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41. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

approaches to HIV prevention to achieve maximum impact on reducing HIV transmission and acquisition. ART (ANTIRETROVIRAL THERAPY) ARV (antiretroviral) drugs refer to the medicines themselves and not to their use. ART refers to the use of a combination of three or more Ar V drugs to achieve viral suppression. This generally refers to lifelong treatment. Synonyms are combination Ar T and highly active Ar T. ART for prevention is used to describe the HIV prevention benefits of A r T. Eligible for ART refers (...) Library Cataloguing-in-Publication Data Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: r ecommendations for a public health approach June 2013. 1.HIV infections – drug therapy. 2.HIV infections – prevention and control. 3.Anti-r etroviral agents – therapeutic use. 4.Guideline. I.World Health Organization. ISBN 978 92 4 150572 7 (NLM classification: WC 503.2) © World Health Organization 2013 All rights reserved. Publications of the World Health

2013 World Health Organisation HIV Guidelines

42. Drug introduction

from: http://www.opsi.gov.uk/si/si1989/Uksi_1989019 2_en_1.htm. 2 HM Government. The Prescription Only Medicines (Human Use) Amendment Order 2003. Statutory Instrument 2003 No. 696: London: HMSO. Available from: http://www.opsi.gov.uk/si/si2003/20030696.htm 3 Joint Formulary Committee, editor. British National Formulary. 50th ed. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2005. APPENDIX 1 – Some common abbreviations 4 ac ante cibum (before food) approx (...) Drug introduction Adrenaline (epinephrine) ADM/ADX Drugs October 2006 Page 1 of 2 Drugs Drug Introduction Drugs October 2006 Page 1 of 2 This section outlines the common drugs currently available for administration by Ambulance Clinicians (refer to speci?c drug protocols). Legal Considerations Drugs administered by Ambulance Clinicians fall into two categories: 1. non-prescription drugs such as aspirin 2. drugs under the Medicines Act 1968 1 designated prescription-only medicines (POMs). Under

2006 Joint Royal Colleges Ambulance Liaison Committee

43. Drug and Alcohol Abuse amongst Anaesthetists - Guidance on Identification and Management 2

professional. Critical Care Medicine 2007; 35 (Suppl 2): S106-16. 25. O’Connor P, Spickard Jr A. Physician impairment by substance abuse. Medical Clinics of North America 1997; 81: 1037-52. 26. Berge K, Seppala MD, Schipper AM. Chemical dependency and the physician. Mayo Clinic Proceedings 2009; 84: 625-31. 27. American Society of Anesthesiologists Committee on Occupational Health. Model curriculum on drug abuse for residents in anesthesiology. www.asahq.org/clinical/curriculum.pdf (accessed 15/10/2009 (...) of Disease (ICD) is termed ‘harmful use’, and is defined as “A pattern of psychoactive substance use that is causing damage to health. The damage may be physical (as in cases of hepatitis from the self-administration of injected drugs) or mental, (e.g. episodes of depressive disorder secondary to heavy consumption of alcohol).” [40] The term ‘substance’ is used to cover alcohol, illicit drugs and prescription medications taken inappropriately. It is used to describe: • The use of a substance that leads

2011 Association of Anaesthetists of GB and Ireland

44. Guidance on competencies for intrathecal drug delivery

competencies, a programme of continuous professional development appropriate to IDD therapies and regular assessment and peer review of outcome data. After care requires that emergency full spine MRI scanning must be available. Arrangements must be in place for urgent referral for neurosurgical or spinal surgical opinion. 2 IDD is delivered by a variety of different medical and surgical specialists and teams. Intrathecal drugs may be delivered by external or fully implantable/programmable systems (...) , screening and preparation for therapy a. physical b. psychological c. social d. balanced assessment of benefits and risks e. comprehensive understanding of alternatives to IDD therapy f. management of patient, family and carer expectations g. delivering IDD as part of wider rehabilitative intervention 4. Interactions of IDD systems with a. Medical, electrical and magnetic equipment e.g. diathermy, physiotherapy equipment b. MRI scanners c. other implanted devices e.g. cardiac pacemakers 5. Indications

2010 Faculty of Pain Medicine

45. Drugs - Thrombolytics (Reteplase, Tenecteplase)

Drugs - Thrombolytics (Reteplase, Tenecteplase) Drugs October 2006 Page 1 of 5 Drugs Thrombolytics (Reteplase, Tenecteplase) – HEP Rpa/Tnk and Adjunctive Heparin PRESENTATION Vials of reteplase 10 units for reconstitution with 10ml water for injection. Vials of tenecteplase 10,000 units for reconstitution with 10ml water for injection, or 8,000 units for reconstitution with 8ml water for injection. NOTE: Whilst the strength of thrombolytics is traditionally expressed in ‘units’ these units (...) are unique to each particular drug and are NOT interchangeable. ACTIONS Activates the fibrinolytic system, inducing the breaking up of intravascular thrombi and emboli. INDICATIONS Acute myocardial infarction within six hours of symptom onset. Ensure patient fulfils the criteria for drug administration following the model checklist (below). Variation of these criteria is justi?able at local level with agreement of appropriate key stakeholders (e.g. cardiac network). JRCALC MODEL CHECKLIST PRIMARY

2007 Joint Royal Colleges Ambulance Liaison Committee

46. Drugs - Naloxone Hydrochloride (Narcan)

is reversed by naloxone. Unconsciousness associated with respiratory depression of unknown cause, where opioid overdose is a possibility. (Refer to depressed level of consciousness guideline). CONTRA-INDICATIONS 1. Neonatal patients of opioid addicted mothers, as serious withdrawal effects may occur – emphasis should be on bag-valve-mask ventilation and oxygenation. SIDE EFFECTS In patients who are physically dependent on narcotic drugs, violent withdrawal symptoms, including cardiac arrhythmias, may (...) Drugs - Naloxone Hydrochloride (Narcan) Naloxone Hydrochloride (Narcan) NLX Drugs October 2006 Page 1 of 2 Drugs PRESENTATION Naloxone Hydrochloride 400 micrograms/1ml ampoule. ACTIONS Antagonism of the effects (including respiratory depression) of opioid drugs. ADDITIONAL INFORMATION Naloxone may be administered intramuscularly, undiluted, (into the outer aspect of the thigh or upper arm) when IV access is impossible, but absorption may be slow. Wherever possible, the IV route should be used

2007 Joint Royal Colleges Ambulance Liaison Committee

47. Drug-Induced Liver Injury

andpathologicalphenotypesandthecurrentabsenceofspeci?c biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of aware- ness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evi- dence on risk factors, diagnosis, management and risk (...) . Clinical trials produce reliable information about the devel- opment of abnormal liver biochemistries and DILI if the inci- dence is high. However, such trials usually include a limited number of patients and are therefore underpowered to detect rare adverse effects such as idiosyncratic hepatotoxicity. Conse- quently,themajorityofdataareprovidedbyretrospectivestud- ies of databases from pharmacovigilance centres and/or pharmaceutical companies, aimed to determine the most fre- quently associated drugs

2019 European Association for the Study of the Liver

48. Drug Misuse and the Emergency Department

Drug Misuse and the Emergency Department Drug Misuse and the Emergency Department, May 2019 1 The Royal College of Emergency Medicine Best Practice Guideline Drug Misuse and the Emergency Department May 2019 Drug Misuse and the Emergency Department, May 2019 2 Contents Summary of recommendations 3 Scope 4 Reason for development 4 Introduction 4 Considerations 5 NICE recommendations 5 Refer patients 5 Medical history 6 Illicit drug screening questions 6 Written information 6 Existing resources 6 (...) to the patient’s death. The aim of the guidance is to provide recommendations for clinicians with regard patients who potentially misuse drugs. Introduction Substance abuse or drug misuse may formally be defined as the continued misuse of any mind-altering substance that severely affects person's physical and mental health, social situation and responsibilities. Alcohol dependence is the most common form of substance misuse, but any drug, including heroin, cocaine, crack and cannabis, comes into this category

2019 Royal College of Emergency Medicine

49. Unhealthy Drug Use: Screening

feasible in busy primary care settings. Longer tools (eg, the 8-item ASSIST [Alcohol, Smoking and Substance Involvement Screening Test]) that assess risks associated with unhealthy drug use or comorbid conditions. The PRO (Prenatal Risk Overview) for pregnant people. Providers should be aware of state requirements and best practices on informed consent for screening, documenting screening results in medical records, and confidentiality protections. For adolescents: Evidence is insufficient, so (...) or the U.S. Department of Health and Human Services. Many people in the US experience problems related to unhealthy drug use, defined in this recommendation statement as the use of illegal drugs and the nonmedical use of prescription psychoactive medications (ie, use of medications for reasons, for duration, in amounts, or with frequency other than prescribed or use by persons other than the prescribed individual). In 2018, an estimated 12% of US residents 18 years or older reported current unhealthy

2020 U.S. Preventive Services Task Force

50. Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia

Grading of Recommendations Assessment, Development and Evaluation GDG Guideline Development Group GDP Global Domestic Product MCI Mild Cognitive Impairment MHBC Ministry of Health British Columbia MHRA Medicines and Healthcare products Regulatory Agency NCEC National Clinical Effectiveness Committee NHMRC National Health and Medical Research Council NHS National Health Service NICE National Institute for Health and Care Excellence NPI Neuropsychiatric Inventory PBS Pharmaceutical Benefit Scheme PDD (...) . However, most evidence is based on common dementia types, particularly Alzheimer’s dementia; this needs to be borne in mind by the user when applying the evidence to other dementia types. Clinicians’ attention is also drawn to the fact that many psychotropic medications are used “off label” for people with dementia, particularly antipsychotic medication. While this is not prohibited by medicine regulations, it does require particular caution by the prescriber. This National Clinical Guideline

2019 National Clinical Guidelines (Ireland)

51. Guideline for Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients

and other health care providers who care for children aged 1 month to 18 years who are receiving antineoplastic medication with an approach to assess the emetogenic potential of antineoplastic regimens. Assessment of the emetogenic potential of antineoplastic therapy is the first step in the decision of whether or not, and to what extent, to provide antiemetic prophylaxis. The scope of this guideline is limited to the assessment of antineoplastic therapy emetogenicity in the acute phase (within 24 hours (...) of administration of an antineoplastic agent). Its scope does not include anticipatory, breakthrough or delayed phase AINV, or nausea and vomiting that is related to radiation therapy, disease, co- incident conditions or end-of-life care. In addition, this guideline is most applicable to children who are naïve to antineoplastic therapy and who are about to receive their first course of antineoplastic therapy. In the case of children who have received antineoplastic medication in the past, estimation

2010 SickKids Supportive Care Guidelines

52. Prevention of Acute Nausea and Vomiting due to Antineoplastic Medication in Pediatric Cancer Patients

: Additional Literature Search: Dronabinol and Levomepromazine 142 Appendix E: Quality of Evidence and Strength of Recommendation 148 Appendix F: Tables of Included Studies 149 F.1 Summary of studies used to inform recommendation #2a 149 F.1a Highly emetogenic antineoplastic therapy as ranked by POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients 5 Version date: February 28, 2013 F.1b Highly emetogenic antineoplastic therapy (...) as ranked by study investigators where insufficient information available to assign emetogenic risk using the POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients F.2 Summary of studies used to inform recommendation #2b 154 F.2a Moderately emetogenic antineoplastic therapy as ranked by POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients F.2b Moderately

2013 SickKids Supportive Care Guidelines

53. Policy on Medically-Necessary Care

and pro-vision of individual and community-based health care programs to achieve comprehensive health care. 2. Establishment of a dental home for all children by 12 months of age in order to institute an individualized preventive oral health program based upon each patient’s unique caries risk assessment. 3. Healthcare providers who diagnose oral disease to either provide therapy or refer the patient to a primary care dentist or dental/medical specialist as dictated by the nature and complexity (...) 2000;22(1):27-32. 67. Prabhu NT, Nunn JH, Evans DJ. A comparison of costs in providing dental care for special needs patients under sedation or general anesthesia in the North East of England. Prim Dent Care 2006;13(4):125-8. 68. Institute of Medicine Committee on Medicare Coverage Extensions. Medically necessary dental services. In; Field MJ, Lawrence RL, Zwanziger L, eds. Extending Medicare Coverage for Preventive and Other Services. Washington (DC): National Academies Press (US); 2000. Available

2019 American Academy of Pediatric Dentistry

54. Australian Institute of Sport and Australian Medical Association position statement on concussion in sport

is suspected, the athlete must be immediately removed from sport and not be allowed to return to activity until they have been assessed by a medical practitioner. “If in doubt, sit them out.” A diagnosis of concussion requires immediate physical and cognitive rest, followed by a structured, graduated return to physical activity. Children require a longer period of recovery from concussion. Algorithms are provided for use by medical and non-medically trained stakeholders in the recognition and management (...) Australian Institute of Sport and Australian Medical Association position statement on concussion in sport Australian Institute of Sport and Australian Medical Association position statement on concussion in sport | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect

2017 MJA Clinical Guidelines

55. Medical Abortion

, clinical trials, and observational studies published from June 1986 to November 2015 in English. Additionally, existing guidelines from other countries were consulted for review. A grey literature search was not required. Values The quality of evidence in this document was rated using the criteria described in the Report of the Canadian Task Force for Preventive Medicine rating scale ( Table 1 ). Benefits, Harms and/or Costs Medical abortion is safe and effective. Complications from medical abortion (...) , gestational age can be estimated using last menstrual period (LMP), clinical history, and physical examination, in women who are certain of the date of their LMP. Ultrasound is needed when uncertainty remains. (Level II-2) 4. The probability of ectopic pregnancy among women requesting abortion is consistently lower than in the general population. (Level II-3) Medical abortion regimens 5. There is limited evidence regarding teratogenicity of mifepristone, but overall the risk appears to be low. (Level III

2016 Society of Obstetricians and Gynaecologists of Canada

56. Intrapartum care for women with existing medical conditions or obstetric complications and their babies

medical conditions or obstetric complications and their babies (NG121) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Last updated April 2019 Page 24 of 961.6.11 Be aware that non-steroidal anti-inflammatory drugs can add to the risk of bleeding. 1.6.12 Before discharge from hospital, inform women with bleeding disorders of the risk of secondary bleeding postpartum and how to access care. T o find out why the committee (...) Intrapartum care for women with existing medical conditions or obstetric complications and their babies Intr Intrapartum care for women with apartum care for women with e existing medical conditions or obstetric xisting medical conditions or obstetric complications and their babies complications and their babies NICE guideline Published: 6 March 2019 www.nice.org.uk/guidance/ng121 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

57. Medical management of abortion

of abortion (medical abortion): Use of pharmacological drugs to terminate pregnancy. Sometimes the terms “non-surgical abortion” or “medication abortion” are also used. Routes of misoprostol administration: oral pills are swallowed; buccal pills are placed between the cheek and gums and swallowed after 30 minutes; sublingual pills are placed under the tongue and swallowed after 30 minutes; vaginal pills are placed in the vaginal fornices (deepest portions of the vagina) and the individual is instructed (...) , auxiliary nurse midwives, nurses, midwives, associate/advanced associate clinicians, and non-specialist and specialist doctors. Doctors of complementary systems of medicine can be providers of this service in health system contexts with an established mechanism for the participation of such doctors in other tasks related to maternal and reproductive health (10). Alongside non-specialist and specialist doctors, the following cadres can provide medical abortion for pregnancies = 12 weeks in contexts where

2019 World Health Organisation Guidelines

58. A guide to understanding the implications of the Ionising Radiation (Medical Exposure) Regulations in diagnostic and interventional radiology

and definitions 7 The employer 7 The employer’s responsibilities 7 The employer’s responsibilities for training 8 The referrer 9 Information required for a referral 9 Electronic requesting 10 The practitioner 10 Detriments to be considered in justifying an exposure 12 The operator 12 Professional responsibility 13 Authorisation 13 The role of the medical physics expert 13 The role of individuals who are not registered healthcare professionals such as radiography assistant practitioners in practical aspects (...) Royal College of Radiologists (RCR), Society and College of Radiographers (SCoR) and Institute of Physics and Engineering in Medicine (IPEM) document was published offering guidance on IR(ME)R for the radiotherapy community. 2 This was well received and became a respected guidance document. It is now apparent that practical guidance on the implications of IR(ME)R would benefit the radiology and interventional imaging community. The RCR, the SCoR, and the BIR (British Institute of Radiology) have

2015 Royal College of Radiologists

59. Medical eligibility criteria for contraceptive use

for meta-analyses was provided by Rochelle Fu. Technical and copy-editing were provided by Jura Editorial Services (jura-eds.com) and Green Ink, United Kingdom (greenink.co.uk). Funding The development of this guideline was financially supported by the National Institutes of Health (NIH) and United States Agency for International Development (USAID).Medical eligibility criteria for contraceptive use - Executive summary | 3 Abbreviations ART antiretroviral therapy ARV antiretroviral (medication) ß-hCG (...) device CVR combined contraceptive vaginal ring CYP3A4 cytochrome P450 3A4 enzyme DMPA depot medroxyprogesterone acetate DMPA-IM depot medroxyprogesterone acetate – intramuscular DMPA-SC depot medroxyprogesterone acetate – subcutaneous DVT deep vein thrombosis ECP emergency contraceptive pill EE ethinyl estradiol E-IUD emergency intrauterine device EMA European Medicines Agency ETG etonogestrel FAB fertility awareness-based methods FDA United States Food and Drug Administration GDG Guideline

2015 World Health Organisation Guidelines

60. Chronic pain disorder medical treatment guideline.

of habit-forming potential, withdrawal symptoms, and sedating side effects. Flurazepam has an active metabolite with a very long half-life, resulting in drug accumulation and next-day somnolence. These medications are not recommended for use in the working populations. Evidence Statements Regarding Hypnotics and Sedatives Some Evidence Zolpidem does not appreciably enhance the effectiveness of cognitive behavioral therapy (Design: Randomized clinical trial ). Nonsteroidal Anti-Inflammatory Drugs (...) of individual and/or group patient education as a means of facilitating self-management of symptoms Psychological or psychosocial screening should be performed on all chronic pain patients. Acupuncture Acupuncture is recommended for subacute or chronic pain patients who are trying to increase function and/or decrease medication usage and have an expressed interest in this modality. It is also recommended for subacute or acute pain for patients who cannot tolerate nonsteroidal anti-inflammatory drugs (NSAIDs

2017 National Guideline Clearinghouse (partial archive)

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