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1. Mortality of triple long-acting inhaled agents therapies for treating chronic obstructive pulmonary disease (COPD) :a systematic review and meta-analysis

Mortality of triple long-acting inhaled agents therapies for treating chronic obstructive pulmonary disease (COPD) :a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2021 PROSPERO

2. Topotecan plus platinum-based chemotherapy versus etoposide plus platinum-based chemotherapy for small cell lung cancer: A meta-analysis based on Randomized Controlled Trials

Topotecan plus platinum-based chemotherapy versus etoposide plus platinum-based chemotherapy for small cell lung cancer: A meta-analysis based on Randomized Controlled Trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2021 PROSPERO

3. Dexmedetomidine attenuates OLV-associated lung injury by suppressing inflammatory responses: a systematic review and meta-analysis

Dexmedetomidine attenuates OLV-associated lung injury by suppressing inflammatory responses: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2021 PROSPERO

4. The analgesic effect of erector spinae plane block in thoracic surgery:A systematic review and meta-analysis of randomized controlled trials.

The analgesic effect of erector spinae plane block in thoracic surgery:A systematic review and meta-analysis of randomized controlled trials. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2021 PROSPERO

5. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

(95% CI 6·2-52·3, p=0·0209). The most common adverse events (occurring in at least 10% of patients and more frequently in the fenfluramine groups) were decreased appetite, diarrhoea, fatigue, lethargy, somnolence, and decreased weight. Echocardiographic examinations revealed valve function within the normal physiological range in all patients during the trial and no signs of pulmonary arterial hypertension.In Dravet syndrome, fenfluramine provided significantly greater reduction in convulsive (...) seizure frequency compared with placebo and was generally well tolerated, with no observed valvular heart disease or pulmonary arterial hypertension. Fenfluramine could be an important new treatment option for patients with Dravet syndrome.Zogenix.Copyright © 2019 Elsevier Ltd. All rights reserved.

2020 Lancet

6. Does the carer support needs assessment tool cover the established support needs of carers of patients with chronic obstructive pulmonary disease? A systematic literature search and narrative review. Full Text available with Trip Pro

Does the carer support needs assessment tool cover the established support needs of carers of patients with chronic obstructive pulmonary disease? A systematic literature search and narrative review. Informal carers play a key supportive role for patients with chronic obstructive pulmonary disease. However, caring can have a considerable impact on health and wellbeing. Carers may have unidentified support needs that could be a target for intervention. Literature on the support needs of informal (...) carers has not been fully synthesised, and our knowledge of the comprehensiveness of the Carer Support Needs Assessment Tool for these individuals is limited.To explore whether the Carer Support Needs Assessment Tool covers the support needs of carers of patients with chronic obstructive pulmonary disease identified in published literature.English language studies were identified against predetermined inclusion/exclusion criteria through database searching. Further studies were identified through

2020 Palliative medicine

7. The preferences of patients with chronic obstructive pulmonary disease are to discuss palliative care plans with familiar respiratory clinicians, but to delay conversations until their condition deteriorates: A study guided by interpretative phenomenologi Full Text available with Trip Pro

The preferences of patients with chronic obstructive pulmonary disease are to discuss palliative care plans with familiar respiratory clinicians, but to delay conversations until their condition deteriorates: A study guided by interpretative phenomenologi Chronic obstructive pulmonary disease is associated with an uncertain trajectory, which challenges prognostication and means that most patients are not involved in advance care planning and do not receive palliative and end-of-life care.To (...) understand the preferences of patients with chronic obstructive pulmonary disease for discussions about palliative and advance care planning with clinicians.Semi-structured interviews were conducted with patients with chronic obstructive pulmonary disease. Data analysis was guided by principles of interpretative phenomenological analysis, of which symbolic interactionism and interpretation principles were employed throughout.A total of 33 British patients with chronic obstructive pulmonary disease

2020 Palliative medicine

8. Heart-type fatty acid-binding protein: an overlooked cardiac biomarker. Full Text available with Trip Pro

in myocardial injury The routine use in the emergency department complements the use of troponins in ruling out acute coronary syndromes in patients presenting early with chest pain It also is useful in risk stratifying patients with other conditions such as heart failure and acute pulmonary embolism. (...) Heart-type fatty acid-binding protein: an overlooked cardiac biomarker. Cardiac troponins (cTn) are currently the standard of care for the diagnosis of acute coronary syndromes (ACS) in patients presenting to the emergency department (ED) with chest pain (CP). However, their plasma kinetics necessitate a prolonged ED stay or overnight hospital admission, especially in those presenting early after CP onset. Moreover, ruling out ACS in low-risk patients requires prolonged ED observation

2020 Annals of Medicine

9. COVID-19: Managing the COVID-19 pandemic in care homes for older people

England have suggested that COVID-19 should be suspected in any resident with a new continuous cough and/or high temperature (at least 37.8°C). However, COVID-19 in care home residents may commonly present with non-respiratory tract symptoms, such as new onset/worsening confusion or diarrhoea. Care home staff, with detailed knowledge of residents, are well-placed to intuitively recognise these subtle signs (‘soft signs’) of deterioration. Care home staff – particularly in care homes without nursing (...) video consultations, in order to inform triage and medical decisions. Care homes who do not yet have the capability to measure heart rate, blood pressure, respiratory rate and pulse oximetry should be provided with, or consider buying, equipment (approximate cost £50). The 1 system employs ‘soft signs’ to identify deterioration, vital sign measurement and the National Early Warning Score (NEWS) to guide response, and the SBAR tool (situation, background, action, recommendation) tool to communicate

2020 British Geriatrics Society

10. Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors: Behavioral Counseling Interventions

this intervention, including participant manuals, food and fitness guides, and food diaries, are available online at www.kpchr.org/research/public/premier/premier.htm. Information about the DASH diet is available from the National Heart, Lung, and Blood Institute . Research Needs and Gaps Trials examining the effectiveness of less intensive counseling that can be delivered in the primary care setting, including the minimum intensity, number of interactions, and duration necessary for effectiveness, are needed (...) modification on diet, weight, physical fitness, and blood pressure control: 18 month results of a randomized trial. Ann Intern Med . 2006;144(7):485-95. National Heart, Lung, and Blood Institute. In Brief: Your Guide to Lowering Your Blood Pressure With DASH. Bethesda, MD: National Heart, Lung, and Blood Institute: 2006. Accessed at on 29 July 2014. Centers for Disease Control and Prevention. Million Hearts: strategies to reduce the prevalence of leading cardiovascular disease risk factors—United States

2020 U.S. Preventive Services Task Force

11. Child and maternal health data and intelligence: guide for health professionals

at young mothers, the tool will allow you to investigate the potential impact. You can find further user guidance in the ‘how to’ guide within the tool itself. Further show trends and variation in teenage pregnancies across local authorities from 1998 to 2014. Improving services for childhood illness tools There are 2 improving services tools: the , which provides hospital admissions information for children with asthma, diabetes or epilepsy the , which provides hospital admissions information (...) for children with common illnesses, such as respiratory or gastric conditions, as well as for those with complex conditions, such as congenital heart conditions, cerebral palsy or metabolic disorders With these tools you can: examine the use of hospital services by children living in your area compare your area to other similar areas, the top performing areas, your region and the England average view trends to see if activity levels are going up or down identify potential relationships between different

2020 Public Health England

12. Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19

, Mohamad Kalot, Yngve Falck-Ytter, Valery Lavergne, Rebecca L. Morgan, M. Hassan Murad, Shahnaz Sultan Last updated May 6, 2020 and posted online at www.idsociety.org/COVID19guidelines/dx. Please check website for most updated version of these guidelines. Supplementary materials are available here. Version 1.0.1 Abstract Background: Accurate molecular diagnostic tests are necessary for confirming a diagnosis of coronavirus disease 2019 (COVID-19). Direct detection of severe acute respiratory syndrome (...) coronavirus 2 (SARS-CoV-2) nucleic acids in respiratory tract specimens informs patient, healthcare institution and public health level decision-making. The numbers of available SARS- CoV-2 nucleic acid detection tests are rapidly increasing, as is the COVID-19 diagnostic literature. Thus, the Infectious Diseases Society of America (IDSA) recognized a significant need for frequently updated systematic reviews of the literature to inform evidence-based best practice guidance. Objective: The IDSA’s goal

2020 Infectious Diseases Society of America

13. Syphilis in pregnancy

: clinician with specialist knowledge and experience in the testing, result interpretation, management and treatment of syphilis in the pregnant woman and/or her baby Additional investigations Consider · FBC, ELFT · Chest x-ray · Long bone radiographs · CSF · Neuroimaging · Ophthalmologic exam · Auditory brain stem response Treatment for congenital syphilis 0–7 days of age · Benzyl penicillin 50 mg/kg IV 12 hourly for 10 days 8–30 days of age · Benzyl penicillin 50 mg/kg IV 8 hourly for 10 days > 30 days

2020 Queensland Health

14. Droperidol for the Management of Agitation in the ED

you wait for the next patient to arrive, you begin to perform a literature search to see what the evidence says… PICO Question Population : Adult patients in the ED with behavioral disturbance of any etiology requiring chemical sedation Intervention : Droperidol administration (IV or IM) Comparison : Haloperidol administration (IV or IM) Outcome : Time to adequate sedation, failed sedation/need for rescue sedation, ED length of stay, respiratory depression, QT prolongation, Torsades de Pointes

2020 Washington University Emergency Medicine Journal Club

15. Risk of Transmitting COVID-19 During Nebulizer Treatment: A Living Ultra-Rapid Review

visualized; Fine aerosols detected but not quantified due “to abundance”. N=8 patients were included. Unclear how many times each patient was evaluated (up to 5 times) McGrath, 2019 57 Ireland Human patient simulator experiment NA Room with no external doors/windo ws, Breathing simulator via absolute filter set to adult respiratory rate, Vibrating Mesh nebulizer with aerosol chamber (air flow 6L/min) and Jet nebulizer (8L/min); Aerosols measured by two aerodynamic particle sizers at 0.8m and 2.2m from (...) in COVID-19: risks and suggestions for viral transmission. Expert Opin Drug Deliv. 2020:1-5. 11. UpToDate. Delivery of inhaled medication in adults. Available at: https://www.uptodate.com/contents/delivery-of-inhaled-medication-in-adults. Accessed October 16, 2020. 12. Camargo CA, Rachelefsky G, Schatz M. Managing asthma exacerbations in the emergency department. Proc Am Thorac Soc. 2009;6(4):357-366. 13. Cochrane. Cochrane's work on Rapid Reviews in response to COVID-19. Available at: https

2020 Veterans Affairs Evidence-based Synthesis Program Reports

16. Is Per-oral Endoscopic Myotomy (POEM) More Effective than Pneumatic Dilation and Heller myotomy? A Systematic Review and Meta-Analysis

by Ernst Heller in 1914 [7], was the first surgical approach to divide the LES muscle. The “peroral endoscopic myotomy” (POEM) reported by Inoue et al. [8] has gained popularity and become a viable first line therapy [9]. As a natural orifice approach, POEM has the potential for less morbidity, quicker recovery, better cosmesis, longer myotomy, and spared need of dissecting the thoracic and abdominal esophagus. Nevertheless, demonstration of POEM’s safety profile and effectiveness relative (...) as heartburn symptoms or regurgitation, in addition to reflux symptoms not otherwise specified, and pain was defined as postoperative pain or chest pain. When multiple papers reported on the same study population, data extraction was still performed on all studies, but outcomes from an earlier paper were only included in meta-analysis if unique from the more contemporary publication. Internal Validity Assessment Concurrent with data extraction, internal validity of included studies was assessed

2020 Society of American Gastrointestinal and Endoscopic Surgeons

17. Drug Safety Advisories: A need for international coordination

exacerbations of chronic obstructive pulmonary disease, acute bacterial sinusitis, and acute otitis media. 18 An October 29, 2020 EMA alert warns of an association of recent fluoroquinolone use with mitral and aortic regurgitation. 19 We still prescribe too many flouroquino- lone antibiotics. Global coordination in the international response to Covid-19 shows the potential to coordinate responses to health emergencies. Like viruses, drug safety concerns tran- scend borders. Consistent and coordinated pan

2020 Therapeutics Letter

18. Chronic Pain in Veterans and Service members with a History of Mild Traumatic Brain Injury: A Systematic Review

these studies, the prevalence of chronic pain among Veterans and SMs varied widely but, overall, was high. As expected in this population, prevalence estimates of head pain and chronic pain generally were higher than estimates of other specific chronic pain conditions (eg, chest pain, abdominal/stomach pain). However, across studies, there were wide ranges of prevalence estimates for each pain type, likely due to the varying study designs, target populations or samples, pain definitions, operationalization

2020 Veterans Affairs Evidence-based Synthesis Program Reports

19. Chronic Mesentric Ischemia (CMI)

disease (VOYAGER PAD). American heart journal. 2018; 199 : 83-91 Patel M.R. Becker R.C. Wojdyla D.M. et al. Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial. European journal of preventive cardiology. 2015; 22 : 734-742 Barr J. Kokotsakis J. Velissarios K. Athanasiou T. Is the thoracic aorta a safe site for the proximal anastomosis for bypassing the mesenteric arteries in patients (...) with chronic mesenteric ischaemia?. Interactive cardiovascular and thoracic surgery. 2017; 24 : 796-798 Wang L.L. Choong A.M. Kovalic A. Jenkins J. Kruger A. Extra-Anatomic Axillo-Mesenteric Reconstruction for Chronic Mesenteric Ischemia. Annals of vascular surgery. 2016; 31 ( 206.e5-8 ) Wyers M.C. Powell R.J. Nolan B.W. Cronenwett J.L. Retrograde mesenteric stenting during laparotomy for acute occlusive mesenteric ischemia. J Vasc Surg. 2007; 45 : 269-275 Oderich G.S. Macedo R. Stone D.H. et al

2020 Society for Vascular Surgery

20. What is known about aerosol transmission of SARS-CoV-2?

Distance travelled including if >2m Location (ward, ICU, ED, other, not stated Results/findings Notes/comments different environmental settings. especially confined spaces is yet to be fully understood. 9 Leung, 2020 experimental to explore the importance of respiratory droplet and aerosol routes of transmission with a particular focus on corona- , influenza- , and rhino- , viruses by quantifying the amount of respiratory virus in exhaled breath and determining the potential efficacy of surgical face (...) masks to prevent n=246, 111 infected with human (seasonal) coronavirus, influenza virus or rhinovirus. Testing of exhaled breath samples for respiratory viruses. Randomized (50/50) to wearing and not wearing a face mask during breath collection. Compared respiratory droplet samples and aerosol samples between samples collected with and without a face mask. Coronavirus RNA was detected from respiratory droplets (30% of samples) and aerosols (40% of samples) in the not-mask-wearing group. Coronavirus

2020 Sax Institute Evidence Check

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