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Latest & greatest articles for Famciclovir
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Oral famciclovir for the suppression of recurrent genital herpes: a randomized controlled trial. Collaborative Famciclovir Genital Herpes Research Group. Recurrent genital herpes simplex virus (HSV) may be treated episodically, but this may not be sufficient for patients with frequent recurrences.To determine the efficacy and safety of famciclovir in the suppression of recurrent genital HSV infection.A randomized, double-blind, placebo-controlled, parallel-group study.Thirty university (...) , hospital, or private outpatient referral centers in Canada and Europe.A total of 455 patients (223 men, 232 women) aged 18 years or older with a history of 6 or more episodes of genital herpes during 12 of the most recent 24 months, in the absence of suppressive therapy, received study medication.Oral famciclovir, 125 mg or 250 mg 3 times daily or 250 mg twice daily, or placebo for 52 weeks.Time to the first recurrence of genital HSV infection; the proportion of patients remaining free of HSV
Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Huse D M, Schainbaum S, Kirsch A J, Tyring S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Famciclovir therapy for reducing the duration of post-herpetic neuralgia (PHN). Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Immunocompetent adults with uncomplicated herpes zoster, diagnosed within 72 hours of onset of rash. Setting Primary care centres in the US, Canada and Australia. Dates to which data relate
Patient-initiated, twice-daily oral famciclovir for early recurrent genital herpes. A randomized, double-blind multicenter trial. Canadian Famciclovir Study Group. To compare the efficacy and safety of episodic patient-initiated oral famciclovir with placebo in recurrent genital herpes.Randomized, double-blind, frequent-observation, dose-ranging study comparing twice-daily 125-mg, 250-mg, or 500-mg oral famciclovir with placebo. Patients initiated therapy after self-culturing, reported (...) of lesion edema, vesicles, ulcers, and crusts. Times to cessation of all symptoms and of moderate to severe lesion tenderness, pain, and burning were also reduced. Patients who initiated famciclovir prior to viral shedding were more likely to not shed virus throughout. All doses were equally effective, safe, and well tolerated.Oral famciclovir reduced the onset and duration of viral shedding, lesion persistence, and uncomfortable symptoms. Several individual symptoms and lesion stages were also reduced