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Latest & greatest articles for Benign Prostatic Hyperplasia
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Comparative Effectiveness of Tadalafil versus Tamsulosin in Treating Lower Urinary Tract Symptoms Suggestive of BenignProstateHyperplasia: A Meta-Analysis of Randomized Controlled Trials. BACKGROUND Evidence directly evaluating the efficacy of tadalafil vs. tamsulosin for lower urinary tract symptoms (LUTS) secondary to benignprostatehyperplasia (BPH) is limited. We performed a meta-analysis of published studies to assess the comparative effectiveness of tadalafil vs. tamsulosin in treating (...) included in our analysis. There was no statistically significant difference between tadalafil and tamsulosin in improving the clinical outcomes of total International Prostate Symptom Score (IPSS),voiding subscores, storage subscores, quality of life (QoL) scores, maximum flow rate (Qmax), and postvoid residual urine (PVR), but a statistically significant difference was observed in the International Index of Erectile Function scores (IIEF scores). CONCLUSIONS Tadalafil and tamsulosin have similar
Defining the Efficacy and Safety of Phosphodiesterase Type 5 Inhibitors with Tamsulosin for the Treatment of Lower Urinary Tract Symptoms Secondary to BenignProstaticHyperplasia with or without Erectile Dysfunction: A Network Meta-Analysis. The purpose of this study was to compare the relative safety and efficacy of different types of phosphodiesterase type 5 inhibitors (PDE5-Is) with tamsulosin for the treatment of lower urinary tract symptoms (LUTS) secondary to benignprostatehyperplasia (...) (BPH) (BPH-LUTS) with or without erectile dysfunction (ED).We use the Stata version 13.0 to conduct the network meta-analysis (NMA) with a random effects model of the Bayesian framework. The International Prostate Symptom Score (IPSS), Maximum Urinary Flow Fate (Qmax), International Index of Erectile Function (IIEF), and their credible intervals (CI) were used to compare the efficacy and safety of every medical intervention, including sildenafil plus tamsulosin, tadalafil plus tamsulosin
[Efficacy and safety of Serenoa repens extract combined with Î±-receptor blocker in the treatment of benignprostatichyperplasia]. To evaluate the effect and safety of Serenoa repens extract (SR) combined with α-receptor blocker (αRB) in the treatment of BPH.We included 7 published randomized controlled trials (RCT) studying the effect and safety of SR+αRB versus αRB monotherapy in the treatment of 1 009 BPH patients, and performed a meta-analysis on the data obtained using the RevMan 5.1.3 (...) software.The baseline data from the RCTs were all comparable. Compared with the patients treated by αRB monotherapy, those of the SR+αRB group showed significant decreases in the total IPSS, sub-IPSS in the storage and voiding stages, quality of life score (QOL) and PSA level (all P < 0.05), an increase in the maximum urinary flow rate (Qmax) (P = 0.04), but no statistically significant differences in the prostate volume and postvoid residual urine volume (P > 0.05).Serenoa repens extract combined with α
Model-based meta-analysis of individual International Prostate Symptom Score trajectories in patients with benignprostatichyperplasia with moderate or severe symptoms. International Prostate Symptom Score (IPSS) is a marker of lower urinary tract symptoms (LUTS) deterioration or improvement in benignprostatehyperplasia (BPH). Whereas changes in IPSS relative to baseline have been used as endpoints in clinical trials, little attention has been given to the time course of symptoms
Re: Comparative Efficacy and Safety of New Surgical Treatments for BenignProstaticHyperplasia: Systematic Review and Network Meta-Analysis. 31909657 2020 04 09 2020 04 09 1527-3792 203 4 2020 04 The Journal of urology J. Urol. Re: Comparative Efficacy and Safety of New Surgical Treatments for BenignProstaticHyperplasia: Systematic Review and Network Meta-Analysis. 639-640 10.1097/JU.0000000000000715.02 Kaplan Steven A SA eng Journal Article Comment 2020 01 07 United States J Urol 0376374 (...) 0022-5347 AIM IM BMJ. 2019 Nov 14;367:l5919 31727627 Humans Lower Urinary Tract Symptoms Male Network Meta-Analysis ProstaticHyperplasia surgery Transurethral Resection of Prostate 2020 1 8 6 0 2020 4 10 6 0 2020 1 8 6 0 ppublish 31909657 10.1097/JU.0000000000000715.02
The relationship of embolic particle size to patient outcomes in prostate artery embolisation for benignprostatichyperplasia: a systematic review and meta-regression. To explore the relationship of embolic particle size used in prostate artery embolisation (PAE) to patient outcomes.A systematic review of PubMed, EMBASE, and the Cochrane database was undertaken to identify all existing studies using PAE for benignprostatichyperplasia (BPH). Inclusion criteria included prospective studies (...) reporting baseline and 12-month International Prostate Symptom Score (IPSS) and particle size. Exclusion criteria were overlapping studies, commentaries, abstracts, and letters. Data extraction from eligible studies included the size of embolic particle, particle material, and baseline and 12-month values for the following patient outcomes: IPSS, IPSS quality of life, urinary flow rate (Q-max), prostate volume, prostate specific antigen, and post-void residual volume. A meta-regression analysis
Impact on Sexual Function of Endoscopic Enucleation Versus Transurethral Resection of the Prostate for Lower Urinary Tract Symptoms Due to BenignProstaticHyperplasia: a Systematic Review and Metaâ€‘Analysis. Although the transurethral resection of the prostate (TURP) has been regarded as the gold standard surgical option for lower urinary tract symptoms due to benignprostatichyperplasia, the endoscopic enucleation of the prostate (EEP) with novel techniques is also recommended. However (...) Manager 5.3 to compare the International Index of Erectile Function 5 (IIEF-5) scores and retrograde ejaculation rates from short to long term follow-ups.Ten articles with 1435 patients were included. EEP group showed higher IIEF-5 scores than TURP group with mean difference (MD)=1.00, 95% confidence interval (CI): 0.95-1.05 at 48 months and MD=1.08, 95% CI: 1.03-1.13 at ≥60 months, respectively. In subgroup analysis, the holmium laser enucleation of the prostate showed significantly better IIEF
Dutasteride, tamsulosin, alfuzosin and dutasteride/tamsulosin combination for benignprostatichyperplasia 1 Driving better decision-making in healthcare Dutasteride, tamsulosin, alfuzosin and dutasteride/tamsulosin combination for treating benignprostatichyperplasia Technology Guidance from the MOH Drug Advisory Committee Update published on 1 April 2020 Guidance Recommendations The Ministry of Health’s Drug Advisory Committee has recommended: ? Alfuzosin 10 mg tablet and dutasteride 0.5 mg (...) capsule for treating benignprostatichyperplasia. Subsidy status Alfuzosin 10 mg tablet and dutasteride 0.5 mg capsule are recommended for inclusion on the MOH Standard Drug List (SDL). SDL subsidy does not apply to tamsulosin 0.4 mg tablet or dutasteride 0.5 mg/tamsulosin 0.4 mg capsule. 2 Driving better decision-making in healthcare Factors considered to inform the recommendations for subsidy Technology evaluation 1.1 1.2 1.3 1.4 The MOH Drug Advisory Committee (“the Committee”) considered
[Effect and safety of the Chinese medicine Qianlieshutong Capsules in the treatment of benignprostatichyperplasia: A meta-analysis]. To evaluate the effect and safety of Qianlieshutong Capsules (QC) in the treatment of BPH.We searched 10 Chinese and English databases up to July 2019 for randomized controlled trials (RCT) on treatment of BPH with QC followed by a meta-analysis on the included articles using Cochrane Handbook 5.1.0 and Revman5.3 software.A total of 18 RCTs involving 1 802 cases (...) of BPH were included out of the 175 articles identified. The baseline data from the RCTs were all comparable. Compared with the controls, the patients treated with QC showed a significantly higher rate of clinical effectiveness and better improvement in IPSS as well as in the maximum urinary flow rate (Qmax), postvoid residual urine (PVR) and prostate volume after 3 months of medication. No serious adverse drug events or reactions were reported.The existing data and methodology indicate the efficacy
Prostate artery embolisation for benignprostatichyperplasia: a systematic review and meta-analysis. Prostate artery embolisation (PAE) is a new minimally invasive treatment for lower urinary tract symptoms (LUTS) in men with benignprostatichyperplasia (BPH). The purpose of this study was to review the efficacy and safety of PAE in the treatment of BPH with LUTS.A systematic review performed according to the PRISMA guidelines with a pre-specified search strategy for PubMed, Web of Science (...) , Cochrane Library and Embase databases protocol (PROSPERO ID: CRD42017059196). Trials studying the efficacy of prostate artery embolisation to treat LUTS with more than ten participants and follow-up longer than 6 months were included by two independent authors. Outcomes investigated were International Prostate Symptom Score (IPSS), quality of life (QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual
Holmium laser enucleation of the prostate in benignprostatehyperplasia patients with or without oral antithrombotic drugs: a meta-analysis. The continuous intake of antithrombotic drugs during holmium laser enucleation of the prostate (HoLEP) remains nonconsensual. We aim to pool those controversial evidence and provide practical guidance of oral antithrombotics on HoLEP for benignprostatehyperplasia (BPH).PubMed, Embase and CENTRAL database were systematically searched up to June 2019
Meta-Analysis of Efficacy and Safety of Tadalafil Plus Tamsulosin Compared with Tadalafil Alone in Treating Men with BenignProstaticHyperplasia and Erectile Dysfunction. This meta-analysis was performed to evaluate the efficacy and safety of tadalafil plus tamsulosin compared with tadalafil alone in treating men with benignprostatichyperplasia (BPH) and erectile dysfunction (ED) after 12 weeks' treatment. Systematic review was carried out using the Preferred Reporting Items for Systematic (...) Reviews and Meta-analyses. MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched to collect randomized controlled trials. The references of related articles were also searched. Four articles including 621 patients were involved in the analysis. The study identified that combination-therapy had significant improvements in total international prostate symptom score (IPSS), quality of life (QoL) and maximum urine flow rate (Qmax) compared with monotherapy, and there were no obvious
Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for BenignProstaticHyperplasia. 5-alpha reductase inhibitors (5ARIs) decrease the androgen levels in vivo and are currently used for the treatment of benignprostatichyperplasia (BPH) in men. However, these inhibitors can also increase the risk of gynecomastia, breast tenderness, and breast cancer. Hence, we did a systematic review and meta-analysis to evaluate the rate of breast-related diseases in men treated
"AquabeamÂ® System" for benignprostatichyperplasia and LUTS: birth of a new era. A systematic review of functional and sexual outcome and adverse events of the technique. Aim of this systematic review is to evaluate functional outcomes (Qmax, QoL, IPSS, PVR), sexual outcome (erectile dysfunction and anejaculation rate), and adverse events evaluated according to the Clavien-Dindo classification.The bibliographic search with the included terms (prostate, benignprostatichyperplasia, benign (...) prostatic enlargement, lower urinary tract symptoms, water jet dissection, aquablation, Aquabeam®) produced a literature of 32 articles altogether. After removing papers of not interest or articles which the outcomes could not be deduced, nine studies were examined for a total of 664 patients screened.The functional outcomes, evaluated after water jet dissection, have shown improvement with respect to the baseline in all the selected articles. In the comparison papers with the TURP, the Aquablation has
Association between benignprostatehyperplasia and metabolic syndrome in men under 60 years old: a meta-analysis. 31612766 2020 02 26 1473-2300 47 11 2019 Nov The Journal of international medical research J. Int. Med. Res. Association between benignprostatehyperplasia and metabolic syndrome in men under 60 years old: a meta-analysis. 5389-5399 10.1177/0300060519876823 Wu Shuiqing S Department of Urology, The Second Xiangya Hospital, Central South University, Hunan Province, People's Republic (...) Department of Urology, The Second Xiangya Hospital, Central South University, Hunan Province, People's Republic of China. Zhao Xiaokun X Department of Urology, The Second Xiangya Hospital, Central South University, Hunan Province, People's Republic of China. eng Journal Article 2019 10 15 England J Int Med Res 0346411 0300-0605 IM Benignprostatehyperplasia meta-analysis metabolic syndrome prevalence prostate volume young population 2019 10 16 6 0 2019 10 16 6 0 2019 10 16 6 0 ppublish 31612766 10.1177
Effect of warm bladder irrigation fluid for benignprostatichyperplasia patients on perioperative hypothermia, blood loss and shiver: A meta-analysis. To find out whether warm bladder irrigation fluid can decrease the occurrence of perioperative hypothermia, blood loss and shiver in patients treated with benignprostatichyperplasia (BPH).A comprehensive literature review and meta-analysis that included randomized controlled trials (RCTs) related to temperature of irrigation fluid
Enucleation of the prostate for benignprostatichyperplasia thulium laser versus holmium laser: a systematic review and meta-analysis. To evaluate the clinical efficacy and safety of thulium laser vapoenucleation/enucleation of the prostate (ThuEP) versus holmium laser enucleation of the prostate (HoLEP) in the management of benignprostatichyperplasia (BPH). A systematic literature search was performed using PubMed, Embase, and Web of Science to identify eligible studies published before
Standardization of 532â€‰nm Laser Terminology for Surgery in BenignProstaticHyperplasia: A Systematic Review. Introduction: The use of GreenLight™ laser technology to remove the prostatic transitional zone transurethrally has grown considerably in recent years. This increased utilization has resulted in an increase in the number of terms that are used to describe various laser techniques. Variable terminology complicates literature analysis and publication, which can cause confusion when (...) performing reviews and comparisons of the techniques in the available literature. It has therefore become necessary to simplify and standardize terminology used to describe transurethral prostate debulking procedures using the 532 nm laser to simplify communication on these techniques. Materials and Methods: We conducted a search on September 17, 2019, in the following databases: Ovid MEDLINE®, Ovid EMBASE, and PubMed. Results: Of the 1115 unique records found in our database search, a total of 27
The efficacy and safety of mirabegron on overactive bladder induced by benignprostatichyperplasia in men receiving tamsulosin therapy: A systematic review and meta-analysis. We conducted a meta-analysis to assess the efficacy and safety of mirabegron on overactive bladder (OAB) induced by benignprostatichyperplasia (BPH) in men receiving tamsulosin therapy.We performed the analysis by using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The databases including