Latest & greatest articles for Dystonia

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Top results for Dystonia

1. Botulinum toxin A for cervical dystonia

Botulinum toxin A for cervical dystonia '); } else { document.write(' '); } ACE | Botulinum toxin A for treating cervical dystonia Search > > Botulinum toxin A for treating cervical dystonia - Botulinum toxin A for treating cervical dystonia Published on 2 September 2019 Guidance Recommendations The Ministry of Health's Drug Advisory Committee has recommended: Clostridium botulinum toxin type A neurotoxin complex (Botox) 50 U and 100 U injection vials for treating adults with cervical dystonia

2019 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

2. Dystonias

Dystonias Dystonias - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Dystonias Last reviewed: February 2019 Last updated: January 2019 Summary Movement disorder characterised by sustained involuntary muscle contractions and abnormal postures of the trunk, neck, face, or extremities. The involuntary movements are associated with simultaneous contraction of agonist and antagonist muscles, with unwanted 'overflow (...) ' contraction of adjacent muscles. In some cases, pain in the affected muscles can be a prominent feature. Dystonia may improve with simple 'sensory tricks' such as lightly touching the affected body part (geste antagoniste). Can be generalised or focal, primary (with no other neurological abnormalities), or secondary to a structural lesion. Dopa-responsive dystonias, although rare, should always be considered if generalised, as levodopa is dramatically effective in these situations. Treatment

2019 BMJ Best Practice

3. Trihexyphenidyl for dystonia in cerebral palsy. Full Text available with Trip Pro

Trihexyphenidyl for dystonia in cerebral palsy. Cerebral palsy occurs in up to 2.1 of every 1000 live births and encompasses a range of motor problems and movement disorders. One commonly occurring movement disorder amongst those with cerebral palsy is dystonia: sustained or intermittent involuntary muscle spasms and contractions that cause twisting, repetitive movements and abnormal postures. The involuntary contractions are often very painful and distressing and cause significant limitations (...) to activity and participation.Oral medications are often the first line of medical treatment for dystonia. Trihexyphenidyl is one such medication that clinicians often use to treat dystonia in people with cerebral palsy.To assess the effects of trihexyphenidyl in people with dystonic cerebral palsy, according to the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF) domains of impairment, activity and participation. We also assessed the type

2018 Cochrane

4. Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose‐Escalation Multicenter Study Full Text available with Trip Pro

Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose‐Escalation Multicenter Study Injectable daxibotulinumtoxinA (an investigational botulinum toxin, RT002) may offer a more prolonged duration of response-and therefore less frequent dosing-than onabotulinumtoxinA.To perform a phase 2, open-label, dose-escalation study to assess the efficacy and safety of daxibotulinumtoxinA in cervical dystonia.Subjects with moderate-to-severe isolated cervical dystonia were enrolled (...) site erythema (8%).Preliminary assessments suggest that injectable daxibotulinumtoxinA at doses up to 450 U is well tolerated and may offer prolonged efficacy in the treatment of cervical dystonia. Further studies involving larger numbers of patients are now warranted.

2018 Movement disorders clinical practice

5. Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor (Abstract)

Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor Trials for additional or alternative treatments for cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed the first trial to investigate whether dystonic jerks/tremor in patients with CD respond to the selective serotonin reuptake inhibitor (SSRI) escitalopram.In a randomised, double-blind, crossover trial, patients with CD received escitalopram (...) and placebo for 6 weeks. Treatment with BoNT was continued, and scores on rating scales regarding dystonia, psychiatric symptoms and quality of life (QoL) were compared. Primary endpoint was the proportion of patients that improved at least one point on the Clinical Global Impression Scale for jerks/tremor scored by independent physicians with experience in movement disorders.Fifty-threepatients were included. In the escitalopram period, 14/49 patients (29%) improved on severity of jerks/tremor versus 11

2018 EvidenceUpdates

6. Switching Botulinum Toxin A Products for Patients with Upper Limb Spasticity or Cervical Dystonia: A Review of Clinical Effectiveness

Switching Botulinum Toxin A Products for Patients with Upper Limb Spasticity or Cervical Dystonia: A Review of Clinical Effectiveness Switching Botulinum Toxin A Products for Patients with Upper Limb Spasticity or Cervical Dystonia: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Switching Botulinum Toxin A Products for Patients with Upper Limb Spasticity or Cervical Dystonia: A Review of Clinical Effectiveness Switching Botulinum Toxin A Products for Patients (...) with Upper Limb Spasticity or Cervical Dystonia: A Review of Clinical Effectiveness Last updated: February 9, 2018 Project Number: RC0960-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of switching botulinum toxin A products for patients with upper limb spasticity? What is the clinical effectiveness of switching botulinum toxin A products for patients with cervical dystonia? Key Message No literature

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Dystonias

Dystonias Dystonias - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Dystonias Last reviewed: February 2019 Last updated: January 2019 Summary Movement disorder characterised by sustained involuntary muscle contractions and abnormal postures of the trunk, neck, face, or extremities. The involuntary movements are associated with simultaneous contraction of agonist and antagonist muscles, with unwanted 'overflow (...) ' contraction of adjacent muscles. In some cases, pain in the affected muscles can be a prominent feature. Dystonia may improve with simple 'sensory tricks' such as lightly touching the affected body part (geste antagoniste). Can be generalised or focal, primary (with no other neurological abnormalities), or secondary to a structural lesion. Dopa-responsive dystonias, although rare, should always be considered if generalised, as levodopa is dramatically effective in these situations. Treatment

2018 BMJ Best Practice

8. Assessment of infantile dystonia

Assessment of infantile dystonia Assessment of infantile dystonia - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of infantile dystonia Last reviewed: February 2019 Last updated: June 2018 Summary Abnormal movement disorders are classified as parkinsonism, dystonia, tremor, chorea, myoclonus, tics, stereotypies, and complex movement disorder. Dystonia is described as contraction of both agonist (...) and antagonist muscles simultaneously, causing twisting and repetitive movements or abnormal postures. Fahn S, Bressman SB, Marsden CD. Classification of dystonia. Adv Neurol. 1998;78:1-10. http://www.ncbi.nlm.nih.gov/pubmed/9750897?tool=bestpractice.com The earlier the age of onset, the more generalised and severe the condition tends to be. Dystonic movements Dystonic movements are patterned and sustained. They repeatedly involve the same muscle groups. The urge to perform the dystonic movements is absent

2018 BMJ Best Practice

9. Ataxia Telangiectasia Gene Mutation in Isolated Segmental Dystonia Without Ataxia and Telangiectasia Full Text available with Trip Pro

Ataxia Telangiectasia Gene Mutation in Isolated Segmental Dystonia Without Ataxia and Telangiectasia https://onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312564-sup-v001_1.htm.

2017 Movement disorders clinical practice

10. Deep Brain Stimulation for the Dystonias: Evidence, Knowledge Gaps, and Practical Considerations Full Text available with Trip Pro

Deep Brain Stimulation for the Dystonias: Evidence, Knowledge Gaps, and Practical Considerations Deep brain stimulation (DBS) of the globus pallidus internus (GPi-DBS) is among the most effective treatment options for dystonias. Because the term "dystonia" is defined by a characteristic phenomenology of involuntary muscle contractions, which may present with a large clinical and pathogenetic heterogeneity, decision making for or against GPi-DBS can be difficult in individual patients.A search (...) of the PubMed database for research and review articles, focused on "deep brain stimulation" and "dystonia" was used to identify clinical trials and to determine current concepts in the surgical management of dystonia. Patient selection in previous studies was recategorized by the authors using the new dystonia classification put forward by a consensus committee of experts in dystonia research. The evidence and knowledge gaps are summarized and commented by the authors taking into account expert opinion

2017 Movement disorders clinical practice

11. Validation of the XDP–MDSP rating scale for the evaluation of patients with X-linked dystonia-parkinsonism Full Text available with Trip Pro

Validation of the XDP–MDSP rating scale for the evaluation of patients with X-linked dystonia-parkinsonism X-linked dystonia-parkinsonism(XDP) is a neurodegenerative disorder endemic to the Philippines. A rating scale was developed by the authors under the guidance of the Movement Disorder Society of the Philippines (MDSP) to assess XDP severity and progression, functional impact, and response to treatment in future clinical trials. Our main objective was to validate our new scale, the XDP (...) -MDSP scale. The initial validation process included pragmatic testing to XDP patients followed by a modified Delphi procedure with an international advisory panel of dystonia, parkinsonism and scale development experts. Pearson correlation was used to assess construct validity of our new scale versus the assess construct validity of our new scale versus standard dystonia, parkinsonism, non-motor and functional scales; and also to assess divergent validity against behavioral and cognitive scales

2017 NPJ Parkinson's disease

12. Providing an imputation algorithm for missing values of longitudinal data using Cuckoo search algorithm: A case study on cervical dystonia Full Text available with Trip Pro

Providing an imputation algorithm for missing values of longitudinal data using Cuckoo search algorithm: A case study on cervical dystonia Missing values in data are found in a large number of studies in the field of medical sciences, especially longitudinal ones, in which repeated measurements are taken from each person during the study. In this regard, several statistical endeavors have been performed on the concepts, issues, and theoretical methods during the past few decades.Herein, we (...) focused on the missing data related to patients excluded from longitudinal studies. To this end, two statistical parameters of similarity and correlation coefficient were employed. In addition, metaheuristic algorithms were applied to achieve an optimal solution. The selected metaheuristic algorithm, which has a great search functionality, was the Cuckoo search algorithm.Profiles of subjects with cervical dystonia (CD) were used to evaluate the proposed model after applying missingness

2017 Electronic physician

13. The Frequency and Self‐perceived Impact on Daily Life of Motor and Non‐motor Symptoms in Cervical Dystonia Full Text available with Trip Pro

The Frequency and Self‐perceived Impact on Daily Life of Motor and Non‐motor Symptoms in Cervical Dystonia Evidence suggests that non-motor symptoms (NMS) are the most important predictors of decreased health-related quality of life (HR-QoL) in patients with cervical dystonia (CD). In this study, we evaluate an NMS screening list and examine the influence of motor symptoms and NMS on HR-QoL.In 40 patients with CD, the frequency of NMS was evaluated using an extended NMS questionnaire (...) . Several domains of HR-QoL were significantly influenced by NMS, whereas motor symptoms had only a small influence on the physical functioning domain of HR-QoL.Our findings highlight the impact of NMS on HR-QoL and emphasize the importance of a standardized, validated NMS questionnaire for patients with dystonia. This would enable us to monitor the effect of treatment for motor symptoms and NMS on an individual basis and improve treatment options.

2017 Movement disorders clinical practice

14. A History of Dystonia: Ancient to Modern Full Text available with Trip Pro

A History of Dystonia: Ancient to Modern Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to identify in historical documents. Torticollis is an exception, although there is difficulty distinguishing dystonic torticollis from congenital muscular torticollis. There are, nevertheless, possible (...) representations of dystonia in literature and visual art from the pre-modern world. Eighteenth century systematic nosologists such as Linnaeus, de Sauvages, and Cullen had attempted to classify some spasmodic conditions, including torticollis. But only after Charcot's contributions to clinical neuroscience were the various forms of generalized and focal dystonia clearly delineated. They were categorized as névroses: Charcot's term for conditions without an identifiable neuroanatomical cause. For a time

2017 Movement disorders clinical practice

16. Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients Full Text available with Trip Pro

Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients Nonmotor symptoms (NMS) are highly prevalent in cervical dystonia (CD). In general, fatigue and sleep are important NMS that determine a decreased health-related quality of life (HR-QoL), but their influence in CD is unknown. The authors systematically investigated fatigue, excessive daytime sleepiness (EDS), and sleep quality in patients with CD and controls and assessed the influence (...) of psychiatric comorbidity, pain, and dystonia motor severity. They also examined the predictors of HR-QoL.The study included 44 patients with CD and 43 matched controls. Fatigue, EDS, and sleep quality were assessed with quantitative questionnaires and corrected for depression and anxiety using analysis of covariance. The Toronto Western Spasmodic Torticollis Rating Scale and the Clinical Global Impression Scale-jerks/tremor subscale were used to score motor severity and to assess whether motor

2016 Movement disorders clinical practice

17. Tiagabine treatment in kainic acid induced cerebellar lesion of dystonia rat model Full Text available with Trip Pro

Tiagabine treatment in kainic acid induced cerebellar lesion of dystonia rat model Dystonia is a neurological disorder characterized by excessive involuntary muscle contractions that lead to twisting movements. The exaggerated movements have been studied and have implicated basal ganglia as the point of origin. In more recent studies, the cerebellum has also been identified as the possible target of dystonia, in the search for alternative treatments. Tiagabine is a selective GABA transporter (...) inhibitor, which blocks the reuptake and recycling of GABA. The study of GABAergic drugs as an alternative treatment for cerebellar induced dystonia has not been reported. In our study, tiagabine was i.p. injected into kainic acid induced, cerebellar dystonic adult rats, and the effects were compared with non-tiagabine injected and sham-operated groups. Beam walking apparatus, telemetric electromyography (EMG) recording, and histological verification were performed to confirm dystonic symptoms

2016 EXCLI journal

18. Botulinum toxin type A versus botulinum toxin type B for cervical dystonia. Full Text available with Trip Pro

Botulinum toxin type A versus botulinum toxin type B for cervical dystonia. This is an update of a Cochrane review first published in 2003. Cervical dystonia is the most common form of focal dystonia and is a disabling disorder characterised by painful involuntary head posturing. There are two available formulations of botulinum toxin, with botulinum toxin type A (BtA) usually considered the first line therapy for this condition. Botulinum toxin type B (BtB) is an alternative option (...) at the time. Therefore, with this update we are able to change the conclusions of this review. There is low quality evidence that a single treatment session of BtA (specifically onabotulinumtoxinA) and a single treatment session of BtB (rimabotulinumtoxinB) are equally effective and safe in the treatment of adults with certain types of cervical dystonia. Treatment with BtB appears to present an increased risk of sore throat/dry mouth, compared to BtA. Overall, there is no clinical evidence from

2016 Cochrane

19. High Botulinum Toxin‐Neutralizing Antibody Prevalence Under Long‐Term Cervical Dystonia Treatment Full Text available with Trip Pro

High Botulinum Toxin‐Neutralizing Antibody Prevalence Under Long‐Term Cervical Dystonia Treatment The aim of this study was to determine the prevalence of neutralizing antibodies in a large cohort of long-term treated patients with cervical dystonia (CD) still responding to repetitive injections with botulinum toxin (BoNT).Consecutively recruited CD patients (n = 221) under long-term BoNT treatment (≥2-21 years) underwent a clinical examination at the same time blood samples were taken

2016 Movement disorders clinical practice

20. Ranking of Dystonia Severity by Pairwise Video Comparison Full Text available with Trip Pro

Ranking of Dystonia Severity by Pairwise Video Comparison Reviewers of dystonia rating scales agree on the need to assess symptoms more comprehensively. During the development of a quantitative dystonia assessment by video-perceptive computing, we devised a video-based severity ranking as a procedure to create a validation standard without the use of clinical scales.Thirty-four patients with dystonia (17 with dystonic tremor) and 2 controls were assessed with clinical scales and video (...) . This supports video-based ranking as a more comprehensive rating of dystonia and as a possible validation instrument applicable in situations in which no reference standard is available.

2016 Movement disorders clinical practice