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Latest & greatest articles for Multinodular Goiter
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Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter The aim of this study was to validate in a 10-year follow-up the initial outcomes of various thyroid resection methods for multinodular non-toxic goiter (MNG) reported in World J Surg 2010;34:1203-13.Six hundred consenting patients with MNG were randomized to three groups of 200 patients each: total thyroidectomy (TT (...) ), Dunhill operation (DO), bilateral subtotal thyroidectomy (BST). Obligatory follow-up period of 60 months was extended up to 120 months for all the consenting patients. The primary outcome measure was the prevalence of recurrent goiter and need for revision thyroid surgery. The secondary outcome measure was the cumulative postoperative and post-revision morbidity rate.The primary outcomes were twice as inferior at 10 years when compared to 5-year results for DO and BST, but not for TT. Recurrent goiter
An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodulargoitre The association of myasthenia gravis (MG) with other autoimmune diseases including autoimmune thyroid disease (ATD) is well recognised, although rare. The occurrence of both diseases can occur in two ways: either disease preceding the other, or concurrently. The presentation of MG in association with ATD can range from ocular to generalised disease.A 26-year-old Malay female with persistent (...) hyperthyroidism secondary to Hashimoto's thyroiditis in multinodulargoitre was diagnosed with generalised MG after 2 years. She presented with right eye ptosis (ocular) and difficulty in swallowing and chewing (bulbar). The diagnosis of MG was confirmed by fatigability testing, electromyography and the presence of AChR antibodies. Her symptoms showed improvement with pyridostigmine (Mestinon) 60 mg 6-hourly. Her antithyroid drug was tapered down according to her thyroid function test. Throughout a year
Toxic multinodulargoitre Toxic multinodulargoitre - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Toxic multinodulargoitre Last reviewed: February 2019 Last updated: December 2017 Summary Most common in older patients. Onset of symptoms is more insidious and symptoms less dramatic than for Graves' disease. Patients may have apathetic hyperthyroidism (minimal signs/symptoms) or sub-clinical hyperthyroidism (...) (isolated TSH suppression). Spontaneous remission is rare. Definitive treatment, most commonly radioactive iodine, is usually required. If untreated, complications may include sequelae of hyperthyroidism, such as cardiac dysfunction or bone loss, or tracheal compression by large goitres. Definition A toxic multinodulargoitre (MNG; also known as Plummer's disease) contains multiple autonomously functioning nodules, resulting in hyperthyroidism. These nodules function independently of thyroid-stimulating
DICER1 mutations in familial multinodulargoiter with and without ovarian Sertoli-Leydig cell tumors. Nontoxic multinodulargoiter (MNG) is frequently observed in the general population, but little is known about the underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual with a Sertoli-Leydig cell tumor of the ovary (SLCT). Germline mutations in DICER1, a gene that codes