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1. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. (Abstract)

(95% CI 6·2-52·3, p=0·0209). The most common adverse events (occurring in at least 10% of patients and more frequently in the fenfluramine groups) were decreased appetite, diarrhoea, fatigue, lethargy, somnolence, and decreased weight. Echocardiographic examinations revealed valve function within the normal physiological range in all patients during the trial and no signs of pulmonary arterial hypertension.In Dravet syndrome, fenfluramine provided significantly greater reduction in convulsive (...) seizure frequency compared with placebo and was generally well tolerated, with no observed valvular heart disease or pulmonary arterial hypertension. Fenfluramine could be an important new treatment option for patients with Dravet syndrome.Zogenix.Copyright © 2019 Elsevier Ltd. All rights reserved.

2020 Lancet

2. Audit and Feedback: Personal Prescribing Portrait

prescribers of quetiapine in older and disabled adults: a randomized clinical trial. JAMA Psychiatry 2018; 75(10): 1003–11. DOI: 10.1001/jamapsychiatry.2018.1867 6. Tonkin-Crine SKG, Tan PS, van Hecke O et al. Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews. Cochrane Database of Systematic Reviews 2017; Issue 9. Art. No.: CD012252. DOI: 10.1002/14651858.CD012252.pub2 7. Naughton C, Feely J

2020 Therapeutics Letter

3. Genitourinary syndrome of menopause

Health Initiative Observational Study examined risks associated with vaginal ET use. Outcomes assessed included coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, and death. The findings were very reassuring, with no increased risk of CVD or cancer in postmenopausal women using vaginal estrogens. 135 Another prospective cohort study of approximately 54,000 postmenopausal women in the Nurses’ Health Study also was very

2020 The North American Menopause Society

4. Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review

to increase the certainty of the findings reported here. This review should be updated when more evidence is available. Plain language summary available in Approaches to guiding oxygen therapy in adult intensive care patients with acute respiratory distress syndrome Background Acute respiratory distress syndrome (ARDS) is a very severe breathing problem with a high mortality rate (chance of dying). It has many potential causes, including viral infections such as COVID‐19, and there are no specific (...) treatments for it except for giving patients oxygen via a ventilator (artificial breathing machine) on an intensive care unit, often for long periods of time. However, large amounts of oxygen (either a high concentration of oxygen or oxygen administered for a long period of time) are associated with increased harm due to other illnesses (e.g. heart attack or stroke). What did we want to find out? We wanted to know whether patients with severe lung problems (ARDS) would do better (including less chance

2020 Cochrane

5. Quarantine alone or in combination with other public health measures to control COVID?19: a rapid review

(severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) as indirect evidence for the current coronavirus outbreak. Data collection and analysis Two review authors independently screened abstracts and titles in duplicate. Two review authors then independently screened all potentially relevant full‐text publications. One review author extracted data, assessed the risk of bias and assessed the certainty of evidence with GRADE and a second review author checked the assessment. We (...) that these changes do not affect our overall conclusions. We looked for studies that assessed the effect of any type of quarantine, anywhere, on the spread and severity of COVID‐19. We also looked for studies that assessed quarantine alongside other measures, such as isolation, physical distancing or school closures. COVID‐19 is a new disease, so, to find as much evidence as possible, we also looked for studies on similar viruses, such as SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory

2020 Cochrane

6. Universal screening for SARS?CoV?2 infection: a rapid review

Banner Portlet Scolaris Content Display Scolaris Content Display Read comments on this Review(0) Cochrane Clinical Answers Editorials Podcasts Special Collections Universal screening for SARS‐CoV‐2 infection: a rapid review Cochrane Systematic Review - Rapid Version published: 15 September 2020 Collapse all Expand all Abstract available in Background Coronavirus disease 2019 (COVID‐19) is caused by the novel betacoronavirus, severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Most people (...) infected with SARS‐CoV‐2 have mild disease with unspecific symptoms, but about 5% become critically ill with respiratory failure, septic shock and multiple organ failure. An unknown proportion of infected individuals never experience COVID‐19 symptoms although they are infectious, that is, they remain asymptomatic. Those who develop the disease, go through a presymptomatic period during which they are infectious. Universal screening for SARS‐CoV‐2 infections to detect individuals who are infected

2020 Cochrane

7. Pertuzumab (Perjeta) - In combination with trastuzumab and chemotherapy for the adjuvant treatment of adult patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer (eBC) at high risk of recurrence.

); ? ipsilateral local-regional invasive breast cancer recurrence (an invasive breast cancer in the axilla, regional lymph nodes, chest wall, and/or skin of the ipsilateral breast); ? distant recurrence (evidence of breast cancer in any anatomic site – other than the two above mentioned sites—that was either histologically confirmed or clinically diagnosed as recurrent invasive breast cancer); ? death attributable to any cause including breast cancer, non-breast cancer, or unknown cause (but cause of death (...) treated with pertuzumab in combination with trastuzumab and chemotherapy compared with trastuzumab and chemotherapy. Patients who have received prior anthracyclines or prior radiotherapy to the chest area may be at higher risk of LVEF declines. 1 No new cardiac emerged at the interim analysis, following 74.1 months of follow up. 4 Summary of clinical effectiveness issues Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths in women worldwide. The HER2

2020 Scottish Medicines Consortium

8. Pembrolizumab (Keytruda) - As monotherapy or in combination with platinum and 5-fluorouracil (5-FU) chemotherapy, is indicated for the first-line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults who

monotherapy group three treatment-related deaths occurred; these were attributed to disseminated intravascular coagulation, autoinflammatory disease, and pneumonitis in one patient each. In the pembrolizumab plus chemotherapy group there were 11 treatment- related deaths. These were due to infections in seven patients (including five cases of septic shock) and tumour haemorrhage, cerebral ischaemia, interstitial lung disease, and haemorrhage in one patient each. There were 8 treatment-related deaths (...) in the cetuximab plus chemotherapy group. Six of these were due to infections, one due to pulmonary artery thrombosis and one due to hypoxia. 4 Summary of clinical effectiveness issues Head and neck squamous cell carcinomas (HNSCC) are an anatomically heterogeneous group of cancers including tumours originating in the lip, oral cavity, hypopharynx, oropharynx, nasopharynx or larynx. Patients with metastatic or unresectable recurrent HNSCC have a poor prognosis and median overall survival is likely to be less

2020 Scottish Medicines Consortium

9. Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating patients with suspected or confirmed Covid-19

and severity. Plain language summary available in What are the benefits and risks of healthcare workers using antimicrobial mouthwashes or nasal sprays to protect themselves when they treat people with COVID‐19? Why is this question important? COVID‐19 is an infectious disease caused by the SARS‐CoV‐2 virus. Most people infected with COVID‐19 develop a mild to moderate respiratory illness, and some may have no symptoms (asymptomatic infection). Others experience severe symptoms and need specialist (...) to healthcare workers. These workers may be especially at risk when undertaking 'aerosol‐generating procedures' (AGPs). This is any medical, dental or patient‐care procedure that results in the production of airborne particles (aerosols) from the upper aerodigestive tract (mouth, nose, throat, oesophagus) and lower respiratory tract where the virus is shedding. These can remain suspended in the air and travel over a distance. They may cause infection if they are inhaled. Such procedures therefore create

2020 Cochrane

11. Society of Interventional Radiology Clinical Practice Guideline for Inferior Vena Cava Filters in the Treatment of Patients with Venous Thromboembolic Disease Full Text available with Trip Pro

. Vena caval filter utilization and outcomes in pulmonary embolism: MEDICARE hospitalizations from 1999 to 2010. J Am Coll Cardiol. 2016; 67 : 1027-1035 ). The mainstay of treatment for patients with VTE is anticoagulation ( Kearon C. Akl E.A. Ornelas J. et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016; 149 : 315-352 ). Nonetheless, caval interruption (surgical ligation) to prevent PE was first performed by Trendelenburg in the early 1900s (...) . Chest. 2016; 149 : 315-352 ), American Heart Association ( Jaff M.R. McMurtry M.S. Archer S.L. et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011; 123 : 1788-1830 ), Society of Interventional Radiology (SIR) ( Kaufman J.A. Kinney T.B. Streiff M.B. et al. Guidelines for the use of retrievable and convertible vena cava filters

2020 Society of Interventional Radiology

12. Medication abortion up to 70 days of gestation

Contracept Reprod Health Care. 2015; 20 (Level III) : 490-494 Rooney Thompson M. Towers C.V. Howard B.C. Hennessy M.D. Wolfe L. Heitzman C. The use of prostaglandin E1 in peripartum patients with asthma. Am J Obstet Gynecol. 2015; 212 (Level II-2) : e1-e3 Hayes J.L. Achilles S.L. Creinin M.D. Reeves M.F. Outcomes of medical abortion through 63 days in women with twin gestations. Contraception. 2011; 84 (Level III) : 505-507 GenBioPro, Inc. Mifepristone tablets, 200mg for oral use. Highlights

2020 Society of Family Planning

13. Travel?related control measures to contain the COVID?19 pandemic: a rapid review

pandemic. We also included studies concerned with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) as indirect evidence. Primary outcomes were cases avoided, cases detected and a shift in epidemic development due to the measures. Secondary outcomes were other infectious disease transmission outcomes, healthcare utilisation, resource requirements and adverse effects if identified in studies assessing at least one primary outcome. Data collection and analysis One (...) respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). What did we want to find out? We wanted to find out how effective travel‐related control measures are in containing the COVID‐19 pandemic. We also wanted to know about the costs of the measures and what effect they have on healthcare and other resource use, as well as potential negative effects, such as feeling isolated. What we did We searched for studies on the effects of travel‐related control measures on the spread of COVID‐19

2020 Cochrane

14. For people with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, how do conservative and liberal oxygen targets compare?

For people with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, how do conservative and liberal oxygen targets compare? For people with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, how do conservative and liberal oxygen targets compare? - Tort, Sera - 2020 | Cochrane Library Cookies Our site uses cookies to improve your experience. You can find out more about our use of cookies in About Cookies, including instructions on how to turn (...) your preferred language for the Cochrane Library website. Cancel Explore new Cochrane Library features . Scolaris Content Language Banner Portlet Scolaris Content Language Banner Portlet Scolaris Content Display Scolaris Content Display Review Question: For people with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, how do conservative and liberal oxygen targets compare? Sera Tort, Jane Burch 8 September 2020 Clinical Answer: Reviewers conducted a search in May 2020

2020 Cochrane

15. Antimicrobial mouthwashes (gargling) and nasal sprays to protect healthcare workers when undertaking aerosol generating procedures (AGPs) on patients without suspected or confirmed Covid-19 infection

small droplets. For example, people who have surgery under general anaesthesia, or people with a lung disease that makes breathing difficult (such as pneumonia), may need to be placed on a ventilator (artificial breathing machine) to help them breathe. This requires a healthcare worker to insert a tube through the patient's mouth, into their airway – a procedure during which many small droplets are likely to be produced by the patient. Similar droplets can be produced during routine dental (...) is an infectious disease caused by the SARS‐CoV‐2 virus. Most people infected with COVID‐19 develop a mild to moderate respiratory illness, and some may have no symptoms (asymptomatic infection). Others experience severe symptoms and need specialist treatment and intensive care. COVID‐19 spreads from person to person primarily through droplets that are produced when an infected person coughs, sneezes or talks. A person can also become infected by touching a surface or object that has viral droplets

2020 Cochrane

16. Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed Covid-19 infection to protect healthcare workers treating them

healthcare workers who treat them? Why is this question important? COVID‐19 is an infectious disease caused by the SARS‐CoV‐2 virus. Most people infected with COVID‐19 develop a mild to moderate respiratory illness, and some may have no symptoms (asymptomatic infection). Others experience severe symptoms and need specialist treatment and intensive care. COVID‐19 spreads from person to person primarily through droplets that are produced when an infected person coughs, sneezes or talks. A person can also (...) and nasal sprays to patients with COVID‐19, we set out to review the research evidence. In particular, we wanted to investigate the effects of patient use of antimicrobial mouthwashes and nasal sprays on: ‐ patient deaths and healthcare needs – including the need for hospitalisation, artificial breathing support, dialysis or haemofiltration (treatments required when the kidneys do not work properly); ‐ new COVID‐19 infections of healthcare workers; ‐ important adverse effects such as loss of smell

2020 Cochrane

17. Hepatitis C in 2020: A North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper

transmission rates were historically higher in solid organ transplantation recipients (24), the recent availability of DAAs has decreased infections in solid-organ transplant recipients (25). In a clinical trial, recipients of heart and lung transplants from hepatic C viremic donors (median viral load: 890,000 IU/ml) received preemptive therapy with sofos- buvir-velpatasvir within a few hours after transplantation, with undetectable HCV viral loads 6 months posttransplant (25). CLINICAL SIGNS AND SYMPTOMS (...) mg/120 mg) 12–17 1, 2, 3, or 4 47 100% Nasopharyngitis (26%) URI (19%) None AE¼ adverse event; DAAs¼ direct-acting antivirals; SAE¼ serious adverse event; SVR12¼ percentage of patients with a sustained virologic response 12 weeks posttreatment; URI ¼ upper respiratory tract infection. JPGN Volume 71, Number 3, September 2020 Hepatitis C in 2020 www.jpgn.org 413 Copyright © ESPGHAN and NASPGHAN. All rights reserved. was inability to tolerate the medicines because of ‘‘bad taste.’’ It is likely

2020 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

18. Planned Out-of-hospital Birth

disorders that would impact maternal or neonatal health (e.g. epilepsy, myasthenia gravis, previous cerebrovascular accident) Placental Conditions • History of retained placenta requiring surgical removal Psychiatric Conditions • History of postpartum mood disorder with high risk to the infant (e.g. psychosis) • Schizophrenia, other psychotic disorders, bipolar I disorder or schizotypal disorders 3 ¦ Planned Out-of-Hospital Birth Approved 8/13/2020 MEDICAL HISTORY OR OBSTETRIC HISTORY Pulmonary Disease (...) • Chronic pulmonary disease (e.g. cystic fibrosis) Renal Disease • Renal disease requiring supervision by a renal specialist • Renal failure (Preeclampsia and related conditions are listed separately) Shoulder Dystocia • History of, with or without fetal clavicular fracture Uterine Conditions • Prior myomectomy • Prior hysterotomy 4 ¦ Planned Out-of-Hospital Birth Approved 8/13/2020 CONDITIONS OF CURRENT PREGNANCY Abnormal Bleeding in pregnancy • Antepartum hemorrhage, recurrent • Hemorrhage

2020 Oregon Health Evidence Review Commission

19. Andexanet alfa (Ondexxya) - For adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

The proportion of patients who had a thromboembolic event within 30 days following administration of andexanet alfa was 10% (34/352), which included seven with myocardial infarction, 14 with ischaemic (or uncertain classification) stroke, one with transient ischaemic attack, 13 with deep vein thrombosis and five with pulmonary embolus. Anti-coagulant and anti- platelets were stopped at study enrolment. Within 30 days of andexanet alfa 220 patients (62% of the safety population) restarted anticoagulation (...) . Cost-effectiveness of transfers to centers with neurological intensive care units after intracerebral hemorrhage. Stroke 2015; 46: 58-64 11. National Institute for Health and Care Excellence (NICE). Apixaban for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism: technology appraisal guidance [TA341], 2015. Available from: https://www.nice.org.uk/guidance/ta341. Date accessed: April 2020. 12. Luengo-Fernandez R, Yiin GS, Gray AM, Rothwell PM. Population-based

2020 Scottish Medicines Consortium

20. Interventional cardiac catheterization in neonatal age: results in a multicentre Italian experience. (Abstract)

 < 0.01) at the procedure, prematurity (p < 0.01), uni-ventricular physiology (p < 0.01), associated genetic syndromes (p < 0.01) and procedure risk category (p < 0.01). No relationship between volume of activity of any single center and procedure outcome was found. Over time, a trend toward an increased number of procedures and their complexity was recorded. Trans-catheter management of cardiac malformations with critical, duct-dependent pulmonary blood flow by arterial duct stenting or right

2020 International journal of cardiology

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