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: a gateway to novel research and interven- tions. Journal of correctional health care : the official journal of the National Commission on Correc- tional Health Care. 2011;17(1):69- 76. 7. Macgowan R, Margolis A, Richard- son-Moore A, Wang T, Lalota M, French PT, et al. Voluntary rapid humanimmunodeficiencyvirus (HIV) testing in jails. Sexually trans- mitted diseases. 2009;36(2 Suppl):S9-13. 8. Kacanek D, Eldridge GD, Nealey- Moore J, MacGowan RJ, Binson D, Flanigan TP, et al. Young incarcer- ated (...) quality of life and prevent the spread of the virus 7 . The literature indicates a need for more HIVtesting in correctional settings. In a 2002 survey, only 21.6% of inmates reported that they received an HIVtest after admission 7 . Another study noted that fewer than 5% of correctional facilities offer HIVtesting at all 6 . What We Found The literature shows that while prisoners in correctional facilities often welcome HIVtesting 8 , the procedure is not consistently available. 6,7 For a 12-month
Return on public health investment: CDC's expanded HIVtesting initiative Return on public health investment: CDC's expanded HIVtesting initiative Return on public health investment: CDC's expanded HIVtesting initiative Hutchinson AB, Farnham PG, Duffy N, Wolitski RJ, Sansom SL, Dooley SW, Cleveland JC, Mermin JH Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study examined the clinical/economic impact of a large-scale HIVtesting programme – the Expanded HIV-Testing Initiative (EHTI) – for populations affected disproportionally by HIV. The economic evaluation was based on a financial return on investment (ROI) analysis. The authors concluded that the programme averted HIV infections and provided positive ROI
accurately distinguish between individuals with R5-tropic virus (who will respond to HIV treatment regimens involving maraviroc to the same extent as to these alternative regimens) and individuals with X4-tropic virus (who will have a less effective response to regimens involving maraviroc). Where there are existing anti-retroviral therapy options (that is, the proposed PBS listing of maraviroc), a high level of test accuracy is required because any false positive R5-tropism results will mean (...) Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Pathology test to determine if a patient has been infected with CCR5 tropic HIV-1 for access to maraviroc Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has
HIVtesting among men who have sex with men (MSM): systematic review of qualitative evidence. We conducted a systematic review of qualitative evidence relating to the views and attitudes of men who have sex with men (MSM) concerning testing for HIV. Studies conducted in high-income countries (Organisation for Economic Co-operation and Development members) since 1996 were included. Seventeen studies were identified, most of gay or bisexual men. Data were analysed using a thematic analysis (...) methodology. The uncertainty of unknown HIV status is an important motive for testing; however, denial is also a common response to uncertainty. Fear of the consequences of a positive HIVtest is widespread and may take several forms. A sense of responsibility towards oneself or one's partner may be a motive for testing. The perception of stigma, from other gay men or from the wider culture, is a barrier to testing. Gay and other MSM have clear preferences regarding testing services, particularly
Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. Improving the outcomes of HIV/AIDS treatment programs in resource-limited settings requires successful linkage of patients testing positive for HIV to pre-antiretroviral therapy (ART) care and retention in pre-ART care until ART initiation. We conducted a systematic review of pre-ART retention in care in Africa.We searched PubMed, ISI Web of Knowledge, conference abstracts, and reference lists (...) for reports on the proportion of adult patients retained between any two points between testing positive for HIV and initiating ART in sub-Saharan African HIV/AIDS care programs. Results were categorized as Stage 1 (from HIVtesting to receipt of CD4 count results or clinical staging), Stage 2 (from staging to ART eligibility), or Stage 3 (from ART eligibility to ART initiation). Medians (ranges) were reported for the proportions of patients retained in each stage. We identified 28 eligible studies
The cost-effectiveness of introducing nucleic acid testing to test for hepatitis B, hepatitis C, and humanimmunodeficiencyvirus among blood donors in Sweden Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Promoting the uptake of HIVtesting among men who have sex with men: systematic review of effectiveness and cost-effectiveness. What interventions are effective and cost-effective in increasing the uptake of HIVtesting among men who have sex with men (MSM)? A systematic review was conducted of the following databases: AEGIS, ASSIA, BL Direct, BNI, Centre for Reviews and Dissemination, Cochrane Database of Systematic Reviews, CINAHL, Current Contents Connect, EconLit, EMBASE, ERIC, HMIC (...) , Medline, Medline In-Process, NRR, PsychINFO, Scopus, SIGLE, Social Policy and Practice, Web of Science, websites, journal hand-searching, citation chasing and expert recommendations. Prospective studies of the effectiveness or cost-effectiveness of interventions (randomised controlled trial (RCT), controlled trial, one-group or any economic analysis) were included if the intervention aimed to increase the uptake of HIVtesting among MSM in a high-income (Organization for Economic Co-operation
The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA The cost-effectiveness of symptom-based testing and routine screening for acute HIV infection in men who have sex with men in the USA Juusola JL, Brandeau ML, Long EF, Owens DK, Bendavid E Record Status This is a critical abstract (...) was effective over 20 years, but the addition of symptom-based viral load testing was more effective and relatively inexpensive. The methods, analyses, and results were mostly clear, and the authors’ conclusions appear to be reasonable. Type of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective The aim was to examine the cost-effectiveness of strategies to detect and treat HIV in men who have sex with men. The target population was men aged 13 to 64 years, which
and testing in China. Asia-Pacific Journal of Public Health 2011; 23(4): 620-633 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adolescent; Adult; Algorithms; China; Cost-Benefit Analysis; Counseling /economics; Female; HIV Infections; HIV Seropositivity /diagnosis; Humans; Male; Mass Screening; Middle Aged; Young Adult AccessionNumber 22012000196 Date bibliographic record published 22/02/2012 Date abstract record published 25/07/2012 NHS Economic Evaluation Database (...) The cost-effectiveness of HIV voluntary counseling and testing in China The cost-effectiveness of HIV voluntary counseling and testing in China The cost-effectiveness of HIV voluntary counseling and testing in China Wang S, Moss JR, Hiller JE Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment
HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis Long EF Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study assessed the population-based cost-effectiveness of universal or targeted HIV screening with a fourth-generation immunoassay versus screening for acute infection with a pooled nucleic acid amplification test for various screening frequencies and target populations
Promoting the uptake of HIVtesting among men who have sex with men: systematic review of effectiveness and cost-effectiveness Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Operational methods of HIVtesting in emergency departments: a systematic review. Casual review of existing literature reveals a multitude of individualized approaches to emergency department (ED) HIVtesting. Cataloging the operational options of each approach could assist translation by disseminating existing knowledge, endorsing variability as a means to address testing barriers, and laying a foundation for future work in the area of operational models and outcomes investigation (...) . The objective of this study is to provide a detailed account of the various models and operational constructs that have been described for performing HIVtesting in EDs.Systematic review of PUBMED, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the Web of Science through February 6, 2009 was performed. Three investigators independently reviewed all potential abstracts and identified all studies that met the following criteria for inclusion: original research, performance
Social marketing interventions to increase HIV/STI testing uptake among men who have sex with men and male-to-female transgender women. Social marketing interventions have been shown to both promote and change many health-related behaviours and issues. As the HIV epidemic continues to disproportionately affect MSM and transgender women around the world, social marketing interventions have the potential to increase HIV/STI testing uptake among these populations.To assess the impact of social (...) marketing interventions on HIV/STI testing uptake among men who have sex with men and transgender women compared to pre-intervention or control group testing uptake in the same population.We searched the following electronic databasesfor results from 01 January 1980 to the search date, 14 July 2010: Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, LILACS (Latin America and Brazil), PsycINFO, PubMed, Web of Science/Web of Social Science, Chinese National Knowledge Infrastructure (CNKI
of the patient; six on barriers at health care provider level and seven on institutional barriers referring to the policy level. The barriers described are centralized around low-risk perception; fear and worries; accessibility of health services, reluctance to address HIV and to offer the test; and scarcity of financial and well trained human resources.Some barriers to HIVtesting and counselling have been illustrated in the literature. Nevertheless, there is lack of structured information on barriers (...) Barriers to HIVtesting in Europe: a systematic review. In the European Union (EU) and neighbouring countries, HIV/AIDS, of all infectious diseases, has one of the highest morbidity and mortality rates. An estimated 30% of people living with HIV are unaware of their infection, and may therefore not benefit from timely treatment or may transmit HIV to others, unknowingly. Evidence shows that opportunities are being missed to diagnose HIV infections in EU Member States, particularly in regular
Home-based HIV voluntary counselling and testing (VCT) for improving uptake of HIVtesting. The low uptake of HIV voluntary counselling and testing (VCT) has hindered global attempts to prevent new HIV infections and has limited scale-up of HIV care and treatment. Globally, only 10% of HIV-infected individuals are aware of their HIV status. One approach to increase uptake is home-based HIV VCT, which may be effective in increasing the number of patients on treatment and preventing new (...) infections.To establish the effect of home-based HIV VCT on uptake of HIV testingWe searched MEDLINE (February 2007), EMBASE (February 2007), CENTRAL (February 2007), AIDSearch (February 2007), LILACS, CINAHL and Sociofile. We also contacted relevant researchers. The original review search strategy was updated in 2008.Randomised controlled trials comparing home-based HIV VCT with other testing modelsTwo review authors independently selected studies, assessed methodological quality, and extracted data. We
Evaluation of an HIV nucleic acid testing program with automated Internet and voicemail systems to deliver results. Nucleic acid testing (NAT) in routine HIVtesting programs can increase the detection of infected individuals, but the most effective implementation of NAT remains unclear.To determine how many HIV cases can be identified with NAT and how many persons can be contacted, to identify predictors of acute and early HIV infection cases, and to test reporting of negative results (...) by automated Internet and voicemail systems.Prospective study.San Diego County, California.Persons seeking HIV testing.Rates and predictors of HIV infection by stage, notification of positive NAT results, use of automated Internet or voicemail systems to access negative NAT results, and estimated HIV infections prevented.Of 3151 persons tested, 79 had newly diagnosed cases of HIV: 64 had positive results from rapid HIVtest, and 15 had positive results only by NAT (that is, NAT increased the HIV detection
The utility of voluntary counselling and testing data as a source of information on HIV prevalence: a systematic review. We explored the utility of routine HIVtesting data from clinical services for estimating HIV prevalence. A systematic review identified 28 eligible publications, covering concentrated epidemics (16 of 28) and generalized epidemics (12). Of the 16 papers from concentrated epidemics, five presented estimates by risk group and four by testing history with a median HIV (...) prevalence of 1.8% in first-time testers compared with 3% in repeat testers. Two reports from generalized epidemics restricted estimates to asymptomatic clients and three included breakdowns by reason-for-test, with the median HIV prevalence higher in symptomatic clients (62%) than others (24%). Two papers from generalized epidemics showed prevalence estimates based on routine HIVtesting data were slightly higher than estimates derived from other surveillance methods, but did not restrict estimates
Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression. Previous relatively small studies have associated particular amino acid replacements and deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We tested more rigorously whether particular nef amino acid differences and deletions are associated with HIV disease progression. Amino acid replacements and deletions in patients' consensus sequences were (...) , permutation testing indicated that none of the regions displayed significantly excessive deletion in LTNPs. In conclusion, meta-analysis of HIV-1 nef sequences provides no clear evidence of whether defective nef sequences or particular regions of the protein play a significant role in disease progression.