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61. FebriDx for C-reactive protein and myxovirus resistance protein A testing

. The test is done at the point of care and gives results in 10 minutes. • The innovative aspects innovative aspects are that the FebriDx test measures MxA, a marker for viral infection, as well as CRP . This helps clinicians to differentiate between bacterial and viral respiratory tract infections. • The intended place in therapy place in therapy would be in primary or secondary care, to help guide the appropriate use of antibiotics for people with acute febrile respiratory tract infections. It could (...) measurement of MxA and CRP in people with acute febrile respiratory infections is designed to help differentiate between viral and bacterial infections. This can then guide appropriate use of antibiotics. T ests that improve clinical decision making in antibiotic prescription at the point of care could support antimicrobial stewardship. FebriDx is a self-contained, portable, all-in-one test device, which both collects and analyses the blood sample. It consists of a single strip test card, a buffer

2020 National Institute for Health and Clinical Excellence - Advice

62. Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Serologic Testing

Sultan**, Yngve Falck-Ytter**, Valéry Lavergne**, Rebecca L. Morgan**, M. Hassan Murad**, Adarsh Bhimraj, Reem A. Mustafa** * Corresponding Author ** Methodologist Abstract Background: The availability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic testing has rapidly increased. Current assays use a variety of technologies, measure different classes of immunoglobulin or immunoglobulin combinations and detect antibodies directed against different portions of the virus (...) supporting the use of serology for either diagnosis or epidemiology was, however, graded as very low to moderate. Keywords: coronavirus, SARS-CoV-2, COVID, COVID-19, pneumonia, diagnosis, diagnostics, serology, sensitivity, specificity Executive Summary and Background Executive Summary Serologic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now widely available. Unlike nucleic acid amplification tests (NAAT) which detect viral RNA, antibody-based assays measure the host’s

2020 Infectious Diseases Society of America

63. Assessing whether COVID-19 patients will benefit from critical care, and an objective approach to capacity challenges during a pandemic: An Intensive Care Society clinical guideline Full Text available with Trip Pro

, University of Birmingham, Birmingham, UK by this author for this author , 3 National Heart & Lung Institute, Imperial College London, London, UK by this author for this author , 4 Nottingham University Hospitals, Nottingham, UK by this author for this author , 4 Nottingham University Hospitals, Nottingham, UK by this author for this author , 5 London North West University Hospitals, London, UK by this author for this author ... First Published August 17, 2020 Research Article Article Information Article (...) : August 17, 2020 1 , 2 , 3 , 4 , 4 , 5 1 UCL Laws, University College London, London, UK 2 Institute of Clinical Sciences, University of Birmingham, Birmingham, UK 3 National Heart & Lung Institute, Imperial College London, London, UK 4 Nottingham University Hospitals, Nottingham, UK 5 London North West University Hospitals, London, UK Corresponding Author: G Suntharalingam, Intensive Care Society, Churchill House, Red Lion Square, London WC1R 4SG, UK. Email: Abstract This national professional

2020 ICM Anaesthesia COVID-19

64. COVID-19: Guidance for the remobilisation of services within health and care settings

Precautions (SICPs): all pathways or settings 15 5.1 Personal Protective Equipment (PPE) 15 6. Aerosol Generating Procedures: procedures that create a higher risk of respiratory infection transmission 19 7. Low Risk Pathway: Key principles 21 7.1 Maintaining physical distancing 21 7.2 Personal protective equipment** 22 7.3 Safe management of environment/equipment and blood/body fluids 22 7.4 Aerosol Generating Procedures (AGPs): procedures that create a higher risk of respiratory infection transmission 23 (...) 7.5 Visitor guidance 23 7.6 Discharge or transfer 23 8. Transmission Based Precautions (TBPs) 25 9. Medium Risk Pathway: Key principles 26 9.1 Maintaining physical distancing and patient placement 26 9.2 Personal protective equipment 27 9.3 Safe management of care environment/equipment/blood and body fluids 27 9.4 Aerosol Generating Procedures (AGPs): procedures that create a higher risk of respiratory infection transmission 29 9.5 Duration of transmission based precautions 29 9.6 Visitor guidance

2020 ICM Anaesthesia COVID-19

65. An introduction to SARS-CoV-2 Full Text available with Trip Pro

, transmission via smaller droplets or respiratory aerosols (< 5 µm diameter) produced by speaking, singing, shouting, or heavy breathing is considered to be an important route of transmission, with some experts calling for greater awareness of airborne precautions for some activities and in some settings. 37-43 Small respiratory droplets can remain in the air longer than large droplets and could present both a risk of exposure in close contact with an infected individual, and potentially over longer (...) . 76,77 It is not clear what level of infectious virus is shed during the pre-symptomatic phase, or via asymptomatic spreaders, given that a primary route of transmission (large respiratory droplets) is limited by the absence of coughing and sneezing. 72 Other routes of transmission, such as via smaller respiratory droplets released during breathing, speaking, laughing or singing, may be more important for pre-symptomatic or asymptomatic transmission. 78 He et al. (2020) 79 estimated that infected

2020 National Collaborating Centre for Environmental Health

67. Covid-19: Evidence Summary for face masks in the community

is the summary of all relevant studies from 1 January 2000 until 24 June 2020. Background The use of face masks is one of a suite of infection prevention and control measures intended to limit the transmission of respiratory viral diseases. (1) Respiratory viruses can be spread through droplets and or aerosols. Direct droplet transmission refers to virus transfer from an infected person to a susceptible individual through droplets generated during coughing, sneezing, breathing or talking. Aerosol (...) of face masks by persons going out in public has been recommended by an increasing number of countries. In Ireland, cloth face coverings are recommended in situations where physical distancing may not be possible, and are mandatory on public transport and in shops and other retail outlets. ? Nineteen studies that provide direct evidence on the effectiveness of face mask use in community settings to reduce transmission of respiratory viruses were identified. ? Four studies were conducted in the context

2020 Health Information and Quality Authority

68. Evidence summary for spread of COVID-19 by children

. Using this approach (assuming asymptomatic children as the index case), 21% (6/28) of family clusters would have a paediatric index case. (19) A case series describing the dynamics of infection in the families of 39 children ( 10 years: 15 (20.3%) Gender: Male n = 44 (59.5%), female n = 30 (40.5%) Clinical characteristics: Presentation: Cough n=24 (32.4%); fever n=20 (27%); fatigue n=5 (6.8%); chest congestion n=4 (5.4%); anorexia n=3 (4%); diarrhoea (n=3 (4%); dyspnoea n=2 (2.7%); headache n=2 (2.7 (...) %), expectoration, n= 2 (2.7%) Severity of infection: severe pneumonia n=1; mild pneumonia n= 29; acute upper respiratory tract infection n= 24; asymptomatic infection n= 20 RNA positive after symptom onset: Median 2 days (range, 1-6) Confirmed transmission Transmission from infected child to contacts: N=0 Mean time to transmission/symptoms onset Not applicable Evidence summary of potential for children to contribute to transmission of SARS-CoV-2 Health Information and Quality Authority Page 28 of 38 RNA

2020 Health Information and Quality Authority

69. Evidence summary for accuracy of molecular and antigen detection tests for the diagnosis of COVID-19 using alternative clinical specimens or sites

for the diagnosis of COVID-19 using alternative clinical specimens or sites compared with RT-PCR tested nasopharyngeal (with or without oropharyngeal) or lower respiratory tract clinical samples? Background The accurate and timely detection of SARS-CoV-2 facilitates public health surveillance, response and control measures during the COVID-19 pandemic. The current standard of care in Ireland for the detection of SARS-CoV-2 (the virus that causes COVID-19) involves testing of clinician-collected combined (...) Health Information and Quality Authority Page 5 of 44 sputum, faecal matter, urine, blood, ocular, and blood. (4) The clinical sample sites were noted to be inconsistent in their detection of viral material for SARS-CoV-2, with discordance highlighted between clinical samples. Current guidance from the Health Protection Surveillance Centre (HSPC), (5) the World Health Organizatin (WHO), (1) and the UK National Health Service (NHS) (6) endorse the collection of upper respiratory specimens through

2020 Health Information and Quality Authority

70. Protective measures against COVID-19 for service providers

-19) outbreak has affected the entire world since the end of 2019. According to the World Health Organisation, “People of all ages can be infected by the new coronavirus (2019-nCoV). Older people, and people with pre-existing medical conditions (such as asthma, diabetes, heart disease) appear to be more vulnerable to becoming severely ill with the virus. ” Information for service providers conducting home visits Service providers should take appropriate measures to remain healthy and protect

2020 Home Modification Information Clearinghouse

71. Quality Indicators for the Care and Outcomes of Adults with Atrial Fibrillation: Task Force for the Development of Quality Indicators in Atrial Fibrillation of the European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)

Hospital, Jacksonville, FL, USA; 9 Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 10 Centre for Heart Rhythm Disorders, The University of Adelaide and Department of Cardiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 11 Cardiovascular Department, San Gerardo Hospital, ASST-Monza, Monza, Italy; 12 (...) Research Programme ESC European Society of Cardiology INR international normalized ratio LV left ventricle LVEF left ventricular ejection fraction PRISMA Preferred Reporting Items for Systematic Review and Meta-Analyses PROMs patient-reported outcome measures PVs pulmonary veins QI quality indicator QoL quality of life RCT randomized controlled trial Introduction Atrial fibrillation (AF) is a key public health challenge and a major source of morbidity, mortality, and economic burden for govern- ments

2020 Heart Rhythm Society

72. Covid-19: Public health guidance on identification and management of symptoms in school

additional symptoms. The US CDC guidance document recommends focusing on the following five symptoms in CYP: (79) ? temperature 38° Celsius (100.4 degrees Fahrenheit) or higher when taken by mouth ? sore throat ? new uncontrolled cough that causes difficulty breathing (for students with chronic allergic or asthmatic cough, a change in their cough from baseline) ? diarrhoea, vomiting, or abdominal pain ? new onset of severe headache, especially with a fever. The Canadian guidance document states that CYP (...) Open COVID-19 associated symptoms (general population): An acute respiratory infection (with or without fever) with at least one of the following symptoms for which there is no other plausible cause: a cough, sore throat, shortness of breath, catarrh in the upper respiratory tract, sudden loss of the sense of taste/smell. NR NR The student should be accommodated in a separate room. The selected room must be well ventilated and disinfected. Testing should be conducted as recommended by the health

2020 Health Information and Quality Authority

73. Assessment of Costs of Avoidable Delays in Intensive Care Unit Discharge Full Text available with Trip Pro

Pharmacology Physical Medicine and Rehabilitation Physical Therapy Physician Leadership Poetry Population Health Professional Well-being Professionalism Psychiatry Public Health Pulmonary Medicine Radiology Regulatory Agencies Research, Methods, Statistics Resuscitation Rheumatology Scientific Discovery and the Future of Medicine Shared Decision Making and Communication Sleep Medicine Sports Medicine Statistics and Research Methods Stem Cell Transplantation Substance Use and Addiction Surgery Surgical (...) % (eFigure 1 in the ). The mean (SD) avoidable time per patient was 23.3 (34.3) hours; the median, 7.2 (interquartile range [IQR], 2.4-27.7) hours ( ). In multivariable analysis, factors associated with avoidable time included male sex (odds ratio [OR], 0.92; 95% CI, 0.87-0.98); comorbid hemiplegia or paraplegia (OR, 1.47; 95% CI, 1.23-1.75), liver disease (OR, 1.20; 95% CI, 1.04-1.37), chronic pulmonary disease (OR, 1.16; 95% CI, 1.08-1.25), and peptic ulcer disease (OR, 1.18; 1.02-1.38); admission

2020 Institute of Health Economics

75. Evidence summary for the relative importance of droplet versus contact transmission to the spread of SARS-CoV-2

respiratory viruses (that is, other beta-coronaviruses, influenza and respiratory syncytial virus (RSV)). ? Each mode of transmission, and the degree to which it contributes to the overall spread of SARS-CoV-2, has important implications for public health guidance, particularly with regards to healthcare precautions and personal protective equipment (PPE) use. ? This review included six studies with various designs: systematic reviews (n=2), mathematical modelling studies (n=3), and a cross-sectional (...) is unlikely to provide robust evidence. ? In conclusion, there is currently insufficient evidence to determine the relative importance of droplet versus contact transmission to the spread of SARS-CoV-2 and other similar enveloped respiratory viruses. However, it is likely that the relative importance of these modes of transmission is context-specific. Evidence summary for the relative importance of droplet vs. contact transmission Health Information and Quality Authority Page 4 of 30 Evidence summary

2020 Health Information and Quality Authority

76. Sex Differences in All-Cause Mortality in the Decade Following Complex Coronary Revascularization

, Galway, Galway, Ireland; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: patrick.w.j.c.serruys@gmail.com. PMID: 32819461 DOI: Item in Clipboard Sex Differences in All-Cause Mortality in the Decade Following Complex Coronary Revascularization Hironori Hara et al. J Am Coll Cardiol . 2020 . Show details Display options Display options Format J Am Coll Cardiol Actions . 2020 Aug 25;76(8):889-899. doi: 10.1016/j.jacc.2020.06.066. Authors (...) Département of Cardiologie, Hôpital privé Jacques Cartier, Générale de Santé Massy, France. 9 Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, the Netherlands. 10 Department of Cardiology, National University of Ireland, Galway, Galway, Ireland. 11 University Department of Cardiac Surgery, Heart Centre Leipzig, Leipzig, Germany. 12 Department of Cardiology, National University of Ireland, Galway, Galway, Ireland; National Heart and Lung Institute, Imperial College London

2020 EvidenceUpdates

77. Pulmonary Artery Denervation for Patients With Residual Pulmonary Hypertension After Pulmonary Endarterectomy

Pulmonary Artery Denervation for Patients With Residual Pulmonary Hypertension After Pulmonary Endarterectomy Pulmonary Artery Denervation for Patients With Residual Pulmonary Hypertension After Pulmonary Endarterectomy - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get (...) ? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation J Am Coll Cardiol Actions . 2020 Aug 25;76(8):916-926. doi: 10.1016/j.jacc.2020.06.064. Pulmonary Artery Denervation for Patients

2020 EvidenceUpdates

78. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis

, comprising a total of 732 adults, were included in this meta-analysis. Compared to SC alone, CHM plus SC had a superior effect on the change of symptom and sign score (-1.30 by SMD, 95% CI [-2.43, -0.16]; 3 studies; n = 261, P = 0.03), on inflammatory marker C-reactive protein (CRP, mg/L; -11.82 by MD, 95% CI [-17.95, -5.69]; 5 studies; n = 325, P = 0.0002), on number of patients with improved lung CT scans (1.34 by risk ratio, 95% CI [1.19, 1.51]; 4 studies; n = 489, P < 0.00001). No significant adverse

2020 EvidenceUpdates

79. Oxygen Therapy and Risk of Infection for Health Care Workers Caring for Patients With Viral Severe Acute Respiratory Infection: A Systematic Review and Meta-analysis Full Text available with Trip Pro

Oxygen Therapy and Risk of Infection for Health Care Workers Caring for Patients With Viral Severe Acute Respiratory Infection: A Systematic Review and Meta-analysis Oxygen Therapy and Risk of Infection for Health Care Workers Caring for Patients With Viral Severe Acute Respiratory Infection: A Systematic Review and Meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) Actions . 2020 Aug 10;S0196-0644(20)30499-6. doi: 10.1016/j.annemergmed.2020.06.037. Online ahead of print. Oxygen Therapy and Risk of Infection for Health Care Workers Caring for Patients With Viral Severe Acute Respiratory Infection: A Systematic Review and Meta-analysis , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Family Medicine and Emergency Medicine, Université de Montréal, Montreal, Quebec, Canada; Department of Emergency Medicine, Centre intégré

2020 EvidenceUpdates

80. A Randomized Clinical Trial of the Efficacy and Safety of Interferon beta-1a in Treatment of Severe COVID-19 Full Text available with Trip Pro

Sciences, Tehran, Iran. 4 Advanced Thoracic Research Center, Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran. 5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. PMID: 32661006 PMCID: DOI: Free PMC article Item in Clipboard Randomized Controlled Trial A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19 Effat Davoudi-Monfared et al (...) @sina.tums.ac.ir. 3 Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 4 Advanced Thoracic Research Center, Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran. 5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. PMID: 32661006 PMCID: DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract

2020 EvidenceUpdates

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