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101. Progression free survival and overall survival of CDK 4/6 inhibitors plus endocrine therapy in metastatic breast cancer: a systematic review and meta-analysis Full Text available with Trip Pro

Progression free survival and overall survival of CDK 4/6 inhibitors plus endocrine therapy in metastatic breast cancer: a systematic review and meta-analysis Progression free survival and overall survival of CDK 4/6 inhibitors plus endocrine therapy in metastatic breast cancer: a systematic review and meta-analysis | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does (...) not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Progression free survival and overall survival of CDK 4/6 inhibitors plus endocrine therapy in metastatic breast cancer: a systematic review and meta-analysis Michela Piezzo, Paolo Chiodini, Maria Riemma, Stefania Cocco, Roberta Caputo, Daniela

2020 Research Square

102. Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis Full Text available with Trip Pro

Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis | medRxiv Search for this keyword Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis Joseph (...) and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, TX; For correspondence: Harvey Risch 4 Yale School of Public Health For correspondence: Abstract Objective--To determine if hydroxychloroquine (HCQ) reduces the incidence of new illness, hospitalization or death among outpatients at risk for or infected with SARS-CoV-2 (COVID-19). Design--Systematic review and meta-analysis of randomized clinical trials. Data sources--Search of MEDLINE, EMBASE, PubMed, medRxiv

2020 Cold Spring Harbor Laboratory

103. Inflammation Level Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis Full Text available with Trip Pro

, 95%CI: 0.59-0.96) and mortality (OR:0.52, 95%CI: 0.35-0.79). Subgroup analyses showed that, among the general population, application of ACEI/ARB therapy was associated with reduced risks of all-cause death(OR:0.31, 95%CI: 0.13-0.75), and the risk of severe COVID-19(OR:0.79, 95%CI: 0.60-1.05) infection and COVID-19 infection(OR:0.85, 95% CI: 0.66-1.08) were not increased. Among patients with hypertension, the use of an ACEI/ARB was associated with a lower severity of COVID-19(OR:0.73, 95%CI: 0.51 (...) Inflammation Level Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis Association of Renin-Angiotensin-Aldosterone System Inhibition with Risk of COVID-19, Inflammation Level, Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis | medRxiv Search for this keyword Association of Renin-Angiotensin-Aldosterone System Inhibition with Risk of COVID-19, Inflammation Level, Severity and Death in Patients With COVID-19: A Rapid

2020 Cold Spring Harbor Laboratory

104. Epidemiological Risk Factors Associated with Death and Severe Disease in Patients Suffering From COVID-19: A Comprehensive Systematic Review and Meta-analysis Full Text available with Trip Pro

from China. Pooled prevalence of death [%(95% CI)] was 18% (15-22%). Of those that died, 76% were aged≥ 60 years, 68% were males, and 63%, 38%, and 29% had hypertension, diabetes and heart disease, respectively. The case fatality risk [%(95% CI)] were 62% (48-78) for heart disease, 51% (36-71) for COPD, and 42% (34-50) for age≥ 60 years and 49% (33-71) for chronic kidney disease (CKD). Summary relative risk (sRR) of death were higher for age≥ 60 years [sRR=3.8; 95% CI: 2.9-4.8; n=12 studies], males (...) Epidemiological Risk Factors Associated with Death and Severe Disease in Patients Suffering From COVID-19: A Comprehensive Systematic Review and Meta-analysis Epidemiological Risk Factors Associated with Death and Severe Disease in Patients Suffering From COVID-19: A Comprehensive Systematic Review and Meta-analysis | medRxiv Search for this keyword Epidemiological Risk Factors Associated with Death and Severe Disease in Patients Suffering From COVID-19: A Comprehensive Systematic Review

2020 Cold Spring Harbor Laboratory

106. Regulatory and Road Engineering Interventions for Preventing Road Traffic Injuries and Fatalities Among Vulnerable Road Users in Low- and Middle-Income Countries: A Systematic Review Full Text available with Trip Pro

barriers include under-reporting of road crash data as well as limited amount of disaggregated data on road crash fatalities, injuries and intermediate outcomes in crash databases, a lack of technical expertise, and a lack of coordination between agencies responsible for road safety management and amongst different levels of governments ( ). In the light of increasing road traffic deaths and low levels of public investments in road safety measures, international agencies began getting involved (...) , as seen in some studies ( ; ; ; ). For road engineering interventions, the results were uncertain on reducing the number of road traffic injuries and deaths. In one study ( ), because of the construction of an overpass (footbridge), pedestrian injuries increased, although there was a slight decline in fatalities. Since there was no police surveillance or a financial penalization for using roads to cross or any attempts to channel pedestrian traffic to the overpass, most of the pedestrians crossed

2020 Frontiers in Sustainable Cities

107. Risk factors and interventions associated with mortality or survival in adult COVID-19 patients admitted to critical care: a systematic review and meta-analysis Full Text available with Trip Pro

Risk factors and interventions associated with mortality or survival in adult COVID-19 patients admitted to critical care: a systematic review and meta-analysis Risk factors and interventions associated with mortality or survival in adult COVID-19 patients admitted to critical care: a systematic review and meta-analysis | Southern African Journal of Anaesthesia and Analgesia Search / / / Review Articles R Hofmeyr University of Cape Town A Torborg University of KwaZulu-Natal C Van Tonder (...) of Cape Town Keywords: COVID-19, SARS-CoV-2, critical care, outcomes, mortality, risk factors Abstract Background: Patients with confirmed COVID-19 admitted to intensive care units have a high mortality rate, which appears to be associated with increasing age, male sex, smoking history, hypertension and diabetes mellitus. Methods: A systematic review to determine risk factors and interventions associated with mortality/survival in adult patients admitted to an intensive care unit (ICU) with confirmed

2020 Southern African Journal of Anaesthesia and Analgesia

108. Case- fatality rate in COVID- 19 patients: A meta-analysis of publicly accessible database Full Text available with Trip Pro

with country level data. Publicly accessible web database WorldOMeter ( ) was accessed on 24th March 2020 GMT and reported total number of cases, total death, active cases and seriously ill/ critically ill patients were retrieved. Primary outcome of this meta-analysis was case fatality rate defined by total number of deaths divided by total number of diagnosed cases. Pooled case fatality rate (95% CI) was 1.78 (1.34-2.22) %. Between country heterogeneity was 0.018 (p<0.0001). Pooled estimate of composite (...) poor outcome (95% CI) was 4.06 (3.24-4.88) % at that point of time after exclusion of countries reported small number of cases. Pooled mortality rate (95% CI) was 33.97 (27.44-40.49) % amongst closed cases (where patients have recovered or died) with. Meta regression analysis identified statistically significant association between health expenditure and case fatality rate (p=0.0017). Competing Interest Statement The authors have declared no competing interest. Funding Statement No funding received

2020 Cold Spring Harbor Laboratory

109. Basic Reproduction Rate and Case Fatality Rate of COVID-19: Application of Meta-analysis Full Text available with Trip Pro

the risk of death. Aim This study aims to provide the estimates of basic reproduction rate (R 0 ) and case fatality rate (CFR) which applies to a generalised population. Methods A systematic review was carried out to retrieve the published estimates of reproduction rate and case fatality rate in peer-reviewed articles from PubMed MEDLINE database with defined inclusion and exclusion criteria in the period 15 December 2019 to 3 May 2020. The systematic review led to the selection of 24 articles for R 0 (...) Basic Reproduction Rate and Case Fatality Rate of COVID-19: Application of Meta-analysis Basic Reproduction Rate and Case Fatality Rate of COVID-19: Application of Meta-analysis | medRxiv Search for this keyword Basic Reproduction Rate and Case Fatality Rate of COVID-19: Application of Meta-analysis Suryakant Yadav , Pawan Kumar Yadav doi: https://doi.org/10.1101/2020.05.13.20100750 Suryakant Yadav 1 Assistant Professor , Department of Development Studies, International Institute for Population

2020 Cold Spring Harbor Laboratory

110. Sudden Death in Patients with Sleep Apnea: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

this risk and optimize survival in this population. What is the key question? Are individuals with sleep apnea at an increased risk for cardiovascular mortality and sudden death? What is the bottom Line? Sleep apnea is associated with an increased risk of cardiovascular mortality and sudden death, with a dose response relationship, where those with severe sleep apnea are at the highest risk of mortality. Why read on? This is the first systematic review and meta-analyses to synthesize and quantify (...) and potentially increase the risk of mortality. However, this association between OSA and mortality has not been comprehensively and thoroughly explored. This meta-analysis was conducted to conclusively estimate the risk of death for all-cause mortality and cardiovascular mortality in OSA patients. Study Design 4,613 articles from databases including PUBMED, OVID & Joana Briggs, and SCOPUS were comprehensively assessed by two reviewers (AES & ESH) for inclusion criteria. 28 total articles were included

2020 Cold Spring Harbor Laboratory

111. A systematic review and meta-analysis of published research data on COVID-19 infection-fatality rates Full Text available with Trip Pro

of Wollongong For correspondence: Lea Merone 3 James Cook University 4 Apunipima Cape York Health Council Abstract An important unknown during the COVID-19 pandemic has been the infection-fatality rate (IFR). This differs from the case-fatality rate (CFR) as an estimate of the number of deaths as a proportion of the total number of cases, including those who are mild and asymptomatic. While the CFR is extremely valuable for experts, IFR is increasingly being called for by policy-makers and the lay public (...) -analysis, it is difficult to know if this represents the ‘true’ point estimate. It is likely that, due to age and perhaps underlying comorbidities in the population, different places will experience different IFRs due to the disease. Given issues with mortality recording, it is also likely that this represents an underestimate of the true IFR figure. More research looking at age-stratified IFR is urgently needed to inform policy-making on this front. Key messages – COVID-19 infection-fatality rate (IFR

2020 Cold Spring Harbor Laboratory

112. Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies Full Text available with Trip Pro

(WMD=159.77 ng/mL, 95% CI=99.54–220.01, p <0.001) were associated with a significant increase in the mortality of COVID-19 infection. Cardiac injury, as assessed by serum analysis (lactate dehydrogenase, cardiac troponin I, creatine kinase (-MB) and myoglobin), was associated with severe outcome and death from COVID-19 infection. Keywords , , , Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries and territories around the world. As of 31 May 2020, a total (...) and severe outcome or death from COVID-19 infection using random-effects model. WMD: weighted mean difference; CI: confidence interval Figure 6. Forest plot for the association between serum levels of myoglobin and severe outcome or death from COVID-19 infection using fixed-effects model. WMD: weighted mean difference; CI: confidence interval Serum levels of lactate dehydrogenase, creatine kinase-MB, creatine kinase, cardiac troponin I, myoglobin and mortality from COVID-19 infection Six studies

2020 European Heart Journal: Acute Cardiovascular Care

113. Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case fatality rate for COVID-19: Meta-analysis and sensitivity analysis Full Text available with Trip Pro

Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case fatality rate for COVID-19: Meta-analysis and sensitivity analysis Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case fatality rate for COVID-19: Meta-analysis and sensitivity analysis | medRxiv Search for this keyword Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case (...) fatality rate for COVID-19: Meta-analysis and sensitivity analysis Wenqing He , Grace Y. Yi , Yayuan Zhu doi: https://doi.org/10.1101/2020.04.28.20083758 Wenqing He 1 Department of Statistical and Actuarial Sciences, University of Western Ontario , London, Ontario, Canada , For correspondence: Grace Y. Yi 2 Department of Statistical and Actuarial Sciences, Department of Computer Science, University of Western Ontario , London, Ontario, Canada , For correspondence: Yayuan Zhu 3 Department

2020 Cold Spring Harbor Laboratory

114. Relationship Between Blood Group and Risk of Infection and Death in COVID-19: a live Meta-Analysis Full Text available with Trip Pro

Relationship Between Blood Group and Risk of Infection and Death in COVID-19: a live Meta-Analysis Relationship Between Blood Group and Risk of Infection and Death in COVID-19: a live Meta-Analysis | medRxiv Search for this keyword Relationship Between Blood Group and Risk of Infection and Death in COVID-19: a live Meta-Analysis Fateme Pourali , Mahdi Afshari , Reza Alizadeh-Navaei , Javad Javidnia , Mahmood Moosazadeh , Amirhossein Hessami doi: https://doi.org/10.1101/2020.06.07.20124610 (...) Health Sciences Research center, Addiction Institute, Mazandaran University of Medical Sciences , Sari, Iran For correspondence: Amirhossein Hessami 1 Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences , Sari, Iran 5 Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN) , Tehran, Iran Abstract Introduction The relationship between ABO blood group and the incidence of COVID-19 infection and death has

2020 Cold Spring Harbor Laboratory

115. ASSESSING THE AGE SPECIFICITY OF INFECTION FATALITY RATES FOR COVID-19: META-ANALYSIS & PUBLIC POLICY IMPLICATIONS Full Text available with Trip Pro

ASSESSING THE AGE SPECIFICITY OF INFECTION FATALITY RATES FOR COVID-19: META-ANALYSIS & PUBLIC POLICY IMPLICATIONS Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications | medRxiv Search for this keyword Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications Andrew T. Levin , William P. Hanage , Nana Owusu-Boaitey , Kensington B (...) Reserve University School of Medicine Kensington B. Cochran 5 recent graduates of Dartmouth College Seamus P. Walsh 5 recent graduates of Dartmouth College Gideon Meyerowitz-Katz 3 epidemiologist at the University of Wollongong and research monitoring and surveillance coordinator at the Western Sydney Local Health District For correspondence: Structured Abstract Objective Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect

2020 Cold Spring Harbor Laboratory

117. ECG-based Predictors of Re-infarction or Death on the Hospital Admission 12-Lead ECG among UA/NSTEMI Patients: A Protocol for a Systematic Review and Meta-Analysis Full Text available with Trip Pro

ECG-based Predictors of Re-infarction or Death on the Hospital Admission 12-Lead ECG among UA/NSTEMI Patients: A Protocol for a Systematic Review and Meta-Analysis ECG-based Predictors of Re-infarction or Death on the Hospital Admission 12-Lead ECG among UA/NSTEMI Patients: A Protocol for a Systematic Review and Meta-Analysis | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research (...) Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Protocol ECG-based Predictors of Re-infarction or Death on the Hospital Admission 12-Lead ECG among UA/NSTEMI Patients: A Protocol for a Systematic Review and Meta-Analysis Dillon J Dzikowicz, Darcey H. Mulligan, Mary G. Carey Dillon J Dzikowicz

2020 Research Square

118. Ecological association between COVID-19 deaths and vitamin D deficiency among older adults: An international country-level systematic review and analysis Full Text available with Trip Pro

Ecological association between COVID-19 deaths and vitamin D deficiency among older adults: An international country-level systematic review and analysis Ecological association between COVID-19 deaths and vitamin D deficiency among older adults: An international country-level systematic review and analysis | Research Square Browse Tools & Services Your Cart This preprint is under consideration at BMC Nutrition . A preprint is a preliminary version of a manuscript that has not completed peer (...) review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Ecological association between COVID-19 deaths and vitamin D deficiency among older adults: An international country-level systematic review and analysis Kaylin Beiter, Frank H Lau, Denise Danos

2020 Research Square

119. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature Full Text available with Trip Pro

The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature[v1] | Preprints Share this article with Create alert Email: Submit > > > doi: 10.20944/preprints202009.0702.v1 Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed (...) The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature * , , , , Version 1 : Received: 28 September 2020 / Approved: 29 September 2020 / Online: 29 September 2020 (09:14:03 CEST) A of this Preprint also exists. Del Riccio, M.; Lorini, C.; Bonaccorsi, G.; Paget, J.; Caini, S. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review

2020 MDPI AG

120. Estimation of novel coronavirus (covid-19) reproduction number and case fatality rate: a systematic review and meta-analysis Full Text available with Trip Pro

Estimation of novel coronavirus (covid-19) reproduction number and case fatality rate: a systematic review and meta-analysis Estimation of novel coronavirus (covid-19) reproduction number and case fatality rate: a systematic review and meta-analysis | medRxiv Search for this keyword Estimation of novel coronavirus (covid-19) reproduction number and case fatality rate: a systematic review and meta-analysis Tanvir Ahammed , Aniqua Anjum , Mohammad Meshbahur Rahman , Najmul Haider , Richard Kock (...) For correspondence: Md. Jamal Uddin 1 Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh; For correspondence: Abstract Understanding the transmission dynamics and the severity of the novel coronavirus disease 2019 (COVID-19) informs public health interventions, surveillance, and planning. Two important parameters, the basic reproduction number (R0) and case fatality rate (CFR) of COVID-19, help in this understanding process. The objective of this study was to estimate the R0 and CFR of COVID

2020 Cold Spring Harbor Laboratory

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