact of iron chelation therapy (ICT) on MDS patients are controversial
Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review. Serum or plasma ferritin concentration is recommended by WHO as a biomarker to assess iron status in individuals and populations.A systematic review was undertaken to summarise the evidence for ferritin reflecting iron status and to assess the cut-off points in different populations. Electronic databases were searched for studies evaluating ferritin (...) concentrations compared against bone marrow aspirates for iron deficiency and to liver biopsies for risk of iron overload.From 18822 records, 298 studies were assessed in full-text, including 72 studies on iron deficiency and 36 on iron overload in the quantitative analysis. All studies were observational. For iron deficiency, the mean ferritin concentration in healthy individuals was 15.1 μg/L (9 studies, 390 participants) when bone marrow iron content was 0, and 70.4 μg/L (3 studies, 151 participants) when
Association Between Baseline SerumFerritin and Short-term Outcome of Intracerebral Hemorrhage: A Meta-Analysis. Intracerebral hemorrhage is a devastating disease. In recent years, the association of between baseline serumferritin and prognosis of intracerebral hemorrhage is an interesting issue. Although some of the studies have shown that baseline serumferritin can predict the prognosis of intracerebral hemorrhage, there is no clear evidence that baseline serumferritin can be used (...) as an independent predictor of intracerebral hemorrhage.Electronic databases through November 2018 were searched to identify relevant studies that examined association between baseline serumferritin and prognosis of intracerebral hemorrhage.We found 7 eligible studies that included 411 participants. Our results showed that among them, 216 patients with intracerebral hemorrhage of poorer functional outcome were associated with elevated serumferritin at admission. The results of 7 literature meta-analysis
Effect of pre-transplantation serumferritin on outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation: A meta-analysis. Pre-transplantation serumferritin (SF) has been considered to be a potential prognostic biomarker in patients undergoing allogeneic hematopoietic stem cell transplantation (allogeneic HSCT), but this conclusion remains controversial. Thus, we performed a meta-analysis to investigate the prognostic significance of pre-transplantation SF in patients (...) = 1.72; 95% CI: 1.27-2.33; P < .001). In addition, high pre-transplantation SF was closely associated with a lower incidence of chronic graft versus host disease (cGVHD) (OR = 0.74, 95% CI: 0.58-0.96; P < .05), and a higher incidence of blood stream infections (BSIs) (OR = 1.67, 95% CI: 0.93-3.01; P = .09). However, no significance relationship was found between elevated pre-transplantation SF and acute graft versus host disease (aGVHD) (OR = 1.08, 95% CI:.72-1.62; P = .70).In patients undergoing
or treatment (e.g. blood transfusion or iron infusion) that lead to a genuine increase in RES iron stores. Upper limit of the normal range for serumferritin Most UK laboratories simply report 300–400 μg/l as the upper limit of normal for SF in adult males and 150–200 μg/l as the upper limit of normal for adult females (Association for Clinical Biochemistry, ; Worwood et al , ). There is however considerable variation in SF values in response to age, ethnic origin and sex. Mean SF values in neonates (...) , are outside the scope of this guideline, and readers are directed to the recently updated management guideline for this condition (Fitzsimons et al , ). Table 1. Causes of raised serumferritin Increased ferritin synthesis due to iron accumulation Increase in ferritin synthesis not associated with significant iron accumulation Increased ferritin as a result of cellular damage Hereditary (genetic) haemochromatosis Hereditary acaeruloplasminaemia Secondary iron overload from blood transfusion or excessive
Limitations of SerumFerritin in Diagnosing Iron Deficiency in Inflammatory Conditions Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serumferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating (...) the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites. Patients with inflammatory conditions may thus have restricted availability of iron for erythropoiesis and other cell functions due to increased hepcidin expression, despite normal or high levels of serumferritin. The standard threshold for iron deficiency (<30 μg/L) therefore does not apply and transferrin saturation
Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis. Different laboratory methods are used to quantify ferritin concentrations as a marker of iron status. A systematic review was undertaken to assess the accuracy and comparability of the most used methods for ferritin detection.National and regional databases were searched for prospective, retrospective, sectional, longitudinal and case-control (...) studies containing the characteristics and performance of at least one method for serum/plasma ferritin determinations in humans published to date. The analysis included the comparison between at least 2 methods detailing: sensitivity, precision, accuracy, predictive values, inter-methods adjustment, and use of international reference materials. Pooled method performance was analyzed for each method and across methods.Search strategy identified 11893 records. After de-duplication and screening 252
Association of serumferritin with non-alcoholic fatty liver disease: a meta-analysis. A growing number of studies reported the connection between the level of serumferritin (SFL) and non-alcoholic fatty liver disease (NAFLD). However, such connection was still disputable. The aim of our meta-analysis was to estimate SFL between the groups as below: patients with NAFLD against control group; non-alcoholic steatohepatitis (NASH) patients against control group; non-alcoholic fatty liver (NAFL
Role of serumferritin level on overall survival in patients with myelodysplastic syndromes: Results of a meta-analysis of observational studies. The role of serumferritin (SF) as a prognostic factor has been analyzed in patients with myelodysplastic syndromes (MDS) who have undergone hematopoietic stem cell transplantation (HSCT), but the prognostic role of elevated SF levels is still controversial in lower risk MDS patients. Therefore, we performed a meta-analysis of all available published
Serumferritin thresholds for the diagnosis of iron deficiency in pregnancy: a systematic review. The aim of this review was to understand the landscape of serumferritin in diagnosing iron deficiency in the aetiology of anaemia in pregnancy. Iron deficiency in pregnancy is a major public health problem leading to the development of anaemia. Reducing the global prevalence of anaemia in women of reproductive age is a 2025 global nutrition target. Bone marrow aspiration is the gold standard test (...) for iron deficiency but requires an invasive procedure; therefore, serumferritin is the most clinically useful test. We undertook a systematic search of electronic databases and trial registers from inception to January 2016. Studies of iron or micronutrient supplementation in pregnancy with pre-defined serumferritin thresholds were included. Two independent reviewers selected studies, extracted data and assessed quality. There were 76 relevant studies mainly of observational study design (57
A Meta-Analysis for Effects of Elevated Pre-Transplantation SerumFerritin on the Outcomes in Patients Undergoing Hematopoietic Stem Cell Transplantation. The level of pre-transplantation serumferritin (SF) is one of the factors related to outcome for patients undergoing allogeneic hematopoietic stem cell transplantation. We searched PubMed and Cochrane Library databases from 2000 to 2014. The primary efficacy outcome was overall survival rate and non-relapse mortality. Twenty clinical trials
Meta-analysis of the relationship between amyotrophic lateral sclerosis and susceptibility to serumferritin level elevation. To study the possible relationship between amyotrophic lateral sclerosis (ALS) patients and their susceptibility to serumferritin level elevation.We searched the PubMed, Springer, Medline, and OVID databases for any-language original research articles relating to serumferritin levels in ALS patients published between June 2005 and June 2015. The search term used (...) with `amyotrophic lateral sclerosis`, `ferritins`, `ferritin`, `iron`, `iron stores, `iron status, `iron intake`, and `iron consumption`. The meta-analysis software RevMan 5.0 was used for the heterogeneity test, and to test for the overall effect.Six case-control studies met our inclusion criteria including data from a total of 1813 participants. The mean difference of serumferritin levels comparing ALS to healthy controls was 69.05 (95% confidence interval: 52.56-85.54; p<0.00001); heterogeneity: p=0.03; I2
Association between serumferritin levels and metabolic syndrome: an updated meta-analysis. It is definite that the serum iron level has a positive correlation with the risk of obesity. However, the association between increased serumferritin levels and the metabolic syndrome still remains controversial. The purpose of this meta-analysis is to confirm the association between serumferritin levels and metabolic syndrome. We searched PubMed and the China National Knowledge Infrastructure (CNKI (...) ) for relevant articles that assessed the association between serumferritin levels and metabolic syndrome and were published between 2006 and 2014. Review Manage 5.3 software was used to collect and analysis the data cited in the ultimately selected papers. The variance was exhibited using the forest plot and the heterogeneity among studies was examined using the I(2) index. We use the funnel plot to evaluate the publication bias. Cross-sectional study, case-control study and prospective cohort study met
Elevated SerumFerritin 25138336 2014 08 25 2018 11 13 1538-3598 312 7 2014 Aug 20 JAMA JAMA Elevated serumferritin. 743-4 10.1001/jama.2014.302 VanWagner Lisa B LB Departments of Preventive Medicine and Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Green Richard M RM Department of Medicine, Division of Gastroenterology & Hepatology, Section of Hepatology, Northwestern University Feinberg School of Medicine, Chicago (...) , Illinois. eng F32 HL116151 HL NHLBI NIH HHS United States 1F32HL116151-01 HL NHLBI NIH HHS United States Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States JAMA 7501160 0098-7484 9007-73-2 Ferritins AIM IM JAMA. 2014 Dec 17;312(23):2572 25514310 JAMA. 2014 Dec 17;312(23):2572 25514312 Alcohol Drinking Arthritis, Reactive Biopsy Ferritinsblood Hemochromatosis complications diagnosis genetics therapy Humans Liver pathology Male Middle Aged
Estimating Iron Overload in Patients with Suspected Liver Disease and Elevated SerumFerritin Iron status evaluation in patients with suspected liver disease and elevated serumferritin is often challenging because hyperferritinemia does not always indicate iron overload. A reliable approach to estimate iron overload without exposing the patient to unnecessary investigations would help the clinician to identify patients who may take advantage of iron-removal therapy.We analyzed all liver (...) biopsies, including measurement of hepatic iron concentration, performed at the University Hospital Zurich from 1997 to 2010 to identify clinical and laboratory predictors of iron overload in patients with elevated serumferritin (n = 147).Hyperferritinemia was predictive of iron overload only in patients with a high level of serumferritin (>2000 μg/L). In patients with moderate hyperferritinemia, liver transaminases inversely correlated with hepatic iron concentration. A combination of both
[Meta-analysis of studies on cut-off value of serumferritin for identifying iron deficiency]. To synthesize evidence to discuss the appropriate cut-off value of serumferritin (SF) for identifying iron deficiency.A comprehensive electronic search and manual tracking were performed to collect potential studies on cut-off value of SF for identifying iron deficiency. Most relevant studies were identified according to the inclusion and exclusion criteria and data were extracted. All included