Latest & greatest articles for Peripheral Neuropathy

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Top results for Peripheral Neuropathy

1. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. (PubMed)

Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. Identifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 and altered serine metabolism has been established previously.Through exome sequence analysis of a patient with macular telangiectasia type 2 and his family members, we identified a variant in SPTLC1 encoding a subunit of serine palmitoyltransferase (SPT (...) in mice led to increases in levels of retinal deoxysphingolipids and compromised visual function. Deoxysphingolipids caused photoreceptor-cell death in retinal organoids, but not in the presence of regulators of lipid metabolism.Elevated levels of atypical deoxysphingolipids, caused by variant SPTLC1 or SPTLC2 or by low serine levels, were risk factors for macular telangiectasia type 2, as well as for peripheral neuropathy. (Funded by the Lowy Medical Research Institute and others.).Copyright © 2019

2019 NEJM

2. Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review

Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review Acetyl-L-carnitine (ALC) has shown a neuroprotective effect in patients with peripheral neuropathies of different etiologies. Preclinical studies demonstrated a central anti-nociceptive action, both in neuropathic and nociceptive pain models. The present review aims to provide the knowledge on the efficacy of ALC in patients with painful peripheral neuropathy, based on the evidence. Consistent with the PRISMA statement (...) , authors searched PubMed, Embase and the Cochrane Database of Systematic Reviews for relevant papers, including those issued before April 2018. Two authors independently selected studies for inclusion and data extraction: only trials including patients with a diagnosis of peripheral neuropathy and involving at least 10 patients were considered for the purposes of this review. Fourteen clinical trials were revised, to provide the level of evidence for neuropathy. To assess the global efficacy of ALC

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2019 EvidenceUpdates

3. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. (PubMed)

Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. Diabetic peripheral neuropathy (DPN) is a common and severe complication that affects 50% of people with diabetes. Painful DPN is reported to occur in 16% to 24% of people with diabetes. A complete and comprehensive management strategy for the prevention and treatment of DPN, whether painful or not, has not yet been defined.Research into treatment for DPN has been characterised by a series of failed clinical trials (...) , with few noteworthy advances. Strategies that support peripheral nerve regeneration and restore neurological function in people with painful or painless DPN are needed. The amino acid acetyl-L-carnitine (ALC) plays a role in the transfer of long-chain fatty acids into mitochondria for β-oxidation. ALC supplementation also induces neuroprotective and neurotrophic effects in the peripheral nervous system. Therefore, ALC supplementation targets several mechanisms relevant to potential nerve repair

2019 Cochrane

4. Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Recommendations

Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Recommendations Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly encountered disease entity following chemotherapy for cancer treatment. Although only duloxetine is recommended by the American Society of Clinical Oncology (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome for new pharmaceutic therapies and non-pharmaceutic treatments has not been clearly determined.To (...) % amitriptyline). The evidence for tricyclic antidepressants was inconclusive as amitriptyline showed no benefit but nortriptyline had insufficient evidence. Further research on CIPN treatment is needed with larger sample sizes, long-term follow-up, standardized outcome measurements, and standardized treatment timing.Chemotherapy-induced neuropathy, peripheral neuropathy, chemotherapy-tumor, neuropathic pain, chronic pain, toxicology, treatment, reduction of pain, level of evidence.

2019 EvidenceUpdates

5. Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial

Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial To evaluate the effectiveness of automated symptom and side effect monitoring on quality of life among individuals with symptomatic diabetic peripheral neuropathy.We conducted a pragmatic, cluster randomized controlled trial (July 2014 to July 2016) within a large healthcare system. We randomized (...) 1834 primary care physicians and prospectively recruited from their lists 1270 individuals with neuropathy who were newly prescribed medications for their symptoms. Intervention participants received automated telephone-based symptom and side effect monitoring with physician feedback over 6 months. The control group received usual care plus three non-interactive diabetes educational calls. Our primary outcomes were quality of life (EQ-5D) and select symptoms (e.g. pain) measured 4-8 weeks after

2019 EvidenceUpdates

6. A systematic review and meta-analysis of the efficacy of vitamin B in the management of diabetic peripheral neuropathy

A systematic review and meta-analysis of the efficacy of vitamin B in the management of diabetic peripheral neuropathy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

7. Systematic review of psychological interventions effect on pain in adults with diabetes and diabetic peripheral neuropathy

Systematic review of psychological interventions effect on pain in adults with diabetes and diabetic peripheral neuropathy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

8. Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: a meta-analysis

Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

9. Effects of moxibustion combined with western medicine on diabetic peripheral neuropathy (DPN): a systematic review and meta-analysis

Effects of moxibustion combined with western medicine on diabetic peripheral neuropathy (DPN): a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

10. Distinguishing features of multiple myeloma-associated peripheral neuropathy

Distinguishing features of multiple myeloma-associated peripheral neuropathy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

11. Effectiveness of acupuncture for treatment of diabetic peripheral neuropathy (DPN): a protocol of systematic review of randomized controlled trials

Effectiveness of acupuncture for treatment of diabetic peripheral neuropathy (DPN): a protocol of systematic review of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

12. Acupuncture for diabetic peripheral neuropathy: an overview of systematic reviews based on radar charts

Acupuncture for diabetic peripheral neuropathy: an overview of systematic reviews based on radar charts Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

13. A systematic review on examining the role of non-invasive brain stimulation techniques in peripheral neuropathy

A systematic review on examining the role of non-invasive brain stimulation techniques in peripheral neuropathy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

14. Foot bath combined with acupoint massage for the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis

Foot bath combined with acupoint massage for the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

15. Overview of systematic reviews of non-pharmacological interventions for preventing and treating chemotherapy-induced peripheral neuropathy in cancer patients

Overview of systematic reviews of non-pharmacological interventions for preventing and treating chemotherapy-induced peripheral neuropathy in cancer patients Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

16. Prevalence and risk factors of diabetic peripheral neuropathy: a systematic review and meta-analysis

Prevalence and risk factors of diabetic peripheral neuropathy: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

17. Huangqi guizhi wuwu decoction for treating diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials

Huangqi guizhi wuwu decoction for treating diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

18. Neuropad for detecting preclinical diabetic peripheral neuropathy

Neuropad for detecting preclinical diabetic peripheral neuropathy Neuropad for detecting preclinical Neuropad for detecting preclinical diabetic peripher diabetic peripheral neuropath al neuropathy y Medical technologies guidance Published: 10 September 2018 nice.org.uk/guidance/mtg38 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility This guidance represents the view of NICE (...) possible. Neuropad for detecting preclinical diabetic peripheral neuropathy (MTG38) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 14Contents Contents 1 Recommendations 4 2 The technology 5 Description of the technology 5 Current management 5 3 Evidence 7 Summary of clinical evidence 7 EAC's analysis of the clinical evidence 7 Summary of economic evidence 7 EAC's analysis of the economic evidence 8 4 Committee

2018 National Institute for Health and Clinical Excellence - Medical technologies

19. Evaluation of combined radiofrequency and chemical blockade of multi-segmental lumbar sympathetic ganglia in painful diabetic peripheral neuropathy (PubMed)

Evaluation of combined radiofrequency and chemical blockade of multi-segmental lumbar sympathetic ganglia in painful diabetic peripheral neuropathy Painful diabetic peripheral neuropathy (PDPN) is one of the most common complications of diabetes. PDPN seriously affects the quality of life and is difficult to treat; therefore, there is an urgent need for new cost-effective treatment methods for PDPN.To investigate the efficacy and safety of radiofrequency thermocoagulation (RF) combined

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2018 EvidenceUpdates

20. Effect of certain trimethoxy flavones on paclitaxel - induced peripheral neuropathy in mice (PubMed)

Effect of certain trimethoxy flavones on paclitaxel - induced peripheral neuropathy in mice The anti - nociceptive effect of 7, 2', 3' - trimethoxy flavone, 7, 2', 4' - trimethoxy flavone, 7, 3', 4' - trimethoxy flavone and 7, 5, 4' - trimethoxy flavone against inflammatory, neurogenic and thermal pain in mice was reported earlier. The present study was designed to investigate the effect of the above trimethoxy flavones in amelioration of peripheral neuropathy induced by paclitaxel.Peripheral (...) neuropathy was induced in mice by administration of a single i.p. dose (10 mg/kg) of paclitaxel. The manifestations of peripheral neuropathy such as tactile allodynia, cold allodynia and thermal hyperalgesia were assessed 24 h later by employing hair aesthesiometer test, acetone bubble test and hot water tail immersion test respectively. Further, the role of inflammatory cytokines like TNF - α, IL - 1β and free radicals in the action of trimethoxy flavones was investigated using in vitro assays.The test

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2018 Integrative medicine research