Latest & greatest articles for Osteosarcoma

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Top results for Osteosarcoma

1. Osteosarcoma

Osteosarcoma Osteosarcoma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Osteosarcoma Last reviewed: February 2019 Last updated: February 2019 Summary Most common non-haematological primary malignant neoplasm of bone in children and adolescents. Pain and swelling are the most common presenting symptoms. Although it can occur at any age, it usually affects patients in the second and third decade of life with a peak (...) incidence between 13 and 16 years of age. It is more common in males than females. Chemotherapy combined with surgery is the standard of care. Prognosis of patients with localised disease has improved substantially following the introduction of chemotherapy, with 75% to 80% 5-year survival rates. Definition The World Health Organization defines osteosarcoma as a primary osseous malignant neoplasm composed of mesenchymal cells producing osteoid and immature bone, even if only in small amounts. Fletcher

2019 BMJ Best Practice

2. Immunoconjugates for Osteosarcoma Therapy: Preclinical Experiences and Future Perspectives Full Text available with Trip Pro

Immunoconjugates for Osteosarcoma Therapy: Preclinical Experiences and Future Perspectives Osteosarcoma (OS) is an aggressive osteoid-producing tumor of mesenchymal origin, which represents the most common primary bone malignancy. It is characterized by a complex and frequently uncertain etiology. The current standard care for high-grade OS treatment is neoadjuvant chemotherapy, followed by surgery and post-operative chemotherapy. In order to ameliorate survival rates of patients, new

2018 Biomedicines

3. Outcomes in Treatment-Naïve Patients With Metastatic Extremity Osteosarcoma Treated With OGS-12, a Novel Non–High-Dose Methotrexate–Based, Dose-Dense Combination Chemotherapy, in a Tertiary Care Cancer Center Full Text available with Trip Pro

Outcomes in Treatment-Naïve Patients With Metastatic Extremity Osteosarcoma Treated With OGS-12, a Novel Non–High-Dose Methotrexate–Based, Dose-Dense Combination Chemotherapy, in a Tertiary Care Cancer Center Metastatic osteosarcoma is largely treated with high-dose methotrexate (HDMTX)-based therapy, especially in the pediatric population. This mandates complex pharmacokinetic monitoring in a costly inpatient setting to mitigate unpredictable serious toxicities. Hence, a non-HDMTX-based (...) regimen is worth exploring, especially in India and low- and middle-income countries.All consecutive treatment-naïve patients with metastatic osteosarcoma were prospectively treated on the novel OGS-12 protocol consisting of sequential doublets of doxorubicin, cisplatin, and ifosfamide. Four cycles were administered as neoadjuvant therapy followed by planned curative intent surgery and metastasectomy when feasible, followed by four cycles of adjuvant chemotherapy. Baseline characteristics, histologic

2018 Journal of global oncology

4. MicroRNA-567 inhibits cell proliferation, migration and invasion by targeting FGF5 in osteosarcoma Full Text available with Trip Pro

MicroRNA-567 inhibits cell proliferation, migration and invasion by targeting FGF5 in osteosarcoma MicroRNAs (miRNAs) have been widely reported to have important regulatory roles in various human tumors, including osteosarcoma (OS). The aim of this study was to focus on the role of less well-known miRNA-567 (miR-567) in OS. We found the expression of miR-567 was significantly reduced in OS tissues and cell lines (MG-63, U2OS and Saos-2) compared with the adjacent normal tissues and normal

2018 EXCLI journal

5. The Team Approach to Osteosarcoma of the Distal Femur in an Adolescent Full Text available with Trip Pro

The Team Approach to Osteosarcoma of the Distal Femur in an Adolescent 29278618 2018 11 13 2329-9185 5 12 2017 Dec JBJS reviews JBJS Rev Team Approach: Osteosarcoma of the Distal Part of the Femur in Adolescents. e5 10.2106/JBJS.RVW.17.00030 Stitzlein Russell N RN Departments of Orthopaedic Surgery (R.N.S. and K.L.W.), Pathology and Laboratory Medicine (J.W.), Radiology (R.A.S.), and Pediatrics (N.J.B.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Wojcik John J

2017 JBJS reviews

6. MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1 Full Text available with Trip Pro

MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1 MiR-429 functions as a tumor suppressor and has been observed in multiple types of cancer, but the effects and mechanisms of miR-429 in osteosarcoma are poorly understood. This study is performed to evaluate the functions of miR-429 in the progression of osteosarcoma. Firstly, the miR-429 expression in osteosarcoma tissues and osteosarcoma cells was detected using real time PCR, and the relationship between miR (...) -429 expression and overall survival of osteosarcoma was analyzed. Secondly, the effects of miR-429 on the migration, invasion, proliferation and apoptosis of osteosarcoma cells were evaluated using transwell assay, wound-healing assay, CCK-8 assay and flow cytometry, respectively. Proteins related to epithelial-mesenchymal transition (EMT), E-cadherin, Vimentin, N-cadherin and Snail, were also detected using Western blot. Finally, the target gene of miR-429 in osteosarcoma was predicted

2017 EXCLI journal

7. Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review Full Text available with Trip Pro

Unique Image Characteristics of an Occipital Primary Chondroblastic Osteosarcoma: A Rare Case Report and a Brief Literature Review Primary osteosarcomas of the skull and skull base are rare and comprise < 2% of all skull tumors. In head and neck osteosarcomas, the chondroblastic subtype occurs most frequently, which has an exceedingly poor outcome, but its image characteristic remains unknown. Herein, we report a case in the right occipital bone of the skull base and the unique characteristics (...) of image. Pathologic examination of the surgical specimens led to the diagnosis of chondroblastic osteosarcomas. We believe those image characteristics can improve the understanding of skull chondroblastic osteosarcoma and the preoperative diagnosis.

2017 Journal of neurological surgery reports

8. Health-Related Quality of Life and Survival Outcomes of Pediatric Patients With Nonmetastatic Osteosarcoma Treated in Countries With Different Resources Full Text available with Trip Pro

Health-Related Quality of Life and Survival Outcomes of Pediatric Patients With Nonmetastatic Osteosarcoma Treated in Countries With Different Resources Health-related quality of life (HRQOL) improves throughout treatment of patients with nonmetastatic osteosarcoma. We compared HRQOL for patients in the United States and Chile treated on an international trial (OS99) with polychemotherapy and surgery, and we assessed the relationships among HRQOL measures, event-free survival (EFS), and overall (...) survival (OS).Patients with newly diagnosed, localized osteosarcoma and their parents completed three HRQOL instruments (PedsQL v.4, PedsQL Cancer v.3, and Symptom Distress Scale [SDS]). Data were collected at four time points throughout therapy. Repeated measures models were used to investigate the effect of treatment site on instrument scores. The log-rank test examined the impact of treatment site on survival outcomes, and Cox proportional hazards regression models evaluated baseline HRQOL measures

2017 Journal of global oncology

9. Chemotherapy in Nonmetastatic Osteosarcoma: Recent Advances and Implications for Developing Countries Full Text available with Trip Pro

Chemotherapy in Nonmetastatic Osteosarcoma: Recent Advances and Implications for Developing Countries Osteosarcoma (OS) is a relatively chemosensitive primary bone tumor, with the peak age of onset occurring in late childhood and early adolescence. The treatment paradigm of nonmetastatic OS has typically been multimodality therapy, including neoadjuvant and adjuvant chemotherapy with definitive surgery. Over the years, various permutations and combinations of chemotherapeutic agents have been

2017 Journal of global oncology

10. Osteosarcoma

Osteosarcoma Osteosarcoma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Osteosarcoma Last reviewed: February 2019 Last updated: February 2019 Summary Most common non-haematological primary malignant neoplasm of bone in children and adolescents. Pain and swelling are the most common presenting symptoms. Although it can occur at any age, it usually affects patients in the second and third decade of life with a peak (...) incidence between 13 and 16 years of age. It is more common in males than females. Chemotherapy combined with surgery is the standard of care. Prognosis of patients with localised disease has improved substantially following the introduction of chemotherapy, with 75% to 80% 5-year survival rates. Definition The World Health Organization defines osteosarcoma as a primary osseous malignant neoplasm composed of mesenchymal cells producing osteoid and immature bone, even if only in small amounts. Fletcher

2017 BMJ Best Practice

12. Osteosarcoma Overview Full Text available with Trip Pro

Osteosarcoma Overview Osteosarcoma (OS) is the most common primary malignancy of bone and patients with metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little prognostic improvement has been generated from the last 20 years of research and a new perspective is warranted. OS is extremely heterogeneous in both its origins and manifestations. Although multiple associations have been made between the development of osteosarcoma and race, gender, age, various

2016 Rheumatology and therapy

13. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial Full Text available with Trip Pro

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma.EURAMOS-1 was an open-label (...) , international, phase 3 randomised, controlled trial. Consenting patients with newly diagnosed, resectable, high-grade osteosarcoma aged 40 years or younger were eligible for randomisation. Patients were randomly assigned (1:1) to receive either postoperative cisplatin, doxorubicin, and methotrexate (MAP) or MAP plus ifosfamide and etoposide (MAPIE) using concealed permuted blocks with three stratification factors: trial group; location of tumour (proximal femur or proximal humerus vs other limb vs axial

2016 EvidenceUpdates

14. Review of Osteosarcoma and Current Management Full Text available with Trip Pro

Review of Osteosarcoma and Current Management Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical

2016 Rheumatology and therapy

15. Gnathic Osteosarcoma: Clinical, Radiologic, and Pathologic Review of Bone Beard Tumor Full Text available with Trip Pro

Gnathic Osteosarcoma: Clinical, Radiologic, and Pathologic Review of Bone Beard Tumor 29244987 2019 01 14 2019 01 14 2378-9506 3 6 2017 12 Journal of global oncology J Glob Oncol Gnathic Osteosarcoma: Clinical, Radiologic, and Pathologic Review of Bone Beard Tumor. 823-827 10.1200/JGO.2016.006494 Mahajan Abhishek A All authors: Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra, India. Vaish Richa R All authors: Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (...) 101674751 2378-9506 IM Breast Neoplasms diagnosis pathology surgery Carcinoma, Ductal, Breast diagnosis pathology surgery Female Humans Jaw Neoplasms diagnosis surgery Magnetic Resonance Imaging Middle Aged Osteosarcoma diagnosis surgery Tomography, X-Ray Computed 2017 12 16 6 0 2017 12 16 6 0 2019 1 15 6 0 ppublish 29244987 10.1200/JGO.2016.006494 PMC5735964 J Clin Oncol. 1997 Jan;15(1):363-7 8996163 J Oral Maxillofac Surg. 2011 Sep;69(9):2368-75 21288615 Med Oncol. 2014 Sep;31(9):171 25134917 Head

2016 Journal of global oncology

16. Neoadjuvant Chemotherapy With Methotrexate, Cisplatin, and Doxorubicin With or Without Ifosfamide in Nonmetastatic Osteosarcoma of the Extremity: An Italian Sarcoma Group Trial ISG/OS-1 Full Text available with Trip Pro

Neoadjuvant Chemotherapy With Methotrexate, Cisplatin, and Doxorubicin With or Without Ifosfamide in Nonmetastatic Osteosarcoma of the Extremity: An Italian Sarcoma Group Trial ISG/OS-1 We compared two chemotherapy regimens that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (IFO) in patients with nonmetastatic osteosarcoma of the extremity.Patients age ≤ 40 years randomly received regimens with the same cumulative doses of drugs (ADM 420 mg/m(2

2012 EvidenceUpdates Controlled trial quality: uncertain

17. Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture

Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

18. Methotrexate for high-grade osteosarcoma in children and young adults. Full Text available with Trip Pro

Methotrexate for high-grade osteosarcoma in children and young adults. The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has not been unambiguously proven.To compare the effectiveness of treatment including MTX with treatment without MTX for children and young adults (up to 21 years) with primary (...) can be made about the effects on antitumour efficacy, toxicities and quality of life of the addition of MTX to treatment of children and young adults with primary high-grade osteosarcoma. The same is true for combinations of treatment including and not including MTX other than treatment with MTX versus treatment with cisplatin. Only 1 RCT comparing MTX with cisplatin treatment was available and therefore, no definitive conclusions can be made about the effectiveness of these agents in children

2011 Cochrane

19. Mifamurtide for the treatment of osteosarcoma (TA235)

Mifamurtide for the treatment of osteosarcoma (TA235) Overview | Mifamurtide for the treatment of osteosarcoma | Guidance | NICE Mifamurtide for the treatment of osteosarcoma Technology appraisal guidance [TA235] Published date: 26 October 2011 Share Guidance on mifamurtide (Mepact) for treating osteosarcoma in people aged 2 to 30 years. Guidance development process Is this guidance up to date? . We found nothing new that affects the recommendations in this guidance. Next review : This guidance

2011 National Institute for Health and Clinical Excellence - Technology Appraisals

20. Methotrexate for high-grade osteosarcoma in children and young adults. (Abstract)

Methotrexate for high-grade osteosarcoma in children and young adults. The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has not been unambiguously proven.To compare the effectiveness of treatment including MTX with treatment without MTX for children and young adults (up to 21 years) with primary (...) can be made about the effects on antitumour efficacy, toxicities and quality of life of the addition of MTX to treatment of children and young adults with primary high-grade osteosarcoma. The same is true for combinations of treatment including and not including MTX other than treatment with MTX versus treatment with cisplatin. Only 1 RCT comparing MTX with cisplatin treatment was available and therefore, no definitive conclusions can be made about the effectiveness of these agents in children

2009 Cochrane