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141. Penicillin Allergy in Shfayim Clinic

Penicillin Allergy in Shfayim Clinic Penicillin Allergy in Shfayim Clinic - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Penicillin Allergy in Shfayim Clinic The safety and scientific validity (...) , Clalit Health Services Study Details Study Description Go to Brief Summary: revising penicillin allergy in the medical records, by taking full medical history and giving a challange test, in order to imrove the medical records and treatment possibilities. Condition or disease Intervention/treatment Phase Penicillin Allergy Drug: Amoxicillin Not Applicable Detailed Description: issuing a list of patients with a title of penicillin allergy in their medical record. inviting these patients

2018 Clinical Trials

142. De-labeling of Patients With False Diagnosis of Penicillin Allergy

De-labeling of Patients With False Diagnosis of Penicillin Allergy De-labeling of Patients With False Diagnosis of Penicillin Allergy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. De-labeling of Patients (...) With False Diagnosis of Penicillin Allergy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03581604 Recruitment Status : Recruiting First Posted : July 10, 2018 Last Update Posted : July 10, 2018 See Sponsor: Oslo University

2018 Clinical Trials

143. Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES)

Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Penicillin (...) by (Responsible Party): The Leeds Teaching Hospitals NHS Trust Study Details Study Description Go to Brief Summary: Penicillin antibiotics are safe and inexpensive, and target selected bacteria rather than killing a broad range. Unfortunately, around 10% of the population are labelled as 'penicillin allergic'. This is often based on side effects such as rash and diarrhoea, and 90-95% of people with the label are not actually allergic to the drug. The label leads to the use of alternative antibiotics, which

2018 Clinical Trials

144. Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy

Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03708848 Recruitment Status : Recruiting First Posted : October 17

2018 Clinical Trials

145. WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 β-lactamase gene. Full Text available with Trip Pro

WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 β-lactamase gene. Neisseria meningitidis is rarely penicillin resistant. We describe WGS analysis of a penicillin-resistant N. meningitidis collected from a case of invasive meningococcal disease.Serogrouping, serotyping and serosubtyping were performed with specific antibodies. β-Lactamase was detected by nitrocefin. MICs were determined by Etest and agar dilution. Sequencing of N. meningitidis (...) genomes was done on the Illumina MiSeq platform and genome data were analysed using the Bacterial Isolate Genome Sequence Database (BIGSdb) on the PubMLST Neisseria website (https://pubmlst.org/neisseria/). Transformation was used to confirm the genetic basis of the penicillin resistance.An N. meningitidis blood isolate from a female patient in her mid-50s with a painful and septic left shoulder was found to have penicillin MIC values of 3-12 mg/L. The isolate was typed as Y: 14, 19: P1.- and ST3587

2018 Journal of Antimicrobial Chemotherapy

146. New avenues for antimicrobial stewardship: the case for penicillin skin testing by pharmacists. (Abstract)

New avenues for antimicrobial stewardship: the case for penicillin skin testing by pharmacists. It is well-appreciated that patients with documented penicillin allergies often receive broader-spectrum antibiotics. This practice has been associated with increased antimicrobial resistance and cost. In recent years, considerable efforts have been made to spread awareness on the implications of self-reported penicillin allergies. The use of penicillin skin testing to evaluate for true allergies has (...) been strongly recommended by major organizations for decades. However, testing remains underutilized. Current literature has suggested various models incorporating penicillin allergy screening and testing by different health-care practitioners (i.e., physicians, allergists, nurses, pharmacists). We suggest broader adoption for the role of pharmacists in provision of penicillin skin testing. This would help expand the service and maximize the potential benefits of penicillin skin testing.

2018 Clinical Infectious Diseases

147. Beyond penicillin - rapid desensitization for specific flucloxacillin hypersensitivity. Full Text available with Trip Pro

Beyond penicillin - rapid desensitization for specific flucloxacillin hypersensitivity. Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy. For patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for antistaphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and describe (...) the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, for whom a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.© Crown copyright 2018.

2018 Antimicrobial Agents and Chemotherapy

148. Penicillin for 5 or 10 days for Group A streptococcal pharnygitis.

Penicillin for 5 or 10 days for Group A streptococcal pharnygitis. Penicillin for 5 or 10 days for Group A streptococcal pharnygitis. – Less Is More Search for: Simpler & Better Medicine Menu / Summary: For patients over age 6 years with group A streptococcal pharnygitis meeting at least 3 of the treatment with Penicillin V 800 mg 4x daily for 5 days may be associated with a slightly shorter and a lower likelihood of adverse events such as diarrhea, nausea, and vulvovaginal symptoms compared (...) to treatment with Penicillin V 1000 mg 3x daily for 10 days; both approaches may be associated with the same likelihood (~ 90%) of clinical cure after 5-7 days. Strength of Recommendation = A Like this: Like Loading... Categories: Tags: , Post navigation Simpler, Better Medicine Indexing evidence for "less medical” approaches with better outcomes. Recent entries Search by key words Search for: Search By Strength of Recommendation (SOR) (50) (283) (27) Search by clinical category For regular updates, follow

2019 Less Is More Blog

149. Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study. (Abstract)

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study. Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects (...) of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis

2017 Acta neurobiologiae experimentalis Controlled trial quality: uncertain

150. Safety of clarithromycin in treating infection in comparison to penicillin

Safety of clarithromycin in treating infection in comparison to penicillin Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

151. Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia.

Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia. Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia. (PENIPNEUMO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03208361 Recruitment Status : Terminated (Lack of financial support

2017 Clinical Trials

152. Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis

Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03183180

2017 Clinical Trials

153. Determining the Impact of Penicillin in Latent RHD: The GOAL Trial

Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Determining the Impact of Penicillin in Latent RHD: The GOAL Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Determining the Impact (...) of Penicillin in Latent RHD: The GOAL Trial (GOAL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03346525 Recruitment Status : Recruiting First Posted : November 17, 2017 Last Update Posted : October 18, 2018 See Sponsor

2017 Clinical Trials

154. Antibiotic Prophylaxis in Cataract Surgery in The Setting of Penicillin Allergy: A Decision Making Algorithm. (Abstract)

Antibiotic Prophylaxis in Cataract Surgery in The Setting of Penicillin Allergy: A Decision Making Algorithm. Cataract surgery is the most commonly performed surgical procedure in many developed countries. Postoperative endophthalmitis is a rare complication with potentially devastating visual outcomes. Currently, there is no global consensus regarding antibiotic prophylaxis in cataract surgery despite growing evidence of the benefits of prophylactic intracameral cefuroxime at the conclusion (...) of surgery. The decision about which antibiotic regimen to use is further complicated in patients reporting penicillin allergy. Historic statistics suggesting crossreactivity of penicillins and cephalosporins have persisted into modern surgery. It is important for ophthalmologists to consider all available antibiotic options and have an up-to-date knowledge of antibiotic crossreactivity when faced with the dilemma of choosing appropriate antibiotic prophylaxis for patients undergoing cataract surgery

2017 Survey of Ophthalmology

156. High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4). Full Text available with Trip Pro

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4). Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-generated mutant strain, CRB, which expresses high-level resistance to β-lactams

2017 Antimicrobial Agents and Chemotherapy

157. De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing. (Abstract)

De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing. Self-reported penicillin allergy is common among patients attending the ED, but is a poor predictor of true immunoglobulin E-mediated hypersensitivity to penicillin. We hypothesise that with a combination of skin testing and drug provocation testing, selected patients can be safely de-labelled of their allergy.This prospective study enrolled a sample (...) of patients presenting to an urban academic ED between 2011 and 2016 with a self-reported allergy to penicillin. Standardised skin prick and intradermal testing with amoxicillin and both major and minor determinants of penicillin was performed in the department. If negative, testing was followed by a graded oral challenge of amoxicillin over 9 days. The primary end point was the allergy status of participants at the end of the study.A total of 100 patients (mean age 42; standard deviation 14 years; 54

2017 Emergency medicine Australasia

158. A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. Full Text available with Trip Pro

A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. Yaws is a treponemal infection that was almost eradicated fifty years ago; however, the disease has re-emerged in a number of countries including Ghana. A single-dose of intramuscular benzathine penicillin has been the mainstay of treatment for yaws. However, intramuscular injections are painful and pose safety and logistical constraints in the poor (...) areas where yaws occurs. A single center randomized control trial (RCT) carried out in Papua New Guinea in 2012 demonstrated the efficacy of a single-dose of oral azithromycin for the treatment of yaws. In this study, we also compared the efficacy of a single oral dose of azithromycin as an alternative to intramuscular benzathine penicillin for the treatment of the disease in another geographic setting.We conducted an open-label, randomized non-inferiority trial in three neighboring yaws-endemic

2017 PLoS neglected tropical diseases Controlled trial quality: uncertain

159. Penicillin Resistance of Nonvaccine Type Pneumococcus before and after PCV13 Introduction, United States. Full Text available with Trip Pro

Penicillin Resistance of Nonvaccine Type Pneumococcus before and after PCV13 Introduction, United States. Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of penicillin resistance in nonvaccine type serotypes because of the variable success of highly resistant serotypes. Differences in regional serotype distribution and serotype-specific resistance contributed to geographic heterogeneity of penicillin

2017 Emerging Infectious Diseases

160. Modified penicillin molecule with carbapenem-like stereochemistry specifically inhibits Class C β-lactamases. Full Text available with Trip Pro

Modified penicillin molecule with carbapenem-like stereochemistry specifically inhibits Class C β-lactamases. Bacterial β-lactamases readily inactivate most penicillins and cephalosporins by hydrolyzing and "opening" their signature β-lactam ring. In contrast, carbapenems resist hydrolysis by many serine-based class A, C, and D β-lactamases due to their unique stereochemical features. To improve the resistance profile of penicillins, we synthesized a modified penicillin molecule, MPC-1 (...) , by "grafting" carbapenem-like stereochemistry onto the penicillin core. Chemical modifications include the trans conformation of hydrogen atoms at C-5 and C-6 instead of cis, and a 6-α hydroxyethyl moiety to replace the original 6-β aminoacyl group. MPC-1 selectively inhibits class C β-lactamases, such as P99, by forming a nonhydrolyzable acyl adduct, and its inhibitory potency is ∼2 to 5 times higher than that for clinically used β-lactamase inhibitors clavulanate and sulbactam. The crystal structure

2017 Antimicrobial Agents and Chemotherapy

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