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201. Response Surface Optimization of a Rapid Ultrasound-Assisted Extraction Method for Simultaneous Determination of Tetracycline Antibiotics in Manure Full Text available with Trip Pro

Response Surface Optimization of a Rapid Ultrasound-Assisted Extraction Method for Simultaneous Determination of Tetracycline Antibiotics in Manure A rapid and cleanup-free ultrasound-assisted extraction method is proposed for the simultaneous extraction of oxytetracycline, tetracycline, chlortetracycline, and doxycycline in manure. The analytes were determined using high-performance liquid chromatography with ultraviolet detector. The influence of several variables on the efficiency (...) of McIlvaine buffer extraction solution (pH 7.15) mixed with 1 g of manure sample, extraction temperature of 40°C, extraction time of 10 min, and three extraction cycles. Method quantification limits of 1.75-2.32 mg/kg were obtained for the studied compounds. The proposed procedure demonstrated clear reductions in extraction time and elimination of cleanup steps. Finally, the applicability to tetracyclines antibiotics determination in real samples was evaluated through the successful determination of four

2015 Journal of analytical methods in chemistry

202. Comparative Evaluation of a New Endodontic Irrigant - Mixture of a Tetracycline Isomer, an Acid, and a Detergent to Remove the Intracanal Smear Layer: A Scanning Electron Microscopic Study Full Text available with Trip Pro

Comparative Evaluation of a New Endodontic Irrigant - Mixture of a Tetracycline Isomer, an Acid, and a Detergent to Remove the Intracanal Smear Layer: A Scanning Electron Microscopic Study The most important and demanding aspect of endodontic therapy is considered to be cleaning and shaping. Irrigation is considered a vital adjunct to instrumentation of the root canal for canal debridement. Until date, there is no single solution that simultaneously removes the smear layer and disinfects (...) the entire root canal system. Thus, this in vitro study was designed to evaluate the efficiency of a new irrigation solution mixture of a tetracycline isomer, an acid, and a detergent (MTAD) (BioPure, Dentsply) containing a mixture of tetracycline (doxycycline hydrochloride), an acid (citric acid) and a detergent (Tween 80) in comparison with normal saline, 5% NaOCl and 17% ethylenediaminetetraacetic acid (EDTA) to remove intracanal smear layer.A total of 60 single rooted teeth were irrigated with Saline

2015 Journal of international oral health : JIOH

203. Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing. Full Text available with Trip Pro

Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing. The objective of this study was to characterize chromosomal mutations associated with resistance to tetracycline in Streptococcus pneumoniae.Chronological appearance of mutations in two S. pneumoniae R6 mutants (R6M1TC-5 and R6M2TC-4) selected for resistance to tetracycline was determined by next-generation sequencing. A role for the mutations (...) identified was confirmed by reconstructing resistance to tetracycline in a S. pneumoniae R6 WT background. RNA sequencing was performed on R6M1TC-5 and R6M2TC-4 and the relative expression of genes was reported according to R6. Differentially expressed genes were classified according to their ontology.WGS of R6M1TC-5 and R6M2TC-4 revealed mutations in the gene rpsJ coding for the ribosomal protein S10 and in the promoter region and coding sequences of the ABC genes patA and patB. These cells were cross

2015 Journal of Antimicrobial Chemotherapy

204. Clonal lineages detected among tetracycline resistant MRSA isolates of a Tunisian Hospital, with detection of lineage ST398. Full Text available with Trip Pro

Clonal lineages detected among tetracycline resistant MRSA isolates of a Tunisian Hospital, with detection of lineage ST398. Tetracycline resistance has been postulated as a potential phenotypic marker of livestock-associated lineage ST398 amongst meticillin-resistant Staphylococcus aureus (MRSA) clinical isolates in some European hospitals. The objective of this study was to determine if this marker could also be applied to Maghrebian countries. In total, 99 MRSA isolates were collected (...) in a Tunisian hospital during January 2011-October 2012, and 24 tetracycline-resistant MRSA isolates of this collection were characterized. All isolates were tested for antimicrobial resistance phenotypes and genotypes, molecular typing, and virulence genes. Multilocus sequence typing showed that the majority of the isolates (19/24) belonged to clonal complex CC8 (ST247, n = 12 isolates; ST239, n = 6 isolates; ST241, n = 1 isolate). The remaining isolates belonged to CC398 (ST398, n = 1 isolate), CC5 (ST5

2015 Journal of Medical Microbiology

205. Randomized, open-label trial evaluating the preventive effect of tetracycline on afatinib induced-skin toxicities in non-small cell lung cancer patients. (Abstract)

Randomized, open-label trial evaluating the preventive effect of tetracycline on afatinib induced-skin toxicities in non-small cell lung cancer patients. Afatinib has shown long progression free survival and improvement in quality of life in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Although afatinib causes acneiform rash, it can be manageable. Tetracyclines are usually used to treat it; nonetheless, there is no trial that evaluates their prophylactic efficacy on afatinib induced (...) -skin toxicities (AIST).This open-label, randomized, controlled trial assessed the preventive effect of tetracycline for reducing afatinib-skin toxicities in NSCLC patients receiving afatinib 40 mg/day. Patients were randomly assigned to receive pre-emptive treatment with tetracycline 250 mg every 12h for 4 weeks or not. Reactive treatment in both groups included general dermatological recommendations such as use of skin moisturizers, sunscreen and topical steroids, according to toxicity severity

2015 Lung Cancer Controlled trial quality: predicted high

206. Spread of tetracycline resistance genes at a conventional dairy farm Full Text available with Trip Pro

Spread of tetracycline resistance genes at a conventional dairy farm The use of antibiotics in animal husbandry contributes to the worldwide problem of increasing antibiotic resistance in animal and human pathogens. Intensive animal production is considered an important source of antibiotic resistance genes released to the environment, while the contribution of smaller farms remains to be evaluated. Here we monitor the spread of tetracycline resistance (TC-r) genes at a middle-size conventional

2015 Frontiers in microbiology

207. Prevalence of tetracycline resistance genes among multi-drug resistant bacteria from selected water distribution systems in southwestern Nigeria Full Text available with Trip Pro

Prevalence of tetracycline resistance genes among multi-drug resistant bacteria from selected water distribution systems in southwestern Nigeria Antibiotic resistance genes [ARGs] in aquatic systems have drawn increasing attention they could be transferred horizontally to pathogenic bacteria. Water treatment plants (WTPs) are intended to provide quality and widely available water to the local populace they serve. However, WTPs in developing countries may not be dependable for clean water (...) and they could serve as points of dissemination for antibiotic resistant bacteria. Only a few studies have investigated the occurrence of ARGs among these bacteria including tetracycline resistance genes in water distribution systems in Nigeria.Multi-drug resistant (MDR) bacteria, including resistance to tetracycline, were isolated from treated and untreated water distribution systems in southwest Nigeria. MDR bacteria were resistant to >3 classes of antibiotics based on break-point assays. Isolates were

2015 Annals of Clinical Microbiology and Antimicrobials

208. Tetracycline hypersensitivity of an ezrA mutant links GalE and TseB (YpmB) to cell division Full Text available with Trip Pro

Tetracycline hypersensitivity of an ezrA mutant links GalE and TseB (YpmB) to cell division Cell division in bacteria is initiated by the polymerization of FtsZ into a ring-like structure at midcell that functions as a scaffold for the other cell division proteins. In Bacillus subtilis, the conserved cell division protein EzrA is involved in modulation of Z-ring formation and coordination of septal peptidoglycan synthesis. Here, we show that an ezrA mutant is hypersensitive to tetracycline (...) , even when the tetracycline efflux pump TetA is present. This effect is not related to the protein translation inhibiting activity of tetracycline. Overexpression of FtsL suppresses this phenotype, which appears to be related to the intrinsic low FtsL levels in an ezrA mutant background. A transposon screen indicated that the tetracycline effect can also be suppressed by overproduction of the cell division protein ZapA. In addition, tetracycline sensitivity could be suppressed by transposon

2015 Frontiers in microbiology

209. Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline Full Text available with Trip Pro

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline 25629801 2015 06 30 2015 06 05 2041-1723 6 2015 Jan 28 Nature communications Nat Commun Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. 6108 10.1038/ncomms7108 Da Cunha Violette V Davies Mark R MR Douarre Pierre-Emmanuel PE Rosinski-Chupin Isabelle I Margarit Immaculada I Spinali Sebastien

2015 Nature communications

210. Treatment of gonorrhea. Penicillin or tetracyclines? (Abstract)

Treatment of gonorrhea. Penicillin or tetracyclines? 4621449 1972 03 23 2016 10 17 0098-7484 219 4 1972 Jan 24 JAMA JAMA Treatment of gonorrhea. Penicillin or tetracyclines? 471-4 Neumann H H HH Baecker J M JM eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 17R794ESYN Penicillin G Procaine 5R5W9ICI6O Demeclocycline F8VB5M810T Tetracycline N12000U13O Doxycycline X20I9EN955 Oxytetracycline AIM IM Administration, Oral Adolescent (...) Adult Demeclocycline therapeutic use Doxycycline therapeutic use Drug Hypersensitivity etiology Gonorrhea drug therapy microbiology Humans Injections, Intramuscular Male Middle Aged Neisseria gonorrhoeae drug effects isolation & purification Oxytetracycline administration & dosage adverse effects therapeutic use Penicillin G Procaine administration & dosage adverse effects therapeutic use Penicillin Resistance Tetracycline administration & dosage adverse effects 1972 1 24 1972 1 24 0 1 1972 1 24 0 0

1972 JAMA Controlled trial quality: uncertain

211. Spectinomycin versus tetracycline for the treatment of gonorrhea. (Abstract)

Spectinomycin versus tetracycline for the treatment of gonorrhea. Spectinomycin and tetracycline are alternative drugs to penicillin in the treatment of gonorrhea. To compare the efficacy of these agents and their propensity to select resistant gonococci, we treated 4043 patients randomly with either 2 or 4 g of spectinomycin once or 9 g of oral tetracycline for four days. Minimum cure rate for anogenital gonorrhea was 94 per cent with either drug. Oropharyngeal infection responded poorly (...) to spectinomycin in men, with failure of therapy in six of 11. Postgonococcal urethritis in men was less common after tetracycline than after spectinomycin (P less than 0.005). Spectinomycin failure was not related to drug resistance. Tetracycline failure correlated with resistance (P less than 0.0002); one fifth of the isolates resistant to 1.0 mug per milliter of tetracycline were not eradicated. For several reasons, including the appearance of beta-lactamase-producing gonococci, it is no longer clear

1977 NEJM Controlled trial quality: uncertain

212. Tetracycline Resistance and Presence of Tetracycline Resistance Determinants tet(V) and tap in Rapidly Growing Mycobacteria from Agricultural Soils and Clinical Isolates Full Text available with Trip Pro

Tetracycline Resistance and Presence of Tetracycline Resistance Determinants tet(V) and tap in Rapidly Growing Mycobacteria from Agricultural Soils and Clinical Isolates Rapidly growing mycobacteria (RGM) inhabit soil and water but certain strains represent a health risk for human and animals. Both clinical and soil RGM may be under selection pressure for resistance to tetracycline (TET) antibiotics, since tetracyclines are administrated to humans and farm animals, and TET residues enter soil

2012 Microbes and Environments

213. A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. (Abstract)

A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. 4899665 1969 12 05 2016 11 22 0007-0971 63 4 1969 Oct British journal of diseases of the chest Br J Dis Chest A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. 206-14 Pines A A Raafat H H Plucinski K K Greenfield J S JS Solari M M eng Clinical Trial (...) Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial England Br J Dis Chest 7511123 0007-0971 17EC19951N Novobiocin 63937KV33D Erythromycin F8VB5M810T Tetracycline IM Adult Aged Bronchitis diagnostic imaging drug therapy Chronic Disease Clinical Trials as Topic Drug Synergism Erythromycin therapeutic use Haemophilus influenzae isolation & purification Humans Leukocyte Count Lung physiopathology Male Middle Aged Novobiocin adverse effects therapeutic use Radiography

1969 British Journal of Diseases of the Chest Controlled trial quality: uncertain

214. A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. (Abstract)

A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. 4563329 1973 01 05 2013 11 21 0007-0947 26 10 1972 Oct The British journal of clinical practice Br J Clin Pract A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. 475-6 Pines A A Khaja G G Greenfield J S JS Raafat H H Sreedharan K S KS Linsell W D WD eng Clinical Trial (...) Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Delayed-Action Preparations F8VB5M810T Tetracycline IM Bronchitis drug therapy Chronic Disease Clinical Trials as Topic Delayed-Action Preparations Humans Suppuration drug therapy Tetracycline administration & dosage therapeutic use 1972 10 1 1972 10 1 0 1 1972 10 1 0 0 ppublish 4563329

1973 The British journal of clinical practice Controlled trial quality: uncertain

215. Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. (Abstract)

Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. 130921 1976 07 06 2013 11 21 0007-0947 30 3 1976 Mar The British journal of clinical practice Br J Clin Pract Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. 65-6 Stankler L L eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Drug Combinations EC 3.4.21.1 Chymotrypsin EC (...) 3.4.21.4 Trypsin F8VB5M810T Tetracycline IM Acne Vulgaris drug therapy Chymotrypsin therapeutic use Clinical Trials as Topic Drug Combinations Female Humans Male Tetracycline therapeutic use Trypsin therapeutic use 1976 3 1 1976 3 1 0 1 1976 3 1 0 0 ppublish 130921

1976 The British journal of clinical practice Controlled trial quality: uncertain

216. Plasmid-determined tetracycline resistance in Streptococcus faecalis: evidence for gene amplification during growth in presence of tetracycline. Full Text available with Trip Pro

Plasmid-determined tetracycline resistance in Streptococcus faecalis: evidence for gene amplification during growth in presence of tetracycline. The tetracycline (TG)-resistant Streptococcus faecalis strain DS-5Cl harbors two plasmids designated alpha and gamma with molecular masses of approximately 6 and 35 million daltons, respectively. TC-sensitive variants were derived by storing cells at 45 degrees for 2-3 weeks. Analysis of covalently closed circular DNA from five such variants (derived

1975 Proceedings of the National Academy of Sciences of the United States of America

217. Uptake of Minocycline and Tetracycline by Tetracycline-Susceptible and -Resistant Bacteria Full Text available with Trip Pro

Uptake of Minocycline and Tetracycline by Tetracycline-Susceptible and -Resistant Bacteria Minocycline (7-dimethylamino-6-demethyl-6-deoxytetracycline) is a new semisynthetic tetracycline with potent activity against tetracycline-susceptible bacterial pathogens and unique activity against tetracycline-resistant staphylococci. Studies to determine the basis for this unique activity showed that, whereas tetracycline-resistant staphylococci took up less (3)H-tetracycline than the susceptible cells (...) , both the tetracycline-resistant and -susceptible cells accumulated equivalent amounts of (14)C-minocycline. In contrast, tetracycline-resistant Escherichia coli cells were relatively resistant to minocycline and accumulated less of both drugs than did the susceptible organisms. It is proposed that minocycline is effective against tetracycline-resistant staphylococci because of its ability to penetrate the cells sufficiently to reach inhibiting concentrations at sensitive reaction sites.

1973 Antimicrobial Agents and Chemotherapy

218. Effect of Oral Tetracycline on the Occurrence of Tetracycline-Resistant Strains of Escherichia coli in the Intestinal Tract of Humans Full Text available with Trip Pro

Effect of Oral Tetracycline on the Occurrence of Tetracycline-Resistant Strains of Escherichia coli in the Intestinal Tract of Humans Serial samples of feces from normal human subjects were analyzed for tetracycline-resistant strains of Escherichia coli. Subjects were found to be excreting tetracycline-resistant strains in amounts fluctuating with time. Ingestion of tetracycline increased both the number of individuals excreting tetracycline-resistant strains of E. coli and the proportion

1973 Antimicrobial Agents and Chemotherapy

219. Tetracycline Inhibition of Cell-Free Protein Synthesis I. Binding of Tetracycline to Components of the System Full Text available with Trip Pro

Tetracycline Inhibition of Cell-Free Protein Synthesis I. Binding of Tetracycline to Components of the System Day, L. E. (Chas. Pfizer & Co., Inc., Groton, Conn.). Tetracycline inhibition of cell-free protein synthesis. I. Binding of tetracycline to components of the system. J. Bacteriol. 91:1917-1923. 1966.-Tetracycline, an inhibitor of cell-free protein synthesis, effected the dissociation of Escherichia coli 100S ribosomes to 70S particles in vivo and in vitro, but was not observed

1966 Journal of bacteriology

220. Tetracycline Inhibition of Cell-Free Protein Synthesis II. Effect of the Binding of Tetracycline to the Components of the System Full Text available with Trip Pro

Tetracycline Inhibition of Cell-Free Protein Synthesis II. Effect of the Binding of Tetracycline to the Components of the System Day, L. E. (Chas. Pfizer & Co., Inc., Groton, Conn.). Tetracycline inhibition of cell-free protein synthesis. II. Effect of the binding of tetracycline to the components of the system. J. Bacteriol. 92:197-203. 1966.-When tetracycline, an inhibitor of cell-free protein synthesis, was preincubated with each component of the Escherichia coli cell-free system, i.e (...) ., ribosomes, soluble ribonucleic acid (sRNA), polyuridylic acid (poly U), and S-100 (supernatant enzymes), only the ribosomal-bound antibiotic was inhibitory to the cell-free assay. Experiments designed to further localize the site of inhibition to either the 50S (Svedberg) or the 30S ribosomal subunit were not conclusive. Tritiated tetracycline (7-H(3)-tetracycline) was bound to isolated 50S ribosomes, and these were recombined with 30S subunits to form 70S ribosomes. When these ribosomes were

1966 Journal of bacteriology

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