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121. SARS-CoV-2 and the Role of Orofecal Transmission: Systematic Review

In: Analysis of the Transmission Dynamics of COVID-19: An Open Evidence Review. Background Understanding how, when and in what types of settings SARS-CoV-2 spreads between people is critical to developing effective public health and infection prevention measures to break chains of transmission. ? 1 ? Current evidence suggests SARS-CoV-2 is primarily transmitted via respiratory droplets and aerosols; and can occur between pre-symptomatic or symptomatic infected individuals to others in close contact. SARS (...) preprints conducted between November 1, 2019, and March 30, 2020 assessed as moderate quality) including 4,805 patients. ? w31 ? The review reported that approximately 12% of patients with SARS-CoV-2 had gastrointestinal symptoms, including diarrhoea, nausea, and vomiting. Eight studies reported the detection of viral RNA of SARS-CoV-2 in stool of patients confirmed by nasopharyngeal swab testing or respiratory secretion analysis for PCR to have Covid-19: pooled analysis reported RNA shedding in stool

2020 CEBM Covid-19 Open Evidence Reviews

122. Viral cultures for COVID-19 infectivity assessment. Systematic review

and associated synonyms up to 31st August 2020. We carried out citation matching and included studies reporting attempts to culture or observe SARS-CoV-2 matching the with cutoffs for RT-PCR positivity. One reviewer extracted data for each study and a second reviewer checked end edited the extraction and summarised the narratively by sample: fecal, respiratory, environment or mixed. Where necessary we wrote to corresponding authors of the included or background papers for additional information. We assessed

2020 CEBM Covid-19 Open Evidence Reviews

123. Diagnosis and management of sepsis in the paediatric patient

: recognition of changes in clinical condition and vital signs, such as fever, tachycardia, and changes in peripheral perfusion, which should raise concern for sepsis; initial stabilization of airway, breathing, and circulation; timely administration of empiric antimicrobial therapy; use of fluid boluses and vasoactive medications; and specific considerations in patients with underlying medical conditions, such as the use of corticosteroids for possible adrenal insufficiency due to hypothalamic-adrenal

2020 Canadian Paediatric Society

124. The Management of adult patients with severe chronic small intestinal dysmotility

– Infant colic (developmental) ? Autoimmune – Antineuronal antibodies – Ganglionosis ? Infective – Chagas' disease, – Herpes viruses (eg, EBV, CMV, VZV) or – Polyoma viruses (JC virus) Secondary (extrinsic) ? Generalised neurological disorders – Brainstem lesions – Spinal cord injury – Multiple sclerosis – Parkinson’s disease – Neurological effects of diabetes mellitus – Autonomic system degeneration ? Paraneoplastic syndromes (often with antineuronal antibodies (especially anti Hu)) – Small cell lung (...) ileal obstruc- tion. 76 Myotonic dystrophy, multiple sclerosis, Parkinson’s disease and porphyria may all be associated with an enteric neuropathy. Paraneoplastic Small cell lung cancer, carcinoid tumours, neuroblastoma and thymoma with anti- neuronal nuclear antibodies have all been described to cause an enteral neuropathy. There is often a dense inflammatory infiltrate of lymphocytes and plasma cells affecting both plexuses but mainly the myenteric (myenteric ganglion- itis). Anti- Hu neuronal

2020 British Society of Gastroenterology

125. The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management

to determine whether the patient is experiencing or is at risk for developing alcohol withdrawal. For this assessment, it may be helpful to: Use a scale that screens for unhealthy alcohol use (e.g., Alcohol Use Disorders Identification Test-Piccinelli Con- sumption [AUDIT-PC]) Use information from collateral sources (i.e., family and friends) Conduct a laboratory test that provides some measure of hepatic function RecommendationI.4: A biological test (blood, breath, or urine) for alcohol use may

2020 Publication 4891078

127. Critical Care Drug Recommendations for COVID-19 During Times of Drug Shortages

be utilized with caution due to issues with scavenging, excessive inhalational agent consumption, moisture buildup, and limited data on their use in Adult Respiratory Distress Syndrome (ARDS) in general and COVID-19 in particular. Use of these agents mandates the continuous presence of a trained anesthesia professional on a 24/7 basis in order to facilitate their use. Use best clinical judgment if more than one adjunct from each category is felt to be necessary. Propofol Conservation Model 1. Propofol (...) to the length of time to onset (0.5 – 1hr) and the high variability in time to peak (1-7 hr.) IV < 10 min for onset, respiratory depression even from a large IV dose is expected to be resolved in 30-45 minutes secondary to redistribution. Recommend monitoring QTc in the same fashion as antipsychotics especially if both are used together. Inhalational Anesthetics- Inhalational anesthetics may potentially be used for sedation when there is a continuous presence and availability of trained member

2020 American Society of Anesthesiologists

128. AORN, ASA, and APSF Clarification of Powered Air-Purifying Respirator (PAPR) Use in the Operating Room and Other Procedural Areas in Which Sterile Fields are Present

Procedural Areas in Which Sterile Fields are Present Clarification of PAPR use in the Operating Room: When an N95 cannot be properly fit tested for use by healthcare personnel in the operating rooms and other invasive procedure areas or an N95 is not available for urgent/emergent procedures, we recommend that an interdisciplinary team including infection control, nursing, surgery and anesthesia personnel determine how PAPRs may be most safely used for respiratory protection in the perioperative

2020 American Society of Anesthesiologists

129. Benralizumab, mepolizumab and omalizumab for treating severe asthma

from baseline in forced expiratory volume in 1 second (FEV 1), Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ) scores were not clinically significant for both benralizumab and mepolizumab compared with placebo. Mepolizumab was associated with an improvement in St George’s Respiratory Questionnaire (SGRQ; quality of life) scores when compared to placebo. SGRQ results were not available for benralizumab. Biologic vs biologic (benralizumab vs mepolizumab (...) Benralizumab, mepolizumab and omalizumab for treating severe asthma 1 Driving better decision-making in healthcare Benralizumab, mepolizumab and omalizumab for treating severe asthma Technology Guidance from the MOH Drug Advisory Committee Published on 1 September 2020 Guidance recommendations The Ministry of Health’s Drug Advisory Committee has not recommended listing: • Benralizumab and mepolizumab on the Medication Assistance Fund (MAF) for treating severe eosinophilic asthma

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

130. Use of powered air-purifying respirator (PAPR) by healthcare workers for preventing highly infectious viral diseases-a systematic review of evidence Full Text available with Trip Pro

severe acute respiratory syndrome coronaviruses, SARS-CoV-1 and SARS-CoV-2, Middle Eastern Respiratory Syndrome (MERS), and Ebola. With the current (SARS-CoV-2) global pandemic, it is critical to delineate appropriate contextual respiratory protection for HCWs. The aim of this systematic review was to evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination. Methods: Our primary (...) simulation trial reported a lower level of cross-contamination of participants using PAPR compared to alternative respiratory protection. There is moderate quality evidence that PAPR use is associated with greater heat tolerance but lower scores for mobility and communication ability. We identified a trend towards greater self-reported wearer comfort with PAPR technology in low-quality observational simulation studies. Conclusion: Field observational studies do not indicate a difference in healthcare

2020 EvidenceUpdates

131. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Full Text available with Trip Pro

, Affiliations Expand Collaborators CHEST Expert Cough Panel : , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Affiliations 1 Pharmacy Practice Department, Creighton University, Omaha, NE. Electronic address: MarkMalesker@creighton.edu. 2 Adamstown, MD. 3 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA. 4 TheEvidenceDoc, Pacific, MO. PMID: 32105719 DOI: Item in Clipboard Practice Guideline (...) Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: . Get the latest research from

2020 EvidenceUpdates

132. Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events

Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging (...) . Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: ans1023@gmail.com. PMID: 32738469 DOI: Item in Clipboard

2020 EvidenceUpdates

133. Should We Reintroduce Previous Venous Thromboembolism Into Decision-Making for Anticoagulation in Atrial Fibrillation?

; Unit for Clinical Biostatistics, Aalborg University Hospital, Denmark. 3 Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark; Department of Cardiology, Aalborg University Hospital, Denmark. 4 Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, UK. PMID: 32634387 DOI (...) Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, UK. PMID: 32634387 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Background: We aimed to investigate whether history of venous thromboembolism should be considered a prognostic factor for future thromboembolic events in patients with atrial fibrillation

2020 EvidenceUpdates

134. Safety and tolerability of nintedanib in patients with systemic sclerosis-associated interstitial lung disease: data from the SENSCIS trial Full Text available with Trip Pro

, London, UK. 4 Keck School of Medicine, University of Southern California, Los Angeles, California, USA. 5 Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA. 6 University of Texas Houston Medical School, Houston, Texas, USA. 7 Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. 8 Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 9 Interstitial and Rare Lung Disease Unit, Department (...) College London, London, UK. 3 National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK. 4 Keck School of Medicine, University of Southern California, Los Angeles, California, USA. 5 Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA. 6 University of Texas Houston Medical School, Houston, Texas, USA. 7 Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. 8 Division of Rheumatology, Johns

2020 EvidenceUpdates

135. Low-Dose Chest CT for the Diagnosis of COVID-19 Full Text available with Trip Pro

Low-Dose Chest CT for the Diagnosis of COVID-19 Low-Dose Chest CT for the Diagnosis of COVID-19 - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: . Get the latest research from NIH: . Find NCBI SARS-CoV-2 literature, sequence (...) for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Dtsch Arztebl Int Actions . 2020 Jun 1;117(22-23):389-395. doi: 10.3238/arztebl.2020.0389. Low-Dose Chest CT for the Diagnosis of COVID-19 , , , , , , , , , , , , , , Affiliations Expand Affiliation 1 RWTH Aachen University Hospital: Department of Diagnostic

2020 EvidenceUpdates

136. COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission Full Text available with Trip Pro

and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission , , , Affiliations Expand Affiliations 1 The University of Melbourne, Melbourne, Victoria, Australia. 2 Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia. 3 Multiple Pregnancy Clinic, The Royal Women's Hospital, Melbourne, Victoria, Australia. 4 Department of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. PMID (...) Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia. 3 Multiple Pregnancy Clinic, The Royal Women's Hospital, Melbourne, Victoria, Australia. 4 Department of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. PMID: 32779193 PMCID: DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Background: Since its emergence in December 2019, COVID-19 has spread to over 210 countries

2020 EvidenceUpdates

137. Use of inhibitors of the renin-angiotensin system in hypertensive patients and COVID-19 severity: A systematic review and meta-analysis Full Text available with Trip Pro

J Cardiol Heart Vasc. 2020. PMID: 32875060 Free PMC article. Jiang YM, Song TR, Qiu Y, Liu JP, Wang XD, Huang ZL, Lin T. Jiang YM, et al. Kaohsiung J Med Sci. 2018 Jan;34(1):1-13. doi: 10.1016/j.kjms.2017.07.007. Epub 2017 Aug 18. Kaohsiung J Med Sci. 2018. PMID: 29310811 Review. Show more similar articles References WHO Coronavirus Disease (COVID‐19) . Dashboard [Internet]. . [Cited 2020 Jun 6] Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome

2020 EvidenceUpdates

138. The Efficacy and Safety of Opioids in Total Joint Arthroplasty: A Direct Meta-Analysis

. Tramadol reduces postoperative opioid consumption but increases the risk of postoperative nausea, vomiting, dry mouth, and dizziness. Conclusion: Moderate evidence supports the use of opioids in TJA to reduce postoperative pain and opioid consumption. Opioids should be used cautiously as they may increase the risk of complications, such as respiratory depression and sedation, especially if combined with other central nervous system depressants or used in the elderly. Keywords: opioids; pain management

2020 EvidenceUpdates

139. Nasogastric Decompression vs No Decompression After Pancreaticoduodenectomy: The Randomized Clinical IPOD Trial

randomized to no NGTD (n = 52) or to NGTD (n = 59). No patient was lost to follow-up. The 2 groups had similar patient demographic and clinical characteristics at baseline. The median (interquartile range) age was 63.0 (57.0-66.5) years in the group with NGTD (38 [64.4%] were males) and 64.0 (58.0-68.0) years in the group without NGTD (31 [59.6%] were males). The postoperative complication rates grade II or higher were similar between the 2 groups (risk ratio, 0.99; 95% CI, 0.66-1.47; P > .99). Pulmonary

2020 EvidenceUpdates

140. Comparison of catheter and surgical ablation of atrial fibrillation: A systemic review and meta-analysis of randomized trials

: ( ) Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation J Thorac Cardiovasc Surg Actions . 2020 May 18;S0022-5223(20)31143-0. doi: 10.1016/j.jtcvs.2020.04.154. Online (...) of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China. Electronic address: chengxunjmu@163.com. PMID: 32653280 DOI: Item in Clipboard Comparison of catheter and surgical ablation of atrial fibrillation: A systemic review and meta-analysis of randomized trials Haobin Huang et al. J Thorac Cardiovasc Surg . 2020 . Show details Display options Display options Format J

2020 EvidenceUpdates

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