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1. The Ambulance Cardiac Chest Pain Evaluation in Scotland Study (ACCESS): A Prospective Cohort Study Full Text available with Trip Pro

The Ambulance Cardiac Chest Pain Evaluation in Scotland Study (ACCESS): A Prospective Cohort Study The Ambulance Cardiac Chest Pain Evaluation in Scotland Study (ACCESS): A Prospective Cohort Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 Information Show account info Close Account Logged in as: username Search (...) Cite Display options Display options Format Share Permalink Copy Page navigation Ann Emerg Med Actions . 2021 Apr 26;S0196-0644(21)00060-3. doi: 10.1016/j.annemergmed.2021.01.012. Online ahead of print. The Ambulance Cardiac Chest Pain Evaluation in Scotland Study (ACCESS): A Prospective Cohort Study , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Emergency Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom; Department of Applied Medicine, University of Aberdeen, Aberdeen

2021 EvidenceUpdates

2. Is Hydroxychloroquine with Azithromycin a Good Combination in COVID-19 Compared to Hydroxychloroquine Alone from Cardiac Perspective? A Systematic Review and Meta-Analysis Full Text available with Trip Pro

odds need to be considered in clinical practice. Conclusions: The combination of hydroxychloroquine and azithromycin leads to small increased odds of mortality and cardiac events compared to hydroxychloroquine alone. The use of hydroxychloroquine and azithromycin led to increased odds of QT prolongation, although not statistically significant. Keywords: COVID-19; COVID-19 drug treatment; hydroxychloroquine; macrolides; severe acute respiratory syndrome coronavirus 2.. Similar articles Furtado RHM

2021 EvidenceUpdates

3. Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review Full Text available with Trip Pro

., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - - - Bernheim A., Mei X., Huang M., Yang Y., Fayad Z.A., Zhang N., Diao K., Lin B., Zhu X., Li K., et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection. Radiology. 2020;295:200463. doi: 10.1148/radiol.2020200463. - - - Yang X., Yu Y

2021 EvidenceUpdates

4. Continuous Pectoral Nerve Block Compared With Continuous Thoracic Paravertebral Block and Intravenous Opioid Analgesia for the Postoperative Analgesic Efficacy in Patients Undergoing Modified Radical Mastectomy: A Prospective Randomized Tria

Continuous Pectoral Nerve Block Compared With Continuous Thoracic Paravertebral Block and Intravenous Opioid Analgesia for the Postoperative Analgesic Efficacy in Patients Undergoing Modified Radical Mastectomy: A Prospective Randomized Tria Continuous Pectoral Nerve Block Compared With Continuous Thoracic Paravertebral Block and Intravenous Opioid Analgesia for the Postoperative Analgesic Efficacy in Patients Undergoing Modified Radical Mastectomy: A Prospective Randomized Trial - PubMed (...) Thoracic Paravertebral Block and Intravenous Opioid Analgesia for the Postoperative Analgesic Efficacy in Patients Undergoing Modified Radical Mastectomy: A Prospective Randomized Trial , Affiliations Expand Affiliation 1 Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt. PMID: 33734144 DOI: Item in Clipboard Continuous Pectoral Nerve Block Compared With Continuous Thoracic Paravertebral Block and Intravenous Opioid Analgesia for the Postoperative

2021 EvidenceUpdates

5. New forehead device in positional obstructive sleep apnoea: a randomised clinical trial

apnoea: a randomised clinical trial Laura Hidalgo Armas et al. Thorax . 2021 . Show details Display options Display options Format Thorax Actions . 2021 Apr 22;thoraxjnl-2020-216167. doi: 10.1136/thoraxjnl-2020-216167. Online ahead of print. Authors , , , , , , , , Collaborators Spanish Sleep Network : , , Affiliations 1 BioAraba, Osakidetza-Basque Health Service, Vitoria-Gasteiz, Spain. 2 Sleep Unit, Osakidetza-Basque Health Service, Vitoria-Gasteiz, Spain. 3 Respiratory Department, CIBERES, Madrid (...) options Format Share Permalink Copy Page navigation Thorax Actions . 2021 Apr 22;thoraxjnl-2020-216167. doi: 10.1136/thoraxjnl-2020-216167. Online ahead of print. New forehead device in positional obstructive sleep apnoea: a randomised clinical trial , , , , , , , , Collaborators, Affiliations Expand Collaborators Spanish Sleep Network : , , Affiliations 1 BioAraba, Osakidetza-Basque Health Service, Vitoria-Gasteiz, Spain. 2 Sleep Unit, Osakidetza-Basque Health Service, Vitoria-Gasteiz, Spain. 3

2021 EvidenceUpdates

6. Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score >/= 50 Full Text available with Trip Pro

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score >/= 50 Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50 - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID (...) of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation J Clin Oncol Actions . 2021 Apr 19;JCO2100174. doi: 10.1200/JCO.21.00174. Online ahead of print. Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50 , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Lung Clinic Grosshansdorf, Airway

2021 EvidenceUpdates

7. The occurrence of long COVID: a rapid review Full Text available with Trip Pro

, University of Cape Town, Cape Town, South Africa. PMID: 33889231 PMCID: DOI: Item in Clipboard Full text links Cite Display options Display options Format Abstract The long-term effects of the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) are not well understood. This rapid review was aimed at synthesizing evidence on the long-term effects of the SARS-CoV-2 infection among survivors. We considered both randomised controlled trials and non-randomised studies eligible for inclusion (...) are presented narratively. Eleven studies met our inclusion criteria. All these studies were conducted in high-income countries. Study findings demonstrate that COVID-19 survivors can experience persistent symptoms after recovering from their initial illness, especially among previously hospitalized persons. The majority of symptoms reported were fatigue, shortness of breath, cough, and sleep disorders. Mental conditions, such as depression and anxiety disorders, were also reported. In conclusion

2021 EvidenceUpdates

8. The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial Full Text available with Trip Pro

to Akhavan and Sepehri Clinics, Kashan university of medical sciences, Iran. Subjects were divided into two groups (intervention and placebo). This syrup (containing 1.6 mg of methanolic extract along with 450 mg of propolis per 10 mL) was administered three times a day to each patient for 6 days. The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L (...) . (2020). Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency. Science of the Total Environment, 730, 138996. Ai, T., Yang, Z., Hou, H., Zhan, C., Chen, C., Lv, W., … Xia, L. (2020). Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: A report of 1014 cases. Radiology, 296, E32-E40. Ali, I., & Alharbi, O. M. (2020). COVID-19: Disease, management, treatment

2021 EvidenceUpdates

9. Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis Full Text available with Trip Pro

of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Jacobs School of Medicine and Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA. 4 Dept. of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 5 Medical ICU, Peking Union Medical College Hospital, Beijing, China. 6 Biostatistics Unit, The Research Institute, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada. 7 Critical Care Center, Department of Anesthesiology and Critical (...) - U1173, School of Medicine Simone Veil, Hôpital Raymond Poincaré (APHP), University Versailles Saint Quentin - University Paris Saclay, INSERM, Garches, France. 11 Memphis Veterans Affairs Medical Center Research Service and Pulmonary, Critical Care, and Sleep Medicine Service, Memphis, TN, USA. 12 Department of Medicine, McMaster University, Hamilton, ON, Canada. rochwerg@mcmaster.ca. 13 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. rochwerg

2021 EvidenceUpdates

10. The Range of Cardiogenic Shock Survival by Clinical Stage: Data From the Critical Care Cardiology Trials Network Registry

University School of Medicine, Durham, NC. 8 Department of Cardiology, St. Vincent Hospital, Indianapolis, IN. 9 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN. 10 Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH. 11 John Hopkins University, Baltimore, MD. 12 Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT. 13 University of California San Diego, San Diego, CA. 14 Inova Heart (...) , Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 5 Division of Cardiovascular Medicine, Duke University, Durham, NC. 6 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. 7 Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC. 8 Department of Cardiology, St. Vincent Hospital, Indianapolis, IN. 9 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN. 10 Department of Cardiovascular

2021 EvidenceUpdates

11. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave Full Text available with Trip Pro

Infant, Newborn Actions Infectious Disease Transmission, Vertical Actions Intensive Care Units / statistics & numerical data Actions Lung / diagnostic imaging Actions Male Actions Obesity, Maternal / epidemiology Actions Pneumonia, Viral / diagnostic imaging Actions Pneumonia, Viral / physiopathology Actions Pneumonia, Viral / therapy Actions Pregnancy Actions Pregnancy Complications / epidemiology Actions Pregnancy Complications, Infectious / epidemiology* Actions Pregnancy Complications, Infectious (...) / physiopathology Actions Pregnancy Complications, Infectious / therapy Actions Pregnancy Trimester, Second Actions Pregnancy Trimester, Third Actions Premature Birth / epidemiology* Actions Radiography, Thoracic Actions Respiration, Artificial Actions Risk Factors Actions SARS-CoV-2 Actions Severity of Illness Index Actions Spain / epidemiology Actions Substances Anti-Bacterial Agents Actions Antiviral Agents Actions Immunologic Factors Actions Supplementary concepts COVID-19 drug treatment Actions Related

2021 EvidenceUpdates

12. Keeping it Simple for Emergency Room Dyspepsia

“acceptable” pain relief: 69% for antacid + lidocaine versus 35% for antacid alone; number needed to treat=3. ? Limitation: Clinicians not blinded. CONTEXT • Dyspepsia affects up to 16% of healthy individuals, with abdominal pain accounting for up to 9% of emergency room visits. 4,5 • Women with an acute myocardial infarction often experience prodromal symptoms and chest pain is less predictive of coronary artery disease: o Up to 45% of women have gastrointestinal symptoms as the presenting symptom (...) and Prevention. Updated November 10, 2020. Available at: https://www.cdc.gov/nchs/fastats/emergency-department.htm Accessed December 2, 2020. 6. Nanna MG, Hajduk AM, Krumholz HM, et al. Circ Cardiovasc Qual Outcomes. 2019; 12(10):e005691. 7. Chan S, Maurice AP, Davies SR et al. Heart Lung Circ. 2014; 23:913–923. AUTHORS Jingyi Ma, BMSc, Michael R. Kolber, MD CCFP MSc Authors do not have any conflicts of interest to declare.

2021 Tools for Practice

13. Indacaterol/mometasone furoate (Atectura Breezhaler) - as a maintenance treatment of asthma in adults and adolescents

Indacaterol/mometasone furoate (Atectura Breezhaler) - as a maintenance treatment of asthma in adults and adolescents Published 10 May 2021 1 Product update SMC2356 indacaterol / mometasone furoate 125 micrograms / 62.5 micrograms and 125 micrograms / 127.5 micrograms and 125 micrograms / 260 micrograms (Atectura Breezhaler®) 09 April 2021 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards (...) and Area Drug and Therapeutics Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated submission indacaterol / mometasone furoate (Atectura Breezhaler®) is accepted for use within NHSScotland. Indication under review: as a maintenance treatment of asthma in adults and adolescents 12 years of age and older not adequately controlled with inhaled corticosteroids and inhaled short-acting beta 2-agonists. Indacaterol / mometasone furoate (Atectura

2021 Scottish Medicines Consortium

14. Indacaterol/glycopyrronium/mometasone furoate (Enerzair Breezhaler) - as a maintenance treatment of asthma in adult patients

Indacaterol/glycopyrronium/mometasone furoate (Enerzair Breezhaler) - as a maintenance treatment of asthma in adult patients Published 10 May 2021 1 Product update SMC2355 indacaterol / glycopyrronium / mometasone furoate 114 micrograms / 46 micrograms / 136 micrograms (Enerzair Breezhaler®) Novartis Pharmaceuticals UK Ltd 09 April 2021 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards (...) and Area Drug and Therapeutics Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated submission indacaterol / glycopyrronium / mometasone furoate (Enerzair Breezhaler®) is accepted for use within NHSScotland. Indication under review: as a maintenance treatment of asthma in adult patients not adequately controlled with a maintenance combination of a long-acting beta 2-agonist and a high dose of an inhaled corticosteroid who experienced one

2021 Scottish Medicines Consortium

15. Glycopyrronium/formoterol fumarate dihydrate (Bevespi Aerosphere) - Maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease

Glycopyrronium/formoterol fumarate dihydrate (Bevespi Aerosphere) - Maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease Published 10 May 2021 Statement of advice SMC2377 glycopyrronium / formoterol fumarate dihydrate 7.2 micrograms / 5 micrograms pressurised inhalation, suspension (Bevespi Aerosphere®) AstraZeneca UK Limited 9 April 2021 ADVICE: in the absence of a submission from the holder of the marketing authorisation (...) glycopyrronium / formoterol fumarate dihydrate (Bevespi Aerosphere®) is not recommended for use within NHSScotland. Indication under review: Maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole

2021 Scottish Medicines Consortium

16. Management of individuals with bleeding or thrombotic disorders undergoing abortion

Kerns JL Ba D Beam N et al. Association of facility type with procedural-related morbidities and adverse events among patients undergoing induced abortions. JAMA. 2018; 319 : 2497 White K Carroll E Grossman D. Complications from first-trimester aspiration abortion: a systematic review of the literature. Contraception. 2015; 92 : 422-438 Ferraris VA Brown JR Despotis GJ Hammon JW Reece TB Saha SP et al. 2011 update to The Society of Thoracic Surgeons and the Society of Cardiovascular (...) Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011; 91 : 944-982 Schulz KF Grimes DA Christensen DD. Vasopressin reduces blood loss from second-trimester dilatation and evacuation abortion. Lancet. 1985; 2 : 353-356 Whitehouse K Tschann M Soon R Davis J Micks E Salcedo J et al. Effects of Prophylactic oxytocin on bleeding outcomes in women undergoing dilation and evacuation: a randomized controlled trial. Obstet Gynecol. 2019; 133 : 484-491 Kerns JL Pearlson G Mengesha B

2021 Society of Family Planning

17. Updated Intercollegiate General Surgery Guidance on COVID-19

patients undergoing CT abdomen and pelvis for diagnostic purposes, assessment should include CT chest unless equally reliable and rapid alternative testing methods are locally available. 5 The need persists for us to consider safety of all healthcare personnel, resource priorities, and infection rates in addition to the outcome of the individual patient. 6 The risks of viral infection and dissemination from are unknown but there is concern about uncontrolled release of pressurised gas in laparoscopic

2021 Royal College of Surgeons of England

18. Guidance for pre-operative chest CT imaging for elective cancer surgery

Guidance for pre-operative chest CT imaging for elective cancer surgery Intercollegiate guidance for pre-operative chest CT imaging for elective cancer surgery during the COVID-19 pandemic — Royal College of Surgeons Menu Search Close Site Search Site Search Go Account login Username Password Show password Nav Please enter both an email address and a password. Account login Email Password Show/Hide Password Need to reset your password? Enter the email address which you used to register (...) swab negative, proceed with surgery. If a patient is positive for COVID on throat swab then postpone surgery at least by 14 days and repeat swab 48 hours before planned surgery date. Screening CT chest Accumulating evidence clearly demonstrates that a preop CT chest does not add to the detection of Covid 19 in an asymptomatic, isolated and tested patient and is not recommended for screening before elective cancer surgery. Share this page: Share Text Recipient Email Connect with RCS © 2020 The Royal

2021 Royal College of Surgeons of England

19. Effect of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Women: A Randomized Clinical Trial Full Text available with Trip Pro

A, Palumbo A, Chen E, Blanke C, Lopez CD. Bubalo JS, et al. Support Care Cancer. 2018 Apr;26(4):1273-1279. doi: 10.1007/s00520-017-3950-y. Epub 2017 Oct 31. Support Care Cancer. 2018. PMID: 29090385 Clinical Trial. Wu F, Lin X, Yang Z, Sun Z, Zeng F, Heng J, Qu J, Zeng L, Yang N, Zhang Y. Wu F, et al. Clin Lung Cancer. 2018 Nov;19(6):e913-e918. doi: 10.1016/j.cllc.2018.08.006. Epub 2018 Aug 23. Clin Lung Cancer. 2018. PMID: 30197265 Clinical Trial. Hashimoto H, Abe M, Tokuyama O, Mizutani H, Uchitomi Y

2021 EvidenceUpdates

20. Third force in the treatment of COVID-19: A systematic review and meta-analysis Full Text available with Trip Pro

of Abuja Teaching Hospital, Gwagwalada, Nigeria. 3 Department of Medicine, University College Hospital, Ibadan, Nigeria. PMID: 33841878 PMCID: DOI: Item in Clipboard Full text links Cite Display options Display options Format Abstract Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV2) depends on RNA-dependent RNA polymerase (RdRp) enzyme complex for its genomic replications and thus can be inhibited by nucleoside analogues. An example is Remdesivir, which is a non-obligate chain (...) is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J. Biol. Chem. 2020;15(20):6785–6797. doi: 10.1074/jbc.RA120.013679. 295. - - - Malin J.J., Suarez I., Priesner V., Fatkenheuer G., Rybniker J. Remdesivir against COVID-19 and other viral diseases. Clin. Microbiol. Rev. 2020 Oct 14;(1):34. doi: 10.1128/CMR.00162-20. pii: 34/1/e00162-20. - - - Aleem A., Kothadia J.P. StatPearls Publishing; 2020. Remdesivir. 2020

2021 EvidenceUpdates

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