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181. Mosaic tetracycline resistance genes encoding ribosomal protection proteins. Full Text available with Trip Pro

Mosaic tetracycline resistance genes encoding ribosomal protection proteins. First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic (...) genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

2016 Journal of Antimicrobial Chemotherapy

182. Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw: a randomized controlled feasibility study. (Abstract)

Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw: a randomized controlled feasibility study. Recent studies have indicated that bone shows auto-fluorescence under an appropriate fluorescence lamp. The aim of this preliminary study was to compare the success rates of the established tetracycline fluorescence-guided bone surgery with auto-fluorescence-guided bone surgery in the treatment of medication-related (...) osteonecrosis of the jaw (MRONJ). Forty patients suffering from MRONJ were referred for surgical treatment and were divided randomly into two groups: auto-fluorescence (n=20) or tetracycline fluorescence (n=20) guided bone surgery. The primary endpoint was treatment success, defined as the absence of exposed bone at 8 weeks after surgery. Secondary outcomes assessed were mucosal integrity, signs of infection, pain, and loss of sensitivity; these were evaluated descriptively at 10 days, 8 weeks, 6 months

2016 International Journal of Oral and Maxillofacial Surgery Controlled trial quality: uncertain

183. Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria? Full Text available with Trip Pro

Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria? Malaria, a parasite vector-borne disease, is one of the most significant health threats in tropical regions, despite the availability of individual chemoprophylaxis. Malaria chemoprophylaxis and chemotherapy remain a major area of research, and new drug molecules are constantly being developed before drug-resistant parasites strains emerge. The use of anti-malarial drugs (...) is challenged by contra-indications, the level of resistance of Plasmodium falciparum in endemic areas, clinical tolerance and financial cost. New therapeutic approaches are currently needed to fight against this disease. Some antibiotics that have shown potential effects on malaria parasite have been recently studied in vitro or in vivo intensively. Two families, tetracyclines and macrolides and their derivatives have been particularly studied in recent years. However, other less well-known have been

2016 Malaria journal

184. Effect of combination of ethylenediaminetetraacetic acid + tetracycline with coronally positioned flap in the treatment of gingival recession: A clinical study. Full Text available with Trip Pro

Effect of combination of ethylenediaminetetraacetic acid + tetracycline with coronally positioned flap in the treatment of gingival recession: A clinical study. Gingival recession is the apical migration of gingival margin results from destruction of the connective tissue leading to various esthetic problems. Many surgical procedures have been attempted to achieve root coverage that include free gingival grafts, pedicle flaps such as semilunar coronally repositioned flaps (SCRFs) and guided (...) on periodontal wound healing.To evaluate the effect of the combination of ethylenediaminetetraacetic acid (EDTA) and tetracycline as root bio-modifiers along with SCRF for root coverage.Twenty subjects were randomly assigned into two groups as cases (SCRF + EDTA + tetracycline [TTC]) and controls (SCRF).Twenty-four percentage EDTA and 100 mg/ml TTC hydrochloride were used along with semilunar coronally positioned flap. The clinical parameters such as recession height, the width of keratinized tissue

2016 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

185. Tetracyclines and/ or Nicotinamide in blistering dermatoses. (Abstract)

Tetracyclines and/ or Nicotinamide in blistering dermatoses. 27896870 2017 06 16 1468-3083 31 6 2017 Jun Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Tetracyclines and/or nicotinamide in blistering dermatosis. e291 10.1111/jdv.14067 Abdelmaksoud A A Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt. eng Letter 2016 12 19 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2016 11 30 6 0 2016 11 30 6 0 2016 11 30 6

2016 Journal of the European Academy of Dermatology and Venereology

186. Subtherapeutic tetracycline concentrations aggravate Salmonella Typhimurium infection by increasing bacterial virulence. Full Text available with Trip Pro

Subtherapeutic tetracycline concentrations aggravate Salmonella Typhimurium infection by increasing bacterial virulence. Antibiotics are among the most frequently prescribed drugs in human and animal medicine. With antibiotic resistance being a serious threat to veterinary and public health, the prudent use of antibiotics receives much attention. Less well known is that incorrect use of antimicrobial agents may also lead to increased bacterial virulence with the potential of a more severe (...) clinical course of infection. Therefore, the aim of this study was to investigate the effect of subtherapeutic doses of tetracyclines on htpG virulence gene expression in Salmonella Typhimurium and on the course of salmonellosis.Salmonella strains containing an htpG-luxCDABE transcriptional fusion were constructed. Phenotype microarrays and tetracycline treatment were used to investigate their htpG expression. A Salmonella transposon mutant bank was used to identify genes involved in the induction

2016 Journal of Antimicrobial Chemotherapy

187. RIBOSOMAL RNA BINDING SITES AND THE MOLECULAR MECHANISM OF ACTION OF THE TETRACYCLINES. Full Text available with Trip Pro

RIBOSOMAL RNA BINDING SITES AND THE MOLECULAR MECHANISM OF ACTION OF THE TETRACYCLINES. The tetracycline antibiotics are known to be effective in the treatment of both infectious and noninfectious disease conditions. The 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines does not explain their activity against viruses, protozoa that lack mitochondria, and noninfectious conditions. Also, the mechanism by which the tetracyclines selectively inhibit (...) microbial protein synthesis against host eukaryotic protein synthesis despite conservation of ribosome structure and functions is still questionable. Many studies have investigated the binding of the tetracyclines to the 16S rRNA using the small ribosomal subunit of different bacterial species, but there seems to be no agreement between various reports on the exact binding site on the 16S rRNA. The wide range of activity of the tetracyclines against a broad spectrum of bacterial pathogens, viruses

2016 Antimicrobial Agents and Chemotherapy

188. Co-presence of tet(K) and tet(M) in livestock-associated methicillin-resistant Staphylococcus aureus CC398 is associated with increased fitness during exposure to sub-lethal concentrations of tetracycline. Full Text available with Trip Pro

Co-presence of tet(K) and tet(M) in livestock-associated methicillin-resistant Staphylococcus aureus CC398 is associated with increased fitness during exposure to sub-lethal concentrations of tetracycline. The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed (...) tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.Copyright © 2016 Larsen et al.

2016 Antimicrobial Agents and Chemotherapy

189. Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth. Full Text available with Trip Pro

Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth. Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses suggest an adverse effect that may be more common, serious, and persistent than realized previously

2016 Journal of Pediatrics

190. A PhoPQ-Regulated ABC Transporter System Exports Tetracycline in Pseudomonas aeruginosa. Full Text available with Trip Pro

A PhoPQ-Regulated ABC Transporter System Exports Tetracycline in Pseudomonas aeruginosa. Pseudomonas aeruginosa is an important human pathogen whose infections are difficult to treat due to its high intrinsic resistance to many antibiotics. Here, we show that the disruption of PA4456, encoding the ATP binding component of a putative ATP-binding cassette (ABC) transporter, increased the bacterium's susceptible to tetracycline and other antibiotics or toxic chemicals. Fluorescence spectroscopy (...) and antibiotic accumulation tests showed that the interruption of the ABC transporter caused increased intracellular accumulation of tetracycline, demonstrating a role of the ABC transporter in tetracycline expulsion. Site-directed mutagenesis proved that the conserved residues of E170 in the Walker B motif and H203 in the H-loop, which are important for ATP hydrolysis, were essential for the function of PA4456. Through a genome-wide search, the PhoPQ two-component system was identified as a regulator

2016 Antimicrobial Agents and Chemotherapy

191. Antimicrobial resistance of Neisseria gonorrhoeae isolates in south-west Germany, 2004 to 2015: increasing minimal inhibitory concentrations of tetracycline but no resistance to third-generation cephalosporins. Full Text available with Trip Pro

Antimicrobial resistance of Neisseria gonorrhoeae isolates in south-west Germany, 2004 to 2015: increasing minimal inhibitory concentrations of tetracycline but no resistance to third-generation cephalosporins. Increasing antimicrobial resistance of Neisseria gonorrhoeae, particularly to third-generation cephalosporins, has been reported in many countries. We examined the susceptibility (determined by Etest and evaluated using the breakpoints of the European Committee on Antimicrobial (...) Susceptibility Testing) of 434 N. gonorrhoeae isolates collected from 107 female and 327 male patients in Stuttgart, south-west Germany, between 2004 and 2015. During the study period, high proportions of isolates were resistant to ciprofloxacin (70.3%), tetracycline (48.4%; increasing from 27.5% in 2004/2005 to 57.7% in 2014/2015; p = 0.0002) and penicillin (25.6%). The proportion of isolates resistant to azithromycin was low (5.5%) but tended to increase (p = 0.08). No resistance and stable minimum

2016 Euro Surveillance

192. The effect of tooth brushing, irrigation, and topical tetracycline administration on the reduction of oral bacteria in mechanically ventilated patients: a preliminary study. Full Text available with Trip Pro

The effect of tooth brushing, irrigation, and topical tetracycline administration on the reduction of oral bacteria in mechanically ventilated patients: a preliminary study. One of the main causes of ventilator-associated pneumonia (VAP) is thought to be aspiration of oropharyngeal fluid containing pathogenic microorganisms. The aim of this study was to examine the effects of various oral care methods on the reduction of oral bacteria during intubation.First, the effect of mechanical oral (...) cleaning was investigated. The bacterial count on the tongue and in the oropharyngeal fluid was measured after tooth brushing, irrigation, and three hours after irrigation in mechanically ventilated patients at the intensive care unit (ICU). Next, the efficacy of topical administration of tetracycline and povidone iodine on the inhibition of bacterial growth on the tongue and in the oropharyngeal fluid was examined in oral cancer patients during neck dissection.The number of bacteria

2016 BMC Oral Health

193. S06Efficacy of antibiotic prophylaxis with tetracyclines for EGFR induced skin rash: a systematic review and pooled-analysis of 13 studies Full Text available with Trip Pro

S06Efficacy of antibiotic prophylaxis with tetracyclines for EGFR induced skin rash: a systematic review and pooled-analysis of 13 studies Redirecting

2016 Annals of Oncology

194. Treatment of gonorrhea. Penicillin or tetracyclines? (Abstract)

Treatment of gonorrhea. Penicillin or tetracyclines? 4621449 1972 03 23 2016 10 17 0098-7484 219 4 1972 Jan 24 JAMA JAMA Treatment of gonorrhea. Penicillin or tetracyclines? 471-4 Neumann H H HH Baecker J M JM eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 17R794ESYN Penicillin G Procaine 5R5W9ICI6O Demeclocycline F8VB5M810T Tetracycline N12000U13O Doxycycline X20I9EN955 Oxytetracycline AIM IM Administration, Oral Adolescent (...) Adult Demeclocycline therapeutic use Doxycycline therapeutic use Drug Hypersensitivity etiology Gonorrhea drug therapy microbiology Humans Injections, Intramuscular Male Middle Aged Neisseria gonorrhoeae drug effects isolation & purification Oxytetracycline administration & dosage adverse effects therapeutic use Penicillin G Procaine administration & dosage adverse effects therapeutic use Penicillin Resistance Tetracycline administration & dosage adverse effects 1972 1 24 1972 1 24 0 1 1972 1 24 0 0

1972 JAMA Controlled trial quality: uncertain

195. Spectinomycin versus tetracycline for the treatment of gonorrhea. (Abstract)

Spectinomycin versus tetracycline for the treatment of gonorrhea. Spectinomycin and tetracycline are alternative drugs to penicillin in the treatment of gonorrhea. To compare the efficacy of these agents and their propensity to select resistant gonococci, we treated 4043 patients randomly with either 2 or 4 g of spectinomycin once or 9 g of oral tetracycline for four days. Minimum cure rate for anogenital gonorrhea was 94 per cent with either drug. Oropharyngeal infection responded poorly (...) to spectinomycin in men, with failure of therapy in six of 11. Postgonococcal urethritis in men was less common after tetracycline than after spectinomycin (P less than 0.005). Spectinomycin failure was not related to drug resistance. Tetracycline failure correlated with resistance (P less than 0.0002); one fifth of the isolates resistant to 1.0 mug per milliter of tetracycline were not eradicated. For several reasons, including the appearance of beta-lactamase-producing gonococci, it is no longer clear

1977 NEJM Controlled trial quality: uncertain

196. A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. (Abstract)

A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. 4899665 1969 12 05 2016 11 22 0007-0971 63 4 1969 Oct British journal of diseases of the chest Br J Dis Chest A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis. 206-14 Pines A A Raafat H H Plucinski K K Greenfield J S JS Solari M M eng Clinical Trial (...) Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial England Br J Dis Chest 7511123 0007-0971 17EC19951N Novobiocin 63937KV33D Erythromycin F8VB5M810T Tetracycline IM Adult Aged Bronchitis diagnostic imaging drug therapy Chronic Disease Clinical Trials as Topic Drug Synergism Erythromycin therapeutic use Haemophilus influenzae isolation & purification Humans Leukocyte Count Lung physiopathology Male Middle Aged Novobiocin adverse effects therapeutic use Radiography

1969 British Journal of Diseases of the Chest Controlled trial quality: uncertain

197. A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. (Abstract)

A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. 4563329 1973 01 05 2013 11 21 0007-0947 26 10 1972 Oct The British journal of clinical practice Br J Clin Pract A double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis. 475-6 Pines A A Khaja G G Greenfield J S JS Raafat H H Sreedharan K S KS Linsell W D WD eng Clinical Trial (...) Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Delayed-Action Preparations F8VB5M810T Tetracycline IM Bronchitis drug therapy Chronic Disease Clinical Trials as Topic Delayed-Action Preparations Humans Suppuration drug therapy Tetracycline administration & dosage therapeutic use 1972 10 1 1972 10 1 0 1 1972 10 1 0 0 ppublish 4563329

1973 The British journal of clinical practice Controlled trial quality: uncertain

198. Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. (Abstract)

Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. 130921 1976 07 06 2013 11 21 0007-0947 30 3 1976 Mar The British journal of clinical practice Br J Clin Pract Tetracycline and proteolytic enzymes combined compared with tetracycline alone in acne vulgaris. 65-6 Stankler L L eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Drug Combinations EC 3.4.21.1 Chymotrypsin EC (...) 3.4.21.4 Trypsin F8VB5M810T Tetracycline IM Acne Vulgaris drug therapy Chymotrypsin therapeutic use Clinical Trials as Topic Drug Combinations Female Humans Male Tetracycline therapeutic use Trypsin therapeutic use 1976 3 1 1976 3 1 0 1 1976 3 1 0 0 ppublish 130921

1976 The British journal of clinical practice Controlled trial quality: uncertain

199. Effect of Oral Tetracycline on the Occurrence of Tetracycline-Resistant Strains of Escherichia coli in the Intestinal Tract of Humans Full Text available with Trip Pro

Effect of Oral Tetracycline on the Occurrence of Tetracycline-Resistant Strains of Escherichia coli in the Intestinal Tract of Humans Serial samples of feces from normal human subjects were analyzed for tetracycline-resistant strains of Escherichia coli. Subjects were found to be excreting tetracycline-resistant strains in amounts fluctuating with time. Ingestion of tetracycline increased both the number of individuals excreting tetracycline-resistant strains of E. coli and the proportion

1973 Antimicrobial Agents and Chemotherapy

200. Tetracycline Inhibition of Cell-Free Protein Synthesis II. Effect of the Binding of Tetracycline to the Components of the System Full Text available with Trip Pro

Tetracycline Inhibition of Cell-Free Protein Synthesis II. Effect of the Binding of Tetracycline to the Components of the System Day, L. E. (Chas. Pfizer & Co., Inc., Groton, Conn.). Tetracycline inhibition of cell-free protein synthesis. II. Effect of the binding of tetracycline to the components of the system. J. Bacteriol. 92:197-203. 1966.-When tetracycline, an inhibitor of cell-free protein synthesis, was preincubated with each component of the Escherichia coli cell-free system, i.e (...) ., ribosomes, soluble ribonucleic acid (sRNA), polyuridylic acid (poly U), and S-100 (supernatant enzymes), only the ribosomal-bound antibiotic was inhibitory to the cell-free assay. Experiments designed to further localize the site of inhibition to either the 50S (Svedberg) or the 30S ribosomal subunit were not conclusive. Tritiated tetracycline (7-H(3)-tetracycline) was bound to isolated 50S ribosomes, and these were recombined with 30S subunits to form 70S ribosomes. When these ribosomes were

1966 Journal of bacteriology

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