Latest & greatest articles for Herpes Simplex Keratitis

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Top results for Herpes Simplex Keratitis

1. Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Full Text available with Trip Pro

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies (...) which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken.To assess the efficacy of oral antivirals such as acyclovir in any dosage when taken for six months or more, in preventing recurrence of herpetic keratitis in people having corneal graft surgery for herpetic keratitis.We searched CENTRAL (which contains the Cochrane Eyes and Vision

2016 Cochrane

2. What Is the Most Effective Treatment of Herpes Simplex Keratitis?

What Is the Most Effective Treatment of Herpes Simplex Keratitis? TAKE-HOME MESSAGE Treatmentofherpessimplexviruskeratitiscanbeaccomplishedwitheithertopical tri?uridineorganciclovir,whichhavesimilaref?cacy.Oralacyclovirisanacceptable treatment option in cases for which compliance with a topical ophthalmic regimen may be of concern. What Is the Most Effective Treatment of Herpes Simplex Keratitis? EBEM Commentators Joshua Bucher, MD Rutgers–Robert Wood Johnson Medical School New Brunswick, NJ (...) % con?dence interval [CI] 0.8 to 1.1). 1 Similarly, there was no difference in the primary outcome between interferon treatment and antivirals (RR 1.2; 95% CI 0.9 to 1.6). Commentary It is estimated that herpes simplex virus keratitis has an incidence of approximately12to31peopleper 100,000 annually. 2,3 Although it is a relatively uncommon diagno- sis in the emergency department setting, initiation of appropriate treatment is critical, given the potential to lead to serious visual impairment

2016 Annals of Emergency Medicine Systematic Review Snapshots

3. Therapeutic interventions for herpes simplex virus epithelial keratitis. (Abstract)

Therapeutic interventions for herpes simplex virus epithelial keratitis. Many clinical trials have been performed on the acute treatment of dendritic epithelial keratitis. Surveys of ocular antiviral pharmacology and of herpes simplex virus (HSV) eye disease have evaluated different interventions, but a systematic review of all comparative clinical studies has not previously been undertaken.The objective of this review was to compare the effects of various therapeutic interventions (...) after trial enrolment.This review included data from 98 trials that randomised a total of 5211 participants. Compared to idoxuridine, the topical application of vidarabine, trifluridine, or acyclovir resulted in a significantly greater proportion of participants healing within one week of treatment. Among these latter three antiviral agents, no treatment emerged as significantly better for the therapy of dendritic epithelial keratitis. Insufficient placebo-controlled studies were available to assess

2007 Cochrane

4. Evidence-based treatment of herpes simplex virus keratitis: a systematic review

Evidence-based treatment of herpes simplex virus keratitis: a systematic review Evidence-based treatment of herpes simplex virus keratitis: a systematic review Evidence-based treatment of herpes simplex virus keratitis: a systematic review Guess S, Stone D U, Chodosh J CRD summary This review concluded that trifluridine, acyclovir and possibly interferon were effective for herpes simplex virus epithelial keratitis. Corticosteroids with an antiviral were effective for Herpes simplex virus (...) stromal keratitis and long-term acyclovir reduced recurrence. The validity of these conclusions may be limited by the small size of studies, restriction to articles published in English and the method of data extraction. Authors' objectives To systematically review randomised controlled trials for Herpes simplex virus epithelial and stromal keratitis in order to establish an evidence-based foundation for treatment. Searching MEDLINE was searched from January 1966 to May 2006 for studies published

2007 DARE.

5. Interventions for herpes simplex virus epithelial keratitis. (Abstract)

Interventions for herpes simplex virus epithelial keratitis. Many clinical trials have been performed on the acute treatment of dendritic epithelial keratitis. Surveys of antiviral pharmacology and of herpes simplex virus eye disease have evaluated different commercially available agents, but a systematic review of all comparative clinical studies has not previously been undertaken.The objective of this review is to compare the effects of various treatments for dendritic or geographic herpes (...) antiviral agents are effective and nearly equivalent, but the combination of an antiviral nucleoside and interferon seems to speed healing. Future trials of the acute treatment of herpes simplex virus epithelial keratitis must aim to achieve adequate statistical power for assessing the primary outcome and should consider the effect of lesion size and other characteristics on treatment response.

2001 Cochrane