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Latest & greatest articles for Renin Angiotensin System
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Effect of inhibition of the renin-angiotensinsystem on development of type 2 diabetes mellitus (meta-analysis of randomized trials) Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
The impact of suppressing the renin-angiotensinsystem on atrial fibrillation Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Renin-angiotensinsystem inhibition prevents type 2 diabetes mellitus - part 1: a meta-analysis of randomised clinical trials Renin-angiotensinsystem inhibition prevents type 2 diabetes mellitus - part 1: a meta-analysis of randomised clinical trials Renin-angiotensinsystem inhibition prevents type 2 diabetes mellitus - part 1: a meta-analysis of randomised clinical trials Scheen A J CRD summary This review assessed the effects of renin-angiotensinsystem (RAS) inhibition on the development (...) of type 2 diabetes in patients with arterial hypertension or congestive heart failure. The author concluded that RAS inhibition may help prevent type 2 diabetes. Given the lack of a quality assessment and the insufficient reporting of the review methods, the reliability of the author's conclusions cannot be adequately assessed. Authors' objectives To assess the effects of renin-angiotensinsystem (RAS) inhibition on the incidence of new cases of type 2 diabetes mellitus (T2DM) in patients
Genetic variation in the renin-angiotensinsystem and abdominal adiposity in men: the Olivetti Prospective Heart Study. The renin-angiotensinsystem is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism.To investigate the association of polymorphism in the angiotensin-converting enzyme (ACE) I/D gene, angiotensinogen M235T gene, and angiotensin II type 1 receptor A1166C gene with body mass index, body fat pattern, and obesity-associated hypertension.Cross (...) -sectional longitudinal study.The Olivetti factories in Marcianise and Pozzuoli, suburbs of Naples, Italy.959 adult men, 25 to 75 years of age.Renin-angiotensinsystem polymorphism, anthropometric indexes, blood pressure, and serum glucose and insulin levels.No association was detected between angiotensinogen or angiotensin II type 1 receptor gene polymorphism and anthropometric indexes or blood pressure. For ACE I/D polymorphism, significant age-genotype interaction was detected on cross-sectional
Chronic renal diseases: renoprotective benefits of renin-angiotensinsystem inhibition. Progression to renal parenchymal damage and end-stage renal disease, which seems to be largely independent of the initial insult, is the final common pathway for chronic, proteinuric nephropathies in animals and humans. The key event is enhanced glomerular capillary pressure; this impairs glomerular permeability to proteins and permits excessive amounts of proteins to reach the lumen of the proximal tubule (...) . The secondary process of reabsorption of filtered proteins can contribute to renal interstitial injury by activating intracellular events, including upregulation of the genes encoding vasoactive and inflammatory mediators. Both interstitial inflammation and progression of disease can be controlled by such drugs as angiotensin-converting enzyme inhibitors, which strengthen the glomerular permeability barrier to proteins and thereby limit proteinuria and filtered protein-dependent inflammatory signals
Randomised controlled trial of dual blockade of renin-angiotensinsystem in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and type 2 diabetes.Prospective, randomised, parallel group, double blind study with four week placebo run