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The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on CAM S or other clinical topics then use Trip today.
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Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children`s Oncology Group Trial AALL0331 Children's Oncology Group (COG) AALL0331 tested whether intensified postinduction therapy that improves survival in children with high-risk B-cell acute lymphoblastic leukemia (ALL) would also improve outcomes for those with standard-risk (SR) ALL.AALL0331 enrolled 5,377 patients between 2005 and 2010. All patients received a 3-drug induction with dexamethasone
Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow`s Milk Formula at Birth: A Randomized Clinical Trial Cow's milk formula (CMF) is used to supplement breastfeeding (BF) at birth without clear clinical evidence to support the practice.To determine whether avoiding supplementation with CMF at birth can decrease risks of sensitization to cow's milk protein and/or clinical food allergy, including cow's milk allergy (CMA), overall and in subgroups
Randomized clinical trial of open suture repair versus totally extraperitoneal repair for treatment of sportsman`s hernia Sportsman's hernia/athletic pubalgia is a recognized cause of chronic groin pain in athletes. Both open and laparoscopic surgical repairs have been described for treatment, but there are no comparative studies. The hypothesis here was that relief of pain would be achieved earlier in patients treated with open minimal suture repair than totally extraperitoneal repair.A
A randomized controlled trial of Dilapan-S vs Foley balloon for preinduction cervical ripening (DILAFOL trial) The objective of the study was to test the hypothesis that Dilapan-S is not inferior to the Foley balloon for preinduction cervical ripening at term.Pregnant women ≥37 weeks scheduled for induction with unfavorable cervix (≤3 cm dilated and ≤60% effaced) were randomly assigned to 12 hours of either Foley balloon inflated with 60 mL saline or Dilapan-S for cervical ripening (...) balloon; 210 to Dilapan-S). In the intent-to-treat analysis, vaginal delivery was more common in Dilapan-S vs Foley balloon (81.3% vs 76.1%), with an absolute difference with respect to the Foley balloon of 5.2% (95% confidence interval, -2.7% to 13.0%) indicating noninferiority for the prespecified margin. The difference was not large enough to show superiority. Noninferiority was confirmed in the per-protocol population (n = 204 in the Foley balloon, n = 188 in Dilapan-S), supporting the robustness
Rituxumab (MabThera) - in combination with glucocorticoids, for the treatment of adult patients with severe, active granulomatosis with polyangiitis (Wegener?s) (GPA) and microscopic polyangiitis (MPA) Published 11 March 2019 Statement of advice SMC2165 rituxumab 100mg, 500mg solution for infusion (MabThera®) Roche Products Ltd 8 February 2019 ADVICE: in the absence of a submission from the holder of the marketing authorisation rituxumab (MabThera®) is not recommended for use within NHSScotland
Metformin?s role in type 1 diabetes: the removal trial Metformin’s Role in Type 1 Diabetes: the REMOVAL Trial – Clinical Correlations Search Metformin’s Role in Type 1 Diabetes: the REMOVAL Trial February 14, 2019 5 min read By William Plowe Peer Reviewed Metformin has been the first-line drug in type 2 diabetes for over a decade, but its possible benefit in type 1 diabetes (DM1) is still a matter of study. The American Diabetes Association lists metformin as an investigational agent that may (...) prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care. 2003;26(10):2871-2875. Wulffelé MG, Kooy A, Lehert P, et al. Combination of insulin and metformin in the treatment of type 2 diabetes. Diabetes Care. 2002;25(12):2133-2140. Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med . 2008;358(24):2545-2559. Patel A, Macmahon S, Chalmers
Core IM: 5 pearls on Barrett?s esophagus Core IM: 5 Pearls on Barrett’s Esophagus – Clinical Correlations Search Core IM: 5 Pearls on Barrett’s Esophagus January 30, 2019 3 min read Podcast: | Subscribe: | By Vishal Shah MD, Milna Rufin MD, Marty Fried MD, Shreya P. Trivedi MD || Illustration by Amy Ou MD || Audio Editing by Harit Shah. Quiz yourself on the 5 Pearls we will be covering: What is Barrett’s esophagus? (4:12) Who do we screen for Barrett’s, and why? (8:41) How do we screen (...) . Fletcher J, Wirz A, Henry E, et al. Studies of acid exposure immediately above the gastro-oesophageal junction: Evidence of short segment reflux. Gut 2004; 53:168-73. Hayeck T.J., Kong C.Y., Spechler S.J., Gazelle G.S., Hur C. The prevalence of Barrett’s esophagus in the US: estimates from a simulation model confirmed by SEER data. Dis Esophagus. 2010;23:451–457. Rastogi A, Puli S, El-Serag HB et al. Incidence of esophageal adenocarcinoma in patients with Barrett’s esophagus and high-grade dysplasia
There?s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 5,000 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care
Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson`s disease: a randomised, double-blind, placebo-controlled phase 3 trial Patients with Parkinson's disease chronically treated with levodopa commonly have delayed or unpredictable onset of its benefits after oral intake. In this study, we assessed the safety and efficacy of CVT-301, a self-administered levodopa oral inhalation powder, for the treatment of patients
Clinical evaluation of education relating to nutrition and skeletal loading in competitive male road cyclists at risk of relative energy deficiency in sports (RED-S): 6-month randomised controlled trial. To clinically evaluate education to improve eating behaviour and skeletal loading exercise in male cyclists at risk of poor bone health and impaired performance due to relative energy deficiency in sports.Early race season, 50 competitive male road cyclists were matched, in pairs, based on Z
Physiotherapy versus physiotherapy plus cognitive training on cognition and quality of life in ParkinsonÂ´s disease: randomized clinical trial. Verify the effectiveness of physiotherapy associated with cognitive training to improve cognition and quality of life in individuals with Parkinson's disease (PD).randomized clinical trial involving 58 individuals with mild to moderate PD, randomly distributed into two groups: motor group (MG) and cognitive-motor group (CMG). Both groups were assessed