Periodic limb movement disorder Periodic limb movement disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Periodic limb movement disorder Last reviewed: February 2019 Last updated: March 2018 Summary Defined as a periodic limb movements of sleep index (PLMS-I) of 5 or more that is associated with disturbed sleep and excessive daytime sleepiness. The diagnosis is confirmed by polysomnography, and other causes (...) of sleep-wake disturbance must be excluded. The PLMS-I is used to determine the frequency of periodic limb movements of sleep (PLMS) and is calculated as the number of PLMS per total hours of sleep time. PLMS are repetitive limb movements (mostly of the legs), occurring mainly during non-rapid eye movement (non-REM) sleep; they are characterised by dorsiflexion of the toes and ankles and occasionally flexion of the hip and knee. PLMS may arise in normal individuals, and their clinical significance

EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines

A genetic risk factor for periodic limb movements in sleep. The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric.To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic (...) heterogeneity, we focused on patients with RLS who had objectively documented periodic limb movements in sleep. We measured serum ferritin levels, since iron depletion has been associated with the pathogenesis of RLS.In an Icelandic discovery sample of patients with RLS and periodic limb movements in sleep, we observed a genomewide significant association with a common variant in an intron of BTBD9 on chromosome 6p21.2 (odds ratio, 1.8; P=2x10(-9)). This association was replicated in a second Icelandic

EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep Vignatelli L, Billiard M, Clarenbach P, Garcia-Borreguero D, Kaynak D, Liesiene V, Trenkwalder C, Montagna P CRD summary The authors concluded that level A recommendations support the use (...) of cabergoline, gabapentin, pergolide, ropinirole, and short-term levodopa and transdermal rotigotine for primary restless leg syndrome. The evidence appears to support the authors’ conclusions, but the poor reporting of review methods makes it difficult to comment on the reliability of these conclusions. Authors' objectives To evaluate the effectiveness of treatments for restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) in sleep. Searching MEDLINE, EMBASE, CINAHL and the Cochrane

The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder Hening W, Allen R, Earley C, Kushida C, Picchietti D, Silber M Authors' objectives To review the therapy of the restless legs syndromes or periodic movements in sleep. Searching MEDLINE was searched through April 1998 using the following keywords: restless legs both (...) medications; and non- pharmacological therapy including accommodative strategies and sleep hygiene, behavioural and stimulation therapies, invasive therapies, and nutritional considerations. Participants included in the review Patients with restless leg syndrome (RLS) or periodic limb movement disorder (PLMD) were included. Some studies appeared to have included patients with other diagnosis, such as narcolepsy, and some studies had unclear criteria for the diagnosis of RLS. Definitions were as reported