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61. Identifying Child Abuse Fatalities During Infancy

, including baptism, grief counseling, funeral arrangements, religious support, resolution of breastfeeding, and the reactions of surviving siblings. All parents can be provided with information about sudden unexpected infant death and how to contact the medical examiner’s or coroner’s office and local support groups. – Investigation It continues to be difficult to distinguish fatal child abuse by autopsy alone. , In the absence of a complete investigation of the circumstances of death and case review (...) prevention . Deans KJ , Thackeray J , Askegard-Giesmann JR , et al . Mortality increases with recurrent episodes of nonaccidental trauma in children . Farrell CA , Fleegler EW , Monuteaux MC , et al . Community poverty and child abuse fatalities in the United States . Putnam-Hornstein E , Schneiderman JU , Cleves MA , Magruder J , Krous HF . A prospective study of sudden unexpected infant death after reported maltreatment . Putnam-Hornstein E , Cleves MA , Licht R , Needell B . Risk of fatal injury

2019 American Academy of Pediatrics

62. Carfilzomib (Kyprolis): reminder of risk of potentially fatal cardiac events

lenalidomide and dexamethasone or dexamethasone alone for the treatment of adult patients with multiple myeloma who have received at least 1 prior therapy. Carfilzomib has been associated with new or worsening cardiac failure, decreased ejection fraction, pericarditis, atrial fibrillation, tachycardia, myocardial ischaemia, and myocardial infarction – see . Death due to cardiac arrest has occurred within a day of carfilzomib administration and fatal outcomes have also been reported following cardiac (...) Carfilzomib (Kyprolis): reminder of risk of potentially fatal cardiac events Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events Anti-cancer therapy with carfilzomib has been associated with cases of cardiac arrest, cardiac failure, and myocardial infarction

2019 MHRA Drug Safety Update

63. Consent for organ and tissue donation after death

Consent for organ and tissue donation after death MEMBER BRIEFING Consent for organ and tissue donation after deathCONSENT FOR ORGAN AND TISSUE DONATION AFTER DEATH 2 Consent for organ and tissue donation after death This briefing is intended to provide background information to RCN members across the UK who wish to complete the RCN survey on consent for organ and tissue donation after death. The survey will be open from 15 January to 11 February 2018. Why is the RCN reviewing its UK position (...) for organ and tissue donation after death. This factual briefing is intended to help inform RCN members, who we are encouraging to complete a short survey to support that review. The RCN’s reviewed position will be available in spring 2018. Some members will be dealing with these issues every day; many others will not. Whatever your experiences and wherever you live and work, we want to hear your views as a member. The issues surrounding organ and tissue donation are varied and complex. Not every issue

2018 Royal College of Nursing

64. Guidelines for the Role of the Registered Nurse and Advanced Practice Registered Nurse When Hastened Death is Requested

and Advanced Practice Registered Nurse When Hastened Death is Requested This position statement was endorsed by the ONS Board in September 2019 and was republished with permission from the Hospice and Palliative Nurses Association (HPNA). Position Statement People living with advanced illnesses who want to hasten death or avoid prolongation of dying have various options available to them. The Patient Self Determination Act1 allows patients to refuse or stop life-sustaining therapies (e.g., ventilator (...) The essence of nursing is care for patients across the life cycle. Palliative and hospice nurses focus on the promotion of quality of life to enable patients to live as fully as possible, on their terms, from diagnosis to death. Because the trajectory of dying has changed and people are living longer with progressive debilitating diseases, palliative and hospice nurses care for patients in a variety of settings including acute care, critical care, clinic, home care, long-term care, and hospice care

2019 Oncology Nursing Society Putting Evidence into Practice (PEP)

65. Learning disabilities: Dementia is strongly linked to Down syndrome and contributes to early death in people with Down syndrome

Learning disabilities: Dementia is strongly linked to Down syndrome and contributes to early death in people with Down syndrome Dementia is strongly linked to Down syndrome and contributes to early death in people with Down syndrome | Evidence-Based Nursing Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Dementia is strongly linked to Down syndrome and contributes to early death in people with Down syndrome Article Text Commentary Learning disabilities Dementia is strongly linked to Down syndrome and contributes to early death in people with Down syndrome Gareth S Parsons Statistics from Altmetric.com Commentary on: Hithersay R, Startin CM, Hamburg S, et al . Association

2020 Evidence-Based Nursing

66. Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT Full Text available with Trip Pro

Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation (...) or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Permissive hypotension did not significantly reduce mortality at 90 days compared to usual care, in critically ill people aged 65 and over receiving vasopressors for vasodilatory hypotension. {{author}} {{($index , , , , , , , , , , , , , , , & . Paul R Mouncey 1, * , Alvin Richards-Belle 1 , Karen Thomas 1 , David A Harrison 1 , M Zia

2021 NIHR HTA programme

67. Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT Full Text available with Trip Pro

Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue (...) }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This trial found that 3.2% of people treated with adrenaline following out-of-hospital cardiac arrest survived to 30 days, compared with 2.4% of people receiving placebo. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & . Gavin D Perkins 1, 2, * , Chen Ji 1 , Felix Achana 1 , John JM Black 3 , Karl Charlton 4 , James Crawford 1 , Adam de Paeztron 1 , Charles Deakin 5 , Mark Docherty 6 , Judith Finn 7

2021 NIHR HTA programme

68. Randomised controlled trial: In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120?mm?Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from

Randomised controlled trial: In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120?mm?Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause | BMJ (...) OR managers of institutional accounts Username * Password * your user name or password? You are here In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause Article Text Therapeutics/Prevention Randomised controlled trial In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure

2016 Evidence-Based Medicine

69. Normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem death

were 89% and 79% respectively (not significant). 4.5 Specialist advisers listed the following as key efficacy outcomes: an increase in preservation times; a decrease in ischaemia times, the need for organ reconditioning, length of stay in an intensive care unit, primary graft function, and 30-day survival or mortality rates; and an increase in the number of hearts available for transplantation. 5 5 Safety Safety This section describes safety outcomes from the published literature that the Committee (...) Normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem death Normothermic e Normothermic extr xtracorporeal preservation of acorporeal preservation of hearts for tr hearts for transplantation following donation ansplantation following donation after br after brainstem death ainstem death Interventional procedures guidance Published: 24 February 2016 nice.org.uk/guidance/ipg549 Y Y our responsibility our responsibility This guidance represents

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

70. Survival, Nonrelapse Mortality, and Relapse-Related Mortality After Allogeneic Hematopoietic Cell Transplantation: Comparing 2003-2007 Versus 2013-2017 Cohorts. Full Text available with Trip Pro

Survival, Nonrelapse Mortality, and Relapse-Related Mortality After Allogeneic Hematopoietic Cell Transplantation: Comparing 2003-2007 Versus 2013-2017 Cohorts. Allogeneic hematopoietic cell transplantation is indicated for refractory hematologic cancer and some nonmalignant disorders. Survival is limited by recurrent cancer and organ toxicity.To determine whether survival has improved over the past decade and note impediments to better outcomes.The authors compared cohorts that had transplants (...) during 2003 to 2007 versus 2013 to 2017. Survival outcome measures were analyzed, along with transplant-related complications.A center performing allogeneic transplant procedures.All recipients of a first allogeneic transplant during 2003 to 2007 and 2013 to 2017.Patients received a conditioning regimen, infusion of donor hematopoietic cells, then immunosuppressive drugs and antimicrobial approaches to infection control.Day-200 nonrelapse mortality (NRM), recurrence or progression of cancer, relapse

2020 Annals of Internal Medicine

71. Tackling the causes of premature mortality (early death)

Tackling the causes of premature mortality (early death) Tackling the causes of premature mortality (early death) | Advice | NICE Tackling the causes of premature mortality (early death) Local government briefing [LGB26] Published date: February 2015 Advice Between 2012 and 2015 we developed a series of local government briefings for a range of public health topics. We no longer have the capacity to maintain these to an acceptable standard and the information is now out of date, so these were

2015 National Institute for Health and Clinical Excellence - Advice

72. In the aftermath of a perioperative death: who cares for the clinician? Full Text available with Trip Pro

In the aftermath of a perioperative death: who cares for the clinician? In the aftermath of a perioperative death: who cares for the clinician? | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here In the aftermath of a perioperative death: who cares for the clinician? Article Text Editorial In the aftermath of a perioperative death: who cares for the clinician? Daniel Rodger 1 , Heather Hartley 2 , 3 Statistics from Altmetric.com Working

2019 Evidence-Based Nursing

73. Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome

Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public (...) of predictive score in sudden cardiac death for patients with Brugada syndrome , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 l'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France. 2 CHU de Nantes, INSERM, CIC 1413, Pôle Hospitalo-Universitaire 11: Santé Publique, Clinique des données, Nantes, France. 3 l'institut du thorax, Service de cardiologie, CHU Nantes, France. 4 Service de Cardiologie, Institut Lyric, CHU de Bordeaux, Bordeaux, France. 5 Service de

2021 EvidenceUpdates

74. Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis Full Text available with Trip Pro

Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation (...) : ( ) Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Review Ann Fam Med Actions . 2020 Nov;18(6):545-552. doi: 10.1370/afm.2582. Cancer-Specific Mortality, All

2021 EvidenceUpdates

75. Predicting readmission and death after hospital discharge: a comparison of conventional frailty measurement with an electronic health record-based score

of discharge. Methods: patients underwent Fried, Short Physical Performance Battery (SPPB), PRISMA-7 and Clinical Frailty Scale (CFS) assessments. An EHR risk score was derived from the proportion of 31 possible frailty markers present. Electronic follow-up was completed for a primary outcome of 90-day readmission or death. Secondary outcomes were mortality and days alive at home ('home time') at 12 months. Results: in total, 186 patients were included (79 ± 6 years old, 64% males). The primary outcome (...) Predicting readmission and death after hospital discharge: a comparison of conventional frailty measurement with an electronic health record-based score Predicting readmission and death after hospital discharge: a comparison of conventional frailty measurement with an electronic health record-based score - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2021 EvidenceUpdates

76. Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study Full Text available with Trip Pro

independent high-risk factors associated with fatal outcome. We developed the nomogram for identifying survival of severe COVID-19 patients in the training cohort (AUC = 0.900, 95% CI 0.841-0.960, sensitivity 95.5%, specificity 77.5%); in validation cohort 1 (AUC = 0.811, 95% CI 0.763-0.961, sensitivity 77.3%, specificity 73.5%); in validation cohort 2 (AUC = 0.862, 95% CI 0.698-0.924, sensitivity 92.9%, specificity 64.5%). The calibration curve for probability of death indicated a good consistence (...) , and to develop more appropriate treatment strategies to reduce the mortality of severe patients. Tocilizumab may improve the prognosis of severe COVID-19 patients with high levels of IL-6. Keywords: Nomogram; Prediction; Severe COVID-19; Survival. Conflict of interest statement The authors declare that they have no competing interests. Figures Fig. 1 Risk prediction nomogram for patients… Fig. 1 Risk prediction nomogram for patients with COVID-19 Fig. 1 Risk prediction nomogram for patients with COVID-19 Fig

2021 EvidenceUpdates

77. Pretreatment With Mifepristone Compared With Misoprostol Alone for Delivery After Fetal Death Between 14 and 28 Weeks of Gestation: A Randomized Controlled Trial

Pretreatment With Mifepristone Compared With Misoprostol Alone for Delivery After Fetal Death Between 14 and 28 Weeks of Gestation: A Randomized Controlled Trial Pretreatment With Mifepristone Compared With Misoprostol Alone for Delivery After Fetal Death Between 14 and 28 Weeks of Gestation: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Obstet Gynecol Actions . 2021 May 1;137(5):801-809. doi: 10.1097/AOG.0000000000004344. Pretreatment With Mifepristone Compared With Misoprostol Alone for Delivery After Fetal Death Between 14 and 28 Weeks of Gestation: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliation 1 Division

2021 EvidenceUpdates

78. Mortality in psoriatic arthritis: Risk, causes of death, predictors for death. (Abstract)

Mortality in psoriatic arthritis: Risk, causes of death, predictors for death. Mortality studies in psoriatic arthritis (PsA) have provided inconsistent results. This study aimed to: 1) Estimate trends in mortality rates among PsA patients over calendar time; 2) Evaluate cause-specific mortality rates in patients with PsA compared to the general population; 3) Identify predictors for mortality in PsA.The study was carried out at the University of Toronto Psoriatic Arthritis Clinic where (...) patients are followed prospectively according to a standard protocol at 6- to 12- month intervals. Standardized mortality ratios (SMRs) were calculated overall, by age, and by sex with reference to the Ontario population. Causes of death were recorded by ICD9 and ICD10 codes and cause-specific SMRs were computed. Cox regression models were used to identify predictors for mortality among PsA patients.Among 1490 patients followed over 15062.8 patient-years, 225 (15%) confirmed deaths were recorded (111

2020 Seminars in arthritis and rheumatism

79. Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Full Text available with Trip Pro

Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Inhibition of the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis in combination with radiotherapy may be a promising approach to treat cancer. In the present study, we aimed to evaluate serum soluble PD-1/PD-L1 levels in patients with advanced rectal cancer treated (...) with neoadjuvant chemoradiotherapy (CRT).Serum soluble PD-L1 and PD-1 levels were measured using an enzyme-linked immunosorbent assay before and after CRT in 117 patients with low rectal cancer. Changes in the levels of sPD-L1/PD-1 after CRT, and the correlation between sPD-L1/PD-1 level and clinicopathological characteristics or disease-free survival (DFS) were evaluated.sPD-L1 levels significantly increased after CRT (p < 0.0001), whereas sPD-1 levels did not change significantly (p = 0.1050). High sPD-L1

2019 PLoS ONE

80. Cross sectional analysis of Chicago vs suburban Cook County suicide deaths among 10–24-year-olds in the Illinois violent death reporting system Full Text available with Trip Pro

Cross sectional analysis of Chicago vs suburban Cook County suicide deaths among 10–24-year-olds in the Illinois violent death reporting system In 2014, suicide was the second leading cause of death among 10- to 24-year-olds in the US. Studies note disparities in youth suicide based on sex, race/ethnicity, and urban vs rural settings. This study investigates demographics, mental health indicators, and other circumstances surrounding youth/young adult deaths by suicide, comparing Chicago (...) and suburban Cook County from 2005 to 2010.Using the Illinois Violent Death Reporting System (IVDRS), we employed a cross-sectional design to provide descriptive analysis of decedents in three age groups (10-14, 15-19, and 20-24 years) in two geographic areas: urban (city of Chicago) and suburban (suburban Cook County) between January 1, 2005 and December 31, 2010. We used chi-square testing to test for significant differences in each age group by demographics, mental health indicators, and suicide markers

2018 Injury epidemiology

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