Latest & greatest articles for Antibiotics in Pregnancy

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Top results for Antibiotics in Pregnancy

1. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. Full Text available with Trip Pro

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) , 1.14 to 2.19, mainly hypospadias). Erythromycin in the first trimester was associated with an increased risk of any major malformation (27.39 v 17.65 per 1000, 1.50, 1.13 to 1.99). No statistically significant associations were found for other system specific malformations or for neurodevelopmental disorders. Findings were robust to sensitivity analyses.Prescribing macrolide antibiotics during the first trimester of pregnancy was associated with an increased risk of any major malformation

2020 BMJ

2. Antibiotics for treating gonorrhoea in pregnancy. Full Text available with Trip Pro

on antibiotics for treating this infectious condition.To assess the clinical effectiveness and harms of antibiotics for treating gonorrhoea in pregnant women.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2017), LILACS database (1982 to April 5, 2017), the WHO International Clinical Trials Registry Platform (ICTRP; April 5, 2017), ClinicalTrials.gov (April 5, 2017), the ISRCTN Registry (April 5, 2017), and Epistemonikos (April 5, 2017). We also searched reference lists (...) Antibiotics for treating gonorrhoea in pregnancy. Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review

2018 Cochrane

3. Use of antibiotics during pregnancy and risk of spontaneous abortion Full Text available with Trip Pro

Use of antibiotics during pregnancy and risk of spontaneous abortion Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion.We conducted a nested case-control study within the Quebec Pregnancy Cohort (1998-2009). We excluded planned abortions and pregnancies exposed to fetotoxic drugs. Spontaneous abortion was defined (...) as having a diagnosis or procedure related to spontaneous abortion before the 20th week of pregnancy. The index date was defined as the calendar date of the spontaneous abortion. Ten controls per case were randomly selected and matched by gestational age and year of pregnancy. Use of antibiotics was defined by filled prescriptions between the first day of gestation and the index date and was compared with (a) non-exposure and (b) exposure to penicillins or cephalosporins. We studied type of antibiotics

2017 EvidenceUpdates

4. Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women

Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women Prescrire IN ENGLISH - Spotlight ''Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women'', 1 December 2014 {1} {1} {1} | | > > > Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight (...) Antibiotic treatment of uncomplicated pyelonephritis in non-pregnant women The choice of antibiotic treatment for acute uncomplicated pyelonephritis in women should take resistance to antibiotics into account. Acute uncomplicated pyelonephritis is a bacterial kidney infection. It is more frequent in women than in men and is generally caused by the Escherichia coli bacterium. Pyelonephritis is suspected in cases of spontaneous lumbar pain or tenderness during palpation, combined with a high fever

2014 Prescrire

5. Antimicrobials effective for bacterial vaginosis in non-pregnant women

Antimicrobials effective for bacterial vaginosis in non-pregnant women PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Antimicrobials effective for bacterial vaginosis in non-pregnant women Clinical question How effective are antimicrobial agents for bacterial vaginosis (BV) in non-pregnant women? Bottom line Clindamycin cream (NNT* 3), clindamycin ovules and tablets, topical metronidazole (...) immunodeficiency virus. Cochrane Systematic Review Oduyebo OO et al. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Reviews 2009, Issue 3. Article No. CD006055. DOI: 10.1002/14651858.CD006055.pub2. This review contains 24 studies involving 4422 participants PEARLS No. 218, November 2009, written by Brian R McAvoy are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared

2011 Cochrane PEARLS

6. Effect of Antibiotic Exposure on Nugent Score Among Pregnant Women With and Without Bacterial Vaginosis. Full Text available with Trip Pro

Effect of Antibiotic Exposure on Nugent Score Among Pregnant Women With and Without Bacterial Vaginosis. To evaluate whether vaginal flora is altered by antibiotic exposure and associated with a risk of preterm birth, particularly among women with initially normal vaginal flora.This was a secondary analysis of a randomized trial of metronidazole and erythromycin for the prevention of preterm birth among women with a positive fetal fibronectin test. Vaginal swabs for Nugent Gram stain score were (...) collected for classification of bacterial vaginosis before and after antibiotic exposure and read at a central laboratory. Change in Nugent score was assessed for women with (score 7 or higher) or without (score lower than 7) bacterial vaginosis. Linear regression analysis evaluated whether change in Nugent score was associated with preterm birth.Two hundred women without and 69 women with bacterial vaginosis had Gram stain performed before and after antibiotic therapy. Median Nugent score for all women

2011 EvidenceUpdates Controlled trial quality: uncertain

7. Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. Full Text available with Trip Pro

Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. Asymptomatic bacteriuria occurs in 5% to 10% of pregnancies and, if left untreated, can lead to serious complications.To assess which antibiotic is most effective and least harmful as initial treatment for asymptomatic bacteriuria in pregnancy.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (March 2010) and reference lists of retrieved studies.Randomized controlled trials comparing two (...) . Comparing cycloserine with sulphadimidine, no significant differences in symptomatic, persistent, or recurrent infections were noted.We cannot draw any definite conclusion on the most effective and safest antibiotic regimen for the initial treatment of asymptomatic bacteriuria in pregnancy. One study showed advantages with a longer course of nitrofurantoin, and another showed better tolerability with ampicillin compared with pivmecillinam; otherwise, there was no significant difference demonstrated

2010 Cochrane

8. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Full Text available with Trip Pro

Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. The ORACLE I trial compared the use of erythromycin and/or amoxicillin-clavulanate (co-amoxiclav) with that of placebo for women with preterm rupture of the membranes without overt signs of clinical infection, by use of a factorial randomised design. The aim of the present study--the ORACLE Children Study I--was to determine the long-term effects (...) to mothers who received no co-amoxiclav (645 [40.6%] of 1587 vs 604 [38.1%] of 1584; 1.11, 0.96-1.28). Neither antibiotic had a significant effect on the overall level of behavioural difficulties experienced, on specific medical conditions, or on the proportions of children achieving each level in reading, writing, or mathematics at key stage one.The prescription of antibiotics for women with preterm rupture of the membranes seems to have little effect on the health of children at 7 years of age.UK

2008 Lancet

9. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Full Text available with Trip Pro

Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. The ORACLE II trial compared the use of erythromycin and/or amoxicillin-clavulanate (co-amoxiclav) with that of placebo for women in spontaneous preterm labour and intact membranes, without overt signs of clinical infection, by use of a factorial randomised design. The aim of the present study--the ORACLE Children Study II--was to determine the long (...) -term effects on children after exposure to antibiotics in this clinical situation.We assessed children at age 7 years born to the 4221 women who had completed the ORACLE II study and who were eligible for follow-up with a structured parental questionnaire to assess the child's health status. Functional impairment was defined as the presence of any level of functional impairment (severe, moderate, or mild) derived from the mark III Multi-Attribute Health Status classification system. Educational

2008 Lancet

10. Antibiotics for asymptomatic bacteriuria in pregnancy. (Abstract)

the Cochrane Pregnancy and Childbirth Group's Trials Register (January 2007).Randomized trials comparing antibiotic treatment with placebo or no treatment in pregnant women with asymptomatic bacteriuria found on antenatal screening.We assessed trial quality.Fourteen studies were included. Overall the study quality was poor. Antibiotic treatment compared to placebo or no treatment was effective in clearing asymptomatic bacteriuria (risk ratio (RR) 0.25, 95% confidence interval (CI) 0.14 to 0.48 (...) Antibiotics for asymptomatic bacteriuria in pregnancy. Asymptomatic bacteriuria occurs in 2% to 10% of pregnancies and, if not treated, up to 30% of mothers will develop acute pyelonephritis. Asymptomatic bacteriuria has been associated with low birthweight and preterm delivery.To assess the effect of antibiotic treatment for asymptomatic bacteriuria on persistent bacteriuria during pregnancy, the development of pyelonephritis and the risk of low birthweight and preterm delivery.We searched

2007 Cochrane

11. Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: a systematic review

Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

12. Antibiotics for ureaplasma in the vagina in pregnancy. (Abstract)

to eradicate potentially causative agents.The objective of this review is to assess whether antibiotic treatment of pregnant women with ureaplasma in the vagina reduces the incidence of preterm birth and other adverse pregnancy outcomes.We searched the Cochrane Pregnancy and Childbirth Group trials register (April 2003).All randomised controlled trials that compared any antibiotic regimen with placebo or no treatment in pregnant women with ureaplasma detected in the vagina.Three reviewers independently (...) Antibiotics for ureaplasma in the vagina in pregnancy. Preterm birth is a significant obstetric problem in high-income countries. Genital infection including ureaplasmas are suspected of playing a role in preterm birth and preterm rupture of the membranes. Antibiotics are used to treat women with preterm prelabour rupture of the membranes and results in prolongation of pregnancy and lowers the risks of maternal and neonatal infection. However, antibiotics may be beneficial earlier in pregnancy

2004 Cochrane

13. Antibiotics for preventing recurrent urinary tract infection in non-pregnant women. Full Text available with Trip Pro

Antibiotics for preventing recurrent urinary tract infection in non-pregnant women. Urinary tract infection (UTI) is a common health care problem. Recurrent UTI (RUTI) in healthy non-pregnant women is defined as three or more episodes of UTI during a twelve month period. Long-term antibiotics have been proposed as a prevention strategy for RUTI.To determine the efficacy (during and after) and safety of prophylactic antibiotics used to prevent uncomplicated RUTI in adult non-pregnant women.We (...) searched MEDLINE (1966-April 2004), EMBASE (1980-January 2003), Cochrane Central Register of Controlled Trials( in The Cochrane Library Issue 1, 2004) and reference lists of retrieved articlesAny published randomised controlled trial where antibiotics were used as prophylactic therapy in RUTI.Two reviewers independently assessed trial quality and extracted data. Statistical analyses were performed using the random effects model and the results expressed as relative risk (RR) with 95% confidence

2004 Cochrane

14. Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis

Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P CRD summary This review assessed antibiotic treatment for bacterial vaginosis in pregnant women. The authors concluded that the screening of women with a previous pre-term delivery is justified (...) , and that oral antibiotics given for a longer time reduced pre-term delivery. The data for antibiotic treatment of longer duration were derived from only two trials, thus casting some doubt on the reliability of the conclusions. Authors' objectives To assess the effects on pre-term labour of antibiotic treatment for bacterial vaginosis (BV) in pregnant women. Searching MEDLINE (from 1966) EMBASE (from 1988) and the Science Citation Index Expanded (from 1997) were searched in June 2001 for studies published

2003 DARE.

15. Antibiotics for syphilis diagnosed during pregnancy. (Abstract)

Antibiotics for syphilis diagnosed during pregnancy. Congenital syphilis is an increasing problem in many developing countries and in the transitional economies of Eastern Europe and the former Soviet Union. In several countries this increase has been aggravated by HIV/AIDS. While the effectiveness of penicillin in the treatment of syphilis in pregnant women and the prevention of congenital syphilis was established shortly after the introduction of penicillin in the 1940s, there is uncertainty (...) about the optimal treatment regimens.To identify the most effective antibiotic treatment regimen (in terms of dose, length of course and mode of administration) of syphilis with and without concomitant infection with HIV for pregnant women infected with syphilis.MEDLINE 1966 to March 2000; EMBASE 1974 to March 2000, the Cochrane Controlled Trials Register (last searched March 2001), the Cochrane Pregnancy and Childbirth group trials register (last searched March 2001) and the references

2001 Cochrane

16. Antibiotics for asymptomatic bacteriuria in pregnancy. (Abstract)

of pyelonephritis after delivery.I searched the Cochrane Pregnancy and Childbirth Group trials register.Randomised trials comparing antibiotic treatment with placebo or no treatment in pregnant women with asymptomatic bacteriuria found on antenatal screening.Trial quality was assessed.Thirteen studies were included. Overall the study quality was not strong. Antibiotic treatment compared to placebo or no treatment was effective in clearing asymptomatic bacteriuria (odds ratio 0.07, 95% confidence interval 0.05 (...) Antibiotics for asymptomatic bacteriuria in pregnancy. Up to 30% of mothers develop acute pyelonephritis if asymptomatic bacteriuria is untreated. Asymptomatic bacteriuria may have a role in preterm birth, or it may be a marker for low socioeconomic status and thus, low birth weight.The objective of this review was to assess the effect of antibiotic treatment for asymptomatic bacteriuria on persistent bacteriuria during pregnancy, the risk of preterm delivery and the development

2000 Cochrane

17. A decision analysis to guide antibiotic selection for chlamydia infection during pregnancy

A decision analysis to guide antibiotic selection for chlamydia infection during pregnancy A decision analysis to guide antibiotic selection for chlamydia infection during pregnancy A decision analysis to guide antibiotic selection for chlamydia infection during pregnancy Hueston W J, Lenhart J G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treating infection with Chlamydia trachomatis in pregnant women initially with any of 4 antibiotic options (amoxicillin, 500mg 3 times a day for 7 days; erythromycin, 500mg 4 times a day for 7 days; clindamycin hydrochloride, 450mg 4 times a day for 7 days; and azithromycin, a single 1g dose), followed, for non-responders, by 1 of 3 antibiotics not chosen for initial therapy. Type

1997 NHS Economic Evaluation Database.