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81. Deaths in custody in the Irish prison service: 5-year retrospective study of drug toxicology and unnatural deaths Full Text available with Trip Pro

Deaths in custody in the Irish prison service: 5-year retrospective study of drug toxicology and unnatural deaths Mental health and substance misuse disorders are associated with unnatural deaths in prisoners. Deaths in Irish prisons between 2009 and 2014 were retrospectively analysed using coroner's findings, including post-mortem toxicology. There were 69 deaths in custody, 38 of which met inclusion criteria. All deaths by overdose (16) were positive for illicit drugs; 53% of deaths (8 of 15 (...) ) due to hanging were also positive for illicit drugs, and 29% of deaths (2 of 7) from other causes were toxicology positive. In conclusion, 26 unnatural deaths (68%) were associated with use of illicit drugs, which are a major contributory factor to deaths of prisoners.None.

2018 BJPsych open

82. Supplementary Guidance for the Diagnosis of Death using Neurological Criteria when the patient is supported with extracorporeal membrane oxygenation (ECMO)

Supplementary Guidance for the Diagnosis of Death using Neurological Criteria when the patient is supported with extracorporeal membrane oxygenation (ECMO) Supplementary Guidance for the Diagnosis of Death using Neurological Criteria when the patient is supported with extracorporeal membrane oxygenation (ECMO) ? ! 1 May 2018 Pharmacokinetic It is known that ECMO circuits sequester drugs, both by adsorption and absorption, leading to the potential for altered kinetics, particularly clearance (...) as deemed appropriate. If doubt persists, diagnosing death using neurological criteria should be abandoned and consideration given to undertaking ancillary investigations. Apnoea Testing Extracorporeal clearance of CO2 must be taken into account when performing apnoea testing on ECMO, and sweep gas flow titrated carefully to avoid large-scale, acute changes in cerebral PaCO2. In venovenous (VV) ECMO, the cerebral PaCO2 is identical to the PaCO2 at all peripheral arterial blood gas sampling sites

2018 Faculty of Intensive Care Medicine

83. Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused

Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused - GOV.UK GOV.UK uses cookies to make the site simpler. Search Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused Following receipt of a third case of fatal medication error caused by the administration of Fungizone (a non-lipid (...) that feed into the Background Parenteral amphotericin B is available as lipid-based (AmBisome, Abelcet) and non-lipid-based (Fungizone) formulations for the treatment of severe fungal infections. These different formulations of amphotericin B have different dose requirements. The appropriate dose and method of administration differ markedly between the marketed parenteral formulations of amphotericin B and they are therefore not interchangeable. Amphotericin B overdoses may result in potentially fatal

2018 MHRA Drug Safety Update

84. Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children

Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children - GOV.UK GOV.UK uses cookies to make the site simpler. Search Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children Provide clear information to patients and caregivers about how (...) , and ). In 2014, following an EU review, advice on minimising risk of accidental transfer added to Summary of Product Characteristics and the Patient Information Leaflet for transdermal fentanyl products. Reports of accidental exposure to transdermal fentanyl We continue to receive reports of preventable accidental transfer of fentanyl patches. Since July 2014 and up to October 2018, we have received 5 reports of fatal incidents specifying accidental exposure, accidental overdose, or product adhesion issue

2018 MHRA Drug Safety Update

85. A Case of Fatal Colonic Perforation without Abdominal Exam Findings

A Case of Fatal Colonic Perforation without Abdominal Exam Findings Spotlight: A Case of Fatal Colonic Perforation without Abdominal Exam Findings – Clinical Correlations Search Spotlight: A Case of Fatal Colonic Perforation without Abdominal Exam Findings June 14, 2018 6 min read By Christopher Sonne, MD Peer reviewed Learning Objectives: 1. Understand the pathophysiology of peritonitis secondary to bowel perforation. 2. Understand how classic findings of peritonitis can be absent in some

2018 Clinical Correlations

86. Improved Quality of Death and Dying in Care Homes: A Palliative Care Stepped Wedge Randomized Control Trial in Australia Full Text available with Trip Pro

Improved Quality of Death and Dying in Care Homes: A Palliative Care Stepped Wedge Randomized Control Trial in Australia Mortality in care homes is high, but care of dying residents is often suboptimal, and many services do not have easy access to specialist palliative care. This study examined the impact of providing specialist palliative care on residents' quality of death and dying.Using a stepped wedge randomized control trial, care homes were randomly assigned to crossover from control (...) triage meetings to discuss residents at risk of dying without a plan in place. They are chaired by a specialist palliative care clinician and attended by care home staff. A checklist is followed to guide discussions and outcomes, focused on anticipatory planning.This article reports secondary outcomes of staff perceptions of residents' quality of death and dying, care home staff confidence, and completion of advance care planning documentation. We assessed (1) quality of death and dying, and (2

2019 EvidenceUpdates

87. The art of life and death: 14 year follow-up analyses of associations between arts engagement and mortality in the English Longitudinal Study of Ageing. Full Text available with Trip Pro

.Self reported receptive arts engagement (going to museums, art galleries, exhibitions, the theatre, concerts, or the opera).Mortality measured through data linkage to the National Health Service central register.People who engaged with receptive arts activities on an infrequent basis (once or twice a year) had a 14% lower risk of dying at any point during the follow-up (809/3042 deaths, hazard ratio 0.86, 95% confidence interval 0.77 to 0.96) compared with those who never engaged (837/1762 deaths (...) The art of life and death: 14 year follow-up analyses of associations between arts engagement and mortality in the English Longitudinal Study of Ageing. To explore associations between different frequencies of arts engagement and mortality over a 14 year follow-up period.Prospective cohort study.English Longitudinal Study of Ageing cohort of 6710 community dwelling adults aged 50 years and older (53.6% women, average age 65.9 years, standard deviation 9.4) who provided baseline data in 2004-05

2019 BMJ

88. High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation Full Text available with Trip Pro

High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested

2020 NIHR HTA programme

89. Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT Full Text available with Trip Pro

Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try

2020 NIHR HTA programme

90. Clinical Frailty Scale in prediction of mortality, disability and quality of life for patients in need of intensive care

that, there will be patients who are assessed as having a high level of frailty but do not die within 30 days, as well as patients who are assessed as having a low level of frailty but that nevertheless die. Table 1. Identified studies according to age and outcome (reference, risk of bias) a Measures disability or death at 6 months as a combined endpoint. b Also presents 1-year mortality. c Also presents 6 months mortality. d These articles are based on the same patient material. Outcome Age ICU mortality In-hospital (...) Clinical Frailty Scale in prediction of mortality, disability and quality of life for patients in need of intensive care Clinical Frailty Scale in prediction of mortality, disability and quality of life for patients in need of intensive care We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Clinical Frailty Scale in prediction of mortality

2020 Swedish Council on Technology Assessement

91. Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT Full Text available with Trip Pro

Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website (...) search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Annual mammography screening at ages 40 49 years conferred a reduction in breast cancer mortality, which was attenuated after 10 years. {{author}} {{($index , , , , , , , , , , , , & . Stephen Duffy 1, * , Daniel Vulkan 1 , Howard Cuckle 2 , Dharmishta Parmar 1 , Shama Sheikh 3 , Robert Smith 4 , Andrew Evans 5 , Oleg Blyuss 1 , Louise Johns 3 , Ian

2020 NIHR HTA programme

92. Effects of neonatal nutrition interventions on neonatal mortality and child health and development outcomes

language summary Title: Effects of neonatal nutrition interventions on neonatal mortality and child health and development outcomes Library Image: See the full review: https://onlinelibrary.wiley.com/doi/abs/10.1002/cl2.1141 English: PLAIN LANGUAGE SUMMARY Neonatal probiotic supplementation can improve infant illness and reduce death, but vitamin A does not, and may have adverse effects Nutritional support during the first month of life is vital for the short- and long-term survival of the newborn (...) of probiotics administered to neonates in home/community settings in low- and middle-income countries. How up-to-date is this review? The review authors searched for studies published up to November 2019. More in this category: Select language: PLAIN LANGUAGE SUMMARY Neonatal probiotic supplementation can improve infant illness and reduce death, but vitamin A does not, and may have adverse effects Nutritional support during the first month of life is vital for the short- and long-term survival

2021 Campbell Collaboration

93. Do Systemic Corticosteroids Reduce Mortality in Critically Ill Adult Patients With COVID-19? Full Text available with Trip Pro

. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366 : l4898 Results Tabled 1 Odds ratio of mortality in patients given corticosteroids versus control. Intervention No. of Deaths/Total Patients (%) OR (95% CI) Steroids Control Overall 222/678 (32.7) 425/1,025 (41.5) 0.66 (0.53–0.82) OR , Odds ratio; CI , confidence interval. The meta-analysis included 7 randomized studies comprising 1,703 patients. Sterne JAC, Murthy S, Diaz JV, et al; WHO Rapid Evidence Appraisal (...) Do Systemic Corticosteroids Reduce Mortality in Critically Ill Adult Patients With COVID-19? Do Systemic Corticosteroids Reduce Mortality in Critically Ill Adult Patients With COVID-19? - Annals of Emergency Medicine Login to your account Email/Username Password Remember me Don’t have an account? ACEP Member Login ACEP Members, full access to the journal is a member benefit. Use your society credentials to access all journal content and features. If you don't remember your password, you can

2021 Annals of Emergency Medicine Systematic Review Snapshots

94. Does Therapeutic Hypothermia Improve Mortality and Neurologic Outcome in Critically Ill Patients?

Does Therapeutic Hypothermia Improve Mortality and Neurologic Outcome in Critically Ill Patients? Does Therapeutic Hypothermia Improve Mortality and Neurologic Outcome in Critically Ill Patients? - Annals of Emergency Medicine Login to your account Email/Username Password Remember me Don’t have an account? ACEP Member Login ACEP Members, full access to the journal is a member benefit. Use your society credentials to access all journal content and features. If you don't remember your password (...) , you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password Email* If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password Go search Please enter a term before submitting your search. , P374-376, March 01, 2021 Powered By Mendeley Share on Does Therapeutic Hypothermia Improve Mortality and Neurologic Outcome in Critically

2021 Annals of Emergency Medicine Systematic Review Snapshots

95. Beyond maternal death: improving the quality of maternal care through national studies of ?near-miss? maternal morbidity Full Text available with Trip Pro

Beyond maternal death: improving the quality of maternal care through national studies of ?near-miss? maternal morbidity Beyond maternal death: Improving the quality of maternal care through national studies of near-miss maternal morbidity Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find

2016 NIHR HTA programme

96. Infant deaths in the UK community following successful cardiac surgery: building the evidence base for optimal surveillance, a mixed-methods study Full Text available with Trip Pro

Infant deaths in the UK community following successful cardiac surgery: building the evidence base for optimal surveillance, a mixed-methods study Infant deaths in the UK community following successful cardiac surgery: building the evidence base for optimal surveillance, a mixed-methods study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from

2016 NIHR HTA programme

97. Brain death, the determination of brain death, and member guidance for brain death accommodation requests: AAN position statement. Full Text available with Trip Pro

Brain death, the determination of brain death, and member guidance for brain death accommodation requests: AAN position statement. The American Academy of Neurology holds the following positions regarding brain death and its determination, and provides the following guidance to its members who encounter resistance to brain death, its determination, or requests for accommodation including continued use of organ support technology despite neurologic determination of death.© 2019 American Academy

2019 Neurology

98. Relative toxicity of analgesics commonly used for intentional self-poisoning: A study of case fatality based on fatal and non-fatal overdoses. Full Text available with Trip Pro

deaths the case fatality index of dihydrocodeine was considerably elevated (odds ratio (OR) 12.81, 95% Confidence Interval (CI) 10.19-16.12). Case fatality indices for tramadol (OR 4.05, 95% CI 3.38-4.85) and codeine (OR 2.21, 95% CI 1.81-2.70) were also significantly higher than for paracetamol. The results when multiple drug deaths were included produced similar results. The relative toxicity of co-proxamol far exceeded that of the other analgesics.Data on fatal self-poisonings were based (...) Relative toxicity of analgesics commonly used for intentional self-poisoning: A study of case fatality based on fatal and non-fatal overdoses. Analgesics are used most frequently in fatal and non-fatal medicinal self-poisonings. Knowledge about their relative toxicity in overdose is important for clinicians and regulatory agencies.Using data for 2005-2012 we investigated case fatality (number of suicides relative to number of non-fatal self-poisonings) of paracetamol, aspirin, codeine

2019 Journal of Affective Disorders

99. Trends in modes of death in heart failure over the last two decades: less sudden death but cancer deaths on the rise. Full Text available with Trip Pro

Trends in modes of death in heart failure over the last two decades: less sudden death but cancer deaths on the rise. Better management of heart failure (HF) over the past two decades has improved survival, mainly by reducing the incidence of death due to cardiovascular (CV) causes. Deaths due to non-CV causes, particularly cancer, may be increasing. This study explored the modes of death of consecutive patients who attended a HF clinic over 17 years.A total of 935 deaths were ascertained from (...) = 0.26), and a significant increase in non-CV modes of death (P < 0.001). Non-CV deaths accounted for 17.4% of deaths in 2002 and 65.8% of deaths in 2018. A total 138 deaths were due to cancer (37% of non-CV deaths). A significant trend was observed towards a progressive increase in cancer deaths over time (P = 0.002). The main mode of cancer mortality was lung cancer.The modes of death in HF have shifted over the last two decades. Patients with HF die less due to sudden death and more due to non-CV

2019 European Journal of Heart Failure

100. Excess winter deaths and illness and the health risks associated with cold homes

. This represented the lowest figure since 1950/51 and reflects a prolonged period of milder than average weather after November 2013. The 5-year moving average shows a decreasing trend in recent years up to 2005/06, after which there has been a gradual rise (Statistical bulletin: excess winter mortality in England and Wales, 2013/14 Office for National Statistics). It is too early to tell whether the low figures for 2013/14 represent a new downward trend. Most excess winter deaths and illnesses are not caused (...) of heating and their potential exposure to an inadequately heated home. Excess winter deaths and illness and the health risks associated with cold homes (NG6) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 23 of 58Excess winter deaths are more common among, but are by no means confined to, older people. In 2013/14 ('Statistical bulletin: excess winter mortality in England and Wales, 2013/14'): 51% of cold-related deaths

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

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