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121. The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: an observational study Full Text available with Trip Pro

The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: an observational study High-dose penicillin therapy is effective in approximately 90% of pneumococcal pneumonia cases diagnosed based on urinary pneumococcal antigen tests or Gram staining at admission. The efficacy of high-dose penicillin therapy for pneumococcal pneumonia diagnosed based on an initial comprehensive assessment comprising a syndromic approach, Gram (...) staining of sputum and urinary pneumococcal antigen testing was investigated.Seventy adult patients diagnosed with pneumococcal pneumonia based on an initial comprehensive assessment and treated with high-dose penicillin G at admission were included. The median patient age was 76.5 years, and 37.1% of the patients were women. The urinary pneumococcal antigen test was positive in 67.1% of all patients, and Gram staining of sputum showed that gram-positive cocci were dominant in 58.6% of the patients

2018 BMC research notes

122. Actinomyces europaeus Isolated from a Breast Abscess in a Penicillin-Allergic Patient Full Text available with Trip Pro

Actinomyces europaeus Isolated from a Breast Abscess in a Penicillin-Allergic Patient This is a case of Actinomyces europaeus in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature describing nonpenicillin treatment options. A 69-year-old woman presented acutely with a breast abscess which was managed with incision and drainage and antibiotic therapy to good response. 21 days after presentation (...) , Actinomyces were grown from the culture of pus, so the patient was recalled and more rigorous treatment and follow-up were initiated. The penicillin allergy led to difficulty in the identification of an appropriate antimicrobial agent that was also logistically feasible to be given on an outpatient IV basis. IV tigecycline followed by oral clarithromycin was found to be effective treatment.

2018 Case reports in infectious diseases

123. Ceftaroline resistance by clone-specific polymorphism in penicillin-binding protein 2a of methicillin-resistant <i>Staphylococcus aureus</i>. Full Text available with Trip Pro

Ceftaroline resistance by clone-specific polymorphism in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. A total of 281 nonduplicated Staphylococcus aureus blood isolates were collected from January to May 2017 from eight hospitals in South Korea to investigate the epidemiological traits of ceftaroline resistance in methicillin-resistant S. aureus (MRSA). Cefoxitin-disk diffusion tests and the mecA gene PCR revealed that 56.6% (159/281) of the S. aureus (...) isolates were MRSA, and most belonged to ST5 (50.3%, 80/281) and ST72 (41.5%, 66/281). Of the MRSA isolates, 44.0% (70/159) were nonsusceptible to ceftaroline (MIC ≥ 2 mg/liter), whereas all of the methicillin-susceptible S. aureus isolates were susceptible to the drug. Eight amino acid substitutions in penicillin-binding protein 2a (PBP2a), including four (L357I, E447K, I563T, and S649A) in the penicillin-binding domain (PBD) and four (N104K, V117I, N146K, and A228V) in the non-PBD (nPBD) of PBP2a

2018 Antimicrobial Agents and Chemotherapy

124. Increasing Rates of Penicillin Sensitivity in <i>Staphylococcus aureus</i>. Full Text available with Trip Pro

Increasing Rates of Penicillin Sensitivity in Staphylococcus aureus. 29686148 2018 12 26 1098-6596 62 7 2018 Jul Antimicrobial agents and chemotherapy Antimicrob. Agents Chemother. Increasing Rates of Penicillin Sensitivity in Staphylococcus aureus. e00680-18 10.1128/AAC.00680-18 Butler-Laporte Guillaume G https://orcid.org/0000-0001-5388-0396 Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada guillaume.butler-laporte (...) . eng Letter 2018 06 26 United States Antimicrob Agents Chemother 0315061 0066-4804 Staphylococcus aureus methicillin resistance penicillin resistance 2018 4 25 6 0 2018 4 25 6 0 2018 4 25 6 0 epublish 29686148 AAC.00680-18 10.1128/AAC.00680-18 PMC6021674 Clin Infect Dis. 2007 Sep 15;45 Suppl 3:S165-70 17712742 J Infect. 2016 Aug;73(2):129-35 27265236 J Clin Microbiol. 2017 Dec 26;56(1):null 29093105 Am J Med. 2016 Dec;129(12):1331-1333 26924388 J Clin Microbiol. 2014 Apr;52(4):1136-8 24452169

2018 Antimicrobial Agents and Chemotherapy

125. Antibiotic Use After Removal of Penicillin Allergy Label. Full Text available with Trip Pro

Antibiotic Use After Removal of Penicillin Allergy Label. Penicillin allergy is commonly reported in the pediatric emergency department. We previously performed 3-tier penicillin allergy testing on children with low-risk symptoms, and 100% tolerated a penicillin challenge without an allergic reaction. We hypothesized that no serious allergic reactions would occur after re-exposure to penicillin and that prescription practices would change after testing.We performed a follow-up case series (...) of 100 children whose test results were negative for penicillin allergy. Research staff administered a brief follow-up phone survey to the parent and primary care provider of each patient tested. We combined the survey data and summarized baseline patient characteristics and questionnaire responses. We then completed a 3-tier economic analysis from the prescription information gathered from surveys in which cost savings, cost avoidance, and potential cost savings were calculated.A total of 46

2018 Pediatrics

126. Penicillin allergy de-labelling ahead of elective surgery: feasibility and barriers. Full Text available with Trip Pro

Penicillin allergy de-labelling ahead of elective surgery: feasibility and barriers. Around 10-15% of the in-patient population carry unsubstantiated 'penicillin allergy' labels, the majority incorrect when tested. These labels are associated with harm from use of broad-spectrum non-penicillin antibiotics. Current testing guidelines incorporate both skin and challenge tests; this is prohibitively expensive and time-consuming to deliver on a large scale. We aimed to establish the feasibility (...) of a rapid access de-labelling pathway for surgical patients, using direct oral challenge.'Penicillin allergic' patients, recruited from a surgical pre-assessment clinic, were risk-stratified using a screening questionnaire. Patients at low risk of true, immunoglobulin E (IgE)-mediated allergy were offered direct oral challenge using incremental amoxicillin to a total dose of 500 mg. A 3-day course was completed at home. De-labelled patients were followed up to determine antibiotic use in surgery

2018 British Journal of Anaesthesia

127. Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. (Abstract)

Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. Previous studies have focused on antibiotic resistance of Gram-negative bacteria before and after periodontal therapy. The purpose of this analysis is to assess changes in resistance patterns of the commensal Gram-positive microbiota. The viridans group streptococci (VGS) have been suggested to serve as reservoirs of resistance genes for more (...) pathogenic streptococci and may be implicated in some non-oral infections.In this randomized clinical trial, 80 patients with periodontitis are distributed randomly into two groups. In group A, patients received 375 mg amoxicillin and 500 mg metronidazole three times per day for 7 days during the non-surgical treatment phase (T1). In group B, the antibiotics were administered during the surgical phase (T2). Resistance of VGS to penicillin and erythromycin was determined by the epsilometer test.At

2018 Journal of periodontology Controlled trial quality: uncertain

128. Amoxicillin Challenge for Penicillin Allergy Diagnosis

Amoxicillin Challenge for Penicillin Allergy Diagnosis Amoxicillin Challenge for Penicillin Allergy Diagnosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Amoxicillin Challenge for Penicillin Allergy (...) Information provided by (Responsible Party): CHU de Quebec-Universite Laval Study Details Study Description Go to Brief Summary: False diagnosis of penicillin allergy are frequently reported, and have been proven detrimental to patients. Current guidelines for the assessment of drug allergies recommend that penicillin allergy be evaluated first with prick and intradermal skin tests, and then completed with a graded oral challenge, spread over at least two doses. However, it has been shown that these skin

2018 Clinical Trials

129. Diversity and composition of vaginal microbiota of pregnant women at risk for transmitting Group B Streptococcus treated with intrapartum penicillin. Full Text available with Trip Pro

Diversity and composition of vaginal microbiota of pregnant women at risk for transmitting Group B Streptococcus treated with intrapartum penicillin. Administering intravenous antibiotics during labor to women at risk for transmitting Group B Streptococcus (GBS) can prevent infections in newborns. However, the impact of intrapartum antibiotic prophylaxis on mothers' microbial community composition is largely unknown. We compared vaginal microbial composition in pregnant women experiencing (...) preterm birth at ≤ 32 weeks gestation that received intrapartum antibiotic prophylaxis with that in controls.Microbiota in vaginal swabs collected shortly before delivery from GBS positive women that received penicillin intravenously during labor or after premature rupture of membranes was compared to controls. Microbiota was analyzed by 16S rRNA sequencing using the PGM Ion Torrent to determine the effects of penicillin use during hospitalization and GBS status on its composition.Penicillin

2017 PLoS ONE

130. What is the clinical significance of the interaction between methotrexate and penicillins?

What is the clinical significance of the interaction between methotrexate and penicillins? What is the clinical significance of the interaction between methotrexate and penicillins? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Published 19th April 2016, updated 8th August 2017 The evidence for an interaction between methotrexate and penicillins is limited to case reports and animal studies. So far, there is no conclusive evidence that any (...) particular patient group is more at risk of an interaction occurring, and it does not appear to be dose related. If concurrent use of methotrexate and a penicillin is required, patients should be carefully monitored during treatment. Monitoring may include measuring platelets and blood counts twice weekly for two weeks, with methotrexate levels being taken if the patient becomes symptomatic. Attachments · Word · 70 KB Senior Medicines Information Pharmacist , Regional Drug and Therapeutics Centre

2016 Specialist Pharmacy Services

131. An evidence-based approach to penicillin allergy testing and de-labelling: a systematic review

An evidence-based approach to penicillin allergy testing and de-labelling: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2020 PROSPERO

132. Is direct oral challenge a safe and effective method of de-labelling in adults with an unverified penicillin allergy?

Is direct oral challenge a safe and effective method of de-labelling in adults with an unverified penicillin allergy? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2020 PROSPERO

133. Penicillin for 5 or 10 days for Group A streptococcal pharnygitis.

Penicillin for 5 or 10 days for Group A streptococcal pharnygitis. Penicillin for 5 or 10 days for Group A streptococcal pharnygitis. – Less Is More Search for: Simpler & Better Medicine Menu / Summary: For patients over age 6 years with group A streptococcal pharnygitis meeting at least 3 of the treatment with Penicillin V 800 mg 4x daily for 5 days may be associated with a slightly shorter and a lower likelihood of adverse events such as diarrhea, nausea, and vulvovaginal symptoms compared (...) to treatment with Penicillin V 1000 mg 3x daily for 10 days; both approaches may be associated with the same likelihood (~ 90%) of clinical cure after 5-7 days. Strength of Recommendation = A Like this: Like Loading... Categories: Tags: , Post navigation Simpler, Better Medicine Indexing evidence for "less medical” approaches with better outcomes. Recent entries Search by key words Search for: Search By Strength of Recommendation (SOR) (50) (283) (27) Search by clinical category For regular updates, follow

2019 Less Is More Blog

134. Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study. (Abstract)

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study. Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects (...) of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis

2017 Acta neurobiologiae experimentalis Controlled trial quality: uncertain

135. Determining the Impact of Penicillin in Latent RHD: The GOAL Trial

Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Determining the Impact of Penicillin in Latent RHD: The GOAL Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Determining the Impact (...) of Penicillin in Latent RHD: The GOAL Trial (GOAL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03346525 Recruitment Status : Recruiting First Posted : November 17, 2017 Last Update Posted : October 18, 2018 See Sponsor

2017 Clinical Trials

136. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis Full Text available with Trip Pro

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis New Delhi metallo-β-lactamases (NDMs), the recent additions to metallo-β-lactamases (MBLs), pose a serious public health threat due to its highly efficient hydrolysis of β-lactam antibiotics and rapid worldwide dissemination. The MBL-hydrolyzing mechanism for carbapenems is less studied than that of penicillins and cephalosporins. Here, we report crystal structures of NDM-1 (...) . These results strongly suggest a distinct mechanism of NDM-1-catalyzed carbapenem hydrolysis from that of penicillin or cephalosporin hydrolysis, which may provide a novel rationale for design of mechanism-based inhibitors.

2017 Nature communications

137. Surveillance reports: epidemiological/serological evaluation of tropical yaws following mass penicillin campaings (Thailand, Philippines, Nigeria)

Surveillance reports: epidemiological/serological evaluation of tropical yaws following mass penicillin campaings (Thailand, Philippines, Nigeria) Surveillance reports: epidemiological/serological evaluation of tropical yaws following mass penicillin campaings (‎Thailand, Philippines, Nigeria)‎ JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Surveillance reports (...) : epidemiological/serological evaluation of tropical yaws following mass penicillin campaings (‎Thailand, Philippines, Nigeria)‎ View/ Open View Statistics Altmetrics Share Citation Guthe, T. & de Vries, J. L. (‎1966)‎. Surveillance reports: epidemiological/serological evaluation of tropical yaws following mass penicillin campaings (‎Thailand, Philippines, Nigeria)‎. World Health Organization. Description 20 p. Gov't Doc # GES/SR/66.2 WHO/VDT/66.336 Collections Language English Metadata Related items Showing

1966 WHO

138. Modified penicillin molecule with carbapenem-like stereochemistry specifically inhibits Class C β-lactamases. Full Text available with Trip Pro

Modified penicillin molecule with carbapenem-like stereochemistry specifically inhibits Class C β-lactamases. Bacterial β-lactamases readily inactivate most penicillins and cephalosporins by hydrolyzing and "opening" their signature β-lactam ring. In contrast, carbapenems resist hydrolysis by many serine-based class A, C, and D β-lactamases due to their unique stereochemical features. To improve the resistance profile of penicillins, we synthesized a modified penicillin molecule, MPC-1 (...) , by "grafting" carbapenem-like stereochemistry onto the penicillin core. Chemical modifications include the trans conformation of hydrogen atoms at C-5 and C-6 instead of cis, and a 6-α hydroxyethyl moiety to replace the original 6-β aminoacyl group. MPC-1 selectively inhibits class C β-lactamases, such as P99, by forming a nonhydrolyzable acyl adduct, and its inhibitory potency is ∼2 to 5 times higher than that for clinically used β-lactamase inhibitors clavulanate and sulbactam. The crystal structure

2017 Antimicrobial Agents and Chemotherapy

139. Diversity of mosaic <i>pbp2x</i> families of penicillin-resistant <i>Streptococcus pneumoniae</i> from Iran and Romania. Full Text available with Trip Pro

Diversity of mosaic pbp2x families of penicillin-resistant Streptococcus pneumoniae from Iran and Romania. Penicillin-resistant Streptococcus pneumoniae strains are found at high rates in Romania and Iran. The mosaic structure of PBP2x was investigated in 9 strains from Iran and in 15 strains from Romania to understand their evolutionary history. Mutations potentially important for β-lactam resistance were identified by comparison of the PBP2x sequences with the sequence (...) of the related PBP2x of reference penicillin-sensitive S. mitis strains. Two main PBP2x mosaic gene families were recognized. Eight Iranian strains expressed PBP2x variants in group 1, which had a mosaic block highly related to PBP2x of the Spain23F-1 clone, which is widespread among international penicillin-resistant S. pneumoniae clones. A second unique PBP2x group was observed in Romanian strains; furthermore, three PBP2x single mosaic variants were found. Sequence blocks of penicillin-sensitive strain S

2017 Antimicrobial Agents and Chemotherapy

140. Influence of the duration of penicillin prescriptions on outcomes for acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice. Full Text available with Trip Pro

Influence of the duration of penicillin prescriptions on outcomes for acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice. Guidelines recommend 10-day treatment courses for acute sore throat, but shorter courses may be used in practice.To determine whether antibiotic duration predicts adverse outcome of acute sore throat in adults in routine care.A secondary analysis of the DESCARTE (Decision rule for the Symptoms and Complications of Acute Red Throat (...) -days RR 0.86 [95% CI = 0.59 to 1.23]) but these differences did not reach statistical significance.In adults prescribed antibiotics for sore throat, the authors cannot rule out a small advantage in terms of reduced re-consultation for a 10-day course of penicillin, but the effect is likely to be small.© British Journal of General Practice 2017.

2017 British Journal of General Practice

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