Latest & greatest articles for Cornea

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Top results for Cornea

1. Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product

2019 Health Canada - Drug and Health Product Register

2. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Full Text available with Trip Pro

Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 2, Pages 157–159 Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients (...) With Traumatic Corneal Abrasions? x Jason R. West , MD (EBEM Commentator) Department of Emergency Medicine, Lincoln Medical and Mental Health Center, Bronx, NY DOI: | Publication History Published online: December 04, 2018 Expand all Collapse all Article Outline Take-Home Message There is no strong evidence to suggest that topical nonsteroidal anti-inflammatory drugs provide adequate analgesia for patients with traumatic corneal abrasions, yet there is low-quality evidence to suggest that the drugs decreased

2019 Annals of Emergency Medicine Systematic Review Snapshots

3. Intrastromal corneal ring segments for treating keratoconus. (Abstract)

Intrastromal corneal ring segments for treating keratoconus. Keratoconus is a degenerative condition of the cornea that profoundly affects vision and vision-specific quality of life. The axial cornea thins and protrudes, resulting in irregularity and, eventually, scarring of the cornea. There are multiple options available for treating keratoconus. Intrastromal corneal ring segments are small, crescent-shaped plastic rings that are placed in the deep, peripheral corneal stroma in order (...) to flatten the cornea. They are made of polymethylmethacrylate (PMMA). The procedure does not involve corneal tissue nor does it invade the central optical zone. Intrastromal corneal ring segments are approved for use when contact lenses or spectacles are no longer adequate.To evaluate the effectiveness and safety of intrastromal corneal ring segments as a treatment for keratoconus.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials

2019 Cochrane

4. Combined flanged intrascleral intraocular lens fixation with corneal transplant. Full Text available with Trip Pro

Combined flanged intrascleral intraocular lens fixation with corneal transplant. To report clinical outcomes and surgical technique of flanged intrascleral intraocular lens fixation with double-needle combined with either penetrating keratoplasty (PKP) or ultrathin Descemet-stripping automated endothelial keratoplasty (UT-DSAEK).Five patients underwent combined flanged intrascleral intraocular lens fixation with double-needle technique and keratoplasty. Three patients underwent triple procedure (...) (open sky intrascleral intraocular lens fixation with double-needle and PKP) secondary to ocular trauma or a failed corneal transplant. Two patients underwent combined UT-DSAEK and intrascleral intraocular lens fixation for pseudophakic bullous keratopathy (PBK) and anterior chamber intraocular lens (AC IOL).Flanged intrascleral intraocular lens fixation with double-needle technique combined with PKP or UT-DSAEK was shown to be a safe and effective method of visual rehabilitation without additional

2019 American journal of ophthalmology case reports Controlled trial quality: uncertain

5. Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Published 08 October 2018 . Statement of advice SMC2124 cenegermin 20micrograms/ml eye drops, solution (Oxervate®) Dompé UK Ltd In confidence 7 September 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation cenegermin (Oxervate®) is not recommended for use within NHSScotland. Indication under review: Treatment of moderate (...) (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view of the Scottish Medicines Consortium and was arrived at after careful consideration and evaluation

2018 Scottish Medicines Consortium

6. Inadvertent corneal pigmentation following cosmetic blepharopigmentation Full Text available with Trip Pro

Inadvertent corneal pigmentation following cosmetic blepharopigmentation To present a case of inadvertent corneal pigmentation as a complication of cosmetic eyelid tattooing.A 63 year old woman presented with left eye redness and irritation 3 days after undergoing permanent eyeliner tattooing of her upper and lower eyelids. On ocular examination a black pigmentation of the nasal cornea in her left eye was observed, with associated conjunctival injection. Initial slit lamp attempts of pigment (...) components such as copper and lead. Due to minimal inflammatory reaction and the non-central location of the corneal pigmentation, the patient remained under close observation, treated with lubrication and no further interventions, until complete resolution by 6 weeks.While the procedure of cosmetic blepharopigmentation is considered relatively safe, it bares many possible complications, ranging from mild dermal irritation to vision-threatening conditions. Our case of inadvertent keratopigmentation

2018 American journal of ophthalmology case reports

7. ORA G3 to measure corneal hysteresis

by a healthcare professional through an in-built operator display. The patient positions their head in a headrest, which is adjusted to allow for measurements of the left or right eye. The device blows a short puff of air to slightly flatten the cornea, which then returns to its original shape. During this the device takes 2 measurements: the force needed to flatten the cornea and the force needed for it to reshape. The difference between the 2 measurements is defined as the level of corneal hysteresis (...) ORA G3 to measure corneal hysteresis ORA G3 to measure corneal h ORA G3 to measure corneal hysteresis ysteresis Medtech innovation briefing Published: 18 June 2018 nice.org.uk/guidance/mib150 pathways Summary Summary The technology technology described in this briefing is Ocular Response Analyzer (ORA) G3. It can be used to measure corneal hysteresis, a possible risk factor for glaucoma. The inno innovativ vative aspects e aspects are that ORA G3 is currently the only device capable

2018 National Institute for Health and Clinical Excellence - Advice

8. Severe Achromobacter xylosoxidans keratitis with deep corneal involvement Full Text available with Trip Pro

Severe Achromobacter xylosoxidans keratitis with deep corneal involvement To describe a case of Achromobacter xylosoxidans keratitis with deep involvement of the corneal stroma and discuss its management.A 73 year-old monocular male with infectious keratitis of the right eye was referred to the Wilmer Eye Institute after a month of empiric treatment with besifloxacin. On presentation, slit lamp examination of the right eye demonstrated a diffusely edematous cornea with three areas of corneal (...) infiltrates and an overlying epithelial defect and a 1.3 mm hypopyon in the anterior chamber. The corneal culture performed grew A. xylosoxidans. Empiric antibiotic regimen was adjusted once corneal culture susceptibility results were available. Seven days later, slit lamp examination demonstrated a resolving epithelial defect, stable infiltrates, and resolution of the hypopyon. After approximately two months of follow up with his primary ophthalmologist, he was noted to have recurrent hypopyon

2018 American journal of ophthalmology case reports

9. Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course Full Text available with Trip Pro

Delayed-onset Candida parapsilosis cornea tunnel infection and endophthalmitis after cataract surgery: Histopathology and clinical course To describe a patient with late post-operative endophthalmitis and clear cornea tunnel infection caused by Candida parapsilosis that was masquerading as chronic anterior uveitis.A 62-year old woman with history of uncomplicated cataract surgery 7 months prior and chronic postoperative anterior uveitis, presented with an endothelial plaque, hypopyon (...) , and infiltrates in the capsular bag and within the clear corneal tunnel. Anterior chamber cultures identified C. parapsilosis and pathology of the endothelial plaque showed fungus. Anterior chamber washout, scraping of the endothelial plaque, serial intracameral and intravitreal injections with amphotericin B (10 mcg) failed to control the infection. Pars plana vitrectomy, removal of the intraocular lens and capsular bag, a corneal patch graft, and administration of intravitreal antifungal agents were

2018 American journal of ophthalmology case reports

10. Corneal infiltration and xanthoma formation in mycosis fungoides Full Text available with Trip Pro

Corneal infiltration and xanthoma formation in mycosis fungoides To report a case of corneal infiltration and xanthoma formation in mycosis fungoides (cutaneous T-cell lymphoma).A middle aged Japanese man with mycosis fungoides (MF) involving the face was referred to Ophthalmology for evaluation of unilateral, painless conjunctival injection. Biopsy of the conjunctiva revealed a malignant T cell population consistent with MF tumor invasion. Years later, he returned following several episodes (...) of infectious keratitis with a painless, yellow, rapidly forming mass in the left eye over two weeks. Corneal biopsy showed foamy histiocytes and positive staining for CD68, and a diagnosis of corneal xanthoma was made.Severe ocular surface disease can rarely occur in MF by direct invasion of tumor cells. Corneal infiltration and xanthoma development may be avoidable by careful monitoring for infectious keratitis in patients with conjunctival involvement, as in our case.

2018 American journal of ophthalmology case reports

11. Application of femtosecond laser-assisted cataract surgery in patients with corneal pathologies Full Text available with Trip Pro

Application of femtosecond laser-assisted cataract surgery in patients with corneal pathologies 30128369 2018 11 14 2451-9936 11 2018 Sep American journal of ophthalmology case reports Am J Ophthalmol Case Rep Application of femtosecond laser-assisted cataract surgery in patients with corneal pathologies. 170-171 10.1016/j.ajoc.2018.06.015 Awidi Abdelhalim A Faculty of Medicine, University of Jordan, Queen Rania Al Abdullah Street, Amman, 11942, Jordan. Dzhaber Daliya D Cornea, Cataract (...) , and Anterior Segment Division, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA. Daoud Yassine J YJ Cornea, Cataract, and Anterior Segment Division, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA. eng Journal Article 2018 06 19 United States Am J Ophthalmol Case Rep 101679941 2451-9936 2018 03 02 2018 05 01 2018 06 18 2018 8 22 6 0 2018 8 22 6 0 2018 8 22 6 1

2018 American journal of ophthalmology case reports

12. Sequential traumatic corneal open globe rupture in a patient with osteogenesis imperfecta type I Full Text available with Trip Pro

at school while wearing protective lenses. One year ago, he required surgical repair of a left open globe following blunt trauma during a middle school basketball game. His exam was significant for a full-thickness corneal laceration, necessitating open globe repair of his right eye, which was remarkably difficult given the poor tissue constitution of the cornea and sclera. He was referred to a genetics specialist, where he was found to have a pathogenic heterozygous splice site variant in the COL1A1 (...) Sequential traumatic corneal open globe rupture in a patient with osteogenesis imperfecta type I To report a case of sequential open globe rupture in a young patient with osteogenesis imperfecta type I following minor accidental blunt injury. This represented the patient's sole clinical manifestation of connective tissue disease, leading to a diagnosis of osteogenesis imperfecta type I at the age of 12 years old.A 12-year-old male presented with right eye pain following accidental blunt trauma

2018 American journal of ophthalmology case reports

13. Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review Full Text available with Trip Pro

Tectonic corneal lamellar grafting for surgically-induced necrotizing scleritis after strabismus surgery: Case report & literature review To report the first case of infectious surgically-induced necrotizing scleritis following strabismus surgery which was treated successfully with a tectonic corneal graft.We report a case of surgically-induced necrotizing scleritis after strabismus surgery in a 61-year-old gentleman with gout and a subconjunctival abscess. Surgical drainage (...) of the subconjunctival abscess led to a diagnosis of scleral melt which was subsequently treated with a tectonic corneal graft along with aggressive medical management. Over the following eight months, the patient showed no signs of endophthalmitis, graft necrosis, nor graft dehiscence, and serial anterior segment optical coherence tomography imaging demonstrated anatomic stability.This case offers further insights into a rare but vision-threatening and potentially life-threatening diagnosis. In conjunction

2018 American journal of ophthalmology case reports

14. Changes in corneal thickness and corneal endothelial cell density after phacoemulsification cataract surgery: a double-blind randomized trial Full Text available with Trip Pro

Changes in corneal thickness and corneal endothelial cell density after phacoemulsification cataract surgery: a double-blind randomized trial Age-related cataract is a leading cause of visual impairment, considered a global health burden, it is responsible for over 47% of blindness worldwide. Surgical intervention is usually the treatment of choice and phacoemulsification cataract surgery with implantation of an intraocular lens is the most common procedure, which may have several (...) complications.To determine the effects of phacoemulsification surgery on corneal endothelial cell density and corneal thickness in patients undergoing cataract surgery.The present study was conducted on patients diagnosed with immature senile cataract requiring surgical intervention from November 2013 to 2014 in Khatam al Anbia Hospital (a tertiary ophthalmology center). Physical examination included best-corrected visual acuity using the Snellen chart, refraction, slit-lamp bio-microscopy for anterior chamber

2018 Electronic physician Controlled trial quality: uncertain

15. Bilateral corneal denting after surgery under general anesthesia: A case report Full Text available with Trip Pro

Bilateral corneal denting after surgery under general anesthesia: A case report To report a case of temporary bilateral corneal denting in a patient who underwent cardiovascular surgery under general anesthesia.A 71-year-old male with no history of ophthalmological disease experienced bilateral corneal denting immediately after undergoing surgery for aneurysm of the thoracic aorta under general anesthesia. Anesthesia was induced with propofol and maintained with rocuronium bromide (...) and remifentanil hydrochloride. The initial examination revealed significant denting on the surface of both the corneas and ocular hypotension. Visual evaluation could not be performed due to the patient's low level of consciousness resulting from delayed emergence from anesthesia. After applying tropicamide and phenylephrine ophthalmic solution for fundus examination, the ocular morphology improved. Ocular pressure was normal on the day after surgery, and creasing on the surface of the corneas had

2018 American journal of ophthalmology case reports

16. Resorbable and running suture for stable fixation of amniotic membrane multilayers: A useful modification in deep or perforating sterile corneal ulcers Full Text available with Trip Pro

Resorbable and running suture for stable fixation of amniotic membrane multilayers: A useful modification in deep or perforating sterile corneal ulcers To present a modified technique for secure tightening and fixing of multilayer amniotic membranes in deep or perforating corneal ulcers.The modified procedure for application and fixation of multilayer amniotic membranes is retrospectively described step by step, and the results of three patients treated with this technique were retrospectively (...) analysed and presented.The modification consists basically in fixing the inlays with one mini-overlay that is sutured intracorneally with resorbable and running Vicryl 10.0, before a corneoscleral overlay is fixed on top conjunctivally with a running nylon 10.0 suture. The resorbable Vicryl suture is left in place permanently.The method described avoids any risk of destroying or displacing the inlays by removing sutures later. In each of the three patients demonstrated as case reports the cornea

2018 American journal of ophthalmology case reports

17. Spontaneous regression of epithelial downgrowth from clear corneal phacoemulsification wound Full Text available with Trip Pro

Spontaneous regression of epithelial downgrowth from clear corneal phacoemulsification wound To report a case of spontaneous regression of optical coherence tomography (OCT) and confocal microscopy-supported epithelial downgrowth associated with clear corneal phacoemulsification wound.A 66-year-old Caucasian male presented two years after phacoemulsification in the left eye with an enlarging cornea endothelial lesion in that eye. His early post-operative course had been complicated by corneal (...) edema and iris transillumination defects. The patient presented to our clinic with a large geographic sheet of epithelial downgrowth and iris synechiae to the temporal clear corneal wound. His vision was correctable to 20/25 in his left eye. Anterior segment OCT showed a hyperreflective layer on the posterior cornea with an abrupt transition that corresponded to the clinical transition zone of the epithelial downgrowth. Confocal microscopy showed polygonal cells with hyperreflective nuclei

2018 American journal of ophthalmology case reports

18. Case of progressive hyperopia due to flattening of cornea Full Text available with Trip Pro

examinations showed clear corneas but Descemet's folds and fine pigmentations and opacities were present beneath the corneal epithelium in both eyes. Analysis of the corneal shape by anterior segment optical coherence tomography showed that the corneas were flattened, and the corneal refractive power was decreased in both eyes. The large values of the higher-order aberration in the cornea and total eye displayed bilateral irregular astigmatism. She obtained good vision by wearing hard contact lenses (...) Case of progressive hyperopia due to flattening of cornea To report a case that had a progressive decrease in the visual acuity caused by a progressive increase in the hyperopia due to a flattening of the cornea.A 50-year-old woman complained of decreased vision in both eyes. Her decimal best-corrected visual acuity was 1.2 in the right and 0.5 in the left eyes, and the refractive error (spherical equivalent) was +3.75 diopters (D) for the right eye and +6.5 D for the left eye. Slit-lamp

2018 American journal of ophthalmology case reports

19. University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. Full Text available with Trip Pro

University students' knowledge of corneal donation and willingness to donate corneas in the occupied Palestinian territory: a cross-sectional study. Access to corneal transplantation is limited worldwide because of poor knowledge. Ethical, religious, and cultural barriers contribute to low rates of corneal donation. In the occupied Palestinian territory, limited information is available on factors affecting corneal donation. The aim of this study was to assess the knowledge and willingness (...) %) respondents were aware of a lack in corneal donation, but 274 (64%; p=0·01) of these respondents did not show willingness towards corneal donation. 429 (68%) respondents were not willing to donate their corneas, the most common reasons being disapproval by family members and poor awareness. We found no association between sociodemographic factors and willingness was determined.Palestinian students are aware of the lack of local cornea donation but are unwilling to donate their corneas. The study results

2018 Lancet

20. Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment Full Text available with Trip Pro

Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease.We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December (...) 2014. Patients were referred for ocular surface disease of various etiologies. Primary inclusion criterion was corneal opacity that improved with PROSE treatment. Patients were excluded if topical steroids or adjuvant therapy used once PROSE treatment was initiated. Underlying disease, prior treatment, clinical presentation, and clinical course were extracted from the medical record. Four patients are included in this series. There were three females and one male; median age at time of treatment

2018 American journal of ophthalmology case reports