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241. 16S rRNA Gene Mutations Associated with Decreased Susceptibility to Tetracycline in Mycoplasma bovis. Full Text available with Trip Pro

16S rRNA Gene Mutations Associated with Decreased Susceptibility to Tetracycline in Mycoplasma bovis. Mycoplasma bovis isolates with decreased susceptibilities to tetracyclines are increasingly reported worldwide. The acquired molecular mechanisms associated with this phenomenon were investigated in 70 clinical isolates of M. bovis. Sequence analysis of the two 16S rRNA-encoding genes (rrs3 and rrs4 alleles) containing the primary binding pocket for tetracycline (Tet-1 site) was performed (...) on isolates with tetracycline hydrochloride MICs of 0.125 to 16 μg/ml. Mutations at positions A965T, A967T/C (Escherichia coli numbering) of helix 31, U1199C of helix 34, and G1058A/C were identified. Decreased susceptibilities to tetracycline (MICs, ≥2 μg/ml) were associated with mutations present at two (A965 and A967) or three positions (A965, A967, and G1058) of the two rrs alleles. No tet(M), tet(O), or tet(L) determinants were found in the genome of any of the 70 M. bovis isolates. The data

2014 Antimicrobial Agents and Chemotherapy

242. Impact of treatment strategies on cephalosporin and tetracycline resistance gene quantities in the bovine fecal metagenome. Full Text available with Trip Pro

Impact of treatment strategies on cephalosporin and tetracycline resistance gene quantities in the bovine fecal metagenome. The study objective was to determine the effects of two treatment regimens on quantities of ceftiofur and tetracycline resistance genes in feedlot cattle. The two regimens were ceftiofur crystalline-free acid (CCFA) administered to either one or all steers within a pen and subsequent feeding/not feeding of therapeutic doses of chlortetracycline. A 26-day randomized (...) controlled field trial was conducted on 176 steers. Real-time PCR was used to quantify bla(CMY-2), bla(CTX-M), tet(A), tet(B), and 16S rRNA gene copies/gram of feces from community DNA. A significant increase in ceftiofur resistance and a decrease in tetracycline resistance elements were observed among the treatment groups in which all steers received CCFA treatment, expressed as gene copies/gram of feces. Subsequent chlortetracycline administration led to rapid expansion of both ceftiofur

2014 Scientific reports Controlled trial quality: uncertain

243. Intralesional Tetracycline Injection for Treatment of Lower Eyelid Festoons: A Preliminary Report. (Abstract)

Intralesional Tetracycline Injection for Treatment of Lower Eyelid Festoons: A Preliminary Report. To determine the safety and effectiveness of intralesional tetracycline 2% injection for the treatment of lower eyelid festoons.The authors retrospectively reviewed the charts of all patients undergoing tetracycline 2% injection of lower eyelid festoons at the Cole Eye Institute from August 2008 to August 2013. Charts were reviewed for patient demographic data, dose and number of tetracycline (...) injection. Average follow up was 121 days (range, 18-586 days). Patients received up to 0.75 ml (mean, 0.24 ml) of tetracycline 2% per side. Average preinjection grade was 2.1 (standard deviation, 0.89; range, 0-3), and average postinjection grade was 1.2 (standard deviation, 0.72; range, 0-2; p < 0.001). Three patients had follow up less than 60 days (mean, 34 days), with an average preinjection grade of 1.96 and postinjection grade of 1.23 (p < 0.001). Five patients had follow up between 60 and 100

2014 Ophthalmic plastic and reconstructive surgery Controlled trial quality: uncertain

244. Low Doses of Tetracycline Trigger the E. coli Growth: A Case of Hormetic Response Full Text available with Trip Pro

Low Doses of Tetracycline Trigger the E. coli Growth: A Case of Hormetic Response Hormesis is a biphasic dose-response relationship, occurring when low concentrations of toxic agents elicit apparent improvements. In this work, the ability of sub-inhibitory concentrations of Tetracycline to induce hormetic response in a model organism was investigated. To this aim a reference strain of Escherichia coli, MG1655, was exposed to six decreasing doses of Tetracycline (between 0.12 and 0.00375 μg/ml (...) ), much lower than the Minimal Inhibitory Concentration (4 μg/ml). An hormetic increase was observed at the intermediate concentrations (0.015-0.03 μg/ml) of the tested range. The Colony Forming Unit number, indeed, rose up to 141% and 121% as compared to the control. At the highest (0.12 μg/ml) and lowest (0.00375 μg/ml) concentrations a slight decrease in CFU number was found. Results demonstrated that, in Escherichia coli, low concentrations of Tetracycline bias the bacterial numerical increase

2013 Dose-Response

245. Determination of Tetracycline in Pharmaceutical Preparation by Molecular and Atomic Absorption Spectrophotometry and High Performance Liquid Chromatography via Complex Formation with Au(III) and Hg(II) Ions in Solutions Full Text available with Trip Pro

Determination of Tetracycline in Pharmaceutical Preparation by Molecular and Atomic Absorption Spectrophotometry and High Performance Liquid Chromatography via Complex Formation with Au(III) and Hg(II) Ions in Solutions UV-visible and atomic spectrophotometry and HPLC techniques were applied for the determination of tetracycline (TC) in pharmaceutical preparations via complexation of the drug with Au(III) and Hg(II) ions in solutions. The mole ratio of TC to metal ions was 1 : 1. Maximum peak

2013 International Journal of Analytical Chemistry

246. Reply to “Are There Reasons To Prefer Tetracyclines to Macrolides in Older Patients with Community-Acquired Pneumonia?” Full Text available with Trip Pro

Reply to “Are There Reasons To Prefer Tetracyclines to Macrolides in Older Patients with Community-Acquired Pneumonia?” 23858064 2014 01 08 2018 12 02 1098-6596 57 8 2013 Aug Antimicrobial agents and chemotherapy Antimicrob. Agents Chemother. Reply to "Are there reasons to prefer tetracyclines to macrolides in older patients with community-acquired pneumonia?". 4094 10.1128/AAC.00864-13 Brown Kevin A KA Khanafer Nagham N Daneman Nick N Fisman David N DN eng Letter Comment United States

2013 Antimicrobial Agents and Chemotherapy

247. Are There Reasons To Prefer Tetracyclines to Macrolides in Older Patients with Community-Acquired Pneumonia? Full Text available with Trip Pro

Are There Reasons To Prefer Tetracyclines to Macrolides in Older Patients with Community-Acquired Pneumonia? 23858063 2014 01 08 2018 12 02 1098-6596 57 8 2013 Aug Antimicrobial agents and chemotherapy Antimicrob. Agents Chemother. Are there reasons to prefer tetracyclines to macrolides in older patients with community-acquired pneumonia? 4093 10.1128/AAC.00828-13 Di Bella S S Taglietti F F Petrosillo N N eng Letter Comment United States Antimicrob Agents Chemother 0315061 0066-4804 0 Anti

2013 Antimicrobial Agents and Chemotherapy

248. Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids Full Text available with Trip Pro

Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids Intrapleural processing of prourokinase (scuPA) in tetracycline (TCN)-induced pleural injury in rabbits was evaluated to better understand the mechanisms governing successful scuPA-based intrapleural fibrinolytic therapy (IPFT), capable of clearing pleural adhesions in this model. Pleural fluid (PF) was withdrawn 0-80 min and 24 h after

2013 American Journal of Physiology - Lung Cellular and Molecular Physiology

249. Draft Genome Sequence of Mycobacterium massiliense Strain M159, Showing Phenotypic Resistance to β-Lactam and Tetracycline Antibiotics Full Text available with Trip Pro

Draft Genome Sequence of Mycobacterium massiliense Strain M159, Showing Phenotypic Resistance to β-Lactam and Tetracycline Antibiotics Mycobacterium massiliense is a nontuberculous mycobacterium associated with human infections. We report here the draft genome sequence of M. massiliense strain M159, isolated from the bronchial aspirate of a patient who had a pulmonary infection. This strain showed genotypic and in vitro resistance to a number of tetracyclines and beta-lactam antibiotics.

2013 Genome Announcements

250. Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element Full Text available with Trip Pro

Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element Camels are the most valuable livestock species in the Horn of Africa and play a pivotal role in the nutritional sustainability for millions of people. Their health status is therefore of utmost importance for the people living in this region. Streptococcus agalactiae, a Group B Streptococcus (GBS), is an important camel pathogen (...) in the region. Camel GBS sequence types (STs) were distinct from other STs reported so far. We mapped specific STs and capsular types to major disease complexes caused by GBS. Widespread resistance (34%) to tetracycline was associated with acquisition of the tetM gene that is carried on a Tn916-like element, and observed primarily among GBS isolated from mastitis. The presence of tetM within different MLST clades suggests acquisition on multiple occasions. Wound infections and mastitis in camels associated

2013 Veterinary Research

251. Performance of photocatalytic oxidation of tetracycline in aqueous solution by TiO2 nanofibers Full Text available with Trip Pro

Performance of photocatalytic oxidation of tetracycline in aqueous solution by TiO2 nanofibers The presence of pharmaceutical compounds in water and soil has become an environmental concern. The aim of this study was to evaluate the performance of TiO2 nanofiber in the oxidation of the antibiotic tetracycline. TiO2 nanofiber was fabricated by electro-spinning method, and then was calcined at 560°C for 2 h. Central composite design (CCD) statistic model was used to optimize tetracycline (...) concentration, time and pH for TiO2 catalyst. A tubular Pyrex glass reactor with diameter of 15 cm and height of 30 cm was designed and a 125W Philips HPLN lamp (UV, λ > 254 nm) was used as light source. Samples were measured by high-performance liquid chromatography (HPLC). Equation of model suggests a direct relationship between pH and time with efficiency of tetracycline removal. The observations indicated that time is the most significant (scaled estimate = + 28.04) parameter in efficiency

2013 Journal of Environmental Health Science and Engineering

252. Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW 2992

Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW 2992 Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01880515 Recruitment Status : Completed First Posted : June 19, 2013 Results First Posted : April 12

2013 Clinical Trials

253. Intralesional Tetracycline Injection in the Treatment of Chalazia

Intralesional Tetracycline Injection in the Treatment of Chalazia Intralesional Tetracycline Injection in the Treatment of Chalazia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intralesional Tetracycline (...) Party): The Cleveland Clinic Study Details Study Description Go to Brief Summary: The investigators propose a study to investigate the role of tetracycline injection into chalazia versus observation alone. The investigators hypothesize tetracycline injection will result in a significant decrease in lesion size when compared to observation alone. Condition or disease Intervention/treatment Phase Chalazia Chalazion Drug: Tetracycline Early Phase 1 Study Design Go to Layout table for study information

2013 Clinical Trials

254. Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle. Full Text available with Trip Pro

Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle. Digital dermatitis is an infectious disease that causes lameness in dairy cattle, a primary welfare concern of the dairy industry. One of the common treatments for this painful hoof disease is through the application of an antibiotic bandage that must be removed following treatment. The objectives of this randomized clinical (...) trial were to determine if topical application of tetracycline hydrochloride in a paste would be as therapeutically effective for the treatment of digital dermatitis as a powdered form of tetracycline hydrochloride held in place by a bandage, and to quantify pain associated with digital dermatitis lesions. Two hundred and fourteen Holstein cow hooves with digital dermatitis lesions were randomly assigned to 1 of 3 treatments: a tetracycline hydrochloride paste, tetracycline hydrochloride powder held

2013 Journal of dairy science Controlled trial quality: uncertain

255. Susceptibility of Tetracyclines to Tet(A) Resistance is Independent of Interdomain Loop Sequence. Full Text available with Trip Pro

Susceptibility of Tetracyclines to Tet(A) Resistance is Independent of Interdomain Loop Sequence. 23478964 2013 10 24 2018 11 13 1098-6596 57 5 2013 May Antimicrobial agents and chemotherapy Antimicrob. Agents Chemother. Susceptibility of tetracyclines to Tet(a) resistance is independent of interdomain loop sequence. 2430-1 10.1128/AAC.00393-13 Fyfe Corey C Sutcliffe Joyce A JA Grossman Trudy H TH eng Letter 2013 03 11 United States Antimicrob Agents Chemother 0315061 0066-4804 0 Anti-Bacterial (...) Agents 0 Antiporters 0 Bacterial Proteins 0 DNA Transposable Elements 0 Tetracyclines 0 tetA protein, Bacteria IM Anti-Bacterial Agents pharmacology Antiporters genetics metabolism Bacterial Proteins genetics metabolism Cloning, Molecular DNA Transposable Elements Escherichia coli drug effects genetics metabolism Inverted Repeat Sequences Microbial Sensitivity Tests Plasmids Substrate Specificity Tetracycline Resistance genetics Tetracyclines pharmacology 2013 3 13 6 0 2013 3 13 6 0 2013 10 25 6 0

2013 Antimicrobial Agents and Chemotherapy

256. Prevalence of tetracycline resistance genes and identification of tet(M) in clinical isolates of E.coli from sick ducks in China. Full Text available with Trip Pro

Prevalence of tetracycline resistance genes and identification of tet(M) in clinical isolates of E.coli from sick ducks in China. Tetracycline resistance is one of the most frequently encountered resistance properties in bacteria of animal origin. The aim of the present study was to investigate the prevalence and diversity of tetracycline resistance (tet) genes among Escherichia coli clinical isolates from diseased ducks in China and to report the identification and sequencing of the tet(M (...) ) gene. The susceptibility of 85 Escherichia coli strains to tetracyclines was determined by broth microdilution, and the presence of tet genes was investigated by multiplex PCR. All of the 85 isolates were fully resistant to both oxytetracycline and tetracycline, and 76.5 % were resistant to doxycycline. Seventy-seven of the isolates (90.6 %) encoded multiple tet genes, with 17.6, 38.8 and 34.1 % encoding two, three and four tet genes, respectively, and only 7.1 % encoded a single tet(A) gene

2013 Journal of Medical Microbiology

257. Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil. Full Text available with Trip Pro

Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil. To characterize a tetracycline resistance (Tc(R)) determinant, closely related to the TetL efflux pump, in a Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil.Genomic DNA of B. cecembensis DMV42A was shotgun cloned and expressed in Escherichia coli. Antimicrobial susceptibility testing and a [(3)H]tetracycline uptake assay (...) were used to confirm the function of the target gene. Transferability of the gene was examined using filter matings and confirmed by PCR and sequencing. Real-time quantitative PCR was performed on soil metagenomic DNA to evaluate the prevalence of the gene in the soil from which B. cecembensis DMV42A was isolated and in more pristine local soils.The Tc(R) determinant from B. cecembensis DMV42A, designated Tet45, was identified as a tetracycline efflux pump sharing 78% amino acid identity

2013 Journal of Antimicrobial Chemotherapy

258. In Vitro and In Vivo Antimalarial Efficacy of Optimized Tetracyclines. Full Text available with Trip Pro

In Vitro and In Vivo Antimalarial Efficacy of Optimized Tetracyclines. With increasing resistance to existing antimalarials, there is an urgent need to discover new drugs at affordable prices for countries in which malaria is endemic. One approach to the development of new antimalarial drugs is to improve upon existing antimalarial agents, such as the tetracyclines. Tetracyclines exhibit potent, albeit relatively slow, action against malaria parasites, and doxycycline is used for both treatment (...) (with other agents) and prevention of malaria. We synthesized 18 novel 7-position modified tetracycline derivatives and screened them for activity against cultured malaria parasites. Compounds with potent in vitro activity and other favorable drug properties were further tested in a rodent malaria model. Ten compounds inhibited the development of cultured Plasmodium falciparum with a 50% inhibitory concentration (IC50) after 96 h of incubation of <30 nM, demonstrating activity markedly superior

2013 Antimicrobial Agents and Chemotherapy

259. MCM-41 impregnated with A zeolite precursor: Synthesis, characterization and tetracycline antibiotics removal from aqueous solution Full Text available with Trip Pro

MCM-41 impregnated with A zeolite precursor: Synthesis, characterization and tetracycline antibiotics removal from aqueous solution In this paper, the MCM-41 has been modified by impregnation with zeolite A to prepare a kind of new adsorbent. The adsorption of TC from aqueous solutions onto modified MCM-41 has been studied. It was discovered that the adsorption capability of zeolite A modified MCM-41 (A-MCM-41) increased dramatically after modification. The modified MCM-41 was characterized

2013 Chemical Engineering Journal

260. Fibrin clot adhesion to root surface treated with tetracycline hydrochloride and ethylenediaminetetraacetic acid: A scanning electron microscopic study Full Text available with Trip Pro

Fibrin clot adhesion to root surface treated with tetracycline hydrochloride and ethylenediaminetetraacetic acid: A scanning electron microscopic study Connective tissue attachment following periodontal regenerative surgery is directly related to the attachment of fibrin clot on to the root surface during early wound healing events. The adhesion of fibrin clot to the root surface affected by periodontal disease depends on the biologic acceptance of the root surface which can be accomplished (...) by various root conditioning procedures during periodontal therapy. The present in vitro study has been designed to evaluate and compare the degree of fibrin clot adhesion to root surfaces treated with root conditioning agents tetracycline hydrochloride and ethylenediaminetetraacetic acid (EDTA).A total of 30 dentin blocks are divided into three groups and treated with tetracycline hydrochloride, EDTA and phosphate buffered saline and a drop of blood is added to each dentin block. The dentin blocks

2013 Dental research journal

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