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Latest & greatest articles for Malaria Chemoprophylaxis
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The efficacy of malariachemoprophylaxis The efficacy of malariachemoprophylaxis The efficacy of malariachemoprophylaxis Saridi M, Vasiliki P, Saroglou G CRD summary The authors concluded that atovaquone/proguanil, tafenoquine, primaquine were the most effective regimens for malariachemoprophylaxis, but tafenoquine and primaquine should not be prescribed to individuals with G6PD deficiency. Given the limitations of the review data and concerns about the methodology and reporting (...) of the review, the authors' conclusions may not be reliable. Authors' objectives To determine the efficacy, safety and tolerability of malarialchemoprophylaxis. Searching MEDLINE and CINAHL were searched for full papers written in English and published between 1999 and 2006. Search terms were reported. Internet search engines (Google, Lycos and Altavista) were used to search for further studies. World Health Organisation (WHO) and Center for Diseases Control (CDC) websites were searched. Study selection
Reimbursement of malariachemoprophylaxis for travellers from Europe to Sub-Saharan Africa: cost-effectiveness analysis from the perspective of the French national health insurance system Reimbursement of malariachemoprophylaxis for travellers from Europe to Sub-Saharan Africa: cost-effectiveness analysis from the perspective of the French national health insurance system Reimbursement of malariachemoprophylaxis for travellers from Europe to Sub-Saharan Africa: cost-effectiveness analysis (...) compared the cost-effectiveness of reimbursing malariachemoprophylaxis at a rate of 65% against the usual strategy of no reimbursement, for French residents who occasionally travelled to Sub-Saharan Africa. The authors concluded that 65% reimbursement was a cost-effective strategy from the perspective of the French national health insurance system. The analysis had several limitations and the reporting, especially for the effectiveness data, was insufficient. The authors’ conclusions should be treated
guidelines on malariachemoprophylaxis to identify variations in recommendations. We reviewed studies on tolerability of mefloquine with particular focus on its neuropsychiatric adverse effects and influence on performance. We also describe why most recommended chemoprophylactic regimens fail to prevent relapses of Plasmodium vivax malaria and review available options.We searched scientific publications in MEDLINE via PubMED for relevant articles with a cutoff date of December 2006 using the search terms (...) Controversies and misconceptions in malariachemoprophylaxis for travelers. Controversies in malaria prevention arise from the absence of data, conflicting data between different studies, conflicting recommendations, deviation of local practice from scientific data, and varying risk thresholds. Misconceptions about the seriousness of malaria, the tolerability of chemoprophylaxis drugs, and the efficacy and safety of repellents contribute to the controversies.To compare several national
A systematic review and meta-analysis of the effectiveness and safety of atovaquone-proguanil (Malarone) for chemoprophylaxis against malaria Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
with the first of three daily doses of amodiaquine intermittent preventive treatment (IPTi) or placebo. After 60 days, children receiving amodiaquine had significantly fewer malaria fevers than controls.The increasing concordance of malaria control and vaccination, movement toward co-administration of IPTi with immunisation, and the increase in travellers to malarious areas who receive concurrent vaccinations and chemoprophylaxis warrant further study. (...) Malaria intermittent preventive treatment in infants, chemoprophylaxis, and childhood vaccinations. Malaria accounts for 1-3 million deaths yearly worldwide, mostly in children under 5 years of age in sub-Saharan Africa. Laboratory and clinical studies show an association between acute malaria and a decreased response to diphtheria and tetanus toxoids and to meningococcal, salmonella, and Haemophilus influenzae type b vaccinations. Malaria treatment, chemoprophylaxis, or other forms of parasite
of chemoprophylaxis used, and the incubation period.In Israel, from 1994 through 1999, there were 300 cases of malaria among returning travelers in which one species of plasmodium could be identified. In 134 of these cases (44.7 percent), the illness developed more than two months after the traveler's return; nearly all of these cases were due to infection with Plasmodium vivax or P. ovale. In 108 of the 134 cases (80.6 percent), the patient had used an antimalarial regimen according to national guidelines (...) Delayed onset of malaria--implications for chemoprophylaxis in travelers. Most antimalarial agents used by travelers act on the parasite's blood stage and therefore do not prevent late-onset illness, particularly that due to species that cause relapsing malaria. We examined the magnitude of this problem among Israeli and American travelers.We examined malaria surveillance data from Israel and the United States to determine the traveler's destination, the infecting species, the type
Malariachemoprophylaxis in sickle cell disease. Malaria illness is associated with sickle cell crises. Health professionals often recommend life-long malariachemoprophylaxis for people with sickle cell disease living in malaria endemic areas. It is therefore important we have good evidence of benefit.To assess the effects of routine malariachemoprophylaxis in people with sickle cell disease.We searched the Cochrane Infectious Diseases Group trials register (March 2003), Cochrane Central (...) reviewers independently applied the inclusion criteria.One quasi-randomized controlled trial from Uganda gave antimalarial drugs and antibiotic prophylaxis together to 126 children with homozygous sickle cell disease. The authors reported the intervention group had fewer episodes of malaria, dactylitis, and higher mean haemoglobin values.There is very little direct evidence to support or refute giving routine chemoprophylaxis in sickle cell disease in areas where malaria is endemic.
Tolerability of malariachemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. To compare the tolerability of malariachemoprophylaxis regimens in non-immune travellers.Randomised, double blind, study with placebo run-in phase.Travel clinics in Switzerland, Germany, and Israel.Proportion of participants in each treatment arm with subjectively moderate or severe adverse events.623 non-immune travellers to sub-Saharan Africa: 153
Cost-effectiveness of iron supplementation and malariachemoprophylaxis in the prevention of anaemia and malaria among Tanzanian infants Cost-effectiveness of iron supplementation and malariachemoprophylaxis in the prevention of anaemia and malaria among Tanzanian infants Cost-effectiveness of iron supplementation and malariachemoprophylaxis in the prevention of anaemia and malaria among Tanzanian infants Alonso Gonzalez M, Menendez C, Font F, Kahigwa E, Kimario J, Mshinda H, Tanner M, Bosch (...) -Capblanch X, Alonso P L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Iron supplementation and malariachemoprophylaxis (Deltaprim) in the prevention of anaemia and malaria. Type of intervention Primary prevention. Economic study
Malariachemoprophylaxis with tafenoquine: a randomised study. Tafenoquine is an analogue of primaquine with an improved therapeutic and safety profile. It has a long half-life and activity against liver-stage malaria parasites, so may be useful for chemoprophylaxis. In this randomised, double-blind study we assessed the efficacy and safety of tafenoquine in different doses.2144 individuals aged 12-20 years living in Lambaréné, Gabon, an endemic area for Plasmodium falciparum malaria, were (...) to replace currently used drugs for malariachemoprophylaxis.
2000LancetControlled trial quality: predicted high
Randomised placebo-controlled trial of iron supplementation and malariachemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Malaria and anaemia, especially that due to iron deficiency, are two leading causes of morbidity worldwide. Little is known about the relative contribution of Plasmodium falciparum infection and iron deficiency to the aetiology of anaemia in malaria-endemic areas. We undertook a randomised comparison of different strategies for control (...) . supplementation was given from 8 to 24 weeks of age, and the weekly chemoprophylaxis from 8 to 48 weeks. The frequency of severe anaemia (packed-cell volume < 25%) and malaria episodes was assessed through a combination of passive case detection and cross-sectional surveys.The groups that received iron supplementation had a lower frequency of severe anaemia than those that did not receive iron (0.62 vs 0.87 cases per person-year; protective efficacy 28.8% [95% CI 6.3-45.8). Iron supplementation had no effect
1997LancetControlled trial quality: predicted high
Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. After treatment with chloroquine and pyrimethamine/sulfadoxine, 118 school children aged 6 to 10 years living near the Kenyan coast were enrolled in a malariachemoprophylaxis study and followed up for 20 weeks. Children were randomly assigned to receive either chlorproguanil 20 mg weekly (n = 78) or placebo (n = 37). The attack rate of Plasmodium falciparum infection was 42% in chlorproguanil