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1. Sonata system for diagnostic imaging and treatment of symptomatic uterine fibroids

Merck, Gedeon Richter, Ferring and Pharmasure (2001 to 2019). • Mr Stephen D. Quinn, consultant obstetrician and gynaecologist, Imperial College NHS Trust, acted as a non-paid consultant for Gynesonics (2017 to 2019), primary investigator on the OPEN trial (trial funded by Gynesonics). Development of this briefing Development of this briefing This briefing was developed by NICE. The interim process and methods statement for medtech innovation briefings sets out the process NICE uses to select topics

2021 National Institute for Health and Clinical Excellence - Advice

2. Selective internal radiation therapies for treating hepatocellular carcinoma

:// conditions#notice-of-rights). Page 9 of 33• BCLC staging looks at the number and size of tumours in the liver. There are 5 stages: very early stage (BCLC 0), early stage (BCLC A), intermediate stage (BCLC B), advanced stage (BCLC C) and terminal stage (BCLC D). The committee agreed that stages A, B and C align with the scope for this appraisal. • The Child–Pugh score assesses liver function. It has 5 components: serum albumin levels, bilirubin levels, time for blood to clot

2021 National Institute for Health and Clinical Excellence - Technology Appraisals

3. Caesarean birth

and the committee's discussion are in evidence review D: techniques to close the uterus at caesarean birth. Closure of the peritoneum Closure of the peritoneum 1.4.38 Do not suture the visceral or the parietal peritoneum in caesarean birth to reduce operating time and the need for postoperative analgesia, and improve maternal satisfaction. [2004] [2004] Closure of the abdominal wall Closure of the abdominal wall 1.4.39 If a midline abdominal incision is used in caesarean birth, use mass closure with slowly

2021 National Institute for Health and Clinical Excellence - Clinical Guidelines

6. SARS-CoV-2 infection, COVID-19 and timing of elective surgery

. Moonesinghe, 14,15 D. J. Summerton 16,17,18 1 Consultant, Department of Anaesthesia and Peri-operative Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK 2 Honorary Senior Lecturer, King’s College London, London, UK 3 Consultant, Department of Anaesthesia and Intensive Care Medicine, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK 4 Honorary Professor, University of Bristol, Bristol, UK 5 Consultant, Department of Plastic and Reconstructive Surgery, Manor Hospital, Oxford, UK 6 (...) Government. Coronavirus (COVID-19) in the UK. 2021. (accessed 03/02/2021) 3. Nepogodiev D, Omar OM, Glasbey JC, et al. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. British Journal of Surgery 2020; 107: 1440–1449. 4. The Lancet Rheumatology. Too long to wait: the impact of COVID-19 on elective surgery. Lancet Rheumatology 2021; 3: e83. 5. Harwich E, Fetzer M, Rees S

2021 ICM Anaesthesia COVID-19

8. Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain

on social interventions for chronic pain. Full details of the evidence and the committee's discussion are in evidence review D: social interventions for chronic pain (chronic primary pain and chronic secondary pain). Psychotherapy for chronic primary pain Psychotherapy for chronic primary pain What is the clinical and cost effectiveness of psychodynamic psychotherapy for managing chronic primary pain in people aged 16 years and over? For a short explanation of why the committee made the recommendation

2021 National Institute for Health and Clinical Excellence - Clinical Guidelines

9. Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights

and Lung Institute, Imperial College London, London, United Kingdom; and. 8 Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. PMID: 32966755 PMCID: PMC7958516 (available on 2021-09-15 ) DOI: Item in Clipboard Randomized Controlled Trial Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights Jaclyn A Smith et al. Am J Respir Crit Care Med . 2021 . Show details Display options Display options (...) , Manchester, United Kingdom. 5 School of Nursing, Hong Kong Polytechnic University, Hung Hom, Hong Kong. 6 Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom. 7 Division of Airway Disease, Respiratory Pharmacology Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom; and. 8 Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. PMID: 32966755 PMCID

2021 EvidenceUpdates

10. Dialectical Behavior Therapy for Suicidal Self-Harming Youth: Emotion Regulation, Mechanisms, and Mediators

, et al. 2020 Nov 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. StatPearls. 2021 Jan–. PMID: 33351435 Free Books & Documents. Review. Hawton K, Witt KG, Taylor Salisbury TL, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K. Hawton K, et al. Cochrane Database Syst Rev. 2016 May 12;(5):CD012189. doi: 10.1002/14651858.CD012189. Cochrane Database Syst Rev. 2016. PMID: 27168519 Review. Associated data Actions Related

2021 EvidenceUpdates

11. Efficacy of Adjuvant Application of Platelet-Rich Plasma After Needle Aspiration of Calcific Deposits for the Treatment of Rotator Cuff Calcific Tendinitis: A Double-Blinded, Randomized Controlled Trial With 2-Year Follow-up

Witte PB, Selten JW, Navas A, Nagels J, Visser CP, Nelissen RG, Reijnierse M. de Witte PB, et al. Am J Sports Med. 2013 Jul;41(7):1665-73. doi: 10.1177/0363546513487066. Epub 2013 May 21. Am J Sports Med. 2013. PMID: 23696211 Clinical Trial. Page MJ, Green S, Mrocki MA, Surace SJ, Deitch J, McBain B, Lyttle N, Buchbinder R. Page MJ, et al. Cochrane Database Syst Rev. 2016 Jun 10;(6):CD012225. doi: 10.1002/14651858.CD012225. Cochrane Database Syst Rev. 2016. PMID: 27283591 Review. Zhao D, Han YH, Pan (...) JK, Yang WY, Zeng LF, Liang GH, Liu J. Zhao D, et al. J Shoulder Elbow Surg. 2021 Apr;30(4):918-928. doi: 10.1016/j.jse.2020.10.014. Epub 2020 Nov 19. J Shoulder Elbow Surg. 2021. PMID: 33220417 Review. Associated data Actions Related information LinkOut - more resources Full Text Sources Medical Research Materials Full text links [x] [x] Cite Copy Download .nbib Format: Send To [x] NCBI Literature Resources Follow NCBI National Library of Medicine

2021 EvidenceUpdates

12. Astodrimer gel for treatment of bacterial vaginosis: A systematic review and meta-analysis of randomized controlled trials Full Text available with Trip Pro

SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med. 1995;333(26):1737-1742. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C, Pearson J. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ. 1994;308(6924):295-298. Sewankambo N, Gray RH, Wawer MJ, et al. HIV-1 infection associated

2021 EvidenceUpdates

13. Effect of prehospital workflow optimization on treatment delays and clinical outcomes in acute ischemic stroke: A systematic review and meta-analysis

; prehospital workflow; reperfusion therapy; system optimization; thrombectomy; thrombolysis; treatment delay; workflows. © 2021 by the Society for Academic Emergency Medicine. Similar articles Huang Q, Zhang JZ, Xu WD, Wu J. Huang Q, et al. Medicine (Baltimore). 2018 Jun;97(25):e11205. doi: 10.1097/MD.0000000000011205. Medicine (Baltimore). 2018. PMID: 29924046 Free PMC article. Vidale S, Romoli M, Consoli D, Agostoni EC. Vidale S, et al. Cerebrovasc Dis. 2020;49(2):223-232. doi: 10.1159/000507844. Epub (...) 2020 Apr 24. Cerebrovasc Dis. 2020. PMID: 32335550 Zhao H, Coote S, Easton D, Langenberg F, Stephenson M, Smith K, Bernard S, Cadilhac DA, Kim J, Bladin CF, Churilov L, Crompton DE, Dewey HM, Sanders LM, Wijeratne T, Cloud G, Brooks DM, Asadi H, Thijs V, Chandra RV, Ma H, Desmond PM, Dowling RJ, Mitchell PJ, Yassi N, Yan B, Campbell BCV, Parsons MW, Donnan GA, Davis SM. Zhao H, et al. Stroke. 2020 Mar;51(3):922-930. doi: 10.1161/STROKEAHA.119.027843. Epub 2020 Feb 12. Stroke. 2020. PMID: 32078483

2021 EvidenceUpdates

14. A Systematic Review of Clinical Practice Guidelines for Physical Therapist Management of Patellofemoral Pain

The Author(s) 2021. Published by Oxford University Press on behalf of the American Physical Therapy Association. All rights reserved. For permissions, please email: Similar articles Collins NJ, Barton CJ, van Middelkoop M, Callaghan MJ, Rathleff MS, Vicenzino BT, Davis IS, Powers CM, Macri EM, Hart HF, de Oliveira Silva D, Crossley KM. Collins NJ, et al. Br J Sports Med. 2018 Sep;52(18):1170-1178. doi: 10.1136/bjsports-2018-099397. Epub 2018 Jun 20. Br J Sports Med. 2018 (...) . PMID: 29925502 Connell G, To D, Ashraf M, Verville L. Connell G, et al. J Can Chiropr Assoc. 2020 Dec;64(3):180-186. J Can Chiropr Assoc. 2020. PMID: 33487639 Free PMC article. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P. Zhang W, et al. Osteoarthritis Cartilage. 2007 Sep;15(9):981-1000. doi: 10.1016/j.joca.2007.06.014. Epub 2007 Aug 27. Osteoarthritis Cartilage

2021 EvidenceUpdates

15. The effectiveness of blood-flow restricted resistance training in the musculoskeletal rehabilitation of patients with lower limb disorders: A systematic review and meta-analysis

, muscle volume and pain in musculoskeletal rehabilitation that are comparable to conventional RT. This appears to be independent of strength testing in open or closed kinetic chains. Keywords: Resistance exercise; blood-flow restriction; exercise therapy; meta-analysis; open kinetic chain. Similar articles Hughes L, Rosenblatt B, Haddad F, Gissane C, McCarthy D, Clarke T, Ferris G, Dawes J, Paton B, Patterson SD. Hughes L, et al. Sports Med. 2019 Nov;49(11):1787-1805. doi: 10.1007/s40279-019-01137-2 (...) . Sports Med. 2019. PMID: 31301034 Clinical Trial. Ladlow P, Coppack RJ, Dharm-Datta S, Conway D, Sellon E, Patterson SD, Bennett AN. Ladlow P, et al. Front Physiol. 2018 Sep 10;9:1269. doi: 10.3389/fphys.2018.01269. eCollection 2018. Front Physiol. 2018. PMID: 30246795 Free PMC article. Hughes L, Paton B, Rosenblatt B, Gissane C, Patterson SD. Hughes L, et al. Br J Sports Med. 2017 Jul;51(13):1003-1011. doi: 10.1136/bjsports-2016-097071. Epub 2017 Mar 4. Br J Sports Med. 2017. PMID: 28259850 Review

2021 EvidenceUpdates

16. Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial Full Text available with Trip Pro

stratified by baseline SARS-CoV-2 oropharyngeal virus CT value, CT value ≥ 30 (dashed) and CT value < 30 (solid), and treatment arm, Lambda (blue) vs. placebo (red). In both panels, solid lines represent Kaplan–Meier survival probability; shading represents 95% confidence intervals. Source data available at . Similar articles Feld JJ, Kandel C, Biondi MJ, Kozak RA, Zahoor MA, Lemieux C, Borgia SM, Boggild AK, Powis J, McCready J, Tan DHS, Chan T, Coburn B, Kumar D (...) , Humar A, Chan A, O'Neil B, Noureldin S, Booth J, Hong R, Smookler D, Aleyadeh W, Patel A, Barber B, Casey J, Hiebert R, Mistry H, Choong I, Hislop C, Santer DM, Lorne Tyrrell D, Glenn JS, Gehring AJ, Janssen HLA, Hansen BE. Feld JJ, et al. Lancet Respir Med. 2021 Feb 5:S2213-2600(20)30566-X. doi: 10.1016/S2213-2600(20)30566-X. Online ahead of print. Lancet Respir Med. 2021. PMID: 33556319 Free PMC article. Brown LK, Freemantle N, Breuer J, Dehbi HM, Chowdhury K, Jones G, Ikeji F, Ndoutoumou

2021 EvidenceUpdates

17. Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial Full Text available with Trip Pro

Exploratory outcomes (A) Kaplan-Meier curves for clinical improvement up to day 28. (B) Proportion of patients in each category of the ordinal scale during follow-up at 28 days. (C) Kaplan-Meier curves for survival up to day 60. (D) PaO 2 to FiO 2 ratio at baseline and at day 3. The yellow diamond represents the mean, and the red circle represents the median. The first, second, third, and fourth quartiles are blue shaded. At day 3, PaO 2 to FiO 2 ratios were available for 20 of 21 patients who received

2021 EvidenceUpdates

18. Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

Clinical Trial. Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, Iwata H, Masuda N, Otero MT, Gokmen E, Loi S, Guo Z, Zhao J, Aktan G, Karantza V, Schmid P; KEYNOTE-355 Investigators. Cortes J, et al. Lancet. 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9. Lancet. 2020. PMID: 33278935 Clinical Trial. Bellmunt J, Hussain M, Gschwend JE, Albers P, Oudard S, Castellano D, Daneshmand S, Nishiyama H, Majchrowicz M, Degaonkar V, Shi (...) Y, Mariathasan S, Grivas P, Drakaki A, O'Donnell PH, Rosenberg JE, Geynisman DM, Petrylak DP, Hoffman-Censits J, Bedke J, Kalebasty AR, Zakharia Y, van der Heijden MS, Sternberg CN, Davarpanah NN, Powles T; IMvigor010 Study Group. Bellmunt J, et al. Lancet Oncol. 2021 Apr;22(4):525-537. doi: 10.1016/S1470-2045(21)00004-8. Epub 2021 Mar 12. Lancet Oncol. 2021. PMID: 33721560 Clinical Trial. Powles T, van der Heijden MS, Castellano D, Galsky MD, Loriot Y, Petrylak DP, Ogawa O, Park SH, Lee JL, De

2021 EvidenceUpdates

19. A Systematic Review and Meta-Analysis of Cognitive Performance among People with Chronic Use of Opioids for Chronic Non-Cancer Pain

by Oxford University Press on behalf of the American Academy of Pain Medicine. Similar articles Noori A, Busse JW, Sadeghirad B, Siemieniuk RA, Wang L, Couban R, Juurlink DN, Thabane L, Guyatt GH. Noori A, et al. Medicine (Baltimore). 2019 Oct;98(43):e17647. doi: 10.1097/MD.0000000000017647. Medicine (Baltimore). 2019. PMID: 31651885 Free PMC article. Els C, Jackson TD, Kunyk D, Lappi VG, Sonnenberg B, Hagtvedt R, Sharma S, Kolahdooz F, Straube S. Els C, et al. Cochrane Database Syst Rev. 2017 Oct 30;10

2021 EvidenceUpdates

20. Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis Full Text available with Trip Pro

: systematic review of qualitative research. BMJ. 2012;345 - - Gascón JJ, Sánchez-Ortuño M, Llor B, Skidmore D, Saturno PJ. Why hypertensive patients do not comply with the treatment: results from a qualitative study. Fam Pract. 2004;21:125–130. - Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol. 2010;11:627–636. - - Shin D, Lee ES, Kim J, Guerra L, Naik D, Prida X. Association between the use

2021 EvidenceUpdates

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