Latest & greatest articles for Chikungunya

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Top results for Chikungunya

1. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

2. Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. (PubMed)

Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. Chikungunya fever is an emerging viral disease and substantial threat to public health. We aimed to assess the safety, tolerability, and immunogenicity of a live-attenuated, measles-vectored chikungunya vaccine (MV-CHIK).In this double-blind, randomised, placebo-controlled and active-controlled phase 2 trial, we (...) , which was maintained by use of sterile saline as a placebo injection. The primary endpoint was immunogenicity, defined as the presence of neutralising antibodies against chikungunya virus, at day 56, which is 28 days after one or two immunisations. The primary endpoint was assessed in all participants who completed the study without major protocol deviations (per-protocol population) and in all randomised participants who received at least one study treatment (modified intention-to-treat population

2018 Lancet Controlled trial quality: predicted high

3. Treatment of Chronic Chikungunya Arthritis With Methotrexate: A Systematic Review

Treatment of Chronic Chikungunya Arthritis With Methotrexate: A Systematic Review Chikungunya virus infection is a rapidly emerging global viral infection that can cause chronic, debilitating arthritis that in some ways mimics rheumatoid arthritis. The aim of this study was to evaluate the available evidence regarding the efficacy and safety of methotrexate (MTX), a therapy that is widely used in rheumatoid arthritis, for the treatment of chronic chikungunya arthritis.A systematic literature (...) search was performed to identify all published trials that evaluated MTX as monotherapy or combination therapy in patients with chronic chikungunya arthritis. PubMed, SciELO, Scopus, and Cochrane Library databases were searched from study inception to August 2017. We also searched Google Scholar, the International Clinical Trials Registry Platform Search Portal, and clinicaltrials.gov.Among 131 possibly relevant studies, 6 met our criteria for evaluation: 4 were retrospective studies, 1 was a non

2018 EvidenceUpdates

4. Treatment of chikungunya chronic arthritis: A systematic review.

Treatment of chikungunya chronic arthritis: A systematic review. Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014. The initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. Usually, CHIK presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months

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2018 Revista da Associacao Medica Brasileira (1992)

5. A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome (PubMed)

A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA).We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK

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2018 Rheumatology and therapy

6. Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases (PubMed)

Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases The recent emergence and re-emergence of viral infections transmitted by vectors-Zika, chikungunya, dengue, Japanese encephalitis, West Nile, yellow fever and others-is a cause for international concern. Using as examples Zika, chikungunya and dengue, we summarise current knowledge on characteristics of the viruses and their transmission, clinical features, laboratory diagnosis, burden, history (...) , possible causes of the spread and the expectation for future epidemics. Arboviruses are transmitted by mosquitoes, are of difficult diagnosis, can have surprising clinical complications and cause severe burden. The current situation is complex, because there is no vaccine for Zika and chikungunya and no specific treatment for the three arboviruses. Vector control is the only comprehensive solution available now and this remains a challenge because up to now this has not been very effective. Until we

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2018 BMJ global health

7. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

8. A clinical report on mixed infection of malaria, dengue and chikungunya from New Delhi, India (PubMed)

A clinical report on mixed infection of malaria, dengue and chikungunya from New Delhi, India Arthropod-borne infections like malaria, dengue and chikungunya fever are transmitted by mosquitoes. The present report describes an unusual case of mixed infection with malaria, dengue and chikungunya viruses in a 21 year old male patient from New Delhi, India during monsoon season of 2016. The malarial fever was diagnosed by thin slide microscopy and antigen test. Chikungunya virus IgM was detected (...) in the sample by the card test. Dengue and chikungunya viruses were further confirmed by RT-PCR for CprM and E1 gene respectively. Phylogenetic analysis clustered the study dengue virus serotype 3 sequence in the genotype III. Thus, the mono infections can not be differentiated from concurrent infections on the basis of clinical symptoms, the appropriate laboratory diagnosis is essential for the accurate pathogen confirmation. Precise and appropriate identification of the multiple pathogens in such clinical

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2017 Virusdisease

9. Successful Live Kidney Transplantation After Chikungunya Disease in the Donor (PubMed)

Successful Live Kidney Transplantation After Chikungunya Disease in the Donor 29270535 2019 02 26 2468-0249 2 6 2017 Nov Kidney international reports Kidney Int Rep Successful Live Kidney Transplantation After Chikungunya Disease in the Donor. 1250-1253 10.1016/j.ekir.2017.06.003 Moura-Neto José Andrade JA Clinical and Academic Unit of Nephrology, Hospital Universitário Pedro Ernesto, Rio de Janeiro State University, Rio de Janeiro, Brazil. CSB Group of Nephrology, Salvador, Brazil. de Souza

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2017 Kidney international reports

10. Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients (PubMed)

Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients Aedes mosquitoes are well adapted in domestic environments and widespread in tropical regions. Since 2015, Brazil has been experiencing a triple epidemic of dengue (DENV), chikungunya (CHKV), and Zika (ZIKV) viruses. The last 2 viruses are likely following the path of DENV, which has been endemic in most parts of the country since the 1980s. Given this triple epidemic, we

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2017 Blood advances

11. Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies (PubMed)

Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with the host cell. The present study was conceptualized to determine the structure of E2 protein of CHIKV and to identify the potential viral

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2017 Virusdisease

13. Erratum to: Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India (PubMed)

Erratum to: Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India [This corrects the article DOI: 10.1007/s13337-016-0314-z.].

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2016 Virusdisease

14. Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India (PubMed)

Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India Chikungunya fever is an important reemerging arbovirus illness, which is transmitted by the same vector as of dengue virus. Many cases of concurrent infections with multiple dengue virus serotypes have been reported in many countries. Also, concurrent infection with Chikungunya virus and dengue virus has been reported in the past in Delhi. Therefore, this study was done to detect (...) Chikungunya IgM antibodies in suspected dengue fever patients. In this study, 1666 serum samples suspected of dengue fever and collected during the outbreak period (August 2010-December 2010) were tested for dengue IgM antibodies, of which 736 tested negative. Of the 736 dengue IgM negative sera, 666 were tested for Chikungunya IgM antibodies. The demographic profile and essential laboratory investigations were recorded. Chikungunya IgM was detected in 9.91 % of the patients. During the post-monsoon

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2016 Virusdisease

15. Chikungunya and bilateral sacroiliitis–is there a link? (PubMed)

Chikungunya and bilateral sacroiliitis–is there a link? 28293463 2018 11 13 2147-9720 4 1 2017 Mar European journal of rheumatology Eur J Rheumatol Chikungunya and bilateral sacroiliitis-is there a link? 81-82 10.5152/eurjrheum.2015.0071 Nisar Muhammad K MK Department of Rheumatology, Luton and Dunstable University Hospital National Health Service Foundation Trust (NHSFT), Luton, United Kingdom. Packianathan Christabel C Department of Rheumatology, Luton and Dunstable University Hospital

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2016 European journal of rheumatology

16. Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. (PubMed)

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Chikungunya virus--a mosquito-borne alphavirus--is endemic in Africa and south and southeast Asia and has recently emerged in the Caribbean. No drugs or vaccines are available for treatment or prevention. We aimed to assess the safety, tolerability, and immunogenicity of a new candidate vaccine.VRC 311 was a phase 1, dose-escalation, open-label clinical trial of a virus-like (...) particle (VLP) chikungunya virus vaccine, VRC-CHKVLP059-00-VP, in healthy adults aged 18-50 years who were enrolled at the National Institutes of Health Clinical Center (Bethesda, MD, USA). Participants were assigned to sequential dose level groups to receive vaccinations at 10 μg, 20 μg, or 40 μg on weeks 0, 4, and 20, with follow-up for 44 weeks after enrolment. The primary endpoints were safety and tolerability of the vaccine. Secondary endpoints were chikungunya virus-specific immune responses

2014 Lancet

17. Chikungunya at the Door - Déjà Vu All Over Again? (PubMed)

Chikungunya at the Door - Déjà Vu All Over Again? 25029435 2014 09 11 2014 11 20 1533-4406 371 10 2014 Sep 04 The New England journal of medicine N. Engl. J. Med. Chikungunya at the door--déjà vu all over again? 885-7 10.1056/NEJMp1408509 Morens David M DM From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Fauci Anthony S AS eng Historical Article Journal Article 2014 07 16 United States N Engl J Med 0255562 0028-4793 AIM IM Aedes (...) Alphavirus Infections epidemiology history prevention & control Americas epidemiology Animals Chikungunya Fever Chikungunya virus physiology Climate Change history Disease Outbreaks history History, 16th Century History, 18th Century History, 19th Century History, 20th Century History, 21st Century Humans Insect Vectors United States epidemiology 2014 7 17 6 0 2014 7 17 6 0 2014 9 12 6 0 ppublish 25029435 10.1056/NEJMp1408509

2014 NEJM

18. Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006 (PubMed)

Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006 To report the clinical and laboratory findings of adults with serious chikungunya virus acute infection hospitalized in an intensive care unit.Case series study from August 2005 to May 2006.Medical intensive care unit, South Reunion Hospital.We observed 33 episodes of confirmed acute chikungunya virus infection (chikungunya virus-IgM or reverse transcription-polymerase chain (...) reaction positive in the serum) admitted to the intensive care unit.We collected cerebrospinal fluid, serum, and sometimes tissue samples from patients with suspected chikungunya fever in our intensive care unit. These samples underwent viral testing for evidence of acute chikungunya virus infection.Of the 33 patients, 19 (58%) had chikungunya virus specific manifestations, 8 (24%) had associated acute infectious disease and 6 (18%) exacerbations of previous complaints. Among the chikungunya virus

2008 EvidenceUpdates

19. Infection with chikungunya virus in Italy: an outbreak in a temperate region. (PubMed)

Infection with chikungunya virus in Italy: an outbreak in a temperate region. Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy.After reports of a large number of cases of febrile illness of unknown origin in two contiguous villages in northeastern Italy, an outbreak investigation was done to identify the primary source of infection

2007 Lancet