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patient population for genotypic tropism testing – to distinguish between HIV which has the co-receptor to the CD4 receptor solely in the CCR5 state (R5-tropism) or has some of this co-receptor in the CXCR4 state (X4-tropism) – would have humanimmunodeficiencyvirus (HIV-1) infection, and that there was no need or basis to enrich this population for testing. MSAC considered that it could not adequately respond to PBAC’s referral for advice on the characteristics and numbers of patients with HIV-1 (...) by the applicant. 2. Background The process of using specific assays to determine the genetic makeup of the HIVvirus ahead of making treatment decisions is known as genotype-assisted antiretroviral resistance testing (GART). The overarching aim of GART is to collect patient-level information on the genetic 2 makeup of the infecting HIV type in order to guide treatment approaches that are more likely to reduce viral load in patients than if GART was not performed. In Australia, GART testing is performed
accurately distinguish between individuals with R5-tropic virus (who will respond to HIV treatment regimens involving maraviroc to the same extent as to these alternative regimens) and individuals with X4-tropic virus (who will have a less effective response to regimens involving maraviroc). Where there are existing anti-retroviral therapy options (that is, the proposed PBS listing of maraviroc), a high level of test accuracy is required because any false positive R5-tropism results will mean (...) Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has
Return on public health investment: CDC's expanded HIVtesting initiative Return on public health investment: CDC's expanded HIVtesting initiative Return on public health investment: CDC's expanded HIVtesting initiative Hutchinson AB, Farnham PG, Duffy N, Wolitski RJ, Sansom SL, Dooley SW, Cleveland JC, Mermin JH Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study examined the clinical/economic impact of a large-scale HIVtesting programme – the Expanded HIV-Testing Initiative (EHTI) – for populations affected disproportionally by HIV. The economic evaluation was based on a financial return on investment (ROI) analysis. The authors concluded that the programme averted HIV infections and provided positive ROI
: a gateway to novel research and interven- tions. Journal of correctional health care : the official journal of the National Commission on Correc- tional Health Care. 2011;17(1):69- 76. 7. Macgowan R, Margolis A, Richard- son-Moore A, Wang T, Lalota M, French PT, et al. Voluntary rapid humanimmunodeficiencyvirus (HIV) testing in jails. Sexually trans- mitted diseases. 2009;36(2 Suppl):S9-13. 8. Kacanek D, Eldridge GD, Nealey- Moore J, MacGowan RJ, Binson D, Flanigan TP, et al. Young incarcer- ated (...) quality of life and prevent the spread of the virus 7 . The literature indicates a need for more HIVtesting in correctional settings. In a 2002 survey, only 21.6% of inmates reported that they received an HIVtest after admission 7 . Another study noted that fewer than 5% of correctional facilities offer HIVtesting at all 6 . What We Found The literature shows that while prisoners in correctional facilities often welcome HIVtesting 8 , the procedure is not consistently available. 6,7 For a 12-month
Guidance on couples HIVtesting and counselling - including antiretroviral therapy for treatment and prevention in serodiscordant couples WHO | Guidance on couples HIVtesting and counselling - including antiretroviral therapy for treatment and prevention in serodiscordant couples WHO Regional websites Access HIV/AIDS Menu Guidance on couples HIVtesting and counselling - including antiretroviral therapy for treatment and prevention in serodiscordant couples Recommendations for a public health (...) approach Publication details Editors : WHO HIV/AIDS Programme Number of pages : 80 Publication date : April 2012 Languages : English ISBN : 978 92 4 150197 2 Downloads pdf, 727kb Overview New WHO guidelines recommend offering HIVtesting and counselling to couples, wherever HIVtesting and counselling is available, including in antenatal clinics. For couples where only one partner is HIV positive, the guidelines recommend offering antiretroviral therapy to the HIV positive partner, regardless of his
Behaviour change communication CDC U.S. Centers for Disease Control and Prevention Ch TC Couples HIVtesting and counselling Ch W Community health workers CI Confidence interval DALY Disability-adjusted life year Dh S Demographic and Health Surveys GRADE Grading of Recommendations Assessment, Development and Evaluation GRC Guidelines Review Committee h IV Humanimmunodeficiencyvirus h TC HIVtesting and counselling IDU Injecting drug users IEC Information, education and communication IpV Intimate (...) OF RECOMMENDATIONS 20 2.1 Couples HIVtesting and counselling 20 2.2 ART for prevention in serodiscordant couples 24 3. GUIDING pRINCIpLES FOR IMpLEMENTATION 29 3.1 Voluntary utilization of testing services 29 3.2 Five Cs—consent, confidentiality, counselling, correct test results, link to care 29 3.3 Access to justice 30 3.4 Human rights 30 3.5 Provision of earlier treatment 31 4. OpERATIONAL ISSUES FOR IMpLEMENTATION 33 4.1 Overarching issues 33 4.2 Antenatal, perinatal and postnatal care 43 4.3 Other clinical
The cost-effectiveness of introducing nucleic acid testing to test for hepatitis B, hepatitis C, and humanimmunodeficiencyvirus among blood donors in Sweden Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
, Committee on Adolescence . Adolescents and humanimmunodeficiencyvirus infection: the role of the pediatrician in prevention and intervention . 9. Centers for Disease Control and Prevention . HIV/AIDS surveillance in adolescents and young adults (through 2007) . Available at: . Accessed January 14, 2010 10. Hall HI , Song R , Rhodes P , et al. ; HIV Incidence Surveillance Group . Estimation of HIV incidence in the United States . 11. Eaton DK , Kann L , Kinchen S , et al. ; Centers for Disease Control (...) , Cooper E , Flynn P , Futterman DC . Current pediatrician practices in identifying high-risk behaviors of adolescents . Pediatrics . 2010 ; 125 ( 4 ). Available at: 18. Bartlett JG , Branson BM , Fenton K , Hauschild BC , Miller V , Mayer KH . Opt-out testing for humanimmunodeficiencyvirus in the United States: progress and challenges . 19. American Academy of Pediatrics . Bright Futures adolescent supplemental questionnaire 15 to 17 year visits . Available at: . Accessed February 2, 2010 20. Elster
The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA Juusola JL, Brandeau ML, Long EF, Owens DK, Bendavid E Record Status This is a critical abstract (...) was effective over 20 years, but the addition of symptom-based viral load testing was more effective and relatively inexpensive. The methods, analyses, and results were mostly clear, and the authors’ conclusions appear to be reasonable. Type of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective The aim was to examine the cost-effectiveness of strategies to detect and treat HIV in men who have sex with men. The target population was men aged 13 to 64 years, which
Promoting the uptake of HIVtesting among men who have sex with men: systematic review of effectiveness and cost-effectiveness Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
and testing in China. Asia-Pacific Journal of Public Health 2011; 23(4): 620-633 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adolescent; Adult; Algorithms; China; Cost-Benefit Analysis; Counseling /economics; Female; HIV Infections; HIV Seropositivity /diagnosis; Humans; Male; Mass Screening; Middle Aged; Young Adult AccessionNumber 22012000196 Date bibliographic record published 22/02/2012 Date abstract record published 25/07/2012 NHS Economic Evaluation Database (...) The cost-effectiveness of HIV voluntary counseling and testing in China The cost-effectiveness of HIV voluntary counseling and testing in China The cost-effectiveness of HIV voluntary counseling and testing in China Wang S, Moss JR, Hiller JE Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment
HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis Long EF Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study assessed the population-based cost-effectiveness of universal or targeted HIV screening with a fourth-generation immunoassay versus screening for acute infection with a pooled nucleic acid amplification test for various screening frequencies and target populations
Home-based HIV voluntary counselling and testing (VCT) for improving uptake of HIVtesting. The low uptake of HIV voluntary counselling and testing (VCT) has hindered global attempts to prevent new HIV infections and has limited scale-up of HIV care and treatment. Globally, only 10% of HIV-infected individuals are aware of their HIV status. One approach to increase uptake is home-based HIV VCT, which may be effective in increasing the number of patients on treatment and preventing new (...) infections.To establish the effect of home-based HIV VCT on uptake of HIV testingWe searched MEDLINE (February 2007), EMBASE (February 2007), CENTRAL (February 2007), AIDSearch (February 2007), LILACS, CINAHL and Sociofile. We also contacted relevant researchers. The original review search strategy was updated in 2008.Randomised controlled trials comparing home-based HIV VCT with other testing modelsTwo review authors independently selected studies, assessed methodological quality, and extracted data. We
Evaluation of an HIV nucleic acid testing program with automated Internet and voicemail systems to deliver results. Nucleic acid testing (NAT) in routine HIVtesting programs can increase the detection of infected individuals, but the most effective implementation of NAT remains unclear.To determine how many HIV cases can be identified with NAT and how many persons can be contacted, to identify predictors of acute and early HIV infection cases, and to test reporting of negative results (...) by automated Internet and voicemail systems.Prospective study.San Diego County, California.Persons seeking HIV testing.Rates and predictors of HIV infection by stage, notification of positive NAT results, use of automated Internet or voicemail systems to access negative NAT results, and estimated HIV infections prevented.Of 3151 persons tested, 79 had newly diagnosed cases of HIV: 64 had positive results from rapid HIVtest, and 15 had positive results only by NAT (that is, NAT increased the HIV detection
WITHDRAWN: Home-based HIV voluntary counseling and testing in developing countries. The low uptake of HIV voluntary counseling and testing (VCT), an effective HIV prevention intervention, has hindered global attempts to prevent new HIV infections, as well as limiting the scale-up of HIV care and treatment for the estimated 38 million infected persons. According to UNAIDS, only 10% of HIV-infected individuals worldwide are aware of their HIV status. At this point in the HIV epidemic, a renewed (...) focus has shifted to prevention, and with it, a focus on methods to increase the uptake of HIV VCT. This review discusses home-based HIV VCT delivery models, which, given the low uptake of facility-based testing models, may be an effective avenue to get more patients on treatment and prevent new infections.(1) To identify and critically appraise studies addressing the implementation of home-based HIV voluntary counseling and testing in developing countries. (2) To determine whether home-based HIV
Poor sensitivity of field rapid HIVtesting: implications for mother-to-child transmission programme We validated rapid HIVtests among pregnant women in a clinical setting. Field testing was performed using First Response 1,2,3 or Standard Diagnostic and Pareekshak tests. Results were confirmed by third generation HIV ELISA. Discordant or negative, specimens were confirmed by RNA PCR and a fourth generation ELISA test. Sensitivity and specificity were 94.5% (CI: 85.8-98.2) and 100% for First
The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: a cohort study. HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown.To evaluate the association between GPT and survival.Cohort study.10 U.S. HIV clinics.2699 HIV-infected patients eligible for GPT (plasma HIV RNA level >1000 copies/mL) seen from 1999 through 2005.Demographic characteristics (...) , clinical factors, GPT use, all-cause mortality, and crude and adjusted hazard ratios (HRs) for the association of GPT with survival.Patients were followed for a median of 3.3 years; 915 (34%) had GPT. Patients who had GPT had lower mortality rates than those who did not (2.0 vs. 2.7 deaths per 100 person-years). In standard Cox models, GPT was associated with improved survival (adjusted HR, 0.69 [95% CI, 0.51 to 0.94]; P = 0.017) after controlling for demographic characteristics, CD4+ cell count, HIV
Consistency of State Statutes With the Centers for Disease Control and Prevention HIVTesting Recommendations for Health Care Settings. In September 2006, the Centers for Disease Control and Prevention (CDC) released the "Revised Recommendations for HIVTesting of Adults, Adolescents, and Pregnant Women in Health-care Settings" to improve screening and diagnosis. The CDC now recommends that all patients in all health care settings be offered opt-out HIV screening without separate written (...) consent and prevention counseling. State law on HIVtesting is widely assumed to be a barrier to implementing the recommendations. To help policymakers and providers better understand their own legal context and to correct possible misunderstandings about statutory compatibility, a state-by-state review (including Washington, DC) of all statutes pertaining to HIVtesting was performed and the consistency of these laws with the new recommendations was systematically assessed. Criteria were developed