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1. High levels of intrinsic tetracycline resistance in <i>Mycobacterium abscessus</i> is conferred by a tetracycline- modifying monooxygenase. Full Text available with Trip Pro

High levels of intrinsic tetracycline resistance in Mycobacterium abscessus is conferred by a tetracycline- modifying monooxygenase. Tetracyclines have been one of the most successful classes of antibiotics. However, its extensive use has led to the emergence of widespread drug resistance, resulting in discontinuation of use against several bacterial infections. Prominent resistance mechanisms include drug efflux and the use of ribosome protection proteins. Infrequently, tetracyclines (...) can be inactivated by the TetX class of enzymes, also referred to as tetracycline destructases. Low levels of tolerance to tetracycline in Mycobacterium smegmatis and Mycobacterium tuberculosis have been previously attributed to the WhiB7-dependent TetV/Tap efflux pump. However, Mycobacterium abscessus is ∼500-fold more resistant to tetracycline than M. smegmatis and M. tuberculosis In this report, we show that this high level of resistance to tetracycline and doxycycline in M. abscessus

2018 Antimicrobial Agents and Chemotherapy

2. Transfer of a mobile Staphylococcus saprophyticus plasmid isolated from fermented seafood that confers tetracycline resistance. Full Text available with Trip Pro

Transfer of a mobile Staphylococcus saprophyticus plasmid isolated from fermented seafood that confers tetracycline resistance. The complete nucleotide sequence of a tetracycline-resistance gene (tetK)-carrying plasmid from a Staphylococcus saprophyticus isolate from jeotgal, a Korean high-salt-fermented seafood, was determined. The plasmid, designated pSSTET1, was 4439 bp in length and encoded typical elements found in plasmids that replicate via a rolling-circle mechanism, including (...) to an Enterococcus faecalis strain in vitro. Antibiotic susceptibility of the transconjugants was host-dependent and transconjugants maintained a tetracycline-resistant phenotype in the absence of selective pressure over 100 generations.

2019 PLoS ONE

3. Dyspepsia - proven peptic ulcer: Tetracycline

Dyspepsia - proven peptic ulcer: Tetracycline Tetracycline | Prescribing information | Dyspepsia - proven peptic ulcer | CKS | NICE Search CKS… Menu Tetracycline Dyspepsia - proven peptic ulcer: Tetracycline Last revised in October 2019 Tetracycline Contraindications and cautions Do not prescribe tetracycline to people with: Renal impairment — tetracyclines are excreted renally and may exacerbate renal failure. Prescribe tetracycline with caution to people with: Hepatic impairment and those (...) receiving potentially hepatotoxic drugs, such as carbamazepine, isoniazid, and methotrexate. Myasthenia gravis — tetracyclines may increase muscle weakness symptoms. Systemic lupus erythematosus (SLE) — tetracyclines may exacerbate the condition. [ ] Adverse effects Common adverse effects of tetracycline include: Gastrointestinal disturbances such as nausea, vomiting, and diarrhoea. Consider pseudomembranous colitis if a person develops severe diarrhoea during or after treatment with tetracycline

2017 NICE Clinical Knowledge Summaries

4. Dyspepsia - unidentified cause: Tetracycline

Dyspepsia - unidentified cause: Tetracycline Tetracycline | Prescribing information | Dyspepsia - unidentified cause | CKS | NICE Search CKS… Menu Tetracycline Dyspepsia - unidentified cause: Tetracycline Last revised in October 2018 Tetracycline Contraindications and cautions Do not prescribe tetracycline to people with: Renal impairment — tetracyclines are excreted renally and may exacerbate renal failure. Prescribe tetracycline with caution to people with: Hepatic impairment and those (...) receiving potentially hepatotoxic drugs, such as carbamazepine, isoniazid, and methotrexate. Myasthenia gravis — tetracyclines may increase muscle weakness symptoms. Systemic lupus erythematosus (SLE) — tetracyclines may exacerbate the condition. [ ] Adverse effects Common adverse effects of tetracycline include: Gastrointestinal disturbances such as nausea, vomiting, and diarrhoea. Consider pseudomembranous colitis if a person develops severe diarrhoea during or after treatment with tetracycline

2016 NICE Clinical Knowledge Summaries

5. Eravacycline, a novel tetracycline derivative, does not induce Clostridioides difficile infection in an in vitro human gut model. (Abstract)

Eravacycline, a novel tetracycline derivative, does not induce Clostridioides difficile infection in an in vitro human gut model. The approval of new antibiotics is essential to combat infections caused by antimicrobial-resistant pathogens; however, such agents should be tested to determine their effect on the resident microbiota and propensity to select for opportunistic pathogens, such as Clostridioides difficile. Eravacycline is a new antibiotic for the treatment of complicated intra (...) was detected. Moxifloxacin exposure sufficiently disrupted the microbiota to induce simulated CDI, where C. difficile spore germination, outgrowth and toxin production were seen.These model data suggest that, despite the initial impact of eravacycline on the intestinal microbiota, similar to clinical trial data, this novel tetracycline has a low propensity to induce CDI.© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights

2020 Journal of Antimicrobial Chemotherapy

6. <i>In Vitro</i> Activity of KBP-7072, a Novel Third-Generation Tetracycline, against 531 Recent Geographically Diverse and Molecularly Characterized Acinetobacter baumannii Species Complex Isolates. Full Text available with Trip Pro

In Vitro Activity of KBP-7072, a Novel Third-Generation Tetracycline, against 531 Recent Geographically Diverse and Molecularly Characterized Acinetobacter baumannii Species Complex Isolates. KBP-7072 is a novel third-generation tetracycline (aminomethylcycline) antibacterial that overcomes common efflux and ribosomal protection resistance mechanisms that cause resistance in older-generation tetracyclines. KBP-7072 completed phase 1 clinical development studies for safety, tolerability (...) (A. baumannii) isolates from the United States, Europe, Asia-Pacific (excluding China), and Latin America. A. baumannii isolates included carbapenem-resistant, colistin-resistant, tetracycline-resistant, and extended-spectrum-β-lactamase (ESBL)- and metallo-β-lactamase (MBL)-producing isolates. Overall, KBP-7072 (MIC50/90, 0.25/1 mg/liter) was comparable in activity to colistin (92.8%/92.8% susceptible [S] [CLSI/EUCAST]) against A. baumannii isolates, inhibiting 99.2% of isolates at ≤2 mg/liter and 97.6

2020 Antimicrobial Agents and Chemotherapy

7. <i>In Vitro</i> Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile. Full Text available with Trip Pro

In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile. Omadacycline is a potent aminomethylcycline with in vitro activity against Gram-positive, Gram-negative, and anaerobic bacteria. Preliminary data demonstrated that omadacycline has in vitro activity against Clostridioides difficile; however, large-scale in vitro studies have not been done. The purpose of this study was to assess the in vitro susceptibility of omadacycline

2020 Antimicrobial Agents and Chemotherapy

8. A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa. Full Text available with Trip Pro

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa. We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread in relation to nationwide clinical interventions.We whole-genome sequenced 12 254 pneumococcal isolates from 29 countries on an Illumina HiSeq sequencer. Serotype, multilocus ST and antibiotic resistance were inferred from genomes. An SNP tree was built using Gubbins (...) . Temporal spread was reconstructed using a birth-death model.We identified tet(S/M) in 131 pneumococcal isolates and none carried other known tet genes. Tetracycline susceptibility testing results were available for 121 tet(S/M)-positive isolates and all were resistant. A majority (74%) of tet(S/M)-positive isolates were from South Africa and caused invasive diseases among young children (59% HIV positive, where HIV status was available). All but two tet(S/M)-positive isolates belonged to clonal complex

2020 Journal of Antimicrobial Chemotherapy

9. Hypersensitivity to tetracyclines: Skin testing, graded challenge, and desensitization regimens. (Abstract)

Hypersensitivity to tetracyclines: Skin testing, graded challenge, and desensitization regimens. Hypersensitivity reactions (HSRs) to tetracyclines and the related compound, tigecycline, can limit the use of these medications and compromise optimal patient care. Despite this, there is little discussion in the literature describing the presentation of these reactions or guiding clinicians on the management of these reactions in adult and pediatric patients.To describe the clinical features (...) , optimal diagnostic approach, and management of HSRs to tetracyclines.Patients with reactions to tetracyclines at our institution from 2011 to 2019 were identified by retrospective chart review. Skin testing protocols were designed for each antibiotic. Graded challenge and desensitization procedures were devised based on medical history, skin testing results when available, and need for readministration.The HSRs to tetracyclines, their workup, and management are described for 10 patients, aged 7 to 68

2020 Asthma & Immunology

10. Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya. Full Text available with Trip Pro

Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya. Treatment of gonorrhea is complicated by the development of antimicrobial resistance in Neisseria gonorrhoeae (GC) to the antibiotics recommended for treatment. Knowledge on types of plasmids and the antibiotic resistance genes they harbor is useful in monitoring the emergence and spread of bacterial antibiotic resistance. In Kenya, studies on gonococcal antimicrobial resistance are few (...) antimicrobial resistance determinants were done using Bioedit sequence alignment editor.Twenty-four (66.7%) isolates had both β-lactamase (TEM) and TetM encoding plasmids. 8.3% of the isolates lacked both TEM and TetM plasmids and had intermediate to susceptible penicillin and tetracycline MICs. Twenty-six (72%) isolates harbored TEM encoding plasmids. 25 of the TEM plasmids were of African type while one was an Asian type. Of the 36 isolates, 31 (86.1%) had TetM encoding plasmids, 30 of which harbored

2020 BMC Infectious Diseases

11. Long Term Patient Experience with Tetracycline Injections for Festoons. (Abstract)

Long Term Patient Experience with Tetracycline Injections for Festoons. To evaluate the long-term patient experience with tetracycline injections for treatment of festoons.Charts of all patients undergoing tetracycline injection for treatment of lower eyelid festoons at the Cole Eye Institute, Cleveland Clinic between 2008 and 2018 were identified using billing records. Patients were invited to participate in a questionnaire based on the FACE-Q checklist, a previously validated questionnaire (...) for studying cosmetic procedure outcomes. Data from the questionnaire were summarized with size, mean and frequency.One hundred two patients who received tetracycline injection during the study period were identified and sixty-one responses were obtained. The average follow-up time after injection was 3.6 years. Of 61 respondents, 36 (59%) noted improvement in their festoons after treatment and 27/33 (82%) noted improvement occurred within two months of treatment. Overall, 40/60 respondents (67%) would

2020 Plastic and reconstructive surgery

12. Bismuth + metronidazole + tetracycline (Pylera) for peptic ulcer associated with Helicobacter pylori: why risk adding bismuth?

Bismuth + metronidazole + tetracycline (Pylera) for peptic ulcer associated with Helicobacter pylori: why risk adding bismuth? Prescrire IN ENGLISH - Spotlight ''Bismuth + metronidazole + tetracycline (Pylera°) for peptic ulcer associated with Helicobacter pylori: why risk adding bismuth?'', 1 April 2013 {1} {1} {1} | | > > > Bismuth + metronidazole + tetracycline (Pylera°) for peptic ulcer associated with Helicobacter pylori: why risk adding bismuth? Spotlight Every month, the subjects (...) in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Bismuth + metronidazole + tetracycline (Pylera°) for peptic ulcer associated with Helicobacter pylori: why risk adding bismuth? FEATURED REVIEW The standard treatment for peptic ulcer associated with Helicobacter pylori is a combination of omeprazole, amoxicillin and clarithromycin. The 4-drug regimen comprising omeprazole + bismuth subcitrate

2014 Prescrire

13. Omadacycline: A novel tetracycline derivative with oral and intravenous formulations. Full Text available with Trip Pro

Omadacycline: A novel tetracycline derivative with oral and intravenous formulations. Omadacycline, an aminomethylcycline, is a novel member of the tetracycline class of antibiotics. It has received approval by the US Food and Drug Administration for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections, and is available in both oral and intravenous formulations. It is also being evaluated in clinical trials for the treatment of cystitis (...) and pyelonephritis. The omadacycline molecule was designed to overcome tetracycline resistance and has broad-spectrum activity that includes gram-positive bacteria, gram-negative bacteria, anaerobes, atypicals, and other drug-resistant strains, like methicillin-resistant Staphylococcus aureus, as well as Yersinia pestis and Bacillus anthracis, organisms of biodefense interest. Omadacycline has minimal drug-drug pharmacokinetic interactions and a favorable safety profile, with the most common adverse events being

2019 Clinical Infectious Diseases

14. Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up. (Abstract)

Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up. The purpose of the present study was to evaluate clinically and radiographically the effectiveness of formocresol and the antibiotic paste CTZ (chloramphenicol, tetracycline and zinc oxide-eugenol) in primary teeth pulpotomies, during a 6, 12 and 24 month period.A total of 80 pulpotomies were performed in 58 patients (...) between three and six years of age. The patients were selected and assigned to two groups: Group I Formocresol (FC, n=40), Group II chloramphenicol-tetracycline-zinc oxide eugenol (CTZ, n=40). The teeth were restored with glass ionomer and pre-formed stainless steel crowns. The treated teeth were evaluated clinically and radiographically at 6, 12 and 24 months.After 24 months of follow up a 100% and 94.3% clinical success was obtained, in the CTZ and formocresol groups respectively (x2= 0.450, p>0.05

2019 The Journal of clinical pediatric dentistry

15. The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anesthetics and without the use of systemic antibiotics. Full Text available with Trip Pro

The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anesthetics and without the use of systemic antibiotics. Our aim was to investigate the effect of an oxytetracycline-impregnated gauze drain on the incidence of alveolar osteitis (AO) and postoperative pain during the first week after mandibular third molar surgery.Two hundred consecutive patients undergoing third molar surgery under local anesthesia were randomized

2019 Oral surgery, oral medicine, oral pathology and oral radiology Controlled trial quality: uncertain

16. Comparative evaluation of efficacy of three treatment modalities - tetracycline fibers, scaling and root planing, and combination therapy: A clinical study. Full Text available with Trip Pro

Comparative evaluation of efficacy of three treatment modalities - tetracycline fibers, scaling and root planing, and combination therapy: A clinical study. Tetracycline is one of the primary antibiotics prescribed for antimicrobial therapy in periodontics. It has a broad spectrum of activity being effective against most bacteria as well as spirochetes. Due to limitations of systemic drug therapy, recent formulations of the drug for local administration in the subgingival area have been (...) introduced, including collagen fibers impregnated with tetracycline.To compare the effectiveness of tetracycline fibers alone or in combination with scaling and root planing (SRP) on clinical parameters in chronic periodontitis patients.A total of twenty patients comprising of both sexes in the age group of 35-60 years with chronic periodontitis were selected. Split-mouth design was used, and three teeth from each patient with periodontal pocket measuring > 5 mm were selected which were treated

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

17. Protective effects of minocycline, doxycycline and tetracycline on seizure and lethality in a mice cocaine toxicity model. (Abstract)

Protective effects of minocycline, doxycycline and tetracycline on seizure and lethality in a mice cocaine toxicity model. Acute cocaine intoxication is one of the important causes of admission to emergency department, especially in western countries. We aimed to compare the efficacies of tetracycline, minocycline, doxycycline in the prevention of seizures and deaths in mice due to cocaine intoxication.In the study, a total of 120 balb-c male mice weighing 25-30 g were randomized into 4 groups (...) as tetracycline 255 mg/kg, minocycline 170 mg/kg, doxycycline 157 mg/kg, 0.5 ml saline (placebo). The doses of tetracycline, minocycline and doxycycline are the calculated ED50 values. The mice in the groups received 93 mg/kg cocaine intraperitoneally 10 min after drug administration. The dose of cocaine is 50% of the lethal dose. After cocaine injection, all mice were observed for 30 min in terms of cocaine toxicity findings. Mortality rates, death times, seizure activities, and seizure onset times

2019 American Journal of Emergency Medicine

18. Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016. Full Text available with Trip Pro

Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016. In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline

2019 Emerging Infectious Diseases

19. In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline Against Drug-Resistant Clinical Isolates of <i>Mycobacterium abscessus</i>. Full Text available with Trip Pro

In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline Against Drug-Resistant Clinical Isolates of Mycobacterium abscessus. Tigecycline is used in multidrug regimens for salvage therapy of Mycobacterium abscessus infections but is often poorly tolerated and has no oral formulation. Here, we report similar in vitro activity of two newly approved tetracycline analogs, omadacycline and eravacycline, against 28 drug-resistant clinical isolates of M. abscessus complex

2019 Antimicrobial Agents and Chemotherapy

20. Root surface demineralization by citric acid/tetracycline gel and aPDT associated to subepithelial connective tissue graft improves root coverage outcomes. A 12-month preliminary randomized clinical trial. (Abstract)

Root surface demineralization by citric acid/tetracycline gel and aPDT associated to subepithelial connective tissue graft improves root coverage outcomes. A 12-month preliminary randomized clinical trial. Root conditioners are used to promote root surface biomodification to increase the success rate of root coverage. Citric acid and tetracycline are commonly used. There is recent indication for using antimicrobial photodynamic therapy (aPDT) with this purpose. The aim of this study (...) is to evaluate the effects of citric acid/tetracycline gel and aPDT in root coverage of gingival recessions using subepithelial connective tissue graft. This parallel, double-blinded clinical trial enrolled 17 patients (60 recession defects; 20/group). Experimental groups were: Control group (SRP) - scaling and root planing only; Citric acid/tetracycline gel (CAT) group - SRP plus citric acid/tetracycline gel; aPDT - SRP, toluidine blue O (100 μl/ml) and red laser. At baseline and after 3, 6 and 12 months

2019 Journal of photochemistry and photobiology. B, Biology Controlled trial quality: uncertain

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