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41. Live Quantitative Monitoring of Mineral Deposition in Stem Cells Using Tetracycline Hydrochloride Full Text available with Trip Pro

Live Quantitative Monitoring of Mineral Deposition in Stem Cells Using Tetracycline Hydrochloride The final stage of in vitro osteogenic differentiation is characterized by the production of mineral deposits containing calcium cations and inorganic phosphates, which populate the extracellular matrix (ECM) surrounding the cell monolayer. Conventional histological techniques for the assessment of mineralization, such as Von Kossa and Alizarin Red S staining, are end point techniques requiring (...) cell fixation. Moreover, in both cases staining quantitation requires dye extraction, which irreversibly alters the ECM conformation and structure, therefore preventing the use of the sample for further analysis. In this study, the use of tetracycline hydrochloride (TC) is proposed for the nondestructive staining, quantitation, and imaging of mineralizing bone-like nodules in live cultures of human bone marrow mesenchymal stem cells cultured under osteogenic conditions. Overnight administration

2018 Tissue engineering. Part C, Methods

42. A Scanning Electron Microscope Evaluation of Smear Layer Removal and Antimicrobial Action of Mixture of Tetracycline, Acid and Detergent, Sodium Hypochlorite, Ethylenediaminetetraacetic Acid, and Chlorhexidine Gluconate: An In vitro Study Full Text available with Trip Pro

A Scanning Electron Microscope Evaluation of Smear Layer Removal and Antimicrobial Action of Mixture of Tetracycline, Acid and Detergent, Sodium Hypochlorite, Ethylenediaminetetraacetic Acid, and Chlorhexidine Gluconate: An In vitro Study The main objective is to evaluate the efficiency in removal of smear layer of mixture of tetracycline, acid and detergent (MTAD), sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA) and chlorhexidine gluconate by scanning electron microscope

2018 Journal of International Society of Preventive & Community Dentistry

43. TiO2 Nanotubes/Ag/MoS2 Meshy Photoelectrode with Excellent Photoelectrocatalytic Degradation Activity for Tetracycline Hydrochloride Full Text available with Trip Pro

TiO2 Nanotubes/Ag/MoS2 Meshy Photoelectrode with Excellent Photoelectrocatalytic Degradation Activity for Tetracycline Hydrochloride A novel type of TiO₂ nanotubes (NTs)/Ag/MoS₂ meshy photoelectrode was fabricated with highly oriented TiO₂ nanotube arrays grown from a Ti mesh supporting Ag nanoparticles and three-dimensional MoS₂ nanosheets. In this structure, Ag nanoparticles act as bridges to connect MoS₂ and TiO₂ and pathways for electron transfer, ensuring the abundant production of active (...) electrons, which are the source of •O₂-. The TiO₂ NTs/Ag/MoS₂ mesh can be used as both photocatalyst and electrode, exhibiting enhanced photoelectrocatalytic efficiency in degrading tetracycline hydrochloride under visible light irradiation (λ ≥ 420 nm). Compared to unmodified TiO₂ NTs, the improved photoelectrocatalytic activity of the TiO₂ NTs/Ag/MoS₂ arise from the formation of Z-scheme heterojunctions, which facilitate the efficient separation of photogenerated electron-hole pairs through

2018 Nanomaterials

44. Eggshell Membrane-Templated MnO2 Nanoparticles: Facile Synthesis and Tetracycline Hydrochloride Decontamination Full Text available with Trip Pro

Eggshell Membrane-Templated MnO2 Nanoparticles: Facile Synthesis and Tetracycline Hydrochloride Decontamination Taking advantages of reticular proteins and reductive groups on the surface, eggshell membrane (ESM) was selected to synthesize MnO2 nanoparticles from potassium permanganate through a super simple way in which ESM acted as both template and reductant. This process avoided harsh reaction conditions or complicated aftertreatments and thus owned the merits of green synthesis, handy (...) operation, low cost, and easy purification. The ESM-templated MnO2 nanoparticles (MnO2 NPs/ESM) were characterized, and the content of nanomaterials on the template was tested. MnO2 NPs/ESM showed a good capacity for decontamination of tetracycline hydrochloride (TCH). The macroscopical materials can be separated easily by taking the membrane out to stop the degradation instead of centrifugation or filtration. It was studied that 72.27% of TCH (50 mg/L) was decontaminated in 20 min by 0.1920 g/L MnO2

2018 Nanoscale research letters

45. Distribution Characteristics and Ecological Risk Assessment of Tetracyclines Pollution in the Weihe River, China Full Text available with Trip Pro

Distribution Characteristics and Ecological Risk Assessment of Tetracyclines Pollution in the Weihe River, China To examine the residual and distributions of tetracycline antibiotics in the Weihe River, SPE-UPLC (solid phase extraction-ultra performance liquid chromatography with UV-Vis detection) was employed to analyze the oxytetracycline (OTC), chlortetracycline (CTC), and minocycline (MC) of 41 surface water and 35 sediment samples collected from main streams, tributaries, and main sewage (...) outlets. The results showed that: (1) The order of residual levels of tetracycline antibiotics in water and sediment from high to low was the following: OTC > CTC > MC., considering the water solubilities are 313 mg/L, 630 mg/L, and 50200mg/L and octanol water partition coefficients (Kow) are 7.94, 4.16, and 1.12 for OTC, CTC, and MC, respectively. Thus, the distribution of antibiotics was not only related to the basic properties of antibiotics, but also some environmental factors. The concentrations

2018 International journal of environmental research and public health

46. Tetracyclines for Treatment of Tularemia: A Case Series Full Text available with Trip Pro

Tetracyclines for Treatment of Tularemia: A Case Series Tetracyclines for tularemia have been associated with higher failure rates. There were 48 cases of tularemia at the University of Missouri between 1988 and 2015. We retrospectively analyzed 17 patients with tularemia who were successfully treated with tetracyclines, and 9 of these patients also underwent aspiration or incision and drainage.

2018 Open forum infectious diseases

47. Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin Full Text available with Trip Pro

Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin Campylobacter spp. is one of the main cause of bacterial gastroenteritis in the world. The increase of antibiotic resistance in this species is a threat to public health. A Campylobacter spp. surveillance study was performed in Italy in the 2013-2016 period by the Enter-Net Italia network. The most prevalent Campylobacter species identified causing gastroenteritis (...) was Campylobacter jejuni (73.4%) and 45% of all the annual cases of campylobacteriosis were reported in the summer period. High rates of ciprofloxacin and tetracycline resistance in Campylobacter spp. have been observed. An increasing percentage of Campylobacter coli strains simultaneously resistant to ciprofloxacin, tetracycline and erythromycin has been found. Molecular mechanisms of resistance have been investigated and the role of efflux pumps evaluated. Antibiotic resistance in Campylobacter spp

2018 Frontiers in microbiology

48. Effects of 462 nm Light-Emitting Diode on the Inactivation of Escherichia coli and a Multidrug-Resistant by Tetracycline Photoreaction Full Text available with Trip Pro

Effects of 462 nm Light-Emitting Diode on the Inactivation of Escherichia coli and a Multidrug-Resistant by Tetracycline Photoreaction The adaptability of bacterial resistance to antibiotics contributes to its high efficiency during evolution. Tetracycline (TC) is a broad-spectrum antimicrobial agent. Chromatographic analyses and mass spectrometry were used to study the effects of the light illumination of a 462 nm light-emitting diode (LED) on the conformational changes of TC in a phosphate

2018 Journal of clinical medicine

49. Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3 Full Text available with Trip Pro

Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3 Tetracyclines have anticancer properties in addition to their well-known antibacterial properties. It has been proposed that tetracyclines slow metastasis and angiogenesis through inhibition of matrix metalloproteinases. However, we believe that the anticancer effect of tetracyclines is due to their inhibition of mitochondrial protein synthesis, resulting in a decrease of the mitochondrial energy (...) generating capacity. Several groups have developed analogs that are void of antibacterial action. An example is COL-3, which is currently tested for its anticancer effects in clinical trials. We have undertaken a comparative study of the tetracycline analogs COL-3 and doxycycline, which has an antibacterial function, to further investigate the role of the mitochondrial energy generating capacity in the anticancer mechanism and, thereby, evaluate the usefulness of mitochondria as an oncotarget. Our

2018 Oncotarget

50. Synthesis and Phase Transformation Studies of Dysprosium-Doped Bi4V2O11 Nanoparticles and Their Application in Visible Light Photocatalytic Degradation of Tetracycline Drug Full Text available with Trip Pro

Synthesis and Phase Transformation Studies of Dysprosium-Doped Bi4V2O11 Nanoparticles and Their Application in Visible Light Photocatalytic Degradation of Tetracycline Drug Recently, Bi4V2O11 as an electrolyte material has pulled in considerable consideration because of its remarkable novel applications. In this article, novel, dysprosium-doped (x = 0.2, 0.3, 0.4, and 0.5) Bi4V2O11 (Dy/BVO) nanoparticles have been synthesized by sol-gel strategy. The photocatalyst Dy/BVO nanoparticles exhibit (...) higher photocatalytic efficiency than BVO nanoparticles assessed by debasement of tetracycline drug under visible light illumination. Our work focuses on the phase transformation, conducting properties, and mechanisms of the Dy/BVO nanoparticles in relation to execute some methods of processing and manufacturing product in commercial applications. The characterization of Dy/BVO was performed by Fourier transform infrared, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray

2018 ACS Omega

51. Rapid detection of tetracycline resistance in bovine Pasteurella multocida isolates by MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) Full Text available with Trip Pro

Rapid detection of tetracycline resistance in bovine Pasteurella multocida isolates by MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) Pasteurella multocida is notorious for its role as an opportunistic pathogen in infectious bronchopneumonia, the economically most important disease facing cattle industry and leading indication for antimicrobial therapy. To rationalize antimicrobial use, avoiding imprudent use of highly and critically important antimicrobials for human (...) medicine, availability of a rapid antimicrobial susceptibility test is crucial. The objective of the present study was to design a MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) procedure for tetracycline resistance detection in P. multocida. This procedure was validated on 100 clinical isolates with MIC-gradient strip test, and a comparison with disk diffusion was made. Sensitivity and specificity of the MBT-ASTRA procedure were 95.7% (95% confidence interval (CI) = 89.8-101.5

2018 Scientific reports

52. The Presence of Cu Facilitates Adsorption of Tetracycline (TC) onto Water Hyacinth Roots Full Text available with Trip Pro

The Presence of Cu Facilitates Adsorption of Tetracycline (TC) onto Water Hyacinth Roots Batch experiments were conducted to investigate the adsorption characteristics of tetracycline (TC), and the interactive effects of copper (Cu) on the adsorption of TC onto water hyacinth roots. TC removal efficiency by water hyacinth roots was ranging from 58.9% to 84.6%, for virgin TC, 1:1 TC-Cu and 1:2 TC-Cu. The Freundlich isotherm model and the pseudo-second-order kinetic model fitted the adsorption

2018 International journal of environmental research and public health

53. Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China Full Text available with Trip Pro

Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China The widespread use of antibiotics and the induced antibiotic resistance genes have attracted much attention in recent years. The longshore sediments in the water-level-fluctuating zone of the Three Gorges Reservoir were selected to investigate the spatial-temporal distribution of antibiotics and antibiotic resistance genes in two different operation stages (...) (low-water level in summer and high-water level in winter). Three kinds of tetracycline antibiotics (tetracycline, oxytetracycline, and chlortetracycline) and three kinds of tetracycline resistance genes [tet(A), tet(C), and tet(M)] were analyzed and quantified. The results showed that the distribution of tetracyclines and resistance genes in riverine, transition and lacustrine zones showed a certain regularity, and the tetracycline antibiotics concentration and the total abundance

2018 Frontiers in microbiology

54. Improvement of dermal delivery of tetracycline using vesicular nanostructures Full Text available with Trip Pro

Improvement of dermal delivery of tetracycline using vesicular nanostructures The objective of this investigation was to study the potential use of nanoliposomes and nanotransfersomes in dermal delivery of tetracycline hydrochloride (TC) for acne treatment. Vesicular nanostructures were prepared by thin film hydration method and evaluated for their size, zeta potential, morphology, and entrapment efficiency. Minimal inhibitory concentration values of TC-loaded vesicles were evaluated

2018 Research in pharmaceutical sciences

55. Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study Full Text available with Trip Pro

Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study Titanium dioxide (TiO2) nanotubes are often used as carriers for loading materials such as drugs, proteins, and growth factors.In this study, we loaded tetracycline onto TiO2 nanotubes to demonstrate its antibacterial properties and biocompatibility. The two-layered anodic TiO2 nanotubes with a honeycomb-like porous structure were fabricated by using a two-step (...) anodization, and they were loaded with tetracycline by using a simplified lyophilization method and vacuum drying. Their physical properties, such as chemical compositions, wettability, and surface morphologies of the different samples, were observed and measured by X-ray photoelectron spectroscopy (XPS), contact angle measurement, and scanning electron microscopy (SEM). The in vitro growth behaviors of mouse bone marrow stromal cells (BMSCs) on these substrates were investigated.The TiO2 nanotube (NT

2018 International journal of nanomedicine

56. A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression Full Text available with Trip Pro

A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create and characterize a new transgenic mouse strain utilizing the human skeletal muscle α-actin (HSA) promoter to drive skeletal muscle-specific expression of the reverse tetracycline (...) transactivator (rtTA) gene which we have designated as the HSA-rtTA mouse.To confirm the HSA-rtTA mouse was capable of driving skeletal muscle-specific expression, we crossed the HSA-rtTA mouse with the tetracycline-responsive histone H2B-green fluorescent protein (H2B-GFP) transgenic mouse in order to label myonuclei.Reverse transcription-PCR confirmed skeletal muscle-specific expression of rtTA mRNA, while single-fiber analysis showed highly effective GFP labeling of myonuclei in both fast- and slow-twitch

2018 Skeletal muscle

57. Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms Full Text available with Trip Pro

Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms Carriage of antibiotic-resistant foodborne pathogens by food production animals is one of many contributors to treatment failure in health care settings, and it necessitates an integrated approach to investigate the carriage of resistant pathogens harboring integrons in food-producing animals.Escherichia coli (...) isolates with reduced susceptibility to tetracycline antibiotics (n = 92) were tested for associations between carriage of class1 integrons, phylogenetic group affiliation and tetracycline resistance determinants using the MIC method, PFGE analysis, PCR and sequencing.Phylogroups B1 and A were the most common (58.7 and 19.6%, respectively), followed by groups D (20.7%) and B2 (1.1%). All isolates carried at least one of the tet genes examined. In addition, 88 (95.7%) of all tetracycline-resistant

2018 BMC veterinary research

58. Molecular mechanisms underlying heat or tetracycline treatments for citrus HLB control Full Text available with Trip Pro

Molecular mechanisms underlying heat or tetracycline treatments for citrus HLB control Huanglongbing (HLB), a destructive plant bacterial disease, severely impedes worldwide citrus production. In our previous reports, we revealed the molecular mechanisms of host plant responses that underlie thermotherapy against HLB. In this study, we investigated the molecular mechanism underlying heat or tetracycline treatments on the HLB bacterium, 'Candidatus Liberibacter asiaticus' (Las) by focusing (...) on Las prophage/phage conversion under stress conditions. By comparing the prophage FP1 and FP2 copy number to the copy number of 16S rDNA in HLB-affected plants, we found that the relative copy number of both FP1 and FP2 increased significantly, ranging from 3.4- to 6.7-fold change when Las-infected samples underwent a temperature shift from 23 to 37, 42 or 45 °C. When treated with tetracycline at 50-150 and 200-250 µg/ml, respectively, the relative copy number of both FP1 and FP2 increased by 3.4

2018 Horticulture research

59. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue Full Text available with Trip Pro

A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue Due to the abuse of antibiotics, antibiotic residues can be detected in both natural environment and various industrial products, posing threat to the environment and human health. Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline (Tc)-one of the commonly used antibiotics once on humans and now on poultry, cattle and fisheries. A Tc (...) -degrading enzyme, TetX, from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E. coli and fully characterized, including its Km and kcat value. We quantitatively evaluated its activity both in vitro and in vivo by UV-Vis spectrometer and LC-MS. Moreover, we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX, and studied the dose-response of TetX under different inducer

2018 Synthetic and Systems Biotechnology

60. Photocatalytic Degradation of Tetracycline Hydrochloride via a CdS-TiO2 Heterostructure Composite under Visible Light Irradiation Full Text available with Trip Pro

Photocatalytic Degradation of Tetracycline Hydrochloride via a CdS-TiO2 Heterostructure Composite under Visible Light Irradiation A photocatalytic active CdS-TiO₂ heterostructure composite was prepared by hydrothermal method and its morphology and properties were characterized. Results indicate that the CdS nanoparticles deposited on the surface of a TiO₂ nanoparticles, which was in anatase phase. The particle scale of both of the components reached approximately 15 nm. In comparison to pure (...) TiO₂ (410 nm), the light absorption edge of the heterostructure composite was 550 nm, which could extend the light response from UV to the visible region. Under visible light irradiation, the degradation efficiency of tetracycline hydrochloride by the CdS-TiO₂ composite achieved 87.06%, significantly enhancing photocatalytic activity than the as-prepared pure TiO₂ and commercial TiO₂ (Degussa P25). This character is attributed to the synergetic effect of these two components in the absorption

2018 Nanomaterials

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