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41. Genetic Determinants of Tetracycline Resistance in Clinical Streptococcus pneumoniae Serotype 1 Isolates from Niger Full Text available with Trip Pro

Genetic Determinants of Tetracycline Resistance in Clinical Streptococcus pneumoniae Serotype 1 Isolates from Niger Streptococcus pneumoniae serotype 1 is the first cause of pneumococcal meningitis Niger. To determine the underlying mechanism of resistance to tetracycline in serotype 1 Streptococcus pneumoniae, a collection of 37 isolates recovered from meningitis patients over the period of 2002 to 2009 in Niger were analyzed for drug susceptibility, and whole genome sequencing (WGS (...) ) was performed for molecular analyses. MIC level was determined for 31/37 (83.8%) isolates and allowed detection of full resistance (MIC = 8 µg) in 24/31 (77.4%) isolates. No resistance was found to macrolides and quinolones. Sequence-types deduced from WGS were ST217 (54.1%), ST303 (35.1%), ST2206 (5.4%), ST2839 (2.7%) and one undetermined ST (2.7%). All tetracycline resistant isolates carried a Tn5253 like element, which was found to be an association of two smaller transposons of Tn916 and Tn5252 families

2018 Antibiotics

42. Application of tetracycline hydrochloride loaded-fungal chitosan and Aloe vera extract based composite sponges for wound dressing Full Text available with Trip Pro

Application of tetracycline hydrochloride loaded-fungal chitosan and Aloe vera extract based composite sponges for wound dressing Chitosan composite material has been used as an efficient drug carrier for potential drug delivery systems in specific cases of wound dressing management. In the present study, 0.5 g/L of the antibiotic tetracycline hydrochloride (TCH) was loaded into 1% fungal chitosan (FCS) incorporated with 0.2% of Aloe vera extract (AVE). Two types of sponges were prepared

2018 Journal of advanced research

43. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue Full Text available with Trip Pro

A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue Due to the abuse of antibiotics, antibiotic residues can be detected in both natural environment and various industrial products, posing threat to the environment and human health. Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline (Tc)-one of the commonly used antibiotics once on humans and now on poultry, cattle and fisheries. A Tc (...) -degrading enzyme, TetX, from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E. coli and fully characterized, including its Km and kcat value. We quantitatively evaluated its activity both in vitro and in vivo by UV-Vis spectrometer and LC-MS. Moreover, we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX, and studied the dose-response of TetX under different inducer

2018 Synthetic and Systems Biotechnology

44. Molecular mechanisms underlying heat or tetracycline treatments for citrus HLB control Full Text available with Trip Pro

Molecular mechanisms underlying heat or tetracycline treatments for citrus HLB control Huanglongbing (HLB), a destructive plant bacterial disease, severely impedes worldwide citrus production. In our previous reports, we revealed the molecular mechanisms of host plant responses that underlie thermotherapy against HLB. In this study, we investigated the molecular mechanism underlying heat or tetracycline treatments on the HLB bacterium, 'Candidatus Liberibacter asiaticus' (Las) by focusing (...) on Las prophage/phage conversion under stress conditions. By comparing the prophage FP1 and FP2 copy number to the copy number of 16S rDNA in HLB-affected plants, we found that the relative copy number of both FP1 and FP2 increased significantly, ranging from 3.4- to 6.7-fold change when Las-infected samples underwent a temperature shift from 23 to 37, 42 or 45 °C. When treated with tetracycline at 50-150 and 200-250 µg/ml, respectively, the relative copy number of both FP1 and FP2 increased by 3.4

2018 Horticulture research

45. Tetracycline-Inactivating Enzymes Full Text available with Trip Pro

Tetracycline-Inactivating Enzymes Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis and strategic scaffold modifications designed to overcome established clinical resistance mechanisms including efflux and ribosome protection. Emerging new resistance mechanisms, including enzymatic antibiotic inactivation, threaten recent progress on bringing these next (...) -generation tetracyclines to the clinic. Here we review the current state of knowledge on the structure, mechanism, and inhibition of tetracycline-inactivating enzymes.

2018 Frontiers in microbiology

46. Genome Sequences of Acholeplasma laidlawii Strains with Increased Resistance to Tetracycline and Melittin Full Text available with Trip Pro

Genome Sequences of Acholeplasma laidlawii Strains with Increased Resistance to Tetracycline and Melittin Acholeplasma laidlawii is a well-suited model for studying the molecular basis for adapting mollicutes to environmental conditions. Here, we present the whole-genome sequences of two strains of A. laidlawii with increased resistance to tetracycline and melittin.Copyright © 2018 Baranova et al.

2018 Genome Announcements

47. Photocatalytic Degradation of Tetracycline Hydrochloride via a CdS-TiO2 Heterostructure Composite under Visible Light Irradiation Full Text available with Trip Pro

Photocatalytic Degradation of Tetracycline Hydrochloride via a CdS-TiO2 Heterostructure Composite under Visible Light Irradiation A photocatalytic active CdS-TiO₂ heterostructure composite was prepared by hydrothermal method and its morphology and properties were characterized. Results indicate that the CdS nanoparticles deposited on the surface of a TiO₂ nanoparticles, which was in anatase phase. The particle scale of both of the components reached approximately 15 nm. In comparison to pure (...) TiO₂ (410 nm), the light absorption edge of the heterostructure composite was 550 nm, which could extend the light response from UV to the visible region. Under visible light irradiation, the degradation efficiency of tetracycline hydrochloride by the CdS-TiO₂ composite achieved 87.06%, significantly enhancing photocatalytic activity than the as-prepared pure TiO₂ and commercial TiO₂ (Degussa P25). This character is attributed to the synergetic effect of these two components in the absorption

2018 Nanomaterials

48. High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application Full Text available with Trip Pro

High diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application By performing a microcosm experiment mimicking fertilization, we assessed the dynamic distribution of tetracycline-resistant bacteria (TRB) and corresponding tetracycline resistance genes (TRGs) from pig manure (PM) to the fertilized soil, by culture-dependent methods and PCR detection. Cultivable TRB were most abundant in PM, followed by fertilized soil and unfertilized soil

2018 Scientific reports

49. Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin Full Text available with Trip Pro

Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin Campylobacter spp. is one of the main cause of bacterial gastroenteritis in the world. The increase of antibiotic resistance in this species is a threat to public health. A Campylobacter spp. surveillance study was performed in Italy in the 2013-2016 period by the Enter-Net Italia network. The most prevalent Campylobacter species identified causing gastroenteritis (...) was Campylobacter jejuni (73.4%) and 45% of all the annual cases of campylobacteriosis were reported in the summer period. High rates of ciprofloxacin and tetracycline resistance in Campylobacter spp. have been observed. An increasing percentage of Campylobacter coli strains simultaneously resistant to ciprofloxacin, tetracycline and erythromycin has been found. Molecular mechanisms of resistance have been investigated and the role of efflux pumps evaluated. Antibiotic resistance in Campylobacter spp

2018 Frontiers in microbiology

50. Eggshell Membrane-Templated MnO2 Nanoparticles: Facile Synthesis and Tetracycline Hydrochloride Decontamination Full Text available with Trip Pro

Eggshell Membrane-Templated MnO2 Nanoparticles: Facile Synthesis and Tetracycline Hydrochloride Decontamination Taking advantages of reticular proteins and reductive groups on the surface, eggshell membrane (ESM) was selected to synthesize MnO2 nanoparticles from potassium permanganate through a super simple way in which ESM acted as both template and reductant. This process avoided harsh reaction conditions or complicated aftertreatments and thus owned the merits of green synthesis, handy (...) operation, low cost, and easy purification. The ESM-templated MnO2 nanoparticles (MnO2 NPs/ESM) were characterized, and the content of nanomaterials on the template was tested. MnO2 NPs/ESM showed a good capacity for decontamination of tetracycline hydrochloride (TCH). The macroscopical materials can be separated easily by taking the membrane out to stop the degradation instead of centrifugation or filtration. It was studied that 72.27% of TCH (50 mg/L) was decontaminated in 20 min by 0.1920 g/L MnO2

2018 Nanoscale research letters

51. Distribution Characteristics and Ecological Risk Assessment of Tetracyclines Pollution in the Weihe River, China Full Text available with Trip Pro

Distribution Characteristics and Ecological Risk Assessment of Tetracyclines Pollution in the Weihe River, China To examine the residual and distributions of tetracycline antibiotics in the Weihe River, SPE-UPLC (solid phase extraction-ultra performance liquid chromatography with UV-Vis detection) was employed to analyze the oxytetracycline (OTC), chlortetracycline (CTC), and minocycline (MC) of 41 surface water and 35 sediment samples collected from main streams, tributaries, and main sewage (...) outlets. The results showed that: (1) The order of residual levels of tetracycline antibiotics in water and sediment from high to low was the following: OTC > CTC > MC., considering the water solubilities are 313 mg/L, 630 mg/L, and 50200mg/L and octanol water partition coefficients (Kow) are 7.94, 4.16, and 1.12 for OTC, CTC, and MC, respectively. Thus, the distribution of antibiotics was not only related to the basic properties of antibiotics, but also some environmental factors. The concentrations

2018 International journal of environmental research and public health

52. TiO2 Nanotubes/Ag/MoS2 Meshy Photoelectrode with Excellent Photoelectrocatalytic Degradation Activity for Tetracycline Hydrochloride Full Text available with Trip Pro

TiO2 Nanotubes/Ag/MoS2 Meshy Photoelectrode with Excellent Photoelectrocatalytic Degradation Activity for Tetracycline Hydrochloride A novel type of TiO₂ nanotubes (NTs)/Ag/MoS₂ meshy photoelectrode was fabricated with highly oriented TiO₂ nanotube arrays grown from a Ti mesh supporting Ag nanoparticles and three-dimensional MoS₂ nanosheets. In this structure, Ag nanoparticles act as bridges to connect MoS₂ and TiO₂ and pathways for electron transfer, ensuring the abundant production of active (...) electrons, which are the source of •O₂-. The TiO₂ NTs/Ag/MoS₂ mesh can be used as both photocatalyst and electrode, exhibiting enhanced photoelectrocatalytic efficiency in degrading tetracycline hydrochloride under visible light irradiation (λ ≥ 420 nm). Compared to unmodified TiO₂ NTs, the improved photoelectrocatalytic activity of the TiO₂ NTs/Ag/MoS₂ arise from the formation of Z-scheme heterojunctions, which facilitate the efficient separation of photogenerated electron-hole pairs through

2018 Nanomaterials

53. Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China Full Text available with Trip Pro

Occurrence and Distribution of Tetracycline Antibiotics and Resistance Genes in Longshore Sediments of the Three Gorges Reservoir, China The widespread use of antibiotics and the induced antibiotic resistance genes have attracted much attention in recent years. The longshore sediments in the water-level-fluctuating zone of the Three Gorges Reservoir were selected to investigate the spatial-temporal distribution of antibiotics and antibiotic resistance genes in two different operation stages (...) (low-water level in summer and high-water level in winter). Three kinds of tetracycline antibiotics (tetracycline, oxytetracycline, and chlortetracycline) and three kinds of tetracycline resistance genes [tet(A), tet(C), and tet(M)] were analyzed and quantified. The results showed that the distribution of tetracyclines and resistance genes in riverine, transition and lacustrine zones showed a certain regularity, and the tetracycline antibiotics concentration and the total abundance

2018 Frontiers in microbiology

54. Tetracyclines for Treatment of Tularemia: A Case Series Full Text available with Trip Pro

Tetracyclines for Treatment of Tularemia: A Case Series Tetracyclines for tularemia have been associated with higher failure rates. There were 48 cases of tularemia at the University of Missouri between 1988 and 2015. We retrospectively analyzed 17 patients with tularemia who were successfully treated with tetracyclines, and 9 of these patients also underwent aspiration or incision and drainage.

2018 Open forum infectious diseases

55. The Presence of Cu Facilitates Adsorption of Tetracycline (TC) onto Water Hyacinth Roots Full Text available with Trip Pro

The Presence of Cu Facilitates Adsorption of Tetracycline (TC) onto Water Hyacinth Roots Batch experiments were conducted to investigate the adsorption characteristics of tetracycline (TC), and the interactive effects of copper (Cu) on the adsorption of TC onto water hyacinth roots. TC removal efficiency by water hyacinth roots was ranging from 58.9% to 84.6%, for virgin TC, 1:1 TC-Cu and 1:2 TC-Cu. The Freundlich isotherm model and the pseudo-second-order kinetic model fitted the adsorption

2018 International journal of environmental research and public health

56. Rapid detection of tetracycline resistance in bovine Pasteurella multocida isolates by MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) Full Text available with Trip Pro

Rapid detection of tetracycline resistance in bovine Pasteurella multocida isolates by MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) Pasteurella multocida is notorious for its role as an opportunistic pathogen in infectious bronchopneumonia, the economically most important disease facing cattle industry and leading indication for antimicrobial therapy. To rationalize antimicrobial use, avoiding imprudent use of highly and critically important antimicrobials for human (...) medicine, availability of a rapid antimicrobial susceptibility test is crucial. The objective of the present study was to design a MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) procedure for tetracycline resistance detection in P. multocida. This procedure was validated on 100 clinical isolates with MIC-gradient strip test, and a comparison with disk diffusion was made. Sensitivity and specificity of the MBT-ASTRA procedure were 95.7% (95% confidence interval (CI) = 89.8-101.5

2018 Scientific reports

57. Effects of 462 nm Light-Emitting Diode on the Inactivation of Escherichia coli and a Multidrug-Resistant by Tetracycline Photoreaction Full Text available with Trip Pro

Effects of 462 nm Light-Emitting Diode on the Inactivation of Escherichia coli and a Multidrug-Resistant by Tetracycline Photoreaction The adaptability of bacterial resistance to antibiotics contributes to its high efficiency during evolution. Tetracycline (TC) is a broad-spectrum antimicrobial agent. Chromatographic analyses and mass spectrometry were used to study the effects of the light illumination of a 462 nm light-emitting diode (LED) on the conformational changes of TC in a phosphate

2018 Journal of clinical medicine

58. Synthesis and Phase Transformation Studies of Dysprosium-Doped Bi4V2O11 Nanoparticles and Their Application in Visible Light Photocatalytic Degradation of Tetracycline Drug Full Text available with Trip Pro

Synthesis and Phase Transformation Studies of Dysprosium-Doped Bi4V2O11 Nanoparticles and Their Application in Visible Light Photocatalytic Degradation of Tetracycline Drug Recently, Bi4V2O11 as an electrolyte material has pulled in considerable consideration because of its remarkable novel applications. In this article, novel, dysprosium-doped (x = 0.2, 0.3, 0.4, and 0.5) Bi4V2O11 (Dy/BVO) nanoparticles have been synthesized by sol-gel strategy. The photocatalyst Dy/BVO nanoparticles exhibit (...) higher photocatalytic efficiency than BVO nanoparticles assessed by debasement of tetracycline drug under visible light illumination. Our work focuses on the phase transformation, conducting properties, and mechanisms of the Dy/BVO nanoparticles in relation to execute some methods of processing and manufacturing product in commercial applications. The characterization of Dy/BVO was performed by Fourier transform infrared, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray

2018 ACS Omega

59. Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3 Full Text available with Trip Pro

Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3 Tetracyclines have anticancer properties in addition to their well-known antibacterial properties. It has been proposed that tetracyclines slow metastasis and angiogenesis through inhibition of matrix metalloproteinases. However, we believe that the anticancer effect of tetracyclines is due to their inhibition of mitochondrial protein synthesis, resulting in a decrease of the mitochondrial energy (...) generating capacity. Several groups have developed analogs that are void of antibacterial action. An example is COL-3, which is currently tested for its anticancer effects in clinical trials. We have undertaken a comparative study of the tetracycline analogs COL-3 and doxycycline, which has an antibacterial function, to further investigate the role of the mitochondrial energy generating capacity in the anticancer mechanism and, thereby, evaluate the usefulness of mitochondria as an oncotarget. Our

2018 Oncotarget

60. Improvement of dermal delivery of tetracycline using vesicular nanostructures Full Text available with Trip Pro

Improvement of dermal delivery of tetracycline using vesicular nanostructures The objective of this investigation was to study the potential use of nanoliposomes and nanotransfersomes in dermal delivery of tetracycline hydrochloride (TC) for acne treatment. Vesicular nanostructures were prepared by thin film hydration method and evaluated for their size, zeta potential, morphology, and entrapment efficiency. Minimal inhibitory concentration values of TC-loaded vesicles were evaluated

2018 Research in pharmaceutical sciences

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